Tropicamide

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Dongyu Guo - One of the best experts on this subject based on the ideXlab platform.

  • anterior segment biometry with phenylephrine and Tropicamide during accommodation imaged with ultralong scan depth optical coherence tomography
    Journal of Ophthalmology, 2019
    Co-Authors: Junna Zhang, Wen Sun, Mengyun Liu, Dongyu Guo
    Abstract:

    Purpose. To investigate the influence of phenylephrine and Tropicamide on anterior segment biometry with ultralong scan depth optical coherence tomography (UL-OCT) during accommodation. Methods. In this study, 20 left eyes of healthy volunteers with a mean ± standard deviation age of 31.05 ± 5.84 years and a mean refraction of −1.16 ± 1.11 diopters (range 0∼−3.0 D) were imaged using UL-OCT after instillation of artificial tears, phenylephrine, and Tropicamide in three follow-up trials, respectively. At each follow-up trial, two repeated measurements were performed at states of relax and 5D accommodative stimulation. The dimensional parameters included central corneal thickness (CCT), anterior chamber depth (ACD), pupil diameter (PD), lens thickness (LT), and horizontal radii of the lens anterior and posterior surface curvatures (LAC and LPC). Results. Tropicamide led to larger pupil, deeper ACD, thinner LT, and flatter crystalline lens surface ( ). Phenylephrine induced an increase in PD ( ), while no significant changes were seen in ACD, LT, LAC, and LPC ( ). CCT did not change after both phenylephrine and Tropicamide instillation in this study ( ). Tropicamide induced the loss of accommodation and phenylephrine achieved pupil dilation without affecting the accommodation. PD, ACD decreased, LT increased significantly and the anterior and posterior surface of the lens in a 6.294 mm of diameter optical zone became steeper during accommodation after administration of phenylephrine ( ). Conclusion. The anterior segment physiology changed after Tropicamide instillation. Besides, Tropicamide induced the loss of accommodation and phenylephrine preserved the accommodation with a larger pupil. And, the anterior and posterior surface of lens in a 6.294 mm of diameter optical zone became steeper during the accommodation.

  • Anterior Segment Biometry with Phenylephrine and Tropicamide during Accommodation Imaged with Ultralong Scan Depth Optical Coherence Tomography
    Hindawi Limited, 2019
    Co-Authors: Junna Zhang, Wen Sun, Mengyun Liu, Dongyu Guo
    Abstract:

    Purpose. To investigate the influence of phenylephrine and Tropicamide on anterior segment biometry with ultralong scan depth optical coherence tomography (UL-OCT) during accommodation. Methods. In this study, 20 left eyes of healthy volunteers with a mean ± standard deviation age of 31.05 ± 5.84 years and a mean refraction of −1.16 ± 1.11 diopters (range 0∼−3.0 D) were imaged using UL-OCT after instillation of artificial tears, phenylephrine, and Tropicamide in three follow-up trials, respectively. At each follow-up trial, two repeated measurements were performed at states of relax and 5D accommodative stimulation. The dimensional parameters included central corneal thickness (CCT), anterior chamber depth (ACD), pupil diameter (PD), lens thickness (LT), and horizontal radii of the lens anterior and posterior surface curvatures (LAC and LPC). Results. Tropicamide led to larger pupil, deeper ACD, thinner LT, and flatter crystalline lens surface (P0.05). Tropicamide induced the loss of accommodation and phenylephrine achieved pupil dilation without affecting the accommodation. PD, ACD decreased, LT increased significantly and the anterior and posterior surface of the lens in a 6.294 mm of diameter optical zone became steeper during accommodation after administration of phenylephrine (P

Asieh Ehsaei - One of the best experts on this subject based on the ideXlab platform.

