The Experts below are selected from a list of 318 Experts worldwide ranked by ideXlab platform
Joseph Cummiskey - One of the best experts on this subject based on the ideXlab platform.
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progressive improvement of Apnea Index and ventilatory response to co2 after tracheostomy in obstructive sleep Apnea syndrome1 3
The American review of respiratory disease, 2015Co-Authors: Christian Guilleminault, Joseph CummiskeyAbstract:In order to determine whether reversible alterations in ventilatory control are found in obstructive sleep Apnea syndromes, 5 male patients 31 to 57 yr of age presenting with the syndrome were polygraphically monitored before and several times during the 6 months after tracheostomy. They also had a hypercapnic ventilatory response study before surgery and again 3 months after surgery during the daytime. A dramatic decrease in overall Apnea Index was seen immediately after surgery, but the number of central Apneas and the central Apnea Index did not reach low values until several months after tracheostomy. Ventilatory response to CO2 improved in all cases after surgery.
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Progressive Improvement of Apnea Index and Ventilatory Response to CO2 after Tracheostomy in Obstructive Sleep Apnea Syndrome1–3
The American review of respiratory disease, 2015Co-Authors: Christian Guilleminault, Joseph CummiskeyAbstract:In order to determine whether reversible alterations in ventilatory control are found in obstructive sleep Apnea syndromes, 5 male patients 31 to 57 yr of age presenting with the syndrome were polygraphically monitored before and several times during the 6 months after tracheostomy. They also had a hypercapnic ventilatory response study before surgery and again 3 months after surgery during the daytime. A dramatic decrease in overall Apnea Index was seen immediately after surgery, but the number of central Apneas and the central Apnea Index did not reach low values until several months after tracheostomy. Ventilatory response to CO2 improved in all cases after surgery.
W C Weng - One of the best experts on this subject based on the ideXlab platform.
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Central sleep Apnea in obese children with sleep-disordered breathing
International Journal of Obesity, 2014Co-Authors: C H Chou, K T Kang, W C WengAbstract:Objectives: In contrast to obstructive sleep Apnea (OSA), central sleep Apnea (CSA) in obese children has received lesser attention. As pediatric CSA is more prevalent than expected and adversely impacts health, this study aims to elucidate the major factors associated with central Apnea Index (CAI) and compare CSA between obese and non-obese children. Methods: Retrospective analysis was performed in a tertiary referral medical center. Children with sleep-disordered breathing (SDB) ranging from 2–18 years old were enrolled. All participants completed history taking, otolaryngological examination and overnight polysomnography. CSA was defined as having CAI exceeding 1 h^−1. CAI and the prevalence of CSA were analyzed in children of different age groups, weight statuses and adenotonsillar sizes. Results: A total of 487 cases were included. The prevalence of CSA was 13.3% (65/487). CAI was negatively correlated with age ( r =−0.32, P
Christian Guilleminault - One of the best experts on this subject based on the ideXlab platform.
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progressive improvement of Apnea Index and ventilatory response to co2 after tracheostomy in obstructive sleep Apnea syndrome1 3
The American review of respiratory disease, 2015Co-Authors: Christian Guilleminault, Joseph CummiskeyAbstract:In order to determine whether reversible alterations in ventilatory control are found in obstructive sleep Apnea syndromes, 5 male patients 31 to 57 yr of age presenting with the syndrome were polygraphically monitored before and several times during the 6 months after tracheostomy. They also had a hypercapnic ventilatory response study before surgery and again 3 months after surgery during the daytime. A dramatic decrease in overall Apnea Index was seen immediately after surgery, but the number of central Apneas and the central Apnea Index did not reach low values until several months after tracheostomy. Ventilatory response to CO2 improved in all cases after surgery.
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Progressive Improvement of Apnea Index and Ventilatory Response to CO2 after Tracheostomy in Obstructive Sleep Apnea Syndrome1–3
The American review of respiratory disease, 2015Co-Authors: Christian Guilleminault, Joseph CummiskeyAbstract:In order to determine whether reversible alterations in ventilatory control are found in obstructive sleep Apnea syndromes, 5 male patients 31 to 57 yr of age presenting with the syndrome were polygraphically monitored before and several times during the 6 months after tracheostomy. They also had a hypercapnic ventilatory response study before surgery and again 3 months after surgery during the daytime. A dramatic decrease in overall Apnea Index was seen immediately after surgery, but the number of central Apneas and the central Apnea Index did not reach low values until several months after tracheostomy. Ventilatory response to CO2 improved in all cases after surgery.
