The Experts below are selected from a list of 1494 Experts worldwide ranked by ideXlab platform
Leon D. Cohen - One of the best experts on this subject based on the ideXlab platform.
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Effect of a Single ‘Megadose’ Intramuscular Vitamin D (600,000 IU) Injection on Vitamin D Concentrations and Bone Mineral Density Following Biliopancreatic Diversion Surgery
Obesity surgery, 2009Co-Authors: Kristjana Einarsdóttir, David B. Preen, Timothy D. Clay, Laura Kiely, C. D’arcy J. Holman, Leon D. CohenAbstract:Background Vitamin D (VitD) deficiency is common following biliopancreatic diversion (BPD). We conducted a prospective open-label study to evaluate the efficacy of a single intramuscular injection with 600,000 IU of cholecalciferol in an Arachis Oil depot formulation (VitD3, Arachitol Solvay Pharmacia) as an adjunct to regular oral VitD supplementation (Citrical+D) for a period of 12 months following BPD surgery.
David J. Handelsman - One of the best experts on this subject based on the ideXlab platform.
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Pharmacokinetics and Pharmacodynamics of Nandrolone Esters in Oil Vehicle: Effects of Ester, Injection Site and Injection Volume
The Journal of pharmacology and experimental therapeutics, 1997Co-Authors: Charles F. Minto, Christopher J. Howe, Susan M. Wishart, Ann J. Conway, David J. HandelsmanAbstract:We studied healthy men who underwent blood sampling for plasma nandrolone, testosterone and inhibin measurements before and for 32 days after a single i.m. injection of 100 mg of nandrolone ester in Arachis Oil. Twenty-three men were randomized into groups receiving nandrolone phenylpropionate (group 1, n = 7) or nandrolone decanoate (group 2, n = 6) injected into the gluteal muscle in 4 ml of Arachis Oil vehicle or nandrolone decanoate in 1 ml of Arachis Oil vehicle injected into either the gluteal (group 3, n = 5) or deltoid (group 4, n = 5) muscles. Plasma nandrolone, testosterone and inhibin concentrations were analyzed by a mixed-effects indirect response model. Plasma nandrolone concentrations were influenced (P < .001) by different esters and injection sites, with higher and earlier peaks with the phenylpropionate ester, compared with the decanoate ester. After nandrolone decanoate injection, the highest bioavailability and peak nandrolone levels were observed with the 1-ml gluteal injection. Plasma testosterone concentrations were also influenced (P < .001) by the ester and injection site, with the most rapid, but briefest, suppression being due to the phenylpropionate ester, whereas the most sustained suppression was achieved with the 1-ml gluteal injection. Plasma inhibin concentrations were also significantly influenced by injection volume and site, with the lowest nadir occurring after the nandrolone decanoate 1-ml gluteal injection. Thus, the bioavailability and physiological effects of a nandrolone ester in an Oil vehicle are greatest when the ester is injected in a small (1 ml vs. 4 ml) volume and into the gluteal vs. deltoid muscle. We conclude that the side-chain ester and the injection site and volume influence the pharmacokinetics and pharmacodynamics of nandrolone esters in an Oil vehicle in men.
Kristjana Einarsdóttir - One of the best experts on this subject based on the ideXlab platform.
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Effect of a Single ‘Megadose’ Intramuscular Vitamin D (600,000 IU) Injection on Vitamin D Concentrations and Bone Mineral Density Following Biliopancreatic Diversion Surgery
Obesity surgery, 2009Co-Authors: Kristjana Einarsdóttir, David B. Preen, Timothy D. Clay, Laura Kiely, C. D’arcy J. Holman, Leon D. CohenAbstract:Background Vitamin D (VitD) deficiency is common following biliopancreatic diversion (BPD). We conducted a prospective open-label study to evaluate the efficacy of a single intramuscular injection with 600,000 IU of cholecalciferol in an Arachis Oil depot formulation (VitD3, Arachitol Solvay Pharmacia) as an adjunct to regular oral VitD supplementation (Citrical+D) for a period of 12 months following BPD surgery.
C. D’arcy J. Holman - One of the best experts on this subject based on the ideXlab platform.
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Effect of a Single ‘Megadose’ Intramuscular Vitamin D (600,000 IU) Injection on Vitamin D Concentrations and Bone Mineral Density Following Biliopancreatic Diversion Surgery
Obesity surgery, 2009Co-Authors: Kristjana Einarsdóttir, David B. Preen, Timothy D. Clay, Laura Kiely, C. D’arcy J. Holman, Leon D. CohenAbstract:Background Vitamin D (VitD) deficiency is common following biliopancreatic diversion (BPD). We conducted a prospective open-label study to evaluate the efficacy of a single intramuscular injection with 600,000 IU of cholecalciferol in an Arachis Oil depot formulation (VitD3, Arachitol Solvay Pharmacia) as an adjunct to regular oral VitD supplementation (Citrical+D) for a period of 12 months following BPD surgery.
Laura Kiely - One of the best experts on this subject based on the ideXlab platform.
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Effect of a Single ‘Megadose’ Intramuscular Vitamin D (600,000 IU) Injection on Vitamin D Concentrations and Bone Mineral Density Following Biliopancreatic Diversion Surgery
Obesity surgery, 2009Co-Authors: Kristjana Einarsdóttir, David B. Preen, Timothy D. Clay, Laura Kiely, C. D’arcy J. Holman, Leon D. CohenAbstract:Background Vitamin D (VitD) deficiency is common following biliopancreatic diversion (BPD). We conducted a prospective open-label study to evaluate the efficacy of a single intramuscular injection with 600,000 IU of cholecalciferol in an Arachis Oil depot formulation (VitD3, Arachitol Solvay Pharmacia) as an adjunct to regular oral VitD supplementation (Citrical+D) for a period of 12 months following BPD surgery.