Areca Catechu

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Wei Wang - One of the best experts on this subject based on the ideXlab platform.

Gordon Bakker - One of the best experts on this subject based on the ideXlab platform.

  • Comparative study of double blind clinical trial in side-effects among Areca Catechu l., Thai traditional herbal formula and mebendazole.
    Tropical parasitology, 2012
    Co-Authors: Supachai Samappito, Buavaroon Srichaikul, Jaruwan Viroj, Gordon Bakker
    Abstract:

    Background: This study was carried out in Mahasarakham Primary Healthcare Center, Mahasarakham province in the area of Northeastern of Thailand. The experiment was randomized control trial clinical study in order to examine the side effects of Areca Catechu Linn., Thai traditional formulae medicine, mebendazole in the treatment of anti-helmintic activity of mixed worms infection in human. Materials and Methods: The experimental group consisted of 15 patients and 5 patients for control group with inclusion and exclusion criteria, which were screened by parasitologist with the selection of mixed worm infection patient samples. The investigation of side effects was recorded after the treatment of each group of patient with different kinds of 4 group of medicine. Results: The percentage of side effects was collected by nurses and confirmed by the physician at Mahasarakham Health Center, which were diarrhea and nausea side effects. The percentage of side effects by the treatments of Areca Catechu Linn., Thai traditional formulae medicine, mebendazole were investigated by the physician and the pharmacist, which the result showed 20% of diarrhea in Areca Catechu Linn., 20% of nausea in Areca Catechu Linn, 20% in side effect of diarrhea in mebendazole treatment, and no side effects were found by the treatment of TTFM. The result showed that Areca Catechu Linn. had higher side effects among the 3 anti-helmintic drugs. Conclusion: The findings indicate to increase the numbers of samples of worm-infected patients, which the samples can be identified with the specification of helminthes genus and species in order to obtain the efficacy by the treatment using Areca Catechu Linn and also indicates to increase various forms of dosage preparations and various demographic locations in Thailand.

  • Comparative Double Blind Clinical Trial Study of Side Effects of Areca Catechu L., TTHF, and Mebendazole, in Treatment of Human Mixed Worm Infection
    Advances in Natural Science, 2012
    Co-Authors: Buavaroon Srichaikul, Supachai Samappito, Weerasak Seubsoh, Gordon Bakker
    Abstract:

    This study was carried out in Mahasarakham Primary Healthcare Centre, Mahasarakham province in the area of Northeastern of Thailand. The experiment was carried on with 200   samples  with  randomized control trial clinical study in order to examine the side effects of Areca Catechu Linn., TTHF and  Mebendazole  after the treatment of antihelmintic activity of mixed worms infection in human . The 3 experimental groups consisted of 50 patients in each group and 50 patients for control group testing with placebo with inclusion and exclusion criteria which were screened by parasitologist of mixed worm infection symptoms samples. The investigation  of side effects were investigated after treating the first dose of Areca Catechu Linn, TTHF and Mebendazole which were confirmed by the physician and the pharmacist. The side effects data were collected before and after the treatment with Areca Catechu Linn. and with placebo. The result showed that Areca Catechu Linn. had 20% of diarrhea and 20% of nausea, 20% of diarrhea in Mebendazole  and 0% in TTHF. The suggestion of this study should increase the number of samples of worm infected patients and also the numbers of locations in Thailand  in order to obtain various kinds of helminthes. Key words: TTHF (Thai Traditional  Herbal  Formula); Mebendazole; Areca Catechu Linn.; Side effects; Antihelmintic activity

  • The Comparative Double Blind Clinical Trial of Antihelmintic Efficacy Among Mebendazole, Thai Traditional Herbal Formulae and Areca Catechu L.
    Advances in Natural Science, 2012
    Co-Authors: Buavaroon Srichaikul, Supachai Samappito, Choosak Nitiketkoon, Surapote Wongyai, Gordon Bakker
    Abstract:

    This study was carried out in Mahasarakham Primary Healthcare Centre, Mahasarakham province in the area of Northeastern of Thailand. The experiment was randomized control trial clinical comparative study in order to examine the antihelmintic activity efficacy among Mebendazole, Thai Traditional Formulae, Areca Catechu Linn. in the treatment of 200 mixed worms infection in human. The experimental group consisted of 150 patients and 50 patients for control group with inclusion and exclusion criteria which were screened by the selected mix worm infected patients samples. The investigation and extraction of worm eggs per gram of patient feces method (EPG) were performed with Ether Formalin Sedimentation test. The percentage of reduction of eggs per gram (EPG) of patient feces were collected, counted and confirmed by parasitologist and the clinical efficacy were investigated by the physician and the pharmacist. The % EPG data were collected before and after the treatment with Mebendazole, Thai Traditional Formulae, Areca Catechu Linn. and with placebo. The result showed that Thai Traditional Formulae had the highest efficacy in antihelmintic activity followed by the efficacy of Mebendazole and Areca Catechu Linn. respectively. The antihelmintic efficacy which were measured by the % reduction of egg worm per gram of patient feces were 93.69, 87.50, 68.12 respectively. The statistical analysis confirmation in this study were carried out by Wilcoxson Signed Ranks test and Kruskal Wallis method. The suggestion of this study should increase the number of samples of worm infected patients which the samples can be identified with more specific helminthes genus and species in order to obtain various types of efficacy by the treatment of different medicine as mentioned above. Key words: Efficacy; Thai Traditional Formula medicine; Mebendazole; Areca Catechu Lin.; Egg per gram

Swati Guptabhattacharya - One of the best experts on this subject based on the ideXlab platform.

Hanwen Yuan - One of the best experts on this subject based on the ideXlab platform.

Yuqing Jian - One of the best experts on this subject based on the ideXlab platform.