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Manal Mohamed Elhassan Taha - One of the best experts on this subject based on the ideXlab platform.

  • gastroprotective activities of turnera diffusa willd ex schult revisited role of Arbutin
    Journal of Ethnopharmacology, 2012
    Co-Authors: Manal Mohamed Elhassan Taha, Siddig Ibrahim Abdelwahab, Mahmood Ameen Abdulla, Muhammad Saleh Salga, Hamid A A Hadi
    Abstract:

    ETHNOPHARMACOLOGICAL RELEVANCE: Turnera diffusa Willd. ex Schult. has been used for the treatment of several human disorders including peptic ulcer. OBJECTIVES OF THE STUDY: The current study is an attempt to evaluate the anti-ulcerogenic activities of Arbutin, a major constituent of Turnera diffusa on two ulcer models. The possible involvement of lipid peroxidation, nitric oxide, IL-6, IL-10, TNF-α and mucus barrier mechanism has been investigated. MATERIALS AND METHODS: Effects of Arbutin on ulcer index, gastric juice acidity, mucus content and histochemistry, gross and histological gastric lesions, nitric oxide, cytokines levels (IL-6, IL-10 and TNF-α), and thiobarbituric acid reactive substances (TBARS), were evaluated in aspirin or ethanol-induced ulcer in vivo. Acute toxicity of Arbutin was also examined in rodent model. MTT assay was used to assess the cytotoxicity of the compound on normal liver cells (WRL-68). RESULTS: Pre-treatment with Arbutin or omeprazole protected the gastric mucosa as seen by reduction in ulcer area and mucosal content, reduced or absence of edema, inflammation and leucocytes infiltration on both models. Arbutin significantly (P<0.05) lowered the elevated TBARS level into gasteric homogenate. Arbutin did not produce significant inhibition of NO. This natural compound has modulated the levels of interleukin-6, interleukin-10 and TNF-α. No in vitro or in vivo toxicities for Arbutin were observed. CONCLUSION: Thus it can be concluded that Turnera diffusa possesses anti-ulcer activity, which could be attributed to lipid peroxidation inhibitory, immuno modulatory and anti-oxidant mechanisms of Arbutin but not to the intervention with nitric oxide inflammation pathway.

  • Gastroprotective activities of Turnera diffusa Willd. ex Schult. revisited: Role of Arbutin
    Journal of Ethnopharmacology, 2012
    Co-Authors: Manal Mohamed Elhassan Taha, Siddig Ibrahim Abdelwahab, Mahmood Ameen Abdulla, Muhammad Saleh Salga, A. Hamid A. Hadi
    Abstract:

    a b s t r a c t Ethnopharmacological relevance: Turnera diffusa Willd. ex Schult. has been used for the treatment of several human disorders including peptic ulcer. Objectives of the study: The current study is an attempt to evaluate the anti-ulcerogenic activities of Arbutin, a major constituent of Turnera diffusa on two ulcer models. The possible involvement of lipid peroxidation, nitric oxide, IL-6, IL-10, TNF- and mucus barrier mechanism has been investigated. Materials and methods: Effects of Arbutin on ulcer index, gastric juice acidity, mucus content and histo- chemistry, gross and histological gastric lesions, nitric oxide, cytokines levels (IL-6, IL-10 and TNF-), and thiobarbituric acid reactive substances (TBARS), were evaluated in aspirin or ethanol-induced ulcer in vivo. Acute toxicity of Arbutin was also examined in rodent model. MTT assay was used to assess the cytotoxicity of the compound on normal liver cells (WRL-68). Results: Pre-treatment with Arbutin or omeprazole protected the gastric mucosa as seen by reduction in ulcer area and mucosal content, reduced or absence of edema, inflammation and leucocytes infiltration on both models. Arbutin significantly (P < 0.05) lowered the elevated TBARS level into gasteric homogenate. Arbutin did not produce significant inhibition of NO. This natural compound has modulated the levels of interleukin-6, interleukin-10 and TNF-. No in vitro or in vivo toxicities for Arbutin were observed. Conclusion: Thus it can be concluded that Turnera diffusa possesses anti-ulcer activity, which could be attributed to lipid peroxidation inhibitory, immuno modulatory and anti-oxidant mechanisms of Arbutin but not to the intervention with nitric oxide inflammation pathway. © 2012 Elsevier Ireland Ltd. All rights reserved.

