The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
George W Staples - One of the best experts on this subject based on the ideXlab platform.
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A new species of Argyreia (Convolvulaceae) from Myanmar
Willdenowia, 2019Co-Authors: Paweena Traiperm, Natthaphong Chitchak, Kazumi Fujikawa, Prachaya Srisanga, Charun Maknoi, George W StaplesAbstract:Argyreia decemloba Traiperm, Fujikawa & Staples, a new species of Convolvulaceae from Natma Taung National Park, Chin State, Myanmar, is described here with detailed illustrations and summaries for its distribution, ecology and IUCN conservation status. This new species is a high-climbing twiner that can be distinguished by a white or pale yellow corolla with a deep red or purple-black colour inside at the base of the tube, a ten-lobed corolla limb, and staminal filament bases expanded and densely covered by hispid hairs. Argyreia decemloba is here assessed as Near Threatened (NT) following IUCN Red List categories.
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species delimitation of some Argyreia convolvulaceae using phenetic analyses insights from leaf anatomical data reveal a new species
Botany, 2018Co-Authors: Natthaphong Chitchak, Paweena Traiperm, George W Staples, Pantamith Rattanakrajang, Pirada SumanonAbstract:Argyreia Lour. is one of the most taxonomically complex genera of the morning glory family (Convolvulaceae). The number of named species is now 135, and new species are regularly being described. There are several species complexes that are morphologically similar and difficult to tell apart. Therefore, the aim of this study is to explore the species identification criteria for Argyreia, especially new sources for taxonomically informative characters. Ten accessions representing three morphologically similar Argyreia operational taxonomic units (OTUs) were collected and their anatomical characters were investigated using the leaf peeling technique and paraffin sectioning method. Anatomical character states were analyzed using two phenetic analysis methods: clustering analysis (CA) and principal component analysis (PCA). Three distinct clusters were clearly separated in both PCA and CA at the internal similarity coefficient of 0.48 with a high R-value of 0.89757. Nineteen effectively distinguishable charac...
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identification among morphologically similar Argyreia convolvulaceae based on leaf anatomy and phenetic analyses
Botanical Studies, 2017Co-Authors: Paweena Traiperm, George W Staples, Janene Chow, Possathorn Nopun, Sasivimon C. SwangpolAbstract:The genus Argyreia Lour. is one of the species-rich Asian genera in the family Convolvulaceae. Several species complexes were recognized in which taxon delimitation was imprecise, especially when examining herbarium materials without fully developed open flowers. The main goal of this study is to investigate and describe leaf anatomy for some morphologically similar Argyreia using epidermal peeling, leaf and petiole transverse sections, and scanning electron microscopy. Phenetic analyses including cluster analysis and principal component analysis were used to investigate the similarity of these morpho-types. Anatomical differences observed between the morpho-types include epidermal cell walls and the trichome types on the leaf epidermis. Additional differences in the leaf and petiole transverse sections include the epidermal cell shape of the adaxial leaf blade, the leaf margins, and the petiole transverse sectional outline. The phenogram from cluster analysis using the UPGMA method represented four groups with an R value of 0.87. Moreover, the important quantitative and qualitative leaf anatomical traits of the four groups were confirmed by the principal component analysis of the first two components. The results from phenetic analyses confirmed the anatomical differentiation between the morpho-types. Leaf anatomical features regarded as particularly informative for morpho-type differentiation can be used to supplement macro morphological identification.
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Three New Species of Argyreia (Convolvulaceae) from Thailand
Systematic Botany, 2016Co-Authors: Paweena Traiperm, George W StaplesAbstract:Abstract In preparation for a comprehensive nomenclatural review of the genus Argyreia, several unknown species were discovered. Thailand is a center of distribution for this speciose tropical Asian genus; three new Thai species, A. ankylophlebia, A. dokmaihom, and A. inaequisepala are described as a precursor to the nomenclatural review. Detailed descriptions, illustrations, and keys to species, modified from the Flora of Thailand Convolvulaceae account, are provided for each species to aid in their identification.
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Argyreia akoensis (Convolvulaceae), a new species from southern Taiwan
2015Co-Authors: Sheng-zehn Yang, Po-hao Chen, George W StaplesAbstract:A new species, Argyreia akoensis S.-Z. Yang, P.-H. Chen & Staples (Convolvulaceae) from southern Taiwan, is described and illustrated. Compared to its congeners in Taiwan and neighboring areas, Argyreia akoensis can be differentiated by the corolla lobing, sepal size, and exserted pistil and stamens. A morphological description, diagnosis, line drawings, photographs, and conservation status, as well as a key to similar species are provided to aid in identification.
