The Experts below are selected from a list of 39 Experts worldwide ranked by ideXlab platform
Yohko T. Arai - One of the best experts on this subject based on the ideXlab platform.
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New lyssaVirus genotype from the Lesser Mouse-eared Bat (Myotis blythi), Kyrghyzstan.
Emerging Infectious Diseases, 2003Co-Authors: Yohko T. Arai, Yosuke Kameoka, Alexandr D. BotvinkinAbstract:The Aravan Virus was isolated from a Lesser Mouse-eared Bat (Myotis blythi) in the Osh region of Kyrghyzstan, central Asia, in 1991. We determined the complete sequence of the nucleoprotein (N) gene and compared it with those of 26 representative lyssaViruses obtained from databases. The Aravan Virus was distinguished from seven distinct genotypes on the basis of nucleotide and amino acid identity. Phylogenetic analysis based on both nucleotide and amino acid sequences showed that the Aravan Virus was more closely related to genotypes 4, 5, and—to a lesser extent—6, which circulates among insectivorus bats in Europe and Africa. The Aravan Virus does not belong to any of the seven known genotypes of lyssaViruses, namely, rabies, Lagos bat, Mokola, and Duvenhage Viruses and European bat lyssaVirus 1, European bat lyssaVirus 2, and Australian bat lyssaVirus. Based on these data, we propose a new genotype for the LyssaVirus genus.
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Bat lyssaViruses (Aravan and Khujand) from Central Asia: phylogenetic relationships according to N, P and G gene sequences.
Virus research, 2003Co-Authors: Lillian A. Orciari, Yohko T. Arai, Jean S. Smith, Cathleen A. Hanlon, Yosuke KameokaAbstract:Bat lyssaViruses Aravan and Khujand were isolated in southern Kyrgyzstan in 1991 and in northern Tajikistan in 2001, respectively. Preliminary studies with anti-nucleocapsid monoclonal antibodies suggested that the Viruses were distinct from other lyssaVirus serotypes. These data were supported by sequencing of the N gene of Aravan Virus. In the present study, we sequenced the entire N, P and G genes of both Aravan and Khujand Viruses and compared them with respective sequences of other lyssaViruses available from GenBank. The results suggested that each Virus should be considered as a newly recognized genotype according to the current approaches for genotype definition (amount of nucleotide identity of the N gene and bootstrap support of joining to certain phylogenetic groups). Use of different phylogenetic methods and comparison of different parts of the genomes generally suggested that Khujand Virus was mainly related to genotype 6, while Aravan Virus, on the one hand, was related to Khujand Virus, and, on the other hand, demonstrated moderate similarity to genotypes 4, 5 and 6. The potential significance of these new lyssaViruses for veterinary and public health should not be underestimated.
Yosuke Kameoka - One of the best experts on this subject based on the ideXlab platform.
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New lyssaVirus genotype from the Lesser Mouse-eared Bat (Myotis blythi), Kyrghyzstan.
Emerging Infectious Diseases, 2003Co-Authors: Yohko T. Arai, Yosuke Kameoka, Alexandr D. BotvinkinAbstract:The Aravan Virus was isolated from a Lesser Mouse-eared Bat (Myotis blythi) in the Osh region of Kyrghyzstan, central Asia, in 1991. We determined the complete sequence of the nucleoprotein (N) gene and compared it with those of 26 representative lyssaViruses obtained from databases. The Aravan Virus was distinguished from seven distinct genotypes on the basis of nucleotide and amino acid identity. Phylogenetic analysis based on both nucleotide and amino acid sequences showed that the Aravan Virus was more closely related to genotypes 4, 5, and—to a lesser extent—6, which circulates among insectivorus bats in Europe and Africa. The Aravan Virus does not belong to any of the seven known genotypes of lyssaViruses, namely, rabies, Lagos bat, Mokola, and Duvenhage Viruses and European bat lyssaVirus 1, European bat lyssaVirus 2, and Australian bat lyssaVirus. Based on these data, we propose a new genotype for the LyssaVirus genus.
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Bat lyssaViruses (Aravan and Khujand) from Central Asia: phylogenetic relationships according to N, P and G gene sequences.