Hamid A A Hadi - One of the best experts on this subject based on the ideXlab platform.

  • gastroprotective activities of turnera diffusa willd ex schult revisited role of Arbutin
    Journal of Ethnopharmacology, 2012
    Co-Authors: Manal Mohamed Elhassan Taha, Siddig Ibrahim Abdelwahab, Mahmood Ameen Abdulla, Muhammad Saleh Salga, Hamid A A Hadi
    Abstract:

    ETHNOPHARMACOLOGICAL RELEVANCE: Turnera diffusa Willd. ex Schult. has been used for the treatment of several human disorders including peptic ulcer. OBJECTIVES OF THE STUDY: The current study is an attempt to evaluate the anti-ulcerogenic activities of Arbutin, a major constituent of Turnera diffusa on two ulcer models. The possible involvement of lipid peroxidation, nitric oxide, IL-6, IL-10, TNF-α and mucus barrier mechanism has been investigated. MATERIALS AND METHODS: Effects of Arbutin on ulcer index, gastric juice acidity, mucus content and histochemistry, gross and histological gastric lesions, nitric oxide, cytokines levels (IL-6, IL-10 and TNF-α), and thiobarbituric acid reactive substances (TBARS), were evaluated in aspirin or ethanol-induced ulcer in vivo. Acute toxicity of Arbutin was also examined in rodent model. MTT assay was used to assess the cytotoxicity of the compound on normal liver cells (WRL-68). RESULTS: Pre-treatment with Arbutin or omeprazole protected the gastric mucosa as seen by reduction in ulcer area and mucosal content, reduced or absence of edema, inflammation and leucocytes infiltration on both models. Arbutin significantly (P<0.05) lowered the elevated TBARS level into gasteric homogenate. Arbutin did not produce significant inhibition of NO. This natural compound has modulated the levels of interleukin-6, interleukin-10 and TNF-α. No in vitro or in vivo toxicities for Arbutin were observed. CONCLUSION: Thus it can be concluded that Turnera diffusa possesses anti-ulcer activity, which could be attributed to lipid peroxidation inhibitory, immuno modulatory and anti-oxidant mechanisms of Arbutin but not to the intervention with nitric oxide inflammation pathway.

A. Hamid A. Hadi - One of the best experts on this subject based on the ideXlab platform.

  • Gastroprotective activities of Turnera diffusa Willd. ex Schult. revisited: Role of Arbutin
    Journal of Ethnopharmacology, 2012
    Co-Authors: Manal Mohamed Elhassan Taha, Siddig Ibrahim Abdelwahab, Mahmood Ameen Abdulla, Muhammad Saleh Salga, A. Hamid A. Hadi
    Abstract:

    a b s t r a c t Ethnopharmacological relevance: Turnera diffusa Willd. ex Schult. has been used for the treatment of several human disorders including peptic ulcer. Objectives of the study: The current study is an attempt to evaluate the anti-ulcerogenic activities of Arbutin, a major constituent of Turnera diffusa on two ulcer models. The possible involvement of lipid peroxidation, nitric oxide, IL-6, IL-10, TNF- and mucus barrier mechanism has been investigated. Materials and methods: Effects of Arbutin on ulcer index, gastric juice acidity, mucus content and histo- chemistry, gross and histological gastric lesions, nitric oxide, cytokines levels (IL-6, IL-10 and TNF-), and thiobarbituric acid reactive substances (TBARS), were evaluated in aspirin or ethanol-induced ulcer in vivo. Acute toxicity of Arbutin was also examined in rodent model. MTT assay was used to assess the cytotoxicity of the compound on normal liver cells (WRL-68). Results: Pre-treatment with Arbutin or omeprazole protected the gastric mucosa as seen by reduction in ulcer area and mucosal content, reduced or absence of edema, inflammation and leucocytes infiltration on both models. Arbutin significantly (P < 0.05) lowered the elevated TBARS level into gasteric homogenate. Arbutin did not produce significant inhibition of NO. This natural compound has modulated the levels of interleukin-6, interleukin-10 and TNF-. No in vitro or in vivo toxicities for Arbutin were observed. Conclusion: Thus it can be concluded that Turnera diffusa possesses anti-ulcer activity, which could be attributed to lipid peroxidation inhibitory, immuno modulatory and anti-oxidant mechanisms of Arbutin but not to the intervention with nitric oxide inflammation pathway. © 2012 Elsevier Ireland Ltd. All rights reserved.

