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Richard F. Brubaker - One of the best experts on this subject based on the ideXlab platform.

  • comparison of the efficacy of betaxolol brinzolamide and timolol dorzolamide as suppressors of Aqueous Humor Flow in human subjects
    Ophthalmology, 2000
    Co-Authors: Richard F. Brubaker, Cory Ingram, Erik O Schoff, Cherie B Nau
    Abstract:

    Abstract Objective To compare the efficacy of combinations of betaxolol-brinzolamide and timolol-dorzolamide as suppressors of Aqueous Humor Flow and ocular hypotensive agents. Design Placebo-controlled, masked comparison of the two drug combinations. Participants Twenty-five normal human volunteers with the fellow eye serving as control. Methods or testing Fluorophotometric measurement of Aqueous Humor Flow and pneumatonometric measurement of intraocular pressure. Main outcome measures Aqueous Humor Flow and intraocular pressure. Results The betaxolol-brinzolamide combination lowered Aqueous Flow 39% to 44%, and the timolol-dorzolamide combination lowered Aqueous Flow 51%. The betaxolol-brinzolamide combination lowered intraocular pressure 14% to 19%, and the timolol-dorzolamide combination lowered it 18% to 24%. Conclusions Both drug combinations were effective; the timolol-dorzolamide combination appeared to be the more effective of the two after short-term exposure (24 hours).

  • Effect of brinzolamide and dorzolamide on Aqueous Humor Flow in human eyes
    American journal of ophthalmology, 1999
    Co-Authors: Cory Ingram, Richard F. Brubaker
    Abstract:

    Abstract PURPOSE: To measure the relative efficacy of brinzolamide hydrochloride 1% ophthalmic suspension, a new carbonic anhydrase inhibitor, compared with the currently used dorzolamide hydrochloride 2% ophthalmic solution as suppressors of Aqueous Humor Flow in human eyes, and to study the difference of effect during the day and at night. METHODS: A randomized, double-masked, placebo-controlled study of 25 normal human subjects was carried out at Mayo Clinic. The daytime rate of Aqueous Humor Flow was measured every 2 hours from 8 am to 4 pm by means of fluorophotometry. Likewise, the nighttime rate of Aqueous Humor Flow was measured every 2 hours from 12 am to 6 am. Intraocular pressure was measured at 4 pm and 6 am. RESULTS: Brinzolamide reduced Aqueous Flow by 0.47 ± 0.20 μl per min (mean ± SD) during the day, whereas dorzolamide reduced Flow by 0.34 ± 0.20 μl per min. Brinzolamide reduced Aqueous Flow by 0.16 ± 0.12 μl per min during the night, whereas dorzolamide reduced Flow by 0.10 ± 0.13 μl per min. Brinzolamide reduced afternoon intraocular pressure by 1.5 ± 1.1 mm Hg, and dorzolamide reduced afternoon intraocular pressure by 1.1 ± 1.0 mm Hg. Brinzolamide reduced the morning awakening intraocular pressure by 0.3 ± 1.6 mm Hg, and dorzolamide reduced it by 0.8 ± 1.0 mm Hg. CONCLUSIONS: Our data support the idea that brinzolamide is at least as efficacious as dorzolamide as a suppressor of Aqueous Humor Flow in normal human eyes and that there is probably not a clinically significant difference between the two drugs in this efficacy. Clinicians who prescribe brinzolamide should expect similar ocular hypotensive responses from brinzolamide and dorzolamide.