Virus research, 2003Co-Authors: Lillian A. Orciari, Yohko T. Arai, Jean S. Smith, Cathleen A. Hanlon, Yosuke KameokaAbstract:Bat lyssaViruses Aravan and Khujand were isolated in southern Kyrgyzstan in 1991 and in northern Tajikistan in 2001, respectively. Preliminary studies with anti-nucleocapsid monoclonal antibodies suggested that the Viruses were distinct from other lyssaVirus serotypes. These data were supported by sequencing of the N gene of Aravan Virus. In the present study, we sequenced the entire N, P and G genes of both Aravan and Khujand Viruses and compared them with respective sequences of other lyssaViruses available from GenBank. The results suggested that each Virus should be considered as a newly recognized genotype according to the current approaches for genotype definition (amount of nucleotide identity of the N gene and bootstrap support of joining to certain phylogenetic groups). Use of different phylogenetic methods and comparison of different parts of the genomes generally suggested that Khujand Virus was mainly related to genotype 6, while Aravan Virus, on the one hand, was related to Khujand Virus, and, on the other hand, demonstrated moderate similarity to genotypes 4, 5 and 6. The potential significance of these new lyssaViruses for veterinary and public health should not be underestimated.
Alexandr D. Botvinkin - One of the best experts on this subject based on the ideXlab platform.
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New lyssaVirus genotype from the Lesser Mouse-eared Bat (Myotis blythi), Kyrghyzstan.
Emerging Infectious Diseases, 2003Co-Authors: Yohko T. Arai, Yosuke Kameoka, Alexandr D. BotvinkinAbstract:The Aravan Virus was isolated from a Lesser Mouse-eared Bat (Myotis blythi) in the Osh region of Kyrghyzstan, central Asia, in 1991. We determined the complete sequence of the nucleoprotein (N) gene and compared it with those of 26 representative lyssaViruses obtained from databases. The Aravan Virus was distinguished from seven distinct genotypes on the basis of nucleotide and amino acid identity. Phylogenetic analysis based on both nucleotide and amino acid sequences showed that the Aravan Virus was more closely related to genotypes 4, 5, and—to a lesser extent—6, which circulates among insectivorus bats in Europe and Africa. The Aravan Virus does not belong to any of the seven known genotypes of lyssaViruses, namely, rabies, Lagos bat, Mokola, and Duvenhage Viruses and European bat lyssaVirus 1, European bat lyssaVirus 2, and Australian bat lyssaVirus. Based on these data, we propose a new genotype for the LyssaVirus genus.
Myotis Blythi) Kyrghyzstan - One of the best experts on this subject based on the ideXlab platform.
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RESEARCH New LyssaVirus Genotype from the Lesser Mouse-eared Bat
2013Co-Authors: Myotis Blythi) KyrghyzstanAbstract:The Aravan Virus was isolated from a Lesser Mouse-eare
Lillian A. Orciari - One of the best experts on this subject based on the ideXlab platform.
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Bat lyssaViruses (Aravan and Khujand) from Central Asia: phylogenetic relationships according to N, P and G gene sequences.
Virus research, 2003Co-Authors: Lillian A. Orciari, Yohko T. Arai, Jean S. Smith, Cathleen A. Hanlon, Yosuke KameokaAbstract:Bat lyssaViruses Aravan and Khujand were isolated in southern Kyrgyzstan in 1991 and in northern Tajikistan in 2001, respectively. Preliminary studies with anti-nucleocapsid monoclonal antibodies suggested that the Viruses were distinct from other lyssaVirus serotypes. These data were supported by sequencing of the N gene of Aravan Virus. In the present study, we sequenced the entire N, P and G genes of both Aravan and Khujand Viruses and compared them with respective sequences of other lyssaViruses available from GenBank. The results suggested that each Virus should be considered as a newly recognized genotype according to the current approaches for genotype definition (amount of nucleotide identity of the N gene and bootstrap support of joining to certain phylogenetic groups). Use of different phylogenetic methods and comparison of different parts of the genomes generally suggested that Khujand Virus was mainly related to genotype 6, while Aravan Virus, on the one hand, was related to Khujand Virus, and, on the other hand, demonstrated moderate similarity to genotypes 4, 5 and 6. The potential significance of these new lyssaViruses for veterinary and public health should not be underestimated.