Siddig Ibrahim Abdelwahab - One of the best experts on this subject based on the ideXlab platform.

  • gastroprotective activities of turnera diffusa willd ex schult revisited role of Arbutin
    Journal of Ethnopharmacology, 2012
    Co-Authors: Manal Mohamed Elhassan Taha, Siddig Ibrahim Abdelwahab, Mahmood Ameen Abdulla, Muhammad Saleh Salga, Hamid A A Hadi
    Abstract:

    ETHNOPHARMACOLOGICAL RELEVANCE: Turnera diffusa Willd. ex Schult. has been used for the treatment of several human disorders including peptic ulcer. OBJECTIVES OF THE STUDY: The current study is an attempt to evaluate the anti-ulcerogenic activities of Arbutin, a major constituent of Turnera diffusa on two ulcer models. The possible involvement of lipid peroxidation, nitric oxide, IL-6, IL-10, TNF-α and mucus barrier mechanism has been investigated. MATERIALS AND METHODS: Effects of Arbutin on ulcer index, gastric juice acidity, mucus content and histochemistry, gross and histological gastric lesions, nitric oxide, cytokines levels (IL-6, IL-10 and TNF-α), and thiobarbituric acid reactive substances (TBARS), were evaluated in aspirin or ethanol-induced ulcer in vivo. Acute toxicity of Arbutin was also examined in rodent model. MTT assay was used to assess the cytotoxicity of the compound on normal liver cells (WRL-68). RESULTS: Pre-treatment with Arbutin or omeprazole protected the gastric mucosa as seen by reduction in ulcer area and mucosal content, reduced or absence of edema, inflammation and leucocytes infiltration on both models. Arbutin significantly (P<0.05) lowered the elevated TBARS level into gasteric homogenate. Arbutin did not produce significant inhibition of NO. This natural compound has modulated the levels of interleukin-6, interleukin-10 and TNF-α. No in vitro or in vivo toxicities for Arbutin were observed. CONCLUSION: Thus it can be concluded that Turnera diffusa possesses anti-ulcer activity, which could be attributed to lipid peroxidation inhibitory, immuno modulatory and anti-oxidant mechanisms of Arbutin but not to the intervention with nitric oxide inflammation pathway.

  • Gastroprotective activities of Turnera diffusa Willd. ex Schult. revisited: Role of Arbutin
    Journal of Ethnopharmacology, 2012
    Co-Authors: Manal Mohamed Elhassan Taha, Siddig Ibrahim Abdelwahab, Mahmood Ameen Abdulla, Muhammad Saleh Salga, A. Hamid A. Hadi
    Abstract:

    a b s t r a c t Ethnopharmacological relevance: Turnera diffusa Willd. ex Schult. has been used for the treatment of several human disorders including peptic ulcer. Objectives of the study: The current study is an attempt to evaluate the anti-ulcerogenic activities of Arbutin, a major constituent of Turnera diffusa on two ulcer models. The possible involvement of lipid peroxidation, nitric oxide, IL-6, IL-10, TNF- and mucus barrier mechanism has been investigated. Materials and methods: Effects of Arbutin on ulcer index, gastric juice acidity, mucus content and histo- chemistry, gross and histological gastric lesions, nitric oxide, cytokines levels (IL-6, IL-10 and TNF-), and thiobarbituric acid reactive substances (TBARS), were evaluated in aspirin or ethanol-induced ulcer in vivo. Acute toxicity of Arbutin was also examined in rodent model. MTT assay was used to assess the cytotoxicity of the compound on normal liver cells (WRL-68). Results: Pre-treatment with Arbutin or omeprazole protected the gastric mucosa as seen by reduction in ulcer area and mucosal content, reduced or absence of edema, inflammation and leucocytes infiltration on both models. Arbutin significantly (P < 0.05) lowered the elevated TBARS level into gasteric homogenate. Arbutin did not produce significant inhibition of NO. This natural compound has modulated the levels of interleukin-6, interleukin-10 and TNF-. No in vitro or in vivo toxicities for Arbutin were observed. Conclusion: Thus it can be concluded that Turnera diffusa possesses anti-ulcer activity, which could be attributed to lipid peroxidation inhibitory, immuno modulatory and anti-oxidant mechanisms of Arbutin but not to the intervention with nitric oxide inflammation pathway. © 2012 Elsevier Ireland Ltd. All rights reserved.

