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Shaji Sebastian - One of the best experts on this subject based on the ideXlab platform.
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Argon Plasma Coagulation as first line treatment for chronic radiation proctopathy
Journal of Gastroenterology and Hepatology, 2004Co-Authors: Shaji Sebastian, Humphrey J Oconnor, C Omorain, Martin BuckleyAbstract:Background and Aim: Chronic radiation proctopathy is a troublesome complication of radiotherapy to the pelvis, for which current treatment modalities are unsatisfactory. The present prospective study was designed to determine the usefulness and safety of Argon Plasma Coagulation in the management of chronic radiation proctopathy. Methods: Twenty-five consecutive patients (M:F 24:1, mean age: 69 years) with radiation proctopathy were prospectively included. All patients received Argon Plasma Coagulation by a standard protocol. Response to treatment was assessed by symptom response, bleeding severity score, hematological parameters and transfusion requirements over a median 14-month follow up. Results: Patients received a median of one treatment session with Argon Plasma Coagulation. There was significant improvement in rectal bleeding in all patients, with complete cessation of bleeding in 21 (81%) of the patients. The median bleeding severity score fell from 3 to 0 (P < 0.0005). The mean hemoglobin level rose from 10.05 ± 2.21 g/dL before treatment to 12.44 ± 1.09 g/dL at 6 months following treatment (P < 0.002). There was also improvement in other symptoms such as urgency and diarrhea. Over the period of follow up, there was no recurrence of anemia and no complications were noted. Conclusion: These results suggest that Argon Plasma Coagulation is a safe and effective modality in the treatment of chronic radiation proctopathy. © 2004 Blackwell Publishing Asia Pty Ltd
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Argon Plasma Coagulation as first-line treatment for chronic radiation proctopathy.
Journal of Gastroenterology and Hepatology, 2004Co-Authors: Shaji Sebastian, Humphrey J. O'connor, Colm O'morain, Martin BuckleyAbstract:Background and Aim: Chronic radiation proctopathy is a troublesome complication of radiotherapy to the pelvis, for which current treatment modalities are unsatisfactory. The present prospective study was designed to determine the usefulness and safety of Argon Plasma Coagulation in the management of chronic radiation proctopathy. Methods: Twenty-five consecutive patients (M:F 24:1, mean age: 69 years) with radiation proctopathy were prospectively included. All patients received Argon Plasma Coagulation by a standard protocol. Response to treatment was assessed by symptom response, bleeding severity score, hematological parameters and transfusion requirements over a median 14-month follow up. Results: Patients received a median of one treatment session with Argon Plasma Coagulation. There was significant improvement in rectal bleeding in all patients, with complete cessation of bleeding in 21 (81%) of the patients. The median bleeding severity score fell from 3 to 0 (P
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Endoscopic Argon Plasma Coagulation for the treatment of gastric antral vascular ectasia (watermelon stomach): long-term results.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2004Co-Authors: Shaji Sebastian, Colm O'morain, Ramona Mcloughlin, Asghar Qasim, M BuckleyAbstract:Abstract Introduction. Gastric antral vascular ectasia is a rare but well-recognised cause of occult gastrointestinal bleeding. Various endoscopic treatments have been tried in this condition. We report our experience with Argon Plasma Coagulation in the treatment of gastric antral vascular ectasia. Patients and methods. Twelve patients with endoscopically proved gastric antral vascular ectasia were included. All patients received Argon Plasma Coagulation with power of 40 W at a median interval of 4 weeks. The pre-treatment haemoglobin and transfusion requirements were compared with the post-treatment values. Results. There was a sustained increase in mean haemoglobin levels post-treatment. The mean haemoglobin levels pre- and post-treatment were 8.13±0.70 and 12.2±0.32 g/dl, respectively ( P =0.008). All patients were anaemic and 58.3% of the patients were transfusion dependent. The mean number of units of blood transfusion in the period 6 months prior to treatment was 11.3±5.68. Following Argon Plasma Coagulation, the number of transfusions decreased significantly to 1.1±0.57 units ( P =0.018). No significant procedure-related complications were identified. Conclusion. Argon Plasma Coagulation is a safe and effective alternative to the currently available endoscopic modalities of treatment for gastric antral vascular ectasia.
