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Nascimento,j. P. - One of the best experts on this subject based on the ideXlab platform.

  • Aplastic Crisis due to human parvovirus B19 infection in hereditary hemolytic anaemia
    Instituto de Medicina Tropical, 1992
    Co-Authors: Cubel,r. C. N., Valadão,m. C., Magalhães,m. C., Nascimento,j. P.
    Abstract:

    Specific anti-B19 IgM was demonstrated in sera from three children showing transient Aplastic Crisis. A two years-old boy living in Rio de Janeiro suffering from sickle-cell anaemia showed the Crisis during August, 1990. Two siblings living in Santa Maria, RS, developed Aplastic Crisis during May, 1991, when they were also diagnosed for hereditary spherocytosis. For a third child from this same family, who first developed Aplastic Crisis no IgM anti-B19 was detected in her sera

  • Crise aplástica devido à infecção por parvovirus humano B19 em anemia hemolítica hereditária
    Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo, 1992
    Co-Authors: Cubel,r. C. N., Valadão,m. C., Magalhães,m. C., Pereira W., Nascimento,j. P.
    Abstract:

    Specific anti-B19 IgM was demonstrated in sera from three children showing transient Aplastic Crisis. A two years-old boy living in Rio de Janeiro suffering from sickle-cell anaemia showed the Crisis during August, 1990. Two siblings living in Santa Maria, RS, developed Aplastic Crisis during May, 1991, when they were also diagnosed for hereditary spherocytosis. For a third child from this same family, who first developed Aplastic Crisis no IgM anti-B19 was detected in her sera.IgM específica anti-B19 foi demonstrada nos soros de três crianças apresentando aplasia transitória de medula. Um menino de dois anos de idade vivendo no Rio de Janeiro e sendo portador de anemia falciforme, apresentou a crise durante Agosto de 1990. Dois irmãos vivendo em Santa Maria - RS, desenvolveram crise de aplasia em Maio de 1991, quando foram também diagnosticados como portadores de microesferocitose. IgM anti-B19 não foi detectada no soro de uma terceira criança, desta mesma família, a qual primeiramente apresentou crise de aplasia

Masami Takei - One of the best experts on this subject based on the ideXlab platform.

  • human parvovirus b19 induced Aplastic Crisis in an adult patient with hereditary spherocytosis a case report and review of the literature
    BMC Research Notes, 2014
    Co-Authors: Yujin Kobayashi, Yoshihiro Hatta, Yusaku Ishiwatari, Hitoshi Kanno, Masami Takei
    Abstract:

    Although there are several case reports of human parvovirus B19 infection in patients with hereditary spherocytosis, no systematic reviews of adult patients with hereditary spherocytosis with human parvovirus B19 infection have been published as clinical case reports. In this study, we report a case of Aplastic Crisis due to human parvovirus B19 infection in an adult patient with hereditary spherocytosis. A 33-year-old woman with hereditary spherocytosis and gallstones was admitted because of rapid progress in marked anemia and fever. Although empiric antibiotic therapy was prescribed, her clinical symptoms and liver function test worsened. Because the anti-human parvovirus B19 antibody and deoxyribonucleic acid levels assessed by polymerase chain reaction were positive, the patient was diagnosed with Aplastic Crisis due to the human parvovirus B19 infection. We collected and reviewed several case reports of patients with hereditary spherocytosis aged > 18 years with human parvovirus B19 infection between 1984 and 2010. A total of 19 reports with 22 cases [median age, 28 years (range, 18–43 range); male: female ratio, 6:16], including the present case were identified. The male-to-female ratio of 6:16 implied that younger females were predominantly affected. Although fever and abdominal symptoms were common initial symptoms, liver dysfunction or skin eruptions were less commonly documented. Anti-human parvovirus B19 antibody or deoxyribonucleic acid levels assessed by polymerase chain reaction was commonly used to diagnose human parvovirus B19 infection and may be useful to distinguish human parvovirus B19 infection from other abdominal infection in patients with hereditary spherocytosis.

Solange Artimos De Oliveira - One of the best experts on this subject based on the ideXlab platform.

Jussara P. Nascimento - One of the best experts on this subject based on the ideXlab platform.

  • STUDY OF CHRONIC HEMOLYTIC ANAEMIA PATIENTS IN RIO DE JANEIRO: PREVALENCE OF ANTI-HUMAN PARVOVIRUS B19 IgG ANTIBODIES AND THE DEVELOPMENT OF TRANSIENT Aplastic CRISES
    2016
    Co-Authors: Frei Caneca, Rio De Janeiro, Anadayr L. M, Sant’anna( Rita Cássia, Cubel N. Garcia, Mônica Marzoche, Maria Tereza, M. Paula, Clarisse C. Lobo, Jussara P. Nascimento
    Abstract:

    The prevalence of anti-human parvovirus B19 IgG antibodies was determined in sera from 165 chronic hemolytic anemia patients, receiving medical care at Instituto Estadual de Hematologia (IEHE), Rio de Janeiro, during the year of 1994. This sample represents around 10 % of the chronic hemolytic anemia patients attending at IEHE. Most of these patients (140) have sickle cell disease. Anti-B19 IgG antibodies were detected in 32.1 % of patients. No statistically significant difference (p> 0.05) was seen between IgG antibody prevalence in male (27.8%) and female (35.5%) patients. Anti-B19 IgG antibodies were more frequent in older (37.6%) than younger (28.2%) than 20 years old patients, although this difference had no statistical significance (p> 0.05). Anti-B19 IgG antibody prevalence showed that 67.9 % of patients enrolled in the study were susceptible to B19 acute infection. With the aim to detect acute B19 infection, patients follow up continued until February 1996. During this period four patients presented transient Aplastic Crisis due to human parvovirus B19 as confirmed by the detection of specific IgM antibodies. All four patients were younger than 20 years old, and 3 were younger than 10 years old. Three of them were sickle cell disease patients. Three of the four acute B19 infectio

