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Martinus E Huigens - One of the best experts on this subject based on the ideXlab platform.

  • Anti-Aphrodisiac Compounds of Male Butterflies Increase the Risk of Egg Parasitoid Attack by Inducing Plant Synomone Production
    2013
    Co-Authors: Nina E Fatouros, Martinus E Huigens, Foteini G Pashalidou, Wilma Aponte V. Cordero, R. Mumm, M. Dicke, W. Aponte V. Cordero, M. Hilker
    Abstract:

    # The Author(s) 2009. This article is published with open access at Springerlink.com Abstract During mating in many butterfly species, males transfer spermatophores that contain anti-Aphrodisiacs to females that repel conspecific males. For example, males of the large cabbage white, Pieris brassicae (Lepidoptera: Pieridae), transfer the anti-Aphrodisiac, benzyl cyanide (BC) to females. Accessory reproductive gland (ARG) secretion of a mated female P. brassicae that is deposited with an egg clutch contains traces of BC, inducing Brussels sprouts plants (Brassica oleracea var. gemmifera) to arrest certain Trichogramma egg parasitoids. Here, we assessed whether deposition of one egg at a time by the closely related small cabbage white, Pieris rapae, induced B. oleracea var

  • Risk of Egg Parasitoid Attraction Depends on Anti-Aphrodisiac Titre in the Large Cabbage White Butterfly Pieris brassicae
    Journal of Chemical Ecology, 2011
    Co-Authors: Martinus E Huigens, Erik Swart, R. Mumm
    Abstract:

    Males of a variety of insects transfer an anti-Aphrodisiac pheromone to females during mating that renders them less attractive to conspecific males. In cabbage white butterflies, the transfer of an anti-Aphrodisiac can result in the unwanted attraction of tiny egg parasitoid wasps of the genus Trichogramma that hitch-hike with mated female butterflies to a host plant where they parasitize the freshly laid butterfly eggs. Here, we show that the anti-Aphrodisiac benzyl cyanide (BC) of the large cabbage white Pieris brassicae is depleted by frequent display of the mate-refusal posture that signals a female’s unreceptivity to mating. This depletion of BC is ecologically important because it results in a reduced risk of attracting the hitch-hiking egg parasitoid Trichogramma brassicae to mated female butterflies over time since mating. Our results indicate for the first time that a reduction in anti-Aphrodisiac titre in mated females due to frequent adoption of the mate-refusal posture is beneficial to both mated females and males particularly when parasitoid pressure is high.

  • chemical espionage on species specific butterfly anti Aphrodisiacs by hitchhiking trichogramma wasps
    Behavioral Ecology, 2010
    Co-Authors: Martinus E Huigens, Jozef B Woelke, Foteini G Pashalidou, Tibor Bukovinszky, Hans M Smid, Nina E Fatouros
    Abstract:

    Parasitic wasps employ a wide range of chemical cues to find their hosts. Very recently, we discovered how 2 closely related egg parasitoids, Trichogramma brassicae and Trichogramma evanescens, exploit the anti-Aphrodisiac pheromone benzyl cyanide of one of their hosts, the gregarious large cabbage white butterfly Pieris brassicae that deposits a clutch of more than 20 eggs per oviposition bout. The pheromone is transferred by male butterflies to females during mating to enforce female monogamy. On detecting the anti-Aphrodisiac, the tiny parasitic wasps ride on a mated female butterfly to a host plant and then parasitize her freshly laid eggs. The present study demonstrates that both wasp species similarly exploit the anti-Aphrodisiac mixture of methyl salicylate and indole of another host, the more common solitary small cabbage white butterfly Pieris rapae that deposits only one egg at a time. Interestingly, this behavior is innate in T. brassicae, whereas T. evanescens learns it after one successful ride on a mated female butterfly. Moreover, we show that the wasps only respond to the anti-Aphrodisiacs of the 2 cabbage white butterflies when the ubiquitous compounds are part of a complete mated female odor blend. Obviously, parasitic wasps use the sophisticated espionage-and-ride strategy to find eggs of different gregarious and solitary host species. From the wasps' perspective there seems to be a trade-off between the abundance and egg-laying behavior of the butterflies. Our findings suggest that Pieris butterflies are under strong selective pressure to minimize the use of an anti-Aphrodisiac. Copyright 2010, Oxford University Press.

