The Experts below are selected from a list of 132 Experts worldwide ranked by ideXlab platform

Carolyn Hasselmann - One of the best experts on this subject based on the ideXlab platform.

Farrah Nagrampa - One of the best experts on this subject based on the ideXlab platform.

Michael Roffer - One of the best experts on this subject based on the ideXlab platform.

Andrew J. Lees - One of the best experts on this subject based on the ideXlab platform.

  • Does corticobasal degeneration exist? A clinicopathological re-evaluation.
    Brain : a journal of neurology, 2020
    Co-Authors: Helen Ling, Janice L Holton, Luke A Massey, Dominic C Paviour, Sean S O'sullivan, Tamas Revesz, David R Williams, Andrew J. Lees
    Abstract:

    The pathological findings of corticobasal degeneration are associated with several distinct clinical syndromes, and the corticobasal syndrome has been linked with a number of diverse pathologies. We have reviewed all the Archival cases in the Queen Square Brain Bank for Neurological Disorders over a 20-year period with either a clinical diagnosis of corticobasal syndrome or pathological diagnosis of corticobasal degeneration in an attempt to identify the main diagnostic pitfalls. Of 19 pathologically confirmed corticobasal degeneration cases, only five had been diagnosed correctly in life (sensitivity=26.3%) and four of these had received an alternative earlier diagnosis. All five of these had a unilateral presentation, clumsy useless limb, limb apraxia and myoclonus, four had cortical sensory impairment and focal limb dystonia and three had an alien limb. Eight cases of corticobasal degeneration had been clinically diagnosed as progressive supranuclear palsy, all of whom had vertical supranuclear palsy and seven had falls within the first 2 years. On the other hand, of 21 cases with a clinical diagnosis of corticobasal syndrome, only five had corticobasal degeneration pathology, giving a positive predictive value of 23.8%; six others had progressive supranuclear palsy pathology, five had Alzheimer's disease and the remaining five had other non-tau pathologies. Corticobasal degeneration can present very commonly with a clinical picture closely resembling classical progressive supranuclear palsy or Richardson's syndrome, and we propose the term corticobasal degeneration-Richardson's syndrome for this subgroup. Cases of corticobasal degeneration-Richardson's syndrome have delayed onset of vertical supranuclear gaze palsy (>3 years after onset of first symptom) and the infrequent occurrence of predominant downgaze abnormalities, both of which can be helpful pointers to their underlying corticobasal degeneration pathology. Fourty-two per cent of corticobasal degeneration cases presented clinically with a progressive supranuclear palsy phenotype and 29% of cases with corticobasal syndrome had underlying progressive supranuclear palsy pathology. In contrast, in the Queen Square Brain Bank Archival Collection, corticobasal syndrome is a rare clinical presentation of progressive supranuclear palsy occurring in only 6 of the 179 pathologically diagnosed progressive supranuclear palsy cases (3%). Despite these diagnostic difficulties we conclude that corticobasal degeneration is a discrete clinicopathological entity but with a broader clinical spectrum than was originally proposed.

  • normal pressure hydrocephalus or progressive supranuclear palsy a clinicopathological case series
    Journal of Neurology, 2013
    Co-Authors: Nadia K Magdalinou, Helen Ling, James Shand D Smith, Jonathan M Schott, Laurence D Watkins, Andrew J. Lees
    Abstract:

    Idiopathic normal pressure hydrocephalus (iNPH) is a poorly understood condition, which typically presents with the triad of balance impairment, urinary incontinence and subacute cognitive decline, while brain imaging shows a marked enlargement of the cerebral ventricles. Few patients with iNPH have come to post-mortem. We identified four patients from the Queen Square Brain Bank Archival Collection, who had received a diagnosis of iNPH during life, and reviewed their clinical, radiological and pathological characteristics. At post mortem examination, one patient had Parkinson’s disease (PD) while the other three had progressive supranuclear palsy (PSP). All four had presented with pure akinesia with gait freezing, accompanied by unsteadiness and falls. An awareness that PSP or PD can mimic the clinical symptoms of iNPH may help to avoid invasive and futile cerebrospinal fluid shunting procedures.

  • does corticobasal degeneration exist a clinicopathological re evaluation
    Brain, 2010
    Co-Authors: Helen Ling, Janice L Holton, Sean S Osullivan, Luke A Massey, Dominic C Paviour, Tamas Revesz, David R Williams, Andrew J. Lees
    Abstract:

    The pathological findings of corticobasal degeneration are associated with several distinct clinical syndromes, and the corticobasal syndrome has been linked with a number of diverse pathologies. We have reviewed all the Archival cases in the Queen Square Brain Bank for Neurological Disorders over a 20-year period with either a clinical diagnosis of corticobasal syndrome or pathological diagnosis of corticobasal degeneration in an attempt to identify the main diagnostic pitfalls. Of 19 pathologically confirmed corticobasal degeneration cases, only five had been diagnosed correctly in life (sensitivity = 26.3) and four of these had received an alternative earlier diagnosis. All five of these had a unilateral presentation, clumsy useless limb, limb apraxia and myoclonus, four had cortical sensory impairment and focal limb dystonia and three had an alien limb. Eight cases of corticobasal degeneration had been clinically diagnosed as progressive supranuclear palsy, all of whom had vertical supranuclear palsy and seven had falls within the first 2 years. On the other hand, of 21 cases with a clinical diagnosis of corticobasal syndrome, only five had corticobasal degeneration pathology, giving a positive predictive value of 23.8; six others had progressive supranuclear palsy pathology, five had Alzheimer's disease and the remaining five had other non-tau pathologies. Corticobasal degeneration can present very commonly with a clinical picture closely resembling classical progressive supranuclear palsy or Richardson's syndrome, and we propose the term corticobasal degeneration-Richardson's syndrome for this subgroup. Cases of corticobasal degeneration-Richardson's syndrome have delayed onset of vertical supranuclear gaze palsy (>3 years after onset of first symptom) and the infrequent occurrence of predominant downgaze abnormalities, both of which can be helpful pointers to their underlying corticobasal degeneration pathology. Fourty-two per cent of corticobasal degeneration cases presented clinically with a progressive supranuclear palsy phenotype and 29 of cases with corticobasal syndrome had underlying progressive supranuclear palsy pathology. In contrast, in the Queen Square Brain Bank Archival Collection, corticobasal syndrome is a rare clinical presentation of progressive supranuclear palsy occurring in only 6 of the 179 pathologically diagnosed progressive supranuclear palsy cases (3). Despite these diagnostic difficulties we conclude that corticobasal degeneration is a discrete clinicopathological entity but with a broader clinical spectrum than was originally proposed. © 2010 The Author(s).

Ilya Vladimirovich Kukulin - One of the best experts on this subject based on the ideXlab platform.

  • Rediscovery of the Idea of 'Soviet Society' at the End of 1930 - the Second Half of the 1950s [Переоткрытие Идеи «Советской Общественности» В Конце 1930-Х – Второй Половине 1950-Х Годов]
    2020
    Co-Authors: Maria L'vovna Maiofis, Ilya Vladimirovich Kukulin
    Abstract:

    The article is focused on difficulties, boundaries and new approaches in the study of the institutional history of the USSR. It demonstrates applicability and usefulness of microhistory and history of ideas and concepts for this work. It is based on a micro-historical study. Analyzing the documents from the personal Archival Collection of a social activist, pedagogue and military expert Boris Ivanovitch Zhurin (1890-1964), the authors demonstrate that the 1939 turned to be very important in his career. It was just in 1939 when Zhurin changed his previous “modest” profession of engineer-constructor specializing in concrete buildings for a profession of military expert and for the role of social activist and publicist. As a military expert, Zhurin spent the years 1939 and 1940 writing a monograph about interaction of different combat arms, including artillery and reconnaissance aviation, during the advance of Russian troops in June, 1917. He was convinced that this experience would be vital during the next war. As a social activist and publicist, in 1939 Zhurin elaborated a program of mobilization of the so called “parental public” (roditelskaya obshestvennost) for the purposes of supporting Soviet school. Zhurin invented, described and promoted a new social institute which he called “parents’ committees in multiple dwellings,” insisting that this would have been the best instrument to control and improve family education. This second “know-how” was also based on the idea of interaction, as the parents’ committees had to establish close relationship with district executive committees (ispolkom), school administration and school parents’ committees, local Komsomol departments, and house management as well. This program was partly implemented in the 1950s. Zhurin’s program greatly anticipated the new notion of “public” (obschestvennost) and new social politics promoted by N. Khruschev on the XXth Party Congress in 1956. Thorough observation of Zhurin’s archive and publications and reconstruction of the historical context of both 1939 and the “Thaw” years bring the author to the conclusion that Zhurin perceived Soviet society after the Great Terror as being completely atomized, demoralized by low competence of higher command (in army) and state bureaucrats and lacking the channels of knowledge and experience transmission, and strived to invent new models to rebuild and intensify “horizontal” social ties.

  • Rediscovery of the Idea of 'Soviet Society' at the End of 1930 - the Second Half of the 1950s
    2016
    Co-Authors: Maria L'vovna Maiofis, Ilya Vladimirovich Kukulin
    Abstract:

    The article is focused on difficulties, boundaries and new approaches in the study of the institutional history of the USSR. It demonstrates applicability and usefulness of microhistory and history of ideas and concepts for this work. It is based on a micro-historical study. Analyzing the documents from the personal Archival Collection of a social activist, pedagogue and military expert Boris Ivanovitch Zhurin (1890-1964), the authors demonstrate that the 1939 turned to be very important in his career. It was just in 1939 when Zhurin changed his previous “modest” profession of engineer-constructor specializing in concrete buildings for a profession of military expert and for the role of social activist and publicist. As a military expert, Zhurin spent the years 1939 and 1940 writing a monograph about interaction of different combat arms, including artillery and reconnaissance aviation, during the advance of Russian troops in June, 1917. He was convinced that this experience would be vital during the next war. As a social activist and publicist, in 1939 Zhurin elaborated a program of mobilization of the so called “parental public” (roditelskaya obshestvennost) for the purposes of supporting Soviet school. Zhurin invented, described and promoted a new social institute which he called “parents’ committees in multiple dwellings,” insisting that this would have been the best instrument to control and improve family education. This second “know-how” was also based on the idea of interaction, as the parents’ committees had to establish close relationship with district executive committees (ispolkom), school administration and school parents’ committees, local Komsomol departments, and house management as well. This program was partly implemented in the 1950s. Zhurin’s program greatly anticipated the new notion of “public” (obschestvennost) and new social politics promoted by N. Khruschev on the XXth Party Congress in 1956. Thorough observation of Zhurin’s archive and publications and reconstruction of the historical context of both 1939 and the “Thaw” years bring the author to the conclusion that Zhurin perceived Soviet society after the Great Terror as being completely atomized, demoralized by low competence of higher command (in army) and state bureaucrats and lacking the channels of knowledge and experience transmission, and strived to invent new models to rebuild and intensify “horizontal” social ties.