  • Anti-VP1 and anti-VP2 antibodies detected by immunofluorescence assays in patients with acute human parvovirus B19 infection
    Instituto Oswaldo Cruz Ministério da Saúde, 2001
    Co-Authors: Renata Fa Pereira, Walquiria Ns De Paula, Rita De Cássia N Cubel, Jussara P. Nascimento
    Abstract:

    Acute human parvovirus B19 infection is followed by an antibody response to the structural proteins of the viral capsid (VP1 and VP2). We used 80 sera collected from 58 erythema infectiosum and 6 transient Aplastic Crisis patients to test IgM and IgG antibodies against these two proteins in an immunofluorescence assay (IFA) using Sf9 cells infected with recombinant baculovirus expressing either VP1 or VP2 antigen. Although less sensitive than IgM capture enzyme immunoassay using native antigen (MACEIA), we could detect anti-VP1 or anti-VP2 IgM antibodies by IFA in 49 patients with acute infection (76.6%). Detection of IgG anti-VP1 and anti-VP2 by IFA, however, was as sensitive as IgG detection by indirect enzyme immunoassay. By applying IgG avidity IFA to sera of the 15 IgM IFA negative patients we were able to confirm acute infection in further 12 cases by IFA. Overall, acute infection was confirmed by IFA in 61 (95.3%) of the 64 patients

  • Aplastic Crisis caused by parvovirus B19 in an adult patient with sickle-cell disease
    Revista da Sociedade Brasileira de Medicina Tropical, 2000
    Co-Authors: Sérgio Setúbal, Adelmo Henrique Daumas Gabriel, Jussara P. Nascimento, Solange Artimos De Oliveira
    Abstract:

    We describe a case of Aplastic Crisis caused by parvovirus B19 in an adult sickle-cell patient presenting with paleness, tiredness, fainting and dyspnea. The absence of reticulocytes lead to the diagnosis. Anti-B19 IgM and IgG were detected. Reticulocytopenia in patients with hereditary hemolytic anemia suggests B19 infection.

  • Aplastic Crisis caused by parvovirus B19 in an adult patient with sickle-cell disease Crise aplástica por parvovírus B19 em um paciente adulto com doença falciforme
    Sociedade Brasileira de Medicina Tropical (SBMT), 2000
    Co-Authors: Sérgio Setúbal, Adelmo Henrique Daumas Gabriel, Jussara P. Nascimento, Solange Artimos De Oliveira
    Abstract:

    We describe a case of Aplastic Crisis caused by parvovirus B19 in an adult sickle-cell patient presenting with paleness, tiredness, fainting and dyspnea. The absence of reticulocytes lead to the diagnosis. Anti-B19 IgM and IgG were detected. Reticulocytopenia in patients with hereditary hemolytic anemia suggests B19 infection.Descreve-se um caso de crise aplástica devida ao parvovírus B19 num paciente adulto, manifestando-se por palidez, cansaço, lipotímias e dispnéia. A ausência de reticulócitos chamou a atenção para o diagnóstico. Detectaram-se IgM e IgG anti-B19. Reticulocitopenia em pacientes com anemia hemolítica hereditária sugere infecção por B19

Cubel,r. C. N. - One of the best experts on this subject based on the ideXlab platform.

  • Aplastic Crisis due to human parvovirus B19 infection in hereditary hemolytic anaemia
    Instituto de Medicina Tropical, 1992
    Co-Authors: Cubel,r. C. N., Valadão,m. C., Magalhães,m. C., Nascimento,j. P.
    Abstract:

    Specific anti-B19 IgM was demonstrated in sera from three children showing transient Aplastic Crisis. A two years-old boy living in Rio de Janeiro suffering from sickle-cell anaemia showed the Crisis during August, 1990. Two siblings living in Santa Maria, RS, developed Aplastic Crisis during May, 1991, when they were also diagnosed for hereditary spherocytosis. For a third child from this same family, who first developed Aplastic Crisis no IgM anti-B19 was detected in her sera

  • Crise aplástica devido à infecção por parvovirus humano B19 em anemia hemolítica hereditária
    Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo, 1992
    Co-Authors: Cubel,r. C. N., Valadão,m. C., Magalhães,m. C., Pereira W., Nascimento,j. P.
    Abstract:

    Specific anti-B19 IgM was demonstrated in sera from three children showing transient Aplastic Crisis. A two years-old boy living in Rio de Janeiro suffering from sickle-cell anaemia showed the Crisis during August, 1990. Two siblings living in Santa Maria, RS, developed Aplastic Crisis during May, 1991, when they were also diagnosed for hereditary spherocytosis. For a third child from this same family, who first developed Aplastic Crisis no IgM anti-B19 was detected in her sera.IgM específica anti-B19 foi demonstrada nos soros de três crianças apresentando aplasia transitória de medula. Um menino de dois anos de idade vivendo no Rio de Janeiro e sendo portador de anemia falciforme, apresentou a crise durante Agosto de 1990. Dois irmãos vivendo em Santa Maria - RS, desenvolveram crise de aplasia em Maio de 1991, quando foram também diagnosticados como portadores de microesferocitose. IgM anti-B19 não foi detectada no soro de uma terceira criança, desta mesma família, a qual primeiramente apresentou crise de aplasia