Paweena Traiperm - One of the best experts on this subject based on the ideXlab platform.
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a new species of Argyreia convolvulaceae from thailand
PhytoKeys, 2020Co-Authors: Paweena Traiperm, Somran SuddeeAbstract:Argyreia pseudosolanum Traiperm & Suddee, sp. nov. from the NE region of Thailand is described and illustrated. The new species is remarkable in having a very distinctive corolla shape similar to Solanum, and staminal filament bases glabrous or nearly glabrous with a few multicellular, uniseriate hairs at the attachment point on the corolla tube. Detailed descriptions, illustrations, a summary of the ecology and an IUCN conservation status are provided.
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A new species of Argyreia (Convolvulaceae) from Myanmar
Willdenowia, 2019Co-Authors: Paweena Traiperm, Natthaphong Chitchak, Kazumi Fujikawa, Prachaya Srisanga, Charun Maknoi, George W StaplesAbstract:Argyreia decemloba Traiperm, Fujikawa & Staples, a new species of Convolvulaceae from Natma Taung National Park, Chin State, Myanmar, is described here with detailed illustrations and summaries for its distribution, ecology and IUCN conservation status. This new species is a high-climbing twiner that can be distinguished by a white or pale yellow corolla with a deep red or purple-black colour inside at the base of the tube, a ten-lobed corolla limb, and staminal filament bases expanded and densely covered by hispid hairs. Argyreia decemloba is here assessed as Near Threatened (NT) following IUCN Red List categories.
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species delimitation of some Argyreia convolvulaceae using phenetic analyses insights from leaf anatomical data reveal a new species
Botany, 2018Co-Authors: Natthaphong Chitchak, Paweena Traiperm, George W Staples, Pantamith Rattanakrajang, Pirada SumanonAbstract:Argyreia Lour. is one of the most taxonomically complex genera of the morning glory family (Convolvulaceae). The number of named species is now 135, and new species are regularly being described. There are several species complexes that are morphologically similar and difficult to tell apart. Therefore, the aim of this study is to explore the species identification criteria for Argyreia, especially new sources for taxonomically informative characters. Ten accessions representing three morphologically similar Argyreia operational taxonomic units (OTUs) were collected and their anatomical characters were investigated using the leaf peeling technique and paraffin sectioning method. Anatomical character states were analyzed using two phenetic analysis methods: clustering analysis (CA) and principal component analysis (PCA). Three distinct clusters were clearly separated in both PCA and CA at the internal similarity coefficient of 0.48 with a high R-value of 0.89757. Nineteen effectively distinguishable charac...
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Identification among morphologically similar Argyreia (Convolvulaceae) based on leaf anatomy and phenetic analyses
Botanical Studies, 2017Co-Authors: Paweena Traiperm, Janene Chow, Possathorn Nopun, G. Staples, Sasivimon C. SwangpolAbstract:Background The genus Argyreia Lour. is one of the species-rich Asian genera in the family Convolvulaceae. Several species complexes were recognized in which taxon delimitation was imprecise, especially when examining herbarium materials without fully developed open flowers. The main goal of this study is to investigate and describe leaf anatomy for some morphologically similar Argyreia using epidermal peeling, leaf and petiole transverse sections, and scanning electron microscopy. Phenetic analyses including cluster analysis and principal component analysis were used to investigate the similarity of these morpho-types. Results Anatomical differences observed between the morpho-types include epidermal cell walls and the trichome types on the leaf epidermis. Additional differences in the leaf and petiole transverse sections include the epidermal cell shape of the adaxial leaf blade, the leaf margins, and the petiole transverse sectional outline. The phenogram from cluster analysis using the UPGMA method represented four groups with an R value of 0.87. Moreover, the important quantitative and qualitative leaf anatomical traits of the four groups were confirmed by the principal component analysis of the first two components. The results from phenetic analyses confirmed the anatomical differentiation between the morpho-types. Conclusions Leaf anatomical features regarded as particularly informative for morpho-type differentiation can be used to supplement macro morphological identification.