  • effect of cyclopentolate versus Tropicamide on anterior segment angle parameters in three refractive groups
    Clinical and Experimental Optometry, 2020
    Co-Authors: Nasrin Moghadas Sharif, Nasser Shoeibi, Maryam Heydari, Negareh Yazdani, Somayeh Ghasemimoghaddam, Asieh Ehsaei
    Abstract:

    CLINICAL RELEVANCE Frequent clinical application of cycloplegia in clinical practice makes it essential to assess how this condition influences anterior segment angle parameters. BACKGROUND This study aims to compare the effects of cyclopentolate and Tropicamide on anterior segment angle parameters in three adult refractive groups. METHODS Sixty healthy individuals were recruited and assigned into three refractive groups according to inclusion criteria. At baseline visit, anterior segment angle parameters were measured using anterior segment optical coherence tomography in the right eye. All measurements were repeated at two separate visits, one week apart, after administration of Tropicamide 1% and cyclopentolate 1% at similar conditions. Main outcome measures were angle-opening distance, trabecular iris angle, trabecular iris space area and anterior chamber depth. Anterior segment angle parameters were recorded at temporal areas (180 degrees). RESULTS Sixty participants (29 men and 31 women, age: 27.82 ± 4.71 years) completed the experiment. Baseline mean spherical equivalents were +1.52 ± 1.20 D, -0.04 ± 0.33 D and -1.91 ± 0.91 D in hyperopic, emmetropic and myopic groups, respectively. No statistically significant differences were found between Tropicamide and cyclopentolate for all angle parameters in three refractive groups. Both drops induced an increase in all parameters in three refractive groups. Analysis between refractive groups revealed that a more hyperopic refraction was associated with less trabecular iris angle, angle-opening distance and anterior chamber depth parameters in baseline, after Tropicamide and cyclopentolate instillations. CONCLUSIONS Topical application of cycloplegic eye drops in healthy individuals leads to small but significant changes in anterior chamber depth and anterior segment angle parameters, regardless of refractive status. Moreover, lower values of anterior chamber depth and anterior segment angle parameters in hyperopic individuals after administration of cycloplegic drops should be taken into account during biometric measurement and phakic intraocular lens implantation. Due to shorter effect and recovery time and less ocular/systemic reaction of Tropicamide versus cyclopentolate, Tropicamide could be a recommended cycloplegic agent for diagnostic and therapeutic procedures.

  • Comparison of cyclopentolate versus Tropicamide on corneal topography in emmetropic and myopic eyes
    2020
    Co-Authors: Nasrin Moghadas Sharif, Hadi Ostadi Moghadam, Elham Azizi, Elahe Ghoochani, Asieh Ehsaei
    Abstract:

    Abstract Background: To compare the effect of cyclopentolate versus Tropicamide eye drops on anterior surface corneal parameters using Keratograph 4 in myopic and emmetropic individuals.Methods: Fifty-eight participants included 29 emmetropic and 29 myopic individuals, were recruited, according to inclusion and exclusion criteria. At baseline visit, anterior surface corneal parameters were measured using Keratograph 4 Keratograph 4in the right eye. All measurements were repeated at two separate visits, one week apart, after administration of Tropicamide 1% and cyclopentolate 1% at similar conditions.Results: Of 58 participants who completed the study, 29 (24 women, 5 men, age: 23.82± 2.78 years) were emmetropic and 29 (21women, 8 men, age: 23.66± 2.76 years) were myopic. Baseline mean spherical equivalents were -0.23±0.23 D and -2.45±1.03 D in emmetropic and myopic groups, respectively. The analysis of the data showed a significant hyperopic shift following instillation of both cycloplegic eye drops in both refractive groups. However, Tropicamide results was statistically insignificant in comparison with cyclopentolate (p=0.49). The assessment of data revealed no statistically significant differences in anterior surface corneal parameters in baseline, Tropicamide and cyclopentolate instillation in each refractive group, except IHD value with Tropicamide in myopic group (p=0.02). The further analysis between refractive groups also showed no significant differences in anterior surface corneal parameters in each session.Conclusions: Present study indicates that cyclopentolate and Tropicamide do not appear to affect corneal topographic parameters and hence can be trusted to capture topography data.

