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Appendicular Skeleton

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H T Temple – One of the best experts on this subject based on the ideXlab platform.

  • enchondroma versus chondrosarcoma in the Appendicular Skeleton differentiating features
    Radiographics, 1998
    Co-Authors: Mark D Murphey, H T Temple, Donald J Flemming, S R Boyea, J A Bojescul, Donald E Sweet

    Abstract:

    Distinction of enchondroma versus intramedullary chondrosarcoma affecting the Appendicular Skeleton (proximal to the metacarpals and metatarsals) is a frequent diagnostic dilemma. The authors studied a large series of patients with these lesions (92 with enchondromas, 95 with chondrosarcomas) using statistical assessment of both clinical parameters and numerous radiologic manifestations on images from multiple modalities to identify differentiating features. Multiple clinical and imaging parameters demonstrated statistically significant differences between enchondroma and chondrosarcoma, particularly pain related to the lesion, deep endosteal scalloping (greater than two-thirds of cortical thickness), cortical destruction and soft-tissue mass (at computed tomography or magnetic resonance imaging), periosteal reaction (at radiography), and marked uptake of radionuclide (greater than the anterior iliac crest) at bone scintigraphy. All of these features strongly suggested the diagnosis of chondrosarcoma. The…

Daniela Militianu – One of the best experts on this subject based on the ideXlab platform.

  • added value of spect ct in the evaluation of benign bone diseases of the Appendicular Skeleton
    Clinical Nuclear Medicine, 2016
    Co-Authors: Gad Abikhzer, Saher Srour, Zohar Keidar, Rachel Barshalom, Olga Kagna, Ora Israel, Daniela Militianu

    Abstract:

    Bone scintigraphy is a sensitive technique to detect altered bone mineralization but has limited specificity. The use of SPECT/CT has improved significantly the diagnostic accuracy of bone scintigraphy, in patients with cancer as well as in evaluation of benign bone disease. It provides precise localization and characterization of tracer-avid foci, shortens the diagnostic workup, and decreases patient anxiety. Through both the SPECT and the CT components, SPECT/CT has an incremental value in characterizing benign bone lesions, specifically in the Appendicular Skeleton, as illustrated by present case series.

  • Added Value of SPECT/CT in the Evaluation of Benign Bone Diseases of the Appendicular Skeleton.
    Clinical Nuclear Medicine, 2016
    Co-Authors: Gad Abikhzer, Saher Srour, Zohar Keidar, Olga Kagna, Ora Israel, Rachel Bar-shalom, Daniela Militianu

    Abstract:

    Bone scintigraphy is a sensitive technique to detect altered bone mineralization but has limited specificity. The use of SPECT/CT has improved significantly the diagnostic accuracy of bone scintigraphy, in patients with cancer as well as in evaluation of benign bone disease. It provides precise localization and characterization of tracer-avid foci, shortens the diagnostic workup, and decreases patient anxiety. Through both the SPECT and the CT components, SPECT/CT has an incremental value in characterizing benign bone lesions, specifically in the Appendicular Skeleton, as illustrated by present case series.

Kosei Matsue – One of the best experts on this subject based on the ideXlab platform.

  • Medullary Abnormalities in Appendicular Skeletons Detected With 18F-FDG PET/CT Predict an Unfavorable Prognosis in Newly Diagnosed Multiple Myeloma Patients With High-Risk Factors.
    American Journal of Roentgenology, 2019
    Co-Authors: Kentaro Narita, Masami Takeuchi, Hiroki Kobayashi, Akihiro Kitadate, Toshihiro O'uchi, Kosei Matsue

    Abstract:

    OBJECTIVE. The prognostic value of medullary abnormalities in the Appendicular Skeleton (AS) of patients with multiple myeloma (MM) has recently been suggested. However, functional evaluation of th…

  • prognostic significance of bone marrow abnormalities in the Appendicular Skeleton of patients with multiple myeloma
    Blood Advances, 2018
    Co-Authors: Kosei Matsue, Yuya Matsue, Hiroki Kobayashi, Kentaro Narita, Akihiro Kitadate, Masami Takeuchi

    Abstract:

    We aimed to determine the clinical and prognostic significance of medullary abnormalities detected by low-dose whole-body multidetector computed tomography (MDCT) in the Appendicular Skeleton (AS) of patients with newly diagnosed symptomatic multiple myeloma (MM). One hundred ninety-six patients underwent low-dose whole-body MDCT as an initial workup. Patients were categorized into 3 groups based on the medullary pattern of the AS: fatty (36.3%), focal (43.4%), and diffuse (20.4%). Medullary abnormalities were associated with Durie-Salmon and revised International Scoring System stage 3, creatinine levels >2.0 mg/dL, and the proportion of bone marrow plasma cells. The median follow-up was 35.4 months. Patients with fatty, focal, and diffuse patterns had a median survival of not reached, 56 months, and 38 months, respectively. Overall survival (OS) was associated with age, Durie-Salmon stage 3, creatinine levels >2.0 mg/dL, ineligibility for autologous stem cell transplantation, and focal and diffuse patterns on univariate analysis. Multivariate analysis showed that age and diffuse pattern (hazard ratio [HR], 1.92; 95% confidence interval [CI], 1.12-3.31; P = .018) were independent predictors of progression-free survival. Age and focal (HR, 2.51; 95% CI, 1.14-5.56; P = .023) and diffuse (HR, 4.12; 95% CI, 1.74-9.77; P = .001) patterns were also independent predictors of OS. The addition of marrow pattern to preexisting risk factors was associated with a net reclassification improvement for predicting OS (to 0.37, P = .015). Medullary abnormalities in the AS (detected by low-dose whole-body MDCT) are associated with a poor prognosis, independent of other clinical variables.

  • clinical and prognostic significance of bone marrow abnormalities in the Appendicular Skeleton detected by low dose whole body multidetector computed tomography in patients with multiple myeloma
    Blood Cancer Journal, 2015
    Co-Authors: Yuki Nishida, Yuya Matsue, Yasuhito Suehara, Kota Fukumoto, Manabu Fujisawa, Masami Takeuchi, E Ouchi, Kosei Matsue

    Abstract:

    Clinical and prognostic significance of bone marrow abnormalities in the Appendicular Skeleton detected by low-dose whole-body multidetector computed tomography in patients with multiple myeloma