  • Measurement of Aqueous Humor Flow by fluorophotometry in the presence of a dilated pupil.
    Investigative ophthalmology & visual science, 1999
    Co-Authors: T L Maus, Richard F. Brubaker
    Abstract:

    Purpose To determine by means of fluorophotometry whether pharmacologic dilation of the pupil can interfere with the measurement of Aqueous Flow. Methods Ten normal human volunteers underwent dilation with tropicamide, phenylephrine, and a combination of the two drugs. Before and after dilation, the rate of Aqueous Flow was measured by the rate of disappearance of fluorescein from the cornea and the anterior chamber. Results Dilation of the pupil with tropicamide alone had no effect on the rate of clearance of fluorescein. Dilation with phenylephrine increased the rate of clearance of fluorescein by 40% and caused a small increase in the variability among subjects. Dilation with a combination of tropicamide and phenylephrine caused clearance of fluorescein at more than double the normal rate and a marked increase in variability among subjects. Conclusions When the pupil is dilated sufficiently to permit mixing of Aqueous Humor in the posterior and anterior chambers, fluorescein can leave the system by a posterior route, and its rate of clearance may not be an accurate measure of the net rate of Aqueous Humor Flow through the anterior chamber.

  • Comparison of the efficacy of apraclonidine and brimonidine as Aqueous suppressants in humans
    Archives of ophthalmology (Chicago Ill. : 1960), 1998
    Co-Authors: Ramin Schadlu, Cherie B Nau, Todd L Maus, Richard F. Brubaker
    Abstract:

    Objective To measure and compare the effect of apraclonidine hydrochloride and brimonidine tartrate on the rate of Aqueous Humor Flow in human subjects. Subjects and Methods Forty normal human subjects were given apraclonidine or brimonidine by topical instillation. Aqueous Humor Flow was measured by the rate of disappearance of topically applied fluorescein. Intraocular pressure was measured by applanation tonometry. Results Apraclonidine suppressed Aqueous Humor Flow between 39% and 44% and lowered intraocular pressure between 20% and 23%. Brimonidine suppressed Aqueous Humor Flow between 44% and 48% and lowered intraocular pressure between 19% and 22%. Conclusion No statistically significant differences were found between the effects of the 2 drugs on Aqueous Humor dynamics in normal subjects.

  • Additive effect of dorzolamide on Aqueous Humor Flow in patients receiving long-term treatment with timolol.
    Archives of ophthalmology (Chicago Ill. : 1960), 1998
    Co-Authors: Laura L. Wayman, Lillinger Larsson, Todd L Maus, Richard F. Brubaker
    Abstract:

    Additive effect of dorzolamide on Aqueous Humor Flow in patients receiving long-term treatment with timolol.

Günther Karl Krieglstein - One of the best experts on this subject based on the ideXlab platform.

  • The influence of Latanoprost 0.005% on Aqueous Humor Flow and outFlow facility in glaucoma patients: a double-masked placebo-controlled clinical study
    Graefe's Archive for Clinical and Experimental Ophthalmology, 2004
    Co-Authors: Sven Dinslage, Arno Hueber, Michael Diestelhorst, Günther Karl Krieglstein
    Abstract:

    Background Fluorophotometry and pneumotonography were performed to investigate the effect of Latanoprost 0.005% and Placebo on Aqueous Humor Flow and total outFlow facility in human glaucomatous eyes. Methods In a randomised double-blind clinical study patients with POAG and OHT received either latanoprost 0.005% or placebo once in the evening. Fluorophotometry (Fluorotron Master II, Ocumetrics) and Pneumatonography (Model 30 Classic Pneumatonometer, Mentor) was performed in 20 eyes of 10 patients (verum) and 22 eyes of 11 patients (placebo). During a 2 week wash-out period all patients received a systemic antiglaucomatous therapy (Acetazolamide) up to 3 days before baseline measurement. Patients with an IOP higher than 28 mmHg at baseline were excluded. Fluorophotometry, tonography and IOP were measured at baseline after 1 and 2 weeks of treatment. Data was analysed by the Student’s paired t test. Results All patients completed the protocol. The IOP significantly decreased (25%) after 1 and 2 weeks of treatment with Latanoprost ( p

  • The influence of Latanoprost 0.005% on Aqueous Humor Flow and outFlow facility in glaucoma patients: a double-masked placebo-controlled clinical study
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2004
    Co-Authors: Sven Dinslage, Arno Hueber, Michael Diestelhorst, Günther Karl Krieglstein
    Abstract:

    Background Fluorophotometry and pneumotonography were performed to investigate the effect of Latanoprost 0.005% and Placebo on Aqueous Humor Flow and total outFlow facility in human glaucomatous eyes.