Martin Buckley - One of the best experts on this subject based on the ideXlab platform.
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Argon Plasma Coagulation as first line treatment for chronic radiation proctopathy
Journal of Gastroenterology and Hepatology, 2004Co-Authors: Shaji Sebastian, Humphrey J Oconnor, C Omorain, Martin BuckleyAbstract:Background and Aim: Chronic radiation proctopathy is a troublesome complication of radiotherapy to the pelvis, for which current treatment modalities are unsatisfactory. The present prospective study was designed to determine the usefulness and safety of Argon Plasma Coagulation in the management of chronic radiation proctopathy. Methods: Twenty-five consecutive patients (M:F 24:1, mean age: 69 years) with radiation proctopathy were prospectively included. All patients received Argon Plasma Coagulation by a standard protocol. Response to treatment was assessed by symptom response, bleeding severity score, hematological parameters and transfusion requirements over a median 14-month follow up. Results: Patients received a median of one treatment session with Argon Plasma Coagulation. There was significant improvement in rectal bleeding in all patients, with complete cessation of bleeding in 21 (81%) of the patients. The median bleeding severity score fell from 3 to 0 (P < 0.0005). The mean hemoglobin level rose from 10.05 ± 2.21 g/dL before treatment to 12.44 ± 1.09 g/dL at 6 months following treatment (P < 0.002). There was also improvement in other symptoms such as urgency and diarrhea. Over the period of follow up, there was no recurrence of anemia and no complications were noted. Conclusion: These results suggest that Argon Plasma Coagulation is a safe and effective modality in the treatment of chronic radiation proctopathy. © 2004 Blackwell Publishing Asia Pty Ltd
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Argon Plasma Coagulation as first-line treatment for chronic radiation proctopathy.
Journal of Gastroenterology and Hepatology, 2004Co-Authors: Shaji Sebastian, Humphrey J. O'connor, Colm O'morain, Martin BuckleyAbstract:Background and Aim: Chronic radiation proctopathy is a troublesome complication of radiotherapy to the pelvis, for which current treatment modalities are unsatisfactory. The present prospective study was designed to determine the usefulness and safety of Argon Plasma Coagulation in the management of chronic radiation proctopathy. Methods: Twenty-five consecutive patients (M:F 24:1, mean age: 69 years) with radiation proctopathy were prospectively included. All patients received Argon Plasma Coagulation by a standard protocol. Response to treatment was assessed by symptom response, bleeding severity score, hematological parameters and transfusion requirements over a median 14-month follow up. Results: Patients received a median of one treatment session with Argon Plasma Coagulation. There was significant improvement in rectal bleeding in all patients, with complete cessation of bleeding in 21 (81%) of the patients. The median bleeding severity score fell from 3 to 0 (P
Susumu Ito - One of the best experts on this subject based on the ideXlab platform.
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VASCULAR ECTASIA OF THE COLON TREATED BY Argon Plasma Coagulation: REPORT OF A CASE
Digestive Endoscopy, 2001Co-Authors: Yoshie Tada, Seisuke Okamura, Yoshio Okita, Koji Tsujigami, Soichi Ichikawa, Masahiro Sogabe, Naoki Muguruma, Susumu ItoAbstract:A 72-year-old woman presented with hematochezia. Colonoscopy revealed branch-like vasodilation in the ascending colon and chronic hemorrhage from vascular ectasia of the colon was suspected. Argon Plasma Coagulation was performed. After treatment, epithelialization of the lesion site was noted and her anemia improved. Vascular ectasia of the colon is recognized as the etiology of lower gastrointestinal bleeding with increasing frequency. Infrared ray electronic endoscopy is useful for determining the extent of disease and Argon Plasma Coagulation, a new hemostatic technique, is suitable for treatment of this condition.
Cristiano Crosta - One of the best experts on this subject based on the ideXlab platform.
