The Experts below are selected from a list of 278445 Experts worldwide ranked by ideXlab platform
Thierry Ponchon - One of the best experts on this subject based on the ideXlab platform.
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Small-Caliber Endoscopy
2019Co-Authors: Mathieu Pioche, Jérôme Rivory, Jérôme Dumortier, Thierry PonchonAbstract:Abstract Small-caliber endoscopes are an important tool for the diagnosis and treatment of GI disease. Unsedated transnasal Endoscopy is well tolerated and can provide a good optical examination when a detailed assessment of the mucosa is not needed. Thus, it can serve as a first-line option in many centers for exploring GI symptoms, detecting portal hypertension, or screening patients for esophageal neoplasia (squamous cell neoplasia or Barrett's esophagus). Nevertheless, after transnasal detection of a lesion, conventional sedated Endoscopy is typically performed to more precisely examine any detected abnormalities and perform treatment. However, several institutions have shown that performing therapeutic interventions, such as argon plasma coagulation or gastrostomy tube placement, using unsedated transnasal Endoscopy is feasible, safe, and effective. Small caliber endoscopes can not only be used to explore the upper GI tract, but can also be utilized in the diagnosis and treatment of bile duct diseases. Several different types of cholangioscopes have been developed and evaluated and three primary techniques are possible: a percutaneous approach, using mother-baby or disposable single operator endoscope systems, and direct peroral cholangioscopy. Due to the fragility of baby scopes, disposable cholangioscopes have been developed, and important optical improvements have recently been added. Disposable scopes have also been tested to explore the upper GI tract to avoid reprocessing and to allow endoscopic procedures to be performed anywhere without the need for a technical platform, but they are not currently used. Capsule Endoscopy has become an alternate option to transnasal Endoscopy. However, at present, the lack of complete gastric exploration, the inability to perform biopsy samples, and the relatively high cost of the capsule have prevented this technique from replacing standard Endoscopy. Finally, although unsedated transnasal Endoscopy has shown excellent tolerability and is effective, patients still frequently request sedation for upper Endoscopy, and the number of transnasal procedures performed remains relatively low.
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capsule Endoscopy versus colonoscopy for the detection of polyps and cancer
The New England Journal of Medicine, 2009Co-Authors: Andre Van Gossum, Thierry Ponchon, Miguel Munoznavas, Miguel Munoz Navas, Inaqui Fernandezurien, Cristina Carretero, M Delvaux, Marie Georges Lapalus, Horst Neuhaus, Michael PhilipperAbstract:Background An ingestible capsule consisting of an endoscope equipped with a video camera at both ends was designed to explore the colon. This study compared capsule Endoscopy with optical colonoscopy for the detection of colorectal polyps and cancer. Methods We performed a prospective, multicenter study comparing capsule Endoscopy with optical colonoscopy (the standard for comparison) in a cohort of patients with known or suspected colonic disease for the detection of colorectal polyps or cancer. Patients underwent an adapted colon preparation, and colon cleanliness was graded from poor to excellent. We computed the sensitivity and specificity of capsule Endoscopy for polyps, advanced adenoma, and cancer. Results A total of 328 patients (mean age, 58.6 years) were included in the study. The capsule was excreted within 10 hours after ingestion and before the end of the lifetime of the battery in 92.8% of the patients. The sensitivity and specificity of capsule Endoscopy for detecting polyps that were 6 mm ...
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follow up and management of patients exposed to a flawed automated endoscope washer disinfector in a digestive diseases unit
Infection Control and Hospital Epidemiology, 2006Co-Authors: Philippe Vanhems, Thierry Ponchon, Angele Gayetageron, Claude Bernet, J A Chayvialle, Christine Chemorin, Leone Morandat, Marieange Bibollet, P Chevallier, Jacques RitterAbstract:The possible transmission of pathogens to 236 persons exposed to an endoscope processed in a flawed automated endoscope washer-disinfector in a gastrointestinal Endoscopy unit was investigated. During 6 months, 197 patients (83.5%) were followed up, and no cases of acute human immunodeficiency virus, hepatitis C virus, or hepatitis B virus infection were observed. This event created the conditions for improvements in safety procedures.