  • the influence of latanoprost 0 005 on Aqueous Humor Flow and outFlow facility in glaucoma patients a double masked placebo controlled clinical study
    Graefes Archive for Clinical and Experimental Ophthalmology, 2004
    Co-Authors: Sven Dinslage, Arno Hueber, Michael Diestelhorst, Günther Karl Krieglstein
    Abstract:

    Background Fluorophotometry and pneumotonography were performed to investigate the effect of Latanoprost 0.005% and Placebo on Aqueous Humor Flow and total outFlow facility in human glaucomatous eyes.

  • Physiologic aging in Aqueous Humor minute volume of the human eye
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1994
    Co-Authors: M Diestelhorst, Günther Karl Krieglstein
    Abstract:

    In 148 healthy volunteers and 75 older patients the physiological Aqueous Humor secretion was calculated during the afternoon hours (13.00 to 20.00 hours) using the anterior chamber protocol of Fluorotron Master II (Coherent, Palo Alto, USA). Fluorescein eye drops were applied topically to each eye five times, 5 h before measurements. Healthy volunteers as well as patients had no history of ocular pathology, surgery or laser treatment. Further exclusion criteria were hypertension, diabetes, local and systemic drug therapy, neoplasia, kidney or liver diseases, contact lens, ocular trauma. Mean age of volunteers was 26.5 +/- 3.8 years; mean age of patients was 65.5 +/- 10.5 years. The Aqueous Humor Flow in healthy volunteers (mean +/- standard deviation) was 2.26 +/- 1.0 microliters/min and in the older patients 1.91 +/- 1.1 microliters/min. Correlation coefficient between right and left eyes in the younger volunteers: r = 0.8; in the older patients: r = 0.54. The Mann-Whitney-U-test revealed a significant difference comparing mean Aqueous Humor Flow in healthy volunteers with the mean Aqueous Humor Flow in older patients (P < 0.01). The results in our study underline that the mean Aqueous secretion does decrease with age of about 2.5% per decade. However, to date we do not know whether eyes with primary open-angle glaucoma or ocular hypertension show such a decrease in Aqueous Humor Flow with age or whether there is an autoregulation mechanism in eyes with primary open-angle glaucoma that decreases Aqueous Humor secretion in relation to an increase of outFlow facility.

  • The effect of trabeculectomy on the Aqueous Humor Flow of the unoperated fellow eye.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1991
    Co-Authors: Michael Diestelhorst, Günther Karl Krieglstein
    Abstract:

    Computerized anterior-chamber fluorophotometry was used to investigate the effect of unilateral antiglaucomatous trabeculectomy on the dynamics of Aqueous Humor in the unoperated fellow eye. In 14 patients with bilateral primary open-angle glaucoma, pigmentary glaucoma or exfoliation glaucoma, antiglaucomatous trabeculectomy was performed in one eye in which medical management of glaucoma had failed. The fellow eye in all patients had a well-defined history of glaucoma and had been treated with different sorts of medication. The medical management of the unoperated fellow eyes was continued throughout the study. Aqueous Humor Flow was measured in these eyes prior to surgery and on the 5th day after trabeculectomy. Systemic medication was discontinued from 48 h prior to surgery until second fluorophotometry. The average postoperative Flow in the fellow eyes increased from 2.56 to 2.92 μl/min (P

M Diestelhorst - One of the best experts on this subject based on the ideXlab platform.