  • comparison of cyclopentolate versus Tropicamide cycloplegia a systematic review and meta analysis
    Journal of Optometry, 2017
    Co-Authors: Negareh Yazdani, Hamed Momenimoghaddam, Leili Zarifmahmoudi, Ramin Sadeghi, Asieh Ehsaei
    Abstract:

    espanolObjetivo El objetivo del presente meta-analisis es comparar la eficacia de ciclopentolato y tropicamida a la hora de controlar la acomodacion durante la refraccion. Metodos Se realizo una busqueda amplia en la literatura en las bases de datos de PubMed, Scopus, Science direct y Ovid, utilizando las palabras clave: “tropicamida”, “ciclopentolato”, “cicloplejia” y “cicloplejico” desde sus inicios a Abril de 2016. La calidad metodologica de la literatura se evaluo con arreglo a Oxford Center for Evidence Based Medicine y la escala Newcastle-Ottawa modificada. Los analisis estadisticos se realizaron utilizando el software Comprehensive Meta-Analysis (version 2, Biostat Inc., EEUU). Resultados El presente meta-analisis incluyo seis estudios (tres ensayos controlados aleatorizados y tres estudios de casos-control). La diferencia estandarizada combinada de los cambios medios del error refractivo fue de 0,175 D [limites inferior y superior: −0,089, 0,438], mas acusada en el grupo ciclopentolato con respecto al grupo tropicamida aunque, sin embargo, esta diferencia no fue estadisticamente significativa (p=0,194, Valor Q de Cochrane=171,72 (p Conclusion Sugerimos la consideracion de tropicamida como sustituto viable de ciclopentolato, debido a su rapido inicio de accion. Aunque estos resultados deberian utilizarse con precaucion en ninos y en pacientes con elevada hipermetropia o estrabismo al utilizar tropicamida como unico agente cicloplejico, especialmente en situaciones en las que los hallazgos sean variables, o no exista consistencia entre los resultados del examen y las manifestaciones clinicas de los problemas visuales. EnglishPurpose The aim of the present meta-analysis is to compare the efficacy of cyclopentolate and Tropicamide in controlling accommodation during refraction. Methods A comprehensive literature search was performed in PubMed, Scopus, Science direct and Ovid databases by the key words: “Tropicamide”; “cyclopentolate”; “cycloplegia” and “cycloplegic” from inception to April 2016. Methodological quality of the literature was evaluated according to the Oxford Center for Evidence Based Medicine and modified Newcastle-Ottawa scale. Statistical analyses were performed using Comprehensive Meta-Analysis (version 2; Biostat Inc., USA). Results The present meta-analysis included six studies (three randomized controlled trials and three case–control studies). Pooled standardized difference in the mean changes in the refractive error was 0.175 D [lower and upper limits: −0.089; 0.438] more plus in the cyclopentolate group compared to the Tropicamide group; however, this difference was not statistically significant (p=0.194; Cochrane Q value=171.72 (p Conclusion We suggest that Tropicamide may be considered as a viable substitute for cyclopentolate due to its rapid onset of action. Although these results should be used cautiously in infants and in patients with high hyperopia or strabismus when using Tropicamide as the sole cycloplegic agent especially in situations that the findings are variable or there is no consistency between the examination results and clinical manifestations of the visual problems.

  • comparison of cyclopentolate versus Tropicamide cycloplegia a systematic review and meta analysis
    Journal of Optometry, 2017
    Co-Authors: Negareh Yazdani, Hamed Momenimoghaddam, Leili Zarifmahmoudi, Ramin Sadeghi, Asieh Ehsaei
    Abstract:

    Purpose The aim of the present meta-analysis is to compare the efficacy of cyclopentolate and Tropicamide in controlling accommodation during refraction. Methods A comprehensive literature search was performed in PubMed, Scopus, Science direct and Ovid databases by the key words: "Tropicamide"; "cyclopentolate"; "cycloplegia" and "cycloplegic" from inception to April 2016. Methodological quality of the literature was evaluated according to the Oxford Center for Evidence Based Medicine and modified Newcastle-Ottawa scale. Statistical analyses were performed using Comprehensive Meta-Analysis (version 2; Biostat Inc., USA). Results The present meta-analysis included six studies (three randomized controlled trials and three case-control studies). Pooled standardized difference in the mean changes in the refractive error was 0.175 D [lower and upper limits: -0.089; 0.438] more plus in the cyclopentolate group compared to the Tropicamide group; however, this difference was not statistically significant (p=0.194; Cochrane Q value=171.72 (p Conclusion We suggest that Tropicamide may be considered as a viable substitute for cyclopentolate due to its rapid onset of action. Although these results should be used cautiously in infants and in patients with high hyperopia or strabismus when using Tropicamide as the sole cycloplegic agent especially in situations that the findings are variable or there is no consistency between the examination results and clinical manifestations of the visual problems.

Eric Denion - One of the best experts on this subject based on the ideXlab platform.

  • combination of 5 phenylephrine and 0 5 Tropicamide eyedrops for pupil dilation in neonates is twice as effective as 0 5 Tropicamide eyedrops alone
    Acta Ophthalmologica, 2017
    Co-Authors: Al Lux, Alice Degoumois, Amandine Barjol, Eric Denion, Frederic Mouriaux
    Abstract:

    Purpose Comparison of the efficacy of Tropicamide eyedrops to the combination of 0.5% Tropicamide and 5% phenylephrine eyedrops in order to achieve a proper dilation in premature infants undergoing screening for retinopathy of prematurity. Methods A prospective, randomized, double-blind study was conducted to compare the efficacy of two mydriatic regimens: one regimen consisting of three drops of 0.5% Tropicamide (TTT regimen), the other regimen consisting of one drop of 5% phenylephrine and two drops of 0.5% Tropicamide (PTT regimen). Thirty premature infants were enrolled and received both mydriatic regimens: one regimen in each eye. Outcomes were pupil dilation evaluated by the percentage of pupil diameter over cornea diameter, the percentage of pupil surface over cornea surface and the quality of the eye fundus examination. Results The percentage of pupil diameter over cornea diameter was 47.3% (±8.7) with the TTT regimen and 65.9% (±8.8) with the PTT regimen (p < 0.0001). The percentage of pupil surface over cornea surface was 23.1% (±8.3) with the TTT regimen and 43.8% (±7.3) with the PTT regimen (p < 0.0001). Thus, the pupil surface area was 1.9 times greater with the PTT than with the TTT regimen. Visualization of the retinal periphery was possible for 30 of 30 eyes dilated with the PTT regimen and for 16 of 30 eyes dilated with the TTT regimen (p < 0.0001). Conclusion The dilated pupil surface area for the combination of 5% phenylephrine and 0.5% Tropicamide was almost twice that for 0.5% Tropicamide eyedrops alone and provided significantly superior quality of the eye fundus examination.

  • Combination of 5% phenylephrine and 0.5% Tropicamide eyedrops for pupil dilation in neonates is twice as effective as 0.5% Tropicamide eyedrops alone
    Acta Ophtalmologica, 2017
    Co-Authors: Alice Degoumois, Amandine Barjol, Frederic Mouriaux, Eric Denion
    Abstract:

    PURPOSE: Comparison of the efficacy of Tropicamide eyedrops to the combination of 0.5% Tropicamide and 5% phenylephrine eyedrops in order to achieve a proper dilation in premature infants undergoing screening for retinopathy of prematurity. METHODS: A prospective, randomized, double-blind study was conducted to compare the efficacy of two mydriatic regimens: one regimen consisting of three drops of 0.5% Tropicamide (TTT regimen), the other regimen consisting of one drop of 5% phenylephrine and two drops of 0.5% Tropicamide (PTT regimen). Thirty premature infants were enrolled and received both mydriatic regimens: one regimen in each eye. Outcomes were pupil dilation evaluated by the percentage of pupil diameter over cornea diameter, the percentage of pupil surface over cornea surface and the quality of the eye fundus examination. RESULTS: The percentage of pupil diameter over cornea diameter was 47.3% (±8.7) with the TTT regimen and 65.9% (±8.8) with the PTT regimen (p 