  • Chemical espionage on species-specific butterfly anti-Aphrodisiacs by hitchhiking Trichogramma wasps
    Behavioral Ecology, 2010
    Co-Authors: Martinus E Huigens, Jozef B Woelke, Foteini G Pashalidou, Tibor Bukovinszky, Hans Smid, Nina E Fatouros
    Abstract:

    Parasitic wasps employ a wide range of chemical cues to find their hosts. Very recently, we discovered how 2 closely related egg parasitoids, Trichogramma brassicae and Trichogramma evanescens, exploit the anti-Aphrodisiac pheromone benzyl cyanide of one of their hosts, the gregarious large cabbage white butterfly Pieris brassicae that deposits a clutch of more than 20 eggs per oviposition bout. The pheromone is transferred by male butterflies to females during mating to enforce female monogamy. On detecting the anti-Aphrodisiac, the tiny parasitic wasps ride on a mated female butterfly to a host plant and then parasitize her freshly laid eggs. The present study demonstrates that both wasp species similarly exploit the anti-Aphrodisiac mixture of methyl salicylate and indole of another host, the more common solitary small cabbage white butterfly Pieris rapae that deposits only one egg at a time. 'Interestingly, this behavior is innate in T brassicae, whereas T evanescens learns it after one successful ride on a mated female butterfly. Moreover, we show that the wasps only respond to the anti-Aphrodisiacs of the 2 cabbage white butterflies when the ubiquitous compounds are part of a complete mated female odor blend. Obviously, parasitic wasps use the sophisticated espionage-and-ride strategy to find eggs of different gregarious and solitary host species. From the wasps' perspective there seems to be a trade-off between the abundance and egg-laying behavior of the butterflies. Our findings suggest that Pieris butterflies are under strong selective pressure to minimize the use of an anti-Aphrodisiac.

  • anti Aphrodisiac compounds of male butterflies increase the risk of egg parasitoid attack by inducing plant synomone production
    Journal of Chemical Ecology, 2009
    Co-Authors: Nina E Fatouros, Foteini G Pashalidou, Wilma Aponte V. Cordero, R. Mumm, M. Dicke, M. Hilker, Joop J A Van Loon, Martinus E Huigens
    Abstract:

    During mating in many butterfly species, males transfer spermatophores that contain anti-Aphrodisiacs to females that repel conspecific males. For example, males of the large cabbage white, Pieris brassicae (Lepidoptera: Pieridae), transfer the anti-Aphrodisiac, benzyl cyanide (BC) to females. Accessory reproductive gland (ARG) secretion of a mated female P. brassicae that is deposited with an egg clutch contains traces of BC, inducing Brussels sprouts plants (Brassica oleracea var. gemmifera) to arrest certain Trichogramma egg parasitoids. Here, we assessed whether deposition of one egg at a time by the closely related small cabbage white, Pieris rapae, induced B. oleracea var. gemmifera to arrest Trichogramma wasps, and whether this plant synomone is triggered by substances originating from male P. rapae seminal fluid. We showed that plants induced by singly laid eggs of P. rapae arrest T. brassicae wasps three days after butterfly egg deposition. Elicitor activity was present in ARG secretion of mated female butterflies, whereas the secretion of virgin females was inactive. Pieris rapae used a mixture of methyl salicylate (MeSA) and indole as an anti-Aphrodisiac. We detected traces of both anti-Aphrodisiacal compounds in the ARG secretion of mated female P. rapae, whereas indole was lacking in the secretion of virgin female P. rapae. When applied onto the leaf, indole induced changes in the foliar chemistry that arrested T. brassicae wasps. This study shows that compounds of male seminal fluid incur possible fitness costs for Pieris butterflies by indirectly promoting egg parasitoid attack.