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P361 Neurocognitive testing in children with and without OSA
Sleep Medicine, 2006Co-Authors: Yu-shu Huang, Ning-hung Chen, Christian GuilleminaultAbstract:needed supraglottoplasty since they progressed with pectus excavatum, and with weight and height deficit. When comparing the three groups in relation to the polysomnographic findings, the group with laryngomalacia was similar to the group of control infants and different from the infant Apnea group regarding central Apnea Index (p = 0.001) and obstructive Apnea Index (p = 0.008). The laryngomalacia group was similar to the group with infant Apnea and different from control subjects concerning desaturation and bradycardia events (p = 0.012) and SaO2 nadir (p = 0.001). Conclusion: Our study demonstrates that polysomnography was not relevant as a tool to evaluate infants with laryngomalacia. Based on our findings it was not possible to speculate that central nervous system immaturity is a factor involved in the ethiopathogeny of laryngomalacia.
Guangfa Wang - One of the best experts on this subject based on the ideXlab platform.
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Inhibition of central Na(+)/H(+) exchanger type 3 can alleviate sleep Apnea in Sprague-Dawley rats.
Chinese Medical Journal, 2020Co-Authors: Qimin Wang, Cheng Zhang, Rong Zhou, Hui Dong, Jing Ma, Guangfa WangAbstract:BACKGROUND: Recent studies showed the central Na+/H+ exchanger type 3 (NHE3) has a close relationship with ventilation control. The objective of the study is to investigate the role of NHE3 in sleep Apnea in Sprague-Dawley (SD) rats. METHODS: A sleep study was performed on 20 male SD rats to analyze the correlation between the sleep apneic events and total NHE3 protein content and inactive NHE3(pS552) in the brainstem measured by Western blotting. Another 20 adult male SD rats received 3 days of sleep and respiration monitoring for 6 hours a day, with adaption on the first day, 0.5% DMSO microinjection into the fourth ventricle on the second day, and AVE0657 (specific inhibitor of NHE3) microinjection on the third day. Rats were divided into two groups with injection of 5 µmol/L or 8 µmol/L AVE0657 before the sleep study. The effects of AVE0657 on sleep Apnea and sleep structure of rats were analyzed through self-control. RESULTS: The total post-sigh Apnea Index (TPSAI) and post-sigh Apnea Index in non-rapid eye movement (NREM) sleep (NPSAI) and total Apnea Index (AI) in NREM sleep (NAI) were negatively correlated with NHE3(pS552) protein contents in the brainstem (r = -0.534, -0.547 and -0.505, respectively, P < 0.05). The spontaneous Apnea Index in REM sleep (RSPAI) was positively correlated with the level of NHE3(pS552) protein expression in the brainstem (r = 0.556, P < 0.05). However, the sleep AI had no relationship with total NHE3 protein. Compared with the blank control and microinjection of 0.5% DMSO, 5 µmol/L AVE0657 significantly reduced the total AI and NPSAI (both P < 0.05) without a significant effect on sleep architecture. In contrast to blank control and microinjection of 0.5% DMSO, injection of 8 µmol/L AVE0657 significantly reduced the AI and PSAI in NREM and REM sleep (all P < 0.05). CONCLUSIONS: The severity of sleep Apnea was negatively correlated with central inactive NHE3. A specific inhibitor of NHE3 decreased the sleep AI. Thus, our results indicate that central NHE3 might be a molecular target for sleep Apnea treatment, whose inhibitors may be potential therapeutic drugs for sleep Apnea.
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Effects of 5-HT2 agonist/antagonist on sleep Apnea in Sprague-Dawley rats
Chinese Journal of Tuberculosis and Respiratory Diseases, 2010Co-Authors: Yijue Zhong, Cheng Zhang, Guangfa WangAbstract:Objective To evaluate the effects of 5-HT2 agonist/antagonist Ketanserin on sleep Apnea in Sprague-Dawley(SD)rats. Methods Twenty adult male SD rats were operated for implantation of EEG and EMG electrodes and a microinjection probe was placed within the fourth ventricle. After recovery for a week, rats were monitored for sleep and respiration in three continuous days. There is no intervention on the first day. Before monitoring, 40 μl ACSF were microinjected into the Ⅳ ventricle of the rats on the second day. On the third day before monitoring, 40 μl DOI were microinjected into the Ⅳ ventricle of ten rats and 40 μl Ketanserin into another ten ones. Results Compared with blank control and microinjection of ACSF, DOI significantly reduced the total Apnea Index (AI) from 18.3(11.1, 20.3)times/h and 15.2(11.4, 18.0)times/h to 10.8(3.1, 14.1)times/h(P=0.005 and 0.005, respectively). Post sign Apnea Index (PSAI) during non-rapid eye movement (NREM) and rapid eye movement (REM) sleep as well as spontaneous Apnea Index (SPAI)during NREM sleep were all significantly decreased; (P 0.05). Neither sleep efficiency (the percent of total sleep time in total monitoring time) nor the time ratio of NREM sleep and REM sleep was significantly changed. In contrast to blank control and microinjection of ACSF, Ketanserin significantly reduced the total Apnea Index (AI) from 19.2(13.7, 20.9)times/h and 19.0(12.9, 21.6)times/h to 13.1(9.5, 14.9)times/h(P=0.005and 0.005, respectively). PSAI during NREM and REM sleep were significantly decreased (P 0.05, respectively). It also had no effects on sleep efficiency and the time ratio of NREM sleep and REM sleep. Conclusion Both 5-HT2 agonist and antagonist decreased the sleep Apnea Index and had no effects on sleep structure. It shows that the role of 5-HT2 receptor in the respiratory regulation during sleep is complex. The mechanisms involved remain to be studied in future. Key words: Sleep Apnea syndrome; Serotonin; Rat; Sleep monitoring