  • Neosynephrine and Tropicamide eyedrops for pupil dilation in premature infants is almost twice as efficient as Tropicamide eyedrops alone
    Acta Ophthalmologica, 2014
    Co-Authors: Al Lux, Alice Degoumois, Frederic Mouriaux, B. Guillois, Eric Denion
    Abstract:

    Purpose Retinopathy of prematurity screening requires pupil dilation of premature infants. While essential for reliable fundus examination, proper dilatation may sometimes be difficult to achieve in this population. The aim of our study was to compare the efficacy of two mydriatic regimens: one consisting in three drops of Tropicamide 0.5% and the other one consisting in two drops of Tropicamide 0.5% with one drop of phenylephrine 5%. Methods Thirty premature infants were enrolled and each infant was dilated with one regimen in one eye and the other regimen in the other eye. The side of each regimen was determined by randomization. A photograph of each eye was taken. The photographs were anonymised and randomly presented to two independant readers. The effect of the two regimens was determined by calculating the ratio of pupil diameter divided by cornea diameter. Assuming that pupil and cornea are circle-shaped, we calculated the ratio of pupil surface area relative to cornea surface area for both regimens. Results The pupil to cornea diameters ratio was 46.7% (+/-8.8) with Tropicamide alone and 65.2%(+/-6.0) with Tropicamide-phenylephrine combination. The ratio of pupil to cornea surface areas was 21.8% with Tropicamide alone and 42.6% with Tropicamide-phenylephrine combination. In other words, the pupil surface area was 1.95 fold greater with Tropicamide-phenylephrine combination than with Tropicamide alone. Conclusion The use of a combination of two drops of Tropicamide 0.5% with one drop of phenylephrine 5% is far more efficient than Tropicamide alone to achieve proper pupil in premature infants.

C. M. Bradshaw - One of the best experts on this subject based on the ideXlab platform.

  • Why patients with Alzheimer’s disease may show increased sensitivity to Tropicamide eye drops: role of locus coeruleus
    Psychopharmacology, 2006
    Co-Authors: R. H. Hou, E. R. Samuels, M. Raisi, R. W. Langley, E. Szabadi, C. M. Bradshaw
    Abstract:

    Rationale Patients suffering from Alzheimer’s disease (AD) may show increased sensitivity to Tropicamide, a muscarinic cholinoceptor antagonist. AD is associated with a severe loss of noradrenergic neurones in the locus coeruleus (LC), which can be “switched off” experimentally by the α_2-adrenoceptor agonist clonidine. The possibility arises that increased pupillary sensitivity to Tropicamide in AD may be due to diminished LC activity. Objective To examine the hypothesis that clonidine may potentiate Tropicamide-evoked mydriasis. Materials and methods Sixteen healthy male volunteers participated in two experimental sessions (0.2 mg clonidine or placebo) conducted 1 week apart. In each session Tropicamide (0.01% 10 μl×2) was applied to the left eye and artificial tear (10 μl×2) was applied to the right eye. Pupillary functions (resting pupil diameter and light and darkness reflexes), alertness and non-pupillary autonomic functions (blood pressure, heart rate, core temperature and salivary output) were measured. Data were analysed by ANOVA, with multiple comparisons. Results Tropicamide increased resting pupil diameter, velocity and amplitude of the darkness reflex response, and decreased recovery time of the light reflex response. Clonidine affected all these pupillary measures in the opposite direction with the exception of the recovery time. The mydriatic response to Tropicamide was potentiated by pre-treatment with clonidine. Clonidine reduced critical flicker fusion frequency, subjective alertness, blood pressure, salivation and temperature. Conclusions The potentiation of Tropicamide-evoked pupil dilatation by clonidine may be due to the abolition of the increase in parasympathetically mediated pupil constriction due to reduced LC activity.