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identification among morphologically similar Argyreia convolvulaceae based on leaf anatomy and phenetic analyses
Botanical Studies, 2017Co-Authors: Paweena Traiperm, George W Staples, Janene Chow, Possathorn Nopun, Sasivimon C. SwangpolAbstract:The genus Argyreia Lour. is one of the species-rich Asian genera in the family Convolvulaceae. Several species complexes were recognized in which taxon delimitation was imprecise, especially when examining herbarium materials without fully developed open flowers. The main goal of this study is to investigate and describe leaf anatomy for some morphologically similar Argyreia using epidermal peeling, leaf and petiole transverse sections, and scanning electron microscopy. Phenetic analyses including cluster analysis and principal component analysis were used to investigate the similarity of these morpho-types. Anatomical differences observed between the morpho-types include epidermal cell walls and the trichome types on the leaf epidermis. Additional differences in the leaf and petiole transverse sections include the epidermal cell shape of the adaxial leaf blade, the leaf margins, and the petiole transverse sectional outline. The phenogram from cluster analysis using the UPGMA method represented four groups with an R value of 0.87. Moreover, the important quantitative and qualitative leaf anatomical traits of the four groups were confirmed by the principal component analysis of the first two components. The results from phenetic analyses confirmed the anatomical differentiation between the morpho-types. Leaf anatomical features regarded as particularly informative for morpho-type differentiation can be used to supplement macro morphological identification.
Alexander Paulke - One of the best experts on this subject based on the ideXlab platform.
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studies on the alkaloid composition of the hawaiian baby woodrose Argyreia nervosa a common legal high
Forensic Science International, 2015Co-Authors: Alexander Paulke, Christian Kremer, Cora Wunder, Mario Wurglics, Manfred Schubertzsilavecz, Stefan W ToennesAbstract:Abstract Seeds from the Hawaiian Baby Woodrose Argyreia nervosa of different origin and labelling and with allegedly high levels of ergot alkaloids were analysed using high performance liquid chromatography–high resolution mass spectrometry (HPLC–HRMS/MS) technique. Lysergic acid amide (LSA), ergometrine, lysergol/elymoclavine/setoclavine, chanoclavine, lysergic acid and their respective stereoisomers were identified as well as penniclavine and lysergic acid α-hydroxyethylamide. In addition, methylergometrine, methysergide, and lysergylalanine were detected, some high molecular weight ergot alkaloid derivatives and hydroxyalanine derived ergopeptide fragments were detected indicating the presence of ergopeptides in the seeds. The results of the study demonstrate that the content of ergot alkaloids in Argyreia nervosa seeds depends on the quality of the material. For a consumer the quality of the seeds is unforeseeable. For the toxicological expert it is essential to investigate not only the identity of such a confiscated seed material, but also the various ergot alkaloid constituents to assess the hazardous nature and the toxic potential of the material.
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Argyreia nervosa burm f receptor profiling of lysergic acid amide and other potential psychedelic lsd like compounds by computational and binding assay approaches
Journal of Ethnopharmacology, 2013Co-Authors: Alexander Paulke, Christian Kremer, Cora Wunder, Janosch Achenbach, Bardya Djahanschiri, Anderson Elias, Stefan J Schwed, Harald Hubner, Peter Gmeiner, Ewgenij ProschakAbstract:Abstract Ethnopharmacological relevance The convolvulacea Argyreia nervosa (Burm. f.) is well known as an important medical plant in the traditional Ayurvedic system of medicine and it is used in numerous diseases (e.g. nervousness, bronchitis, tuberculosis, arthritis, and diabetes). Additionally, in the Indian state of Assam and in other regions Argyreia nervosa is part of the traditional tribal medicine (e.g. the Santali people, the Lodhas, and others). In the western hemisphere, Argyreia nervosa has been brought in attention as so called “legal high”. In this context, the seeds are used as source of the psychoactive ergotalkaloid lysergic acid amide (LSA), which is considered as the main active ingredient. Aim of the study As the chemical structure of LSA is very similar to that of lysergic acid diethylamide (LSD), the seeds of Argyreia nervosa (Burm. f.) are often considered as natural substitute of LSD. In the present study, LSA and LSD have been compared concerning their potential