Nina E Fatouros - One of the best experts on this subject based on the ideXlab platform.

  • Anti-Aphrodisiac Compounds of Male Butterflies Increase the Risk of Egg Parasitoid Attack by Inducing Plant Synomone Production
    2013
    Co-Authors: Nina E Fatouros, Martinus E Huigens, Foteini G Pashalidou, Wilma Aponte V. Cordero, R. Mumm, M. Dicke, W. Aponte V. Cordero, M. Hilker
    Abstract:

    # The Author(s) 2009. This article is published with open access at Springerlink.com Abstract During mating in many butterfly species, males transfer spermatophores that contain anti-Aphrodisiacs to females that repel conspecific males. For example, males of the large cabbage white, Pieris brassicae (Lepidoptera: Pieridae), transfer the anti-Aphrodisiac, benzyl cyanide (BC) to females. Accessory reproductive gland (ARG) secretion of a mated female P. brassicae that is deposited with an egg clutch contains traces of BC, inducing Brussels sprouts plants (Brassica oleracea var. gemmifera) to arrest certain Trichogramma egg parasitoids. Here, we assessed whether deposition of one egg at a time by the closely related small cabbage white, Pieris rapae, induced B. oleracea var

  • chemical espionage on species specific butterfly anti Aphrodisiacs by hitchhiking trichogramma wasps
    Behavioral Ecology, 2010
    Co-Authors: Martinus E Huigens, Jozef B Woelke, Foteini G Pashalidou, Tibor Bukovinszky, Hans M Smid, Nina E Fatouros
    Abstract:

    Parasitic wasps employ a wide range of chemical cues to find their hosts. Very recently, we discovered how 2 closely related egg parasitoids, Trichogramma brassicae and Trichogramma evanescens, exploit the anti-Aphrodisiac pheromone benzyl cyanide of one of their hosts, the gregarious large cabbage white butterfly Pieris brassicae that deposits a clutch of more than 20 eggs per oviposition bout. The pheromone is transferred by male butterflies to females during mating to enforce female monogamy. On detecting the anti-Aphrodisiac, the tiny parasitic wasps ride on a mated female butterfly to a host plant and then parasitize her freshly laid eggs. The present study demonstrates that both wasp species similarly exploit the anti-Aphrodisiac mixture of methyl salicylate and indole of another host, the more common solitary small cabbage white butterfly Pieris rapae that deposits only one egg at a time. Interestingly, this behavior is innate in T. brassicae, whereas T. evanescens learns it after one successful ride on a mated female butterfly. Moreover, we show that the wasps only respond to the anti-Aphrodisiacs of the 2 cabbage white butterflies when the ubiquitous compounds are part of a complete mated female odor blend. Obviously, parasitic wasps use the sophisticated espionage-and-ride strategy to find eggs of different gregarious and solitary host species. From the wasps' perspective there seems to be a trade-off between the abundance and egg-laying behavior of the butterflies. Our findings suggest that Pieris butterflies are under strong selective pressure to minimize the use of an anti-Aphrodisiac. Copyright 2010, Oxford University Press.