  • why patients with alzheimer s disease may show increased sensitivity to Tropicamide eye drops role of locus coeruleus
    Psychopharmacology, 2006
    Co-Authors: Ruihua Hou, E. R. Samuels, M. Raisi, R. W. Langley, E. Szabadi, C. M. Bradshaw
    Abstract:

    Rationale Patients suffering from Alzheimer’s disease (AD) may show increased sensitivity to Tropicamide, a muscarinic cholinoceptor antagonist. AD is associated with a severe loss of noradrenergic neurones in the locus coeruleus (LC), which can be “switched off” experimentally by the α2-adrenoceptor agonist clonidine. The possibility arises that increased pupillary sensitivity to Tropicamide in AD may be due to diminished LC activity.

Junna Zhang - One of the best experts on this subject based on the ideXlab platform.

  • anterior segment biometry with phenylephrine and Tropicamide during accommodation imaged with ultralong scan depth optical coherence tomography
    Journal of Ophthalmology, 2019
    Co-Authors: Junna Zhang, Wen Sun, Mengyun Liu, Dongyu Guo
    Abstract:

    Purpose. To investigate the influence of phenylephrine and Tropicamide on anterior segment biometry with ultralong scan depth optical coherence tomography (UL-OCT) during accommodation. Methods. In this study, 20 left eyes of healthy volunteers with a mean ± standard deviation age of 31.05 ± 5.84 years and a mean refraction of −1.16 ± 1.11 diopters (range 0∼−3.0 D) were imaged using UL-OCT after instillation of artificial tears, phenylephrine, and Tropicamide in three follow-up trials, respectively. At each follow-up trial, two repeated measurements were performed at states of relax and 5D accommodative stimulation. The dimensional parameters included central corneal thickness (CCT), anterior chamber depth (ACD), pupil diameter (PD), lens thickness (LT), and horizontal radii of the lens anterior and posterior surface curvatures (LAC and LPC). Results. Tropicamide led to larger pupil, deeper ACD, thinner LT, and flatter crystalline lens surface ( ). Phenylephrine induced an increase in PD ( ), while no significant changes were seen in ACD, LT, LAC, and LPC ( ). CCT did not change after both phenylephrine and Tropicamide instillation in this study ( ). Tropicamide induced the loss of accommodation and phenylephrine achieved pupil dilation without affecting the accommodation. PD, ACD decreased, LT increased significantly and the anterior and posterior surface of the lens in a 6.294 mm of diameter optical zone became steeper during accommodation after administration of phenylephrine ( ). Conclusion. The anterior segment physiology changed after Tropicamide instillation. Besides, Tropicamide induced the loss of accommodation and phenylephrine preserved the accommodation with a larger pupil. And, the anterior and posterior surface of lens in a 6.294 mm of diameter optical zone became steeper during the accommodation.

  • Anterior Segment Biometry with Phenylephrine and Tropicamide during Accommodation Imaged with Ultralong Scan Depth Optical Coherence Tomography
    Hindawi Limited, 2019
    Co-Authors: Junna Zhang, Wen Sun, Mengyun Liu, Dongyu Guo
    Abstract:

    Purpose. To investigate the influence of phenylephrine and Tropicamide on anterior segment biometry with ultralong scan depth optical coherence tomography (UL-OCT) during accommodation. Methods. In this study, 20 left eyes of healthy volunteers with a mean ± standard deviation age of 31.05 ± 5.84 years and a mean refraction of −1.16 ± 1.11 diopters (range 0∼−3.0 D) were imaged using UL-OCT after instillation of artificial tears, phenylephrine, and Tropicamide in three follow-up trials, respectively. At each follow-up trial, two repeated measurements were performed at states of relax and 5D accommodative stimulation. The dimensional parameters included central corneal thickness (CCT), anterior chamber depth (ACD), pupil diameter (PD), lens thickness (LT), and horizontal radii of the lens anterior and posterior surface curvatures (LAC and LPC). Results. Tropicamide led to larger pupil, deeper ACD, thinner LT, and flatter crystalline lens surface (P0.05). Tropicamide induced the loss of accommodation and phenylephrine achieved pupil dilation without affecting the accommodation. PD, ACD decreased, LT increased significantly and the anterior and posterior surface of the lens in a 6.294 mm of diameter optical zone became steeper during accommodation after administration of phenylephrine (P