pharmacological profiles based on the receptor binding affinities since our recent human study with four volunteers on p.o. application of Argyreia nervosa seeds has led to some ambiguous effects. Material and methods In an initial step computer-aided in silico prediction models on receptor binding were employed to screen for serotonin, norepinephrine, dopamine, muscarine, and histamine receptor subtypes as potential targets for LSA. In addition, this screening was extended to accompany ergotalkaloids of Argyreia nervosa (Burm. f.). In a verification step, selected LSA screening results were confirmed by in vitro binding assays with some extensions to LSD. Results In the in silico model LSA exhibited the highest affinity with a pKi of about 8.0 at α1A, and α1B. Clear affinity with pKi>7 was predicted for 5-HT1A, 5-HT1B, 5-HT1D, 5-HT6, 5-HT7, and D2. From these receptors the 5-HT1D subtype exhibited the highest pKi with 7.98 in the prediction model. From the other ergotalkaloids, agroclavine and festuclavine also seemed to be highly affine to the 5-HT1D-receptor with pKi>8. In general, the ergotalkaloids of Argyreia nervosa seem to prefer serotonin and dopamine receptors (pKi>7). However, with exception of ergometrine/ergometrinine only for 5-HT3A, and histamine H2 and H4 no affinities were predicted. Compared to LSD, LSA exhibited lower binding affinities in the in vitro binding assays for all tested receptor subtypes. However, with a pKi of 7.99, 7.56, and 7.21 a clear affinity for 5-HT1A, 5-HT2, and α2 could be demonstrated. For DA receptor subtypes and the α1-receptor the pKi ranged from 6.05 to 6.85. Conclusion Since the psychedelic activity of LSA in the recent human study was weak and although LSA from Argyreia nervosa is often considered as natural exchange for LSD, LSA should not be regarded as LSD-like psychedelic drug. However, vegetative side effects and psychotropic effects may be triggered by serotonin or dopamine receptor subtypes.
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variable adverse effects in subjects after ingestion of equal doses of Argyreia nervosa seeds
Forensic Science International, 2012Co-Authors: Christian Kremer, Alexander Paulke, Cora Wunder, Stefan W ToennesAbstract:As the new drug Spice hit the market in 2006 and was a hot topic in the media, the general issue of legal highs has been brought to the attention of a large number of (young) people. One of these so called legal highs are the seeds of Argyreia nervosa, also known as Hawaiian Baby Woodrose, which contains the psychotropic alkaloid lysergic acid amide (LSA). A study was designed to assess how driving ability is affected by Argyreia nervosa. However, the study could not be continued due to severe adverse effects in 3 of 4 subjects, such as cardiovascular dysregulation in two and a psychosis like state in one subject. All of the participants recovered completely within 9h after ingestion. Despite body normalized doses interindividually highly differing reactions in type and intensity were observed. Furthermore, fluctuating alkaloid contents in seeds and multi-drug intoxications make the use of this legal high far more dangerous than commonly believed.
Stefan W Toennes - One of the best experts on this subject based on the ideXlab platform.
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studies on the alkaloid composition of the hawaiian baby woodrose Argyreia nervosa a common legal high
Forensic Science International, 2015Co-Authors: Alexander Paulke, Christian Kremer, Cora Wunder, Mario Wurglics, Manfred Schubertzsilavecz, Stefan W ToennesAbstract:Abstract Seeds from the Hawaiian Baby Woodrose Argyreia nervosa of different origin and labelling and with allegedly high levels of ergot alkaloids were analysed using high performance liquid chromatography–high resolution mass spectrometry (HPLC–HRMS/MS) technique. Lysergic acid amide (LSA), ergometrine, lysergol/elymoclavine/setoclavine, chanoclavine, lysergic acid and their respective stereoisomers were identified as well as penniclavine and lysergic acid α-hydroxyethylamide. In addition, methylergometrine, methysergide, and lysergylalanine were detected, some high molecular weight ergot alkaloid derivatives and hydroxyalanine derived ergopeptide fragments were detected indicating the presence of ergopeptides in the seeds. The results of the study demonstrate that the content of ergot alkaloids in Argyreia nervosa seeds depends on the quality of the material. For a consumer the quality of the seeds is unforeseeable. For the toxicological expert it is essential to investigate not only the identity of such a confiscated seed material, but also the various ergot alkaloid constituents to assess the hazardous nature and the toxic potential of the material.