  • Chemical espionage on species-specific butterfly anti-Aphrodisiacs by hitchhiking Trichogramma wasps
    Behavioral Ecology, 2010
    Co-Authors: Martinus E Huigens, Jozef B Woelke, Foteini G Pashalidou, Tibor Bukovinszky, Hans Smid, Nina E Fatouros
    Abstract:

    Parasitic wasps employ a wide range of chemical cues to find their hosts. Very recently, we discovered how 2 closely related egg parasitoids, Trichogramma brassicae and Trichogramma evanescens, exploit the anti-Aphrodisiac pheromone benzyl cyanide of one of their hosts, the gregarious large cabbage white butterfly Pieris brassicae that deposits a clutch of more than 20 eggs per oviposition bout. The pheromone is transferred by male butterflies to females during mating to enforce female monogamy. On detecting the anti-Aphrodisiac, the tiny parasitic wasps ride on a mated female butterfly to a host plant and then parasitize her freshly laid eggs. The present study demonstrates that both wasp species similarly exploit the anti-Aphrodisiac mixture of methyl salicylate and indole of another host, the more common solitary small cabbage white butterfly Pieris rapae that deposits only one egg at a time. 'Interestingly, this behavior is innate in T brassicae, whereas T evanescens learns it after one successful ride on a mated female butterfly. Moreover, we show that the wasps only respond to the anti-Aphrodisiacs of the 2 cabbage white butterflies when the ubiquitous compounds are part of a complete mated female odor blend. Obviously, parasitic wasps use the sophisticated espionage-and-ride strategy to find eggs of different gregarious and solitary host species. From the wasps' perspective there seems to be a trade-off between the abundance and egg-laying behavior of the butterflies. Our findings suggest that Pieris butterflies are under strong selective pressure to minimize the use of an anti-Aphrodisiac.

  • anti Aphrodisiac compounds of male butterflies increase the risk of egg parasitoid attack by inducing plant synomone production
    Journal of Chemical Ecology, 2009
    Co-Authors: Nina E Fatouros, Foteini G Pashalidou, Wilma Aponte V. Cordero, R. Mumm, M. Dicke, M. Hilker, Joop J A Van Loon, Martinus E Huigens
    Abstract:

    During mating in many butterfly species, males transfer spermatophores that contain anti-Aphrodisiacs to females that repel conspecific males. For example, males of the large cabbage white, Pieris brassicae (Lepidoptera: Pieridae), transfer the anti-Aphrodisiac, benzyl cyanide (BC) to females. Accessory reproductive gland (ARG) secretion of a mated female P. brassicae that is deposited with an egg clutch contains traces of BC, inducing Brussels sprouts plants (Brassica oleracea var. gemmifera) to arrest certain Trichogramma egg parasitoids. Here, we assessed whether deposition of one egg at a time by the closely related small cabbage white, Pieris rapae, induced B. oleracea var. gemmifera to arrest Trichogramma wasps, and whether this plant synomone is triggered by substances originating from male P. rapae seminal fluid. We showed that plants induced by singly laid eggs of P. rapae arrest T. brassicae wasps three days after butterfly egg deposition. Elicitor activity was present in ARG secretion of mated female butterflies, whereas the secretion of virgin females was inactive. Pieris rapae used a mixture of methyl salicylate (MeSA) and indole as an anti-Aphrodisiac. We detected traces of both anti-Aphrodisiacal compounds in the ARG secretion of mated female P. rapae, whereas indole was lacking in the secretion of virgin female P. rapae. When applied onto the leaf, indole induced changes in the foliar chemistry that arrested T. brassicae wasps. This study shows that compounds of male seminal fluid incur possible fitness costs for Pieris butterflies by indirectly promoting egg parasitoid attack.

Sanjay Kasture - One of the best experts on this subject based on the ideXlab platform.