Mahmood Ameen Abdulla - One of the best experts on this subject based on the ideXlab platform.

  • gastroprotective activities of turnera diffusa willd ex schult revisited role of Arbutin
    Journal of Ethnopharmacology, 2012
    Co-Authors: Manal Mohamed Elhassan Taha, Siddig Ibrahim Abdelwahab, Mahmood Ameen Abdulla, Muhammad Saleh Salga, Hamid A A Hadi
    Abstract:

    ETHNOPHARMACOLOGICAL RELEVANCE: Turnera diffusa Willd. ex Schult. has been used for the treatment of several human disorders including peptic ulcer. OBJECTIVES OF THE STUDY: The current study is an attempt to evaluate the anti-ulcerogenic activities of Arbutin, a major constituent of Turnera diffusa on two ulcer models. The possible involvement of lipid peroxidation, nitric oxide, IL-6, IL-10, TNF-α and mucus barrier mechanism has been investigated. MATERIALS AND METHODS: Effects of Arbutin on ulcer index, gastric juice acidity, mucus content and histochemistry, gross and histological gastric lesions, nitric oxide, cytokines levels (IL-6, IL-10 and TNF-α), and thiobarbituric acid reactive substances (TBARS), were evaluated in aspirin or ethanol-induced ulcer in vivo. Acute toxicity of Arbutin was also examined in rodent model. MTT assay was used to assess the cytotoxicity of the compound on normal liver cells (WRL-68). RESULTS: Pre-treatment with Arbutin or omeprazole protected the gastric mucosa as seen by reduction in ulcer area and mucosal content, reduced or absence of edema, inflammation and leucocytes infiltration on both models. Arbutin significantly (P<0.05) lowered the elevated TBARS level into gasteric homogenate. Arbutin did not produce significant inhibition of NO. This natural compound has modulated the levels of interleukin-6, interleukin-10 and TNF-α. No in vitro or in vivo toxicities for Arbutin were observed. CONCLUSION: Thus it can be concluded that Turnera diffusa possesses anti-ulcer activity, which could be attributed to lipid peroxidation inhibitory, immuno modulatory and anti-oxidant mechanisms of Arbutin but not to the intervention with nitric oxide inflammation pathway.

  • Gastroprotective activities of Turnera diffusa Willd. ex Schult. revisited: Role of Arbutin
    Journal of Ethnopharmacology, 2012
    Co-Authors: Manal Mohamed Elhassan Taha, Siddig Ibrahim Abdelwahab, Mahmood Ameen Abdulla, Muhammad Saleh Salga, A. Hamid A. Hadi
    Abstract:

    a b s t r a c t Ethnopharmacological relevance: Turnera diffusa Willd. ex Schult. has been used for the treatment of several human disorders including peptic ulcer. Objectives of the study: The current study is an attempt to evaluate the anti-ulcerogenic activities of Arbutin, a major constituent of Turnera diffusa on two ulcer models. The possible involvement of lipid peroxidation, nitric oxide, IL-6, IL-10, TNF- and mucus barrier mechanism has been investigated. Materials and methods: Effects of Arbutin on ulcer index, gastric juice acidity, mucus content and histo- chemistry, gross and histological gastric lesions, nitric oxide, cytokines levels (IL-6, IL-10 and TNF-), and thiobarbituric acid reactive substances (TBARS), were evaluated in aspirin or ethanol-induced ulcer in vivo. Acute toxicity of Arbutin was also examined in rodent model. MTT assay was used to assess the cytotoxicity of the compound on normal liver cells (WRL-68). Results: Pre-treatment with Arbutin or omeprazole protected the gastric mucosa as seen by reduction in ulcer area and mucosal content, reduced or absence of edema, inflammation and leucocytes infiltration on both models. Arbutin significantly (P < 0.05) lowered the elevated TBARS level into gasteric homogenate. Arbutin did not produce significant inhibition of NO. This natural compound has modulated the levels of interleukin-6, interleukin-10 and TNF-. No in vitro or in vivo toxicities for Arbutin were observed. Conclusion: Thus it can be concluded that Turnera diffusa possesses anti-ulcer activity, which could be attributed to lipid peroxidation inhibitory, immuno modulatory and anti-oxidant mechanisms of Arbutin but not to the intervention with nitric oxide inflammation pathway. © 2012 Elsevier Ireland Ltd. All rights reserved.