  • effect of mitomycin c on Aqueous Humor Flow flare and intraocular pressure in eyes with glaucoma 2 years after trabeculectomy
    Graefes Archive for Clinical and Experimental Ophthalmology, 1998
    Co-Authors: Can Ustundag, M Diestelhorst
    Abstract:

    · Background: The purpose of this study was to determine the intraocular pressure (IOP), Aqueous Humor Flow, flare and ocular side effects in eyes with a history of hypotony after trabeculectomy with adjunctive mitomycin C (MMC). · Methods: Thirty-six eyes with primary or secondary open-angle glaucoma and IOP ≤8 mmHg during the postoperative period were studied 745±315 days after surgery. MMC (0.2 or 0.5 mg/ml) was applied to the episclera with a cellular sponge. Flare was studied with the Kowa Laser Flare Meter 500. Aqueous Humor Flow was measured in the afternoon (Fluorotron Master II). IOP, visual fields and best corrected visual acuity were also examined. Twenty-two contralateral eyes without surgical intervention served as controls. · Results: The mean age of patients was 44.5±16.8 years. The mean IOP was significantly lower in the MMC group than in the control group: 9.6±6.4 mmHg vs 18.0±13.6 mmHg at 2 years (P<0.001). Aqueous Flow was significantly lower in subjects treated with MMC than in controls (P<0.001). The flare values were significantly higher in the MMC-treated group, with a mean of 12.0±7.7 photon counts/ms, than in the control group, mean 7.9±4.6 photon counts/ms (P<0.019). · Conclusion: Our data suggest that MMC is a useful ocular hypotensive agent which seems to participate in a change in Aqueous Humor dynamics when applied topically as an Aqueous solution.

  • Physiologic aging in Aqueous Humor minute volume of the human eye
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1994
    Co-Authors: M Diestelhorst, Günther Karl Krieglstein
    Abstract:

    In 148 healthy volunteers and 75 older patients the physiological Aqueous Humor secretion was calculated during the afternoon hours (13.00 to 20.00 hours) using the anterior chamber protocol of Fluorotron Master II (Coherent, Palo Alto, USA). Fluorescein eye drops were applied topically to each eye five times, 5 h before measurements. Healthy volunteers as well as patients had no history of ocular pathology, surgery or laser treatment. Further exclusion criteria were hypertension, diabetes, local and systemic drug therapy, neoplasia, kidney or liver diseases, contact lens, ocular trauma. Mean age of volunteers was 26.5 +/- 3.8 years; mean age of patients was 65.5 +/- 10.5 years. The Aqueous Humor Flow in healthy volunteers (mean +/- standard deviation) was 2.26 +/- 1.0 microliters/min and in the older patients 1.91 +/- 1.1 microliters/min. Correlation coefficient between right and left eyes in the younger volunteers: r = 0.8; in the older patients: r = 0.54. The Mann-Whitney-U-test revealed a significant difference comparing mean Aqueous Humor Flow in healthy volunteers with the mean Aqueous Humor Flow in older patients (P < 0.01). The results in our study underline that the mean Aqueous secretion does decrease with age of about 2.5% per decade. However, to date we do not know whether eyes with primary open-angle glaucoma or ocular hypertension show such a decrease in Aqueous Humor Flow with age or whether there is an autoregulation mechanism in eyes with primary open-angle glaucoma that decreases Aqueous Humor secretion in relation to an increase of outFlow facility.

  • Does Aqueous Humor secretion decrease with age?
    International ophthalmology, 1992
    Co-Authors: M Diestelhorst, G K Kriegistein
    Abstract:

    Aqueous Humor Flow was calculated during day-time in 148 healthy volunteers and 75 older patients using the Fluorotron Master II anterior chamber protocol (Coherent, Palo Alto, USA). Healthy volunteers as well as patients had no history of ocular pathology, surgery or laser treatment. Slitlamp examination revealed no ocular pathology. Hypertension, diabetes, local and systemic drug therapy, neoplasia, kidney or liver disease, contact lens and ocular trauma were excluded. Mean age of volunteers was 26.5 +/- 3.8 years; age of patients: 65.5 +/- 10.5 years. Aqueous Humor Flow during day-time in healthy volunteers in the OD: (mean +/- s.d.) 2.26 +/- 1.0 microliters/min, in the OS: 2.17 +/- 1.0 microliters/min, OS: 1.86 +/- 1.1 Ml/min. Correlation coefficient: r = 0.8. The mean Aqueous Humor Flow in the older patients during day-time: OD: 1.91 +/- 1.1 microliters/min. Correlation coefficient: r = 0.54. The Mann-Whitney-U-test revealed a significant difference when comparing the right eyes of healthy volunteers with the right eyes of patients (p < 0.01). When comparing all left eyes the difference is also significant (p = 0.01). The results of the study underline, that the mean Aqueous Humor secretion does significantly decrease with age. However, the data show that there is only a slight decrease of Flow of approximately 2.5% per decade. From the clinical point of view it should be concluded, that although the Aqueous Humor secretion does decrease with age, this is not of clinical importance, even in cases of glaucoma surgery.(ABSTRACT TRUNCATED AT 250 WORDS)

  • the effect of trabeculectomy on the Aqueous Humor Flow of the unoperated fellow eye
    Graefes Archive for Clinical and Experimental Ophthalmology, 1991
    Co-Authors: M Diestelhorst, Günther Karl Krieglstein
    Abstract:

    Computerized anterior-chamber fluorophotometry was used to investigate the effect of unilateral antiglaucomatous trabeculectomy on the dynamics of Aqueous Humor in the unoperated fellow eye. In 14 patients with bilateral primary open-angle glaucoma, pigmentary glaucoma or exfoliation glaucoma, antiglaucomatous trabeculectomy was performed in one eye in which medical management of glaucoma had failed. The fellow eye in all patients had a well-defined history of glaucoma and had been treated with different sorts of medication. The medical management of the unoperated fellow eyes was continued throughout the study. Aqueous Humor Flow was measured in these eyes prior to surgery and on the 5th day after trabeculectomy. Systemic medication was discontinued from 48 h prior to surgery until second fluorophotometry. The average postoperative Flow in the fellow eyes increased from 2.56 to 2.92 μl/min (P<0.05%, paired t-test). The increase in Flow in the fellow eyes was independent of topical antiglaucoma medication and of the diurnal rhythm of Aqueous Humor dynamics. The results of the study indicate that filtration surgery in one eye triggers a CNS-mediated, reflective increase in Aqueous Flow to maintain physiological stability in the anterior chamber of the surgically treated eye. Since this CNS reflex on Aqueous Humor dynamics affects both eyes, the clinical observation of intraocular pressure (10P) dysregulation in the unoperated fellow eye following unilateral trabeculectomy is now understandable.

Lillinger Larsson - One of the best experts on this subject based on the ideXlab platform.

  • Aqueous Humor Flow in normal human eyes treated with brimonidine and dorzolamide, alone and in combination.
    Archives of ophthalmology (Chicago Ill. : 1960), 2004
    Co-Authors: Hidetoshi Tsukamoto, Lillinger Larsson
    Abstract:

    To measure the effectiveness of topical 0.2% brimonidine tartrate as a suppressor of Aqueous Humor Flow in the human eye compared with the effectiveness of 2% dorzolamide hydrochloride, and to measure the additivity of the effects of the 2 drugs. A randomized, double-masked, placebo-controlled study was performed in 20 healthy human subjects. The topical drugs were instilled twice daily the day before and again in the morning on the day of the measurements. The rate of Aqueous Humor Flow was measured from 8 AM to 4 PM by clearance of topically applied fluorescein using a fluorophotometer, after administration of doses of each drug singly and both drugs together. Intraocular pressure (IOP) was measured with applanation tonometry. Compared with placebo, brimonidine reduced the Aqueous Humor Flow by a mean +/- SD of 28.2% +/- 18.0% (P<.001), dorzolamide by 19.3% +/- 22.0% (P =.007), and the combination of brimonidine and dorzolamide by 37.2% +/- 20.6% (P<.001). The combination of both drugs statistically significantly suppressed Aqueous Humor Flow compared with dorzolamide alone (P<.001) and brimonidine alone (P =.04). The IOP was reduced by a mean +/- SD of 11.6% +/- 10.1% (P<.001) by brimonidine, 8.5% +/- 14.1% (P =.02) by dorzolamide, and 17.9% +/- 16.5% (P<.001) by the combination. The combination of drugs reduced IOP better than dorzolamide (P<.001), but not more than brimonidine (P =.06). The combination of brimonidine and dorzolamide caused a further reduction of Aqueous Humor Flow compared with each drug applied alone. The IOP was further reduced by the combination compared with dorzolamide alone, but not compared with brimonidine alone.