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variable adverse effects in subjects after ingestion of equal doses of Argyreia nervosa seeds
Forensic Science International, 2012Co-Authors: Christian Kremer, Alexander Paulke, Cora Wunder, Stefan W ToennesAbstract:As the new drug Spice hit the market in 2006 and was a hot topic in the media, the general issue of legal highs has been brought to the attention of a large number of (young) people. One of these so called legal highs are the seeds of Argyreia nervosa, also known as Hawaiian Baby Woodrose, which contains the psychotropic alkaloid lysergic acid amide (LSA). A study was designed to assess how driving ability is affected by Argyreia nervosa. However, the study could not be continued due to severe adverse effects in 3 of 4 subjects, such as cardiovascular dysregulation in two and a psychosis like state in one subject. All of the participants recovered completely within 9h after ingestion. Despite body normalized doses interindividually highly differing reactions in type and intensity were observed. Furthermore, fluctuating alkaloid contents in seeds and multi-drug intoxications make the use of this legal high far more dangerous than commonly believed.
Christian Kremer - One of the best experts on this subject based on the ideXlab platform.
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studies on the alkaloid composition of the hawaiian baby woodrose Argyreia nervosa a common legal high
Forensic Science International, 2015Co-Authors: Alexander Paulke, Christian Kremer, Cora Wunder, Mario Wurglics, Manfred Schubertzsilavecz, Stefan W ToennesAbstract:Abstract Seeds from the Hawaiian Baby Woodrose Argyreia nervosa of different origin and labelling and with allegedly high levels of ergot alkaloids were analysed using high performance liquid chromatography–high resolution mass spectrometry (HPLC–HRMS/MS) technique. Lysergic acid amide (LSA), ergometrine, lysergol/elymoclavine/setoclavine, chanoclavine, lysergic acid and their respective stereoisomers were identified as well as penniclavine and lysergic acid α-hydroxyethylamide. In addition, methylergometrine, methysergide, and lysergylalanine were detected, some high molecular weight ergot alkaloid derivatives and hydroxyalanine derived ergopeptide fragments were detected indicating the presence of ergopeptides in the seeds. The results of the study demonstrate that the content of ergot alkaloids in Argyreia nervosa seeds depends on the quality of the material. For a consumer the quality of the seeds is unforeseeable. For the toxicological expert it is essential to investigate not only the identity of such a confiscated seed material, but also the various ergot alkaloid constituents to assess the hazardous nature and the toxic potential of the material.
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Argyreia nervosa burm f receptor profiling of lysergic acid amide and other potential psychedelic lsd like compounds by computational and binding assay approaches
Journal of Ethnopharmacology, 2013Co-Authors: Alexander Paulke, Christian Kremer, Cora Wunder, Janosch Achenbach, Bardya Djahanschiri, Anderson Elias, Stefan J Schwed, Harald Hubner, Peter Gmeiner, Ewgenij ProschakAbstract:Abstract Ethnopharmacological relevance The convolvulacea Argyreia nervosa (Burm. f.) is well known as an important medical plant in the traditional Ayurvedic system of medicine and it is used in numerous diseases (e.g. nervousness, bronchitis, tuberculosis, arthritis, and diabetes). Additionally, in the Indian state of Assam and in other regions Argyreia nervosa is part of the traditional tribal medicine (e.g. the Santali people, the Lodhas, and others). In the western hemisphere, Argyreia nervosa has been brought in attention as so called “legal high”. In this context, the seeds are used as source of the psychoactive ergotalkaloid lysergic acid amide (LSA), which is considered as the main active ingredient. Aim of the study As the chemical structure of LSA is very similar to that of lysergic acid diethylamide (LSD), the seeds of Argyreia nervosa (Burm. f.) are often considered as natural substitute of LSD. In the present study, LSA and LSD have been compared concerning their potential pharmacological profiles based on the receptor binding affinities since our recent human study with four volunteers on p.o. application of Argyreia nervosa seeds has led to some ambiguous effects. Material and methods In an initial step computer-aided in silico prediction models on receptor binding were employed to screen for serotonin, norepinephrine, dopamine, muscarine, and histamine receptor subtypes as potential targets for LSA. In addition, this screening was extended to accompany ergotalkaloids of Argyreia nervosa (Burm. f.). In a verification step, selected LSA screening results were confirmed by in vitro binding assays with some extensions to LSD. Results In the in silico model LSA exhibited the highest affinity with a pKi of about 8.0 at α1A, and α1B. Clear affinity with pKi>7 was predicted for 5-HT1A, 5-HT1B, 5-HT1D, 5-HT6, 5-HT7, and D2