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Expression of TASK-1 in brainstem and the occurrence of central sleep Apnea in rats
Respiratory Physiology & Neurobiology, 2007Co-Authors: Jing Wang, Cheng Zhang, Nan Li, Li Su, Guangfa WangAbstract:Recent studies revealed that unstable ventilation control is one of mechanisms underlying the occurrence of sleep Apnea. Thus, we investigated whether TASK-1, an acid-sensitive potassium channel, plays a role in the occurrence of sleep Apnea. First, the expression of TASK-1 transcriptions on brainstem was checked by in situ hybridization. Then, the correlation between the central apneic episodes and protein contents of TASK-1 measured by western blot was analyzed from 27 male rats. Results showed that TASK-1 mRNAs were widely distributed on the putative central chemoreceptors such as locus coeruleus, nucleus tractus solitarius and medullary raphe, etc. Both the total spontaneous Apnea Index (TSAI) and spontaneous Apnea Index in NREM sleep (NSAI) were positively correlated with TASK-1 protein contents (r = 0.547 and 0.601, respectively, p < 0.01). However, the post-sigh sleep Apnea Index (PAI) had no relationship with TASK-1 protein. Thus, we concluded that TASK-1 channels may function as central chemoreceptors that play a role in spontaneous sleep Apneas in rats.
David W. Carley - One of the best experts on this subject based on the ideXlab platform.
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Sleep-disordered Respiration in Phenotypically Normotensive, Genetically Hypertensive Rats
American Journal of Respiratory and Critical Care Medicine, 2000Co-Authors: David W. Carley, Kathleen H. Berecek, Aleksandar Videnovic, Miodrag RadulovackiAbstract:Increased prevalence of sleep-related breathing disorders has been reported in patients with essential hypertension and we have described disordered breathing in spontaneously hypertensive rats, an animal model of genetic hypertension. The mechanisms coupling hypertension to respiratory dysfunction during sleep remain, however, largely unknown. To determine if sleep-related respiratory disorder reflects cardiovascular derangement or, alternatively, represents an independent phenotype in hypertensive rats, we polygraphically recorded groups (n = 10) of genetically hypertensive, genetically normotensive, and phenotypically normotensive rats carrying a genetic background for hypertension. Apnea Index was elevated more than 15-fold during NREM sleep in both animal groups carrying hypertension-related genes (p < 0.0001 for each) versus normotensive Wistar Kyoto rats. During REM sleep, a genetic background for hypertension was associated with an increased Apnea Index of at least 500% versus normotensive Wistar ...
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Protoveratrines A and B increase sleep Apnea Index in Sprague-Dawley rats
Journal of Applied Physiology, 1997Co-Authors: Sinisa M. Trbovic, Miodrag Radulovacki, David W. CarleyAbstract:Trbovic, Sinisa M., Miodrag Radulovacki, and David W. Carley. Protoveratrines A and B increase sleep Apnea Index in Sprague-Dawley rats. J. Appl. Physiol. 83(5): 1602–1606, 1997.—The action of protovertarines A and B, which stimulate carotid sinus baroreceptors and vagal sensory endings in the heart as well as pulmonary bed, were assessed on spontaneous and postsigh central sleep Apneas in freely moving Sprague-Dawley rats. During the 6-h recording period, animals were simultaneously monitored for sleep by using electroencephalogram and electromyogram recordings, for respiration by single-chamber plethysmography, and for blood pressure and heart period by using radiotelemetry. After administration of 0.2, 0.5, or 1 mg/kg sc of protoveratrines, cardiopulmonary changes lasting at least 6 h were observed in all three behavioral states [heart period increased up to 23% in wakefulness, 21% in non-rapid-eye-movement (non-REM) sleep, and 20% in REM sleep; P < 0.005 for each]. At the same time, there was a substantial increase in the number of spontaneous (375% increase; P = 0.04) and postsigh (268% increase, P = 0.0002) Apneas. Minute ventilation decreased by up to 24% in wakefulness, 25% in non-REM, and 35% in REM sleep ( P < 0.05 for each). We conclude that pharmacological stimulation of baroreflexes promotes Apnea expression in the sleeping rat.