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7119 Prospective evaluation of diagnostic transnasal esophagogastroduodenoscopy in daily practice: results from 1,000 consecutive patients.
Gastrointestinal Endoscopy, 2000Co-Authors: Jérôme Dumortier, Bertrand Napoleon, Pierre-edouard Pellissier, Hedelius Franck, Leprince Eric, Pujol Bertrand, Thierry PonchonAbstract:Background: By using a pediatric endoscope, esophagogastroduodenoscopy can be performed through nasal route in adults. In order to evaluate this new procedure, we conducted a large prospective study to evaluate the feasibility and tolerance of diagnostic transnasal esophagogastroduodenoscopy in daily practice and to analyze the factors influencing its feasibility. Methods: To assess its feasibility, unsedated transnasal esophagogastroduodenoscopy was attempted in 1,000 consecutive patients. Two Olympus endoscopes were used : a 6.0-mm pediatric videoendoscope and a 5.3-mm diameter pediatric fiberscope. Patients with previous experience of peroral esophagogastroduodenoscopy were asked about their preference. Results: Transnasal esophagogastroduodenoscopy was feasible in 93.7% of the patients. In 62.5% of the cases of failure, Endoscopy was immediately conducted passing the endoscope through the mouth. The only side-effects observed were epistaxis (1.6%), vaso-vagal reaction (0.3%) and nasal pain (1.5%). Biopsy specimens were taken in 43% of the patients. The causes for failure were refusal (20%), nasal pain (5%) and transnasal insertion failure (75%). Feasibility of transnasal esophagogastroduodenoscopy was related to both sex and endoscope diameter, but not to patient age ( 35) or endoscopist experience (junior or senior). Thus, female sex and large endoscope diameter (6.0-mm) were significant predictive factors of procedure failure. The failure rate of transnasal procedures was 3.5% in men, versus 12% in women, and 4.1% using the 5.3-mm diameter endoscope versus 17% using the 6.0-mm diameter endoscope (p
Sarah E Bohndiek - One of the best experts on this subject based on the ideXlab platform.
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a clinically translatable hyperspectral Endoscopy hyse system for imaging the gastrointestinal tract
Nature Communications, 2019Co-Authors: Jonghee Yoon, James Joseph, Dale J Waterhouse, Siri Luthman, George S D Gordon, Massimiliano Di Pietro, Wladyslaw Januszewicz, Rebecca C Fitzgerald, Sarah E BohndiekAbstract:Hyperspectral imaging (HSI) enables visualisation of morphological and biochemical information, which could improve disease diagnostic accuracy. Unfortunately, the wide range of image distortions that arise during flexible Endoscopy in the clinic have made integration of HSI challenging. To address this challenge, we demonstrate a hyperspectral endoscope (HySE) that simultaneously records intrinsically co-registered hyperspectral and standard-of-care white light images, which allows image distortions to be compensated computationally and an accurate hyperspectral data cube to be reconstructed as the endoscope moves in the lumen. Evaluation of HySE performance shows excellent spatial, spectral and temporal resolution and high colour fidelity. Application of HySE enables: quantification of blood oxygenation levels in tissue mimicking phantoms; differentiation of spectral profiles from normal and pathological ex vivo human tissues; and recording of hyperspectral data under freehand motion within an intact ex vivo pig oesophagus model. HySE therefore shows potential for enabling HSI in clinical Endoscopy.
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A clinically translatable hyperspectral Endoscopy (HySE) system for imaging the gastrointestinal tract
Nature Publishing Group, 2019Co-Authors: Yoon J, Joseph J, Dj Waterhouse, As Luthman, Gordon Gsd, Di Pietro M, Januszewicz W, Rc Fitzgerald, Sarah E BohndiekAbstract:© 2019, The Author(s). Hyperspectral imaging (HSI) enables visualisation of morphological and biochemical information, which could improve disease diagnostic accuracy. Unfortunately, the wide range of image distortions that arise during flexible Endoscopy in the clinic have made integration of HSI challenging. To address this challenge, we demonstrate a hyperspectral endoscope (HySE) that simultaneously records intrinsically co-registered hyperspectral and standard-of-care white light images, which allows image distortions to be compensated computationally and an accurate hyperspectral data cube to be reconstructed as the endoscope moves in the lumen. Evaluation of HySE performance shows excellent spatial, spectral and temporal resolution and high colour fidelity. Application of HySE enables: quantification of blood oxygenation levels in tissue mimicking phantoms; differentiation of spectral profiles from normal and pathological ex vivo human tissues; and recording of hyperspectral data under freehand motion within an intact ex vivo pig oesophagus model. HySE therefore shows potential for enabling HSI in clinical Endoscopy
P Marano - One of the best experts on this subject based on the ideXlab platform.