  • ethanolic extract of rubia peregrina l rubiaceae inhibits haloperidol induced catalepsy and reserpine induced orofacial dyskinesia
    Natural Product Research, 2012
    Co-Authors: Andrea Maxia, Maria Assunta Frau, Caterina Foddis, Maria Cristina Lancioni, Veena S. Kasture, Sanjay Kasture
    Abstract:

    In the traditional Sardinian system of medicine, Rubia peregrina L. (Rubiaceae) is reported as an Aphrodisiac herb. Since the Aphrodisiacs may also have antioxidant and dopaminergic activities, the aim of this study was to study the effect of ethanolic extract of aerial parts of R. peregrina for the scavenging of free DPPH radicals and the inhibition of haloperidol-induced catalepsy in mice and reserpine-induced orofacial dyskinesia in rats. The extract exhibited significant antioxidant activity in a free radical DPPH assay with IC50 = 55.6 µg mL−1, which was very close to IC50 of ascorbic acid. The extract of R. peregrina (100 and 200 mg kg−1 intraperitoneally, i.p.) significantly inhibited haloperidol (1 mg kg−1 i.p.) – induced catalepsy in mice (p < 0.01). In rats, the extract (200 mg kg−1 i.p.) significantly (p < 0.01) inhibited the orofacial dyskinesia induced by intraperitoneal administration of reserpine (1 mg kg−1 on days 1, 3 and 5). This study demonstrates that R. peregrina has antioxidant activ...

  • Ethanolic extract of Rubia peregrina L. (Rubiaceae) inhibits haloperidol-induced catalepsy and reserpine-induced orofacial dyskinesia.
    Natural Product Research, 2011
    Co-Authors: Andrea Maxia, Maria Assunta Frau, Caterina Foddis, Maria Cristina Lancioni, Veena S. Kasture, Sanjay Kasture
    Abstract:

    In the traditional Sardinian system of medicine, Rubia peregrina L. (Rubiaceae) is reported as an Aphrodisiac herb. Since the Aphrodisiacs may also have antioxidant and dopaminergic activities, the aim of this study was to study the effect of ethanolic extract of aerial parts of R. peregrina for the scavenging of free DPPH radicals and the inhibition of haloperidol-induced catalepsy in mice and reserpine-induced orofacial dyskinesia in rats. The extract exhibited significant antioxidant activity in a free radical DPPH assay with IC50 = 55.6 µg mL−1, which was very close to IC50 of ascorbic acid. The extract of R. peregrina (100 and 200 mg kg−1 intraperitoneally, i.p.) significantly inhibited haloperidol (1 mg kg−1 i.p.) – induced catalepsy in mice (p 

Foteini G Pashalidou - One of the best experts on this subject based on the ideXlab platform.

  • Anti-Aphrodisiac Compounds of Male Butterflies Increase the Risk of Egg Parasitoid Attack by Inducing Plant Synomone Production
    2013
    Co-Authors: Nina E Fatouros, Martinus E Huigens, Foteini G Pashalidou, Wilma Aponte V. Cordero, R. Mumm, M. Dicke, W. Aponte V. Cordero, M. Hilker
    Abstract:

    # The Author(s) 2009. This article is published with open access at Springerlink.com Abstract During mating in many butterfly species, males transfer spermatophores that contain anti-Aphrodisiacs to females that repel conspecific males. For example, males of the large cabbage white, Pieris brassicae (Lepidoptera: Pieridae), transfer the anti-Aphrodisiac, benzyl cyanide (BC) to females. Accessory reproductive gland (ARG) secretion of a mated female P. brassicae that is deposited with an egg clutch contains traces of BC, inducing Brussels sprouts plants (Brassica oleracea var. gemmifera) to arrest certain Trichogramma egg parasitoids. Here, we assessed whether deposition of one egg at a time by the closely related small cabbage white, Pieris rapae, induced B. oleracea var

  • chemical espionage on species specific butterfly anti Aphrodisiacs by hitchhiking trichogramma wasps
    Behavioral Ecology, 2010
    Co-Authors: Martinus E Huigens, Jozef B Woelke, Foteini G Pashalidou, Tibor Bukovinszky, Hans M Smid, Nina E Fatouros
    Abstract:

    Parasitic wasps employ a wide range of chemical cues to find their hosts. Very recently, we discovered how 2 closely related egg parasitoids, Trichogramma brassicae and Trichogramma evanescens, exploit the anti-Aphrodisiac pheromone benzyl cyanide of one of their hosts, the gregarious large cabbage white butterfly Pieris brassicae that deposits a clutch of more than 20 eggs per oviposition bout. The pheromone is transferred by male butterflies to females during mating to enforce female monogamy. On detecting the anti-Aphrodisiac, the tiny parasitic wasps ride on a mated female butterfly to a host plant and then parasitize her freshly laid eggs. The present study demonstrates that both wasp species similarly exploit the anti-Aphrodisiac mixture of methyl salicylate and indole of another host, the more common solitary small cabbage white butterfly Pieris rapae that deposits only one egg at a time. Interestingly, this behavior is innate in T. brassicae, whereas T. evanescens learns it after one successful ride on a mated female butterfly. Moreover, we show that the wasps only respond to the anti-Aphrodisiacs of the 2 cabbage white butterflies when the ubiquitous compounds are part of a complete mated female odor blend. Obviously, parasitic wasps use the sophisticated espionage-and-ride strategy to find eggs of different gregarious and solitary host species. From the wasps' perspective there seems to be a trade-off between the abundance and egg-laying behavior of the butterflies. Our findings suggest that Pieris butterflies are under strong selective pressure to minimize the use of an anti-Aphrodisiac. Copyright 2010, Oxford University Press.

  • Chemical espionage on species-specific butterfly anti-Aphrodisiacs by hitchhiking Trichogramma wasps
    Behavioral Ecology, 2010
    Co-Authors: Martinus E Huigens, Jozef B Woelke, Foteini G Pashalidou, Tibor Bukovinszky, Hans Smid, Nina E Fatouros
    Abstract:

    Parasitic wasps employ a wide range of chemical cues to find their hosts. Very recently, we discovered how 2 closely related egg parasitoids, Trichogramma brassicae and Trichogramma evanescens, exploit the anti-Aphrodisiac pheromone benzyl cyanide of one of their hosts, the gregarious large cabbage white butterfly Pieris brassicae that deposits a clutch of more than 20 eggs per oviposition bout. The pheromone is transferred by male butterflies to females during mating to enforce female monogamy. On detecting the anti-Aphrodisiac, the tiny parasitic wasps ride on a mated female butterfly to a host plant and then parasitize her freshly laid eggs. The present study demonstrates that both wasp species similarly exploit the anti-Aphrodisiac mixture of methyl salicylate and indole of another host, the more common solitary small cabbage white butterfly Pieris rapae that deposits only one egg at a time. 'Interestingly, this behavior is innate in T brassicae, whereas T evanescens learns it after one successful ride on a mated female butterfly. Moreover, we show that the wasps only respond to the anti-Aphrodisiacs of the 2 cabbage white butterflies when the ubiquitous compounds are part of a complete mated female odor blend. Obviously, parasitic wasps use the sophisticated espionage-and-ride strategy to find eggs of different gregarious and solitary host species. From the wasps' perspective there seems to be a trade-off between the abundance and egg-laying behavior of the butterflies. Our findings suggest that Pieris butterflies are under strong selective pressure to minimize the use of an anti-Aphrodisiac.

  • anti Aphrodisiac compounds of male butterflies increase the risk of egg parasitoid attack by inducing plant synomone production
    Journal of Chemical Ecology, 2009
    Co-Authors: Nina E Fatouros, Foteini G Pashalidou, Wilma Aponte V. Cordero, R. Mumm, M. Dicke, M. Hilker, Joop J A Van Loon, Martinus E Huigens
    Abstract:

    During mating in many butterfly species, males transfer spermatophores that contain anti-Aphrodisiacs to females that repel conspecific males. For example, males of the large cabbage white, Pieris brassicae (Lepidoptera: Pieridae), transfer the anti-Aphrodisiac, benzyl cyanide (BC) to females. Accessory reproductive gland (ARG) secretion of a mated female P. brassicae that is deposited with an egg clutch contains traces of BC, inducing Brussels sprouts plants (Brassica oleracea var. gemmifera) to arrest certain Trichogramma egg parasitoids. Here, we assessed whether deposition of one egg at a time by the closely related small cabbage white, Pieris rapae, induced B. oleracea var. gemmifera to arrest Trichogramma wasps, and whether this plant synomone is triggered by substances originating from male P. rapae seminal fluid. We showed that plants induced by singly laid eggs of P. rapae arrest T. brassicae wasps three days after butterfly egg deposition. Elicitor activity was present in ARG secretion of mated female butterflies, whereas the secretion of virgin females was inactive. Pieris rapae used a mixture of methyl salicylate (MeSA) and indole as an anti-Aphrodisiac. We detected traces of both anti-Aphrodisiacal compounds in the ARG secretion of mated female P. rapae, whereas indole was lacking in the secretion of virgin female P. rapae. When applied onto the leaf, indole induced changes in the foliar chemistry that arrested T. brassicae wasps. This study shows that compounds of male seminal fluid incur possible fitness costs for Pieris butterflies by indirectly promoting egg parasitoid attack.

Andrea Maxia - One of the best experts on this subject based on the ideXlab platform.

  • ethanolic extract of rubia peregrina l rubiaceae inhibits haloperidol induced catalepsy and reserpine induced orofacial dyskinesia
    Natural Product Research, 2012
    Co-Authors: Andrea Maxia, Maria Assunta Frau, Caterina Foddis, Maria Cristina Lancioni, Veena S. Kasture, Sanjay Kasture
    Abstract:

    In the traditional Sardinian system of medicine, Rubia peregrina L. (Rubiaceae) is reported as an Aphrodisiac herb. Since the Aphrodisiacs may also have antioxidant and dopaminergic activities, the aim of this study was to study the effect of ethanolic extract of aerial parts of R. peregrina for the scavenging of free DPPH radicals and the inhibition of haloperidol-induced catalepsy in mice and reserpine-induced orofacial dyskinesia in rats. The extract exhibited significant antioxidant activity in a free radical DPPH assay with IC50 = 55.6 µg mL−1, which was very close to IC50 of ascorbic acid. The extract of R. peregrina (100 and 200 mg kg−1 intraperitoneally, i.p.) significantly inhibited haloperidol (1 mg kg−1 i.p.) – induced catalepsy in mice (p < 0.01). In rats, the extract (200 mg kg−1 i.p.) significantly (p < 0.01) inhibited the orofacial dyskinesia induced by intraperitoneal administration of reserpine (1 mg kg−1 on days 1, 3 and 5). This study demonstrates that R. peregrina has antioxidant activ...

  • Ethanolic extract of Rubia peregrina L. (Rubiaceae) inhibits haloperidol-induced catalepsy and reserpine-induced orofacial dyskinesia.
    Natural Product Research, 2011
    Co-Authors: Andrea Maxia, Maria Assunta Frau, Caterina Foddis, Maria Cristina Lancioni, Veena S. Kasture, Sanjay Kasture
    Abstract:

    In the traditional Sardinian system of medicine, Rubia peregrina L. (Rubiaceae) is reported as an Aphrodisiac herb. Since the Aphrodisiacs may also have antioxidant and dopaminergic activities, the aim of this study was to study the effect of ethanolic extract of aerial parts of R. peregrina for the scavenging of free DPPH radicals and the inhibition of haloperidol-induced catalepsy in mice and reserpine-induced orofacial dyskinesia in rats. The extract exhibited significant antioxidant activity in a free radical DPPH assay with IC50 = 55.6 µg mL−1, which was very close to IC50 of ascorbic acid. The extract of R. peregrina (100 and 200 mg kg−1 intraperitoneally, i.p.) significantly inhibited haloperidol (1 mg kg−1 i.p.) – induced catalepsy in mice (p