  • Aqueous Humor Flow in normal human eyes treated with brimonidine and timolol, alone and in combination.
    Archives of ophthalmology (Chicago Ill. : 1960), 2001
    Co-Authors: Lillinger Larsson
    Abstract:

    Objective To compare the effect on Aqueous Humor Flow and intraocular pressure(IOP) of topically applied 0.2% brimonidine tartrate with topically administered 0.5% timolol maleate, alone and in combination. Design A randomized, double-masked, placebo-controlled study of 20 human subjects was carried out. The topical drugs were instilled twice daily the day before and again on the morning of the day of the measurements. Aqueous Humor Flow was measured by clearance of topically applied fluorescein with a fluorophotometer, and IOP was measured with an applanation tonometer. Results Brimonidine reduced the Aqueous Humor Flow by 33.1%; timolol, by 49.9%; and the combination of brimonidine and timolol, by 58.9%. Brimonidine reduced the IOP by 20.3%; timolol, by 22.9%; and the combination of brimonidine and timolol, by 34.7%. Conclusions Brimonidine suppressed Aqueous Humor Flow, but not as effectively as timolol. However, the effects on the IOP of both drugs separately were comparable. The short-term effect of brimonidine was partly additive to timolol, and the combination treatment caused a further reduction in Aqueous Humor Flow and IOP. The IOP reduction by timolol could be explained solely by Aqueous Humor Flow reduction. Much of the IOP reduction caused by brimonidine, but not all, could be explained by suppression of the Aqueous Humor Flow, suggesting an additional mechanism for the ocular hypotensive effect of brimonidine.

  • Additive effect of dorzolamide on Aqueous Humor Flow in patients receiving long-term treatment with timolol.
    Archives of ophthalmology (Chicago Ill. : 1960), 1998
    Co-Authors: Laura L. Wayman, Lillinger Larsson, Todd L Maus, Richard F. Brubaker
    Abstract:

    Additive effect of dorzolamide on Aqueous Humor Flow in patients receiving long-term treatment with timolol.

  • Aqueous Humor Flow in Human Eyes Treated With Dorzolamide and Different Doses of Acetazolamide
    Archives of ophthalmology (Chicago Ill. : 1960), 1998
    Co-Authors: Lillinger Larsson, Albert Alm
    Abstract:

    Objective To measure the effect of topically applied 2% dorzolamide hydrochloride (Trusopt, Merck & Co Inc, Whitehouse Station, NJ) and different doses of orally administered acetazolamide (Diamox, Lederle Ophthalmic Pharmaceuticals, Pearl River, NY), alone and in combination, on Aqueous Humor Flow. Design A randomized, double-masked, placebo-controlled study of 20 human subjects was carried out. Aqueous Humor Flow was measured by clearance of topically applied fluorescein. Serum standard bicarbonate and serum acetazolamide levels were analyzed. Results Treatment with dorzolamide reduced Aqueous Flow by 17%, and a maximum dose of acetazolamide alone reduced Flow by 29%. Increasing doses of acetazolamide alone gradually decreased Flow, while small doses of acetazolamide did not suppress Flow further when dorzolamide was already applied topically. Serum acetazolamide concentrations rose with increasing doses of acetazolamide. Serum standard bicarbonate levels were all in the normal range. Conclusions Treatment with dorzolamide reduced Aqueous Humor Flow statistically significantly (2.50 µL/min vs 3.00 µL/min;P=.001) compared with placebo, but less than a maximum dose of acetazolamide. Small doses of acetazolamide added to dorzolamide treatment did not further enhance the decrease in Flow. Since there was no metabolic acidosis as measured by plasma levels of standard bicarbonate, the decrease in Aqueous Flow could be attributed to the direct action of the carbonic anhydrase inhibitors on the carbonic anhydrase enzymes. It is concluded that the smaller effect of dorzolamide, as compared with acetazolamide, is due to insufficient inhibition of at least 1 of the 2 carbonic anhydrase isozymes involved in Aqueous Humor production.

  • Comparison of dorzolamide and timolol as suppressors of Aqueous Humor Flow in humans.
    Archives of ophthalmology (Chicago Ill. : 1960), 1997
    Co-Authors: Laura L. Wayman, Lillinger Larsson, Todd L Maus, Albert Alm, Richard F. Brubaker
    Abstract:

    Objectives: To measure the effectiveness of topical 2% dorzolamide hydrochloride (Trusopt, Merck & Co Inc, Whitehouse Station, NJ) as a suppressor of Aqueous Humor Flow in the human eye as compared with the effectiveness of 0.5% timolol maleate (Timoptic, Merck & Co Inc) and to measure the additivity of the 2 drugs. Design: A randomized, double-masked, placebocontrolled study of 40 human subjects was carried out in 2 academic centers (Mayo Clinic, Rochester, Minn, and University of Uppsala, Uppsala, Sweden). The rate of Aqueous Flow was measured from 8amto 4pmby means of fluorophotometry after administration of doses of each drug singly and both drugs together. Results: Dorzolamide reduced Aqueous Flow from 3.07±0.63 μL/min (mean±SD) to 2.53±0.60 μL/min, a reduction of 18% ( P P P Conclusions: Timolol is more effective than dorzolamide as a suppressor of Aqueous Humor Flow in the normal human eye. Timolol and dorzolamide are additive in their effects, both on Aqueous Flow and intraocular pressure.

Michael E. Yablonski - One of the best experts on this subject based on the ideXlab platform.

  • Acute effects of insulin on Aqueous Humor Flow in patients with type 1 diabetes
    American journal of ophthalmology, 2001
    Co-Authors: James T. Lane, Carol B. Toris, Samer N. Nakhle, David M. Chacko, Yun Liang Wang, Michael E. Yablonski
    Abstract:

    Abstract PURPOSE: Previous studies reported reduced Aqueous Humor Flow through the anterior segment of the eye in patients with type 1 diabetes. This study investigates whether reduced Flow is the result of the diabetic state or of alterations in glucose or insulin concentrations. METHODS: A cross-sectional study, involving patients with type 1 diabetes and healthy controls, measured Aqueous Flow at different insulin concentrations. Eleven patients with type 1 diabetes (hemoglobin A1C=7.0 ± 0.3% [mean ± SEM], normal RESULTS: Control subjects had no change in Aqueous Flow during fasting and hyperinsulinemic conditions (3.0 ± 0.1 vs 2.8 ± 0.1 μl per minute). In the patients with type 1 diabetes, Aqueous Flow was not decreased with hyperinsulinemia, compared with the low insulin state ( P = .7). Compared with control subjects, patients with type 1 diabetes had lower Aqueous Flow during hyperinsulinemia (2.4 ± 0.1 μl per minute, P = .03) and at lower insulin conditions (2.6 ± 0.1 μl per minute, P CONCLUSIONS: Aqueous Flow is decreased in patients with type 1 diabetes under euglycemic conditions of high and relatively low insulin concentrations, despite the absence of microvascular complications.