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Frequency and outcomes of rectal ulcers during Argon Plasma Coagulation for chronic radiation-induced proctopathy
Gastrointestinal endoscopy, 2003Co-Authors: Davide Ravizza, Giancarla Fiori, Cristina Trovato, Cristiano CrostaAbstract:Background : Argon Plasma Coagulation is suitable for treating hemorrhagic GI tract lesions. This study evaluated the frequency and clinical outcomes of complications arising during use of Argon Plasma Coagulation to treat chronic radiation-induced proctopathy. Methods : This uncontrolled prospective study included 27 consecutive patients. Fever and any rectal symptoms or signs were assessed by telephone with a structured questionnaire. Patients with symptoms underwent endoscopy; follow-up examination was performed when rectal complications developed. Results : Fifty-nine therapeutic sessions were performed (mean 2 per patient; mean interval between sessions, 72.5 days); mean follow-up was 11.5 months. The treatment reduced the mean bleeding severity score from 2.8 to 0.5 ( p Conclusions : The frequency of complications during Argon Plasma Coagulation for radiation-induced proctopathy was high in the present series (59%), the most frequent untoward event being the development of rectal ulcers in asymptomatic patients. However, given the benign outcome, these lesions do not necessitate discontinuation of treatment or additional monitoring.
Hendrik Manner - One of the best experts on this subject based on the ideXlab platform.
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Argon Plasma Coagulation in Barrett's Esophagus
Video Journal and Encyclopedia of GI Endoscopy, 2013Co-Authors: Hendrik MannerAbstract:Abstract In the present case, thermal ablation of the Barrett's remainder by Argon Plasma Coagulation (APC) is shown in a patient recently cured of early Barrett's cancer by endoscopic resection. Ablation is carried out in order to reduce the risk of metachronous neoplasia in the residual nonneoplastic Barrett's esophagus. APC is applied dynamically in longitudinal and circumferential stripes, and a wattage of 50 is used. In this patient, the Barrett's segment is completely ablated in one session. This article is part of an expert video encyclopedia.
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Argon Plasma Coagulation therapy.
Current Opinion in Gastroenterology, 2008Co-Authors: Hendrik MannerAbstract:Purpose of reviewTo give a summary of recent advances in Argon Plasma Coagulation (APC) therapy in gastroenterology.Recent findingsAPC has gained importance in gastrointestinal endoscopy during the last decade, and APC technology has improved over time. Recently published studies, mainly consisting
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Multicenter Trial on the Ablation of Nonneoplastic Barrett's Mucosa Using Argon Plasma Coagulation: Response to the Letter
The American Journal of Gastroenterology, 2007Co-Authors: Hendrik MannerAbstract:Multicenter Trial on the Ablation of Nonneoplastic Barrett's Mucosa Using Argon Plasma Coagulation: Response to the Letter
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Safety and efficacy of a new high power Argon Plasma Coagulation system (hp-APC) in lesions of the upper gastrointestinal tract
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2006Co-Authors: Hendrik Manner, Andrea May, M. Faerber, T. Rabenstein, Christian EllAbstract:Abstract Background The aim of this study was to analyze safety and efficacy of a new high power Argon Plasma Coagulation system in the upper gastrointestinal tract. Methods Data of 215 patients treated with a high power Argon Plasma Coagulation system in the upper gastrointestinal tract 04/2003–01/2004, using a VIO APC device (VIO 300 D with APC 2; Erbe Elektromedizin, Tubingen, Germany; pulsed Argon Plasma Coagulation, 20–120 W), were reviewed and analyzed. Indications were as follows: additive ablation therapy in curative treatment of early Barrett's cancer (122 patients); palliative treatment of oesophageal cancer (n = 27); gastric adenoma/carcinoma (n = 19); Zenker's diverticulum (n = 8); and other. In 190/215 patients (149 males; mean age 67 years), the data were completely analyzable. Minor and major complications were evaluated. Results Minor complications (odynophagia, pain, fever) occurred in 24/277 sessions (8.7%); major complications (stenosis) in 3/277 sessions (1.1%) using at least 50 W. No perforation or bleeding occurred. The mean number of treatment sessions required was 1.46 (1–7); in the palliative treatment of oesophageal cancer, it was 2.5 (1–5). Conclusions The high power Argon Plasma Coagulation system was effective and safe in various gastrointestinal conditions. Due to it's high effectiveness and a low number of sessions required in tumour debulking, this high power Argon Plasma Coagulation system might be used as an alternative to Nd:YAG laser.