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a prospective trial comparing small bowel radiographs and video capsule Endoscopy for suspected small bowel disease
Gastroenterology, 2002Co-Authors: Guido Costamagna, Saumil K Shah, Maria Elena Riccioni, Francesca Foschia, Massimiliano Mutignani, Vincenzo Perri, A Vecchioli, Maria Gabriella Brizi, Aurelio Picciocchi, P MaranoAbstract:Abstract Background & Aims: This study was undertaken to prospectively compare the clinical outcomes of small bowel radiographs with the wireless capsule Endoscopy. Methods: Twenty-two patients were selected consecutively because of suspected small bowel disease. Two patients were excluded owing to ileal stenosis. Thus, the results of barium follow-through and the Given M2A wireless video capsule (Given Imaging Ltd., Yoqneam, Israel) Endoscopy were compared in 20 patients (13 men; mean age, 52.5 yr; range, 29–78 yr). Results: Barium follow-through was normal in 17 patients and showed ileal nodularity in 3 patients. Capsule Endoscopy was normal in 3 patients and showed positive findings in the remaining 17 patients. The barium study was considered diagnostic in 4 (20%) patients. The capsule Endoscopy was considered diagnostic in 9 (45%) patients, suspicious in 8 (40%) patients, and failed in 3 (15%) patients. For obscure gastrointestinal (GI) bleeding, the diagnostic potential of barium follow-through was much worse as compared with the capsule Endoscopy (5% vs. 31%, P Conclusions: The video capsule endoscope was found to be superior to small bowel radiograph for evaluation of small bowel diseases. However, this novel wireless endoscope system needs further assessment because of limitations such as difficulties in interpretation of potentially nonspecific findings. GASTROENTEROLOGY 2002;123:999-1005
Jonghee Yoon - One of the best experts on this subject based on the ideXlab platform.
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a clinically translatable hyperspectral Endoscopy hyse system for imaging the gastrointestinal tract
Nature Communications, 2019Co-Authors: Jonghee Yoon, James Joseph, Dale J Waterhouse, Siri Luthman, George S D Gordon, Massimiliano Di Pietro, Wladyslaw Januszewicz, Rebecca C Fitzgerald, Sarah E BohndiekAbstract:Hyperspectral imaging (HSI) enables visualisation of morphological and biochemical information, which could improve disease diagnostic accuracy. Unfortunately, the wide range of image distortions that arise during flexible Endoscopy in the clinic have made integration of HSI challenging. To address this challenge, we demonstrate a hyperspectral endoscope (HySE) that simultaneously records intrinsically co-registered hyperspectral and standard-of-care white light images, which allows image distortions to be compensated computationally and an accurate hyperspectral data cube to be reconstructed as the endoscope moves in the lumen. Evaluation of HySE performance shows excellent spatial, spectral and temporal resolution and high colour fidelity. Application of HySE enables: quantification of blood oxygenation levels in tissue mimicking phantoms; differentiation of spectral profiles from normal and pathological ex vivo human tissues; and recording of hyperspectral data under freehand motion within an intact ex vivo pig oesophagus model. HySE therefore shows potential for enabling HSI in clinical Endoscopy.
Paul Swain - One of the best experts on this subject based on the ideXlab platform.
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wireless capsule Endoscopy
Nature, 2000Co-Authors: Gavriel J Iddan, Gavriel Meron, Arkady Glukhovsky, Paul SwainAbstract:The discomfort of internal gastrointestinal examination may soon be a thing of the past. We have developed a new type of Endoscopy, which for the first time allows painless endoscopic imaging of the whole of the small bowel. This procedure involves a wireless capsule endoscope and we describe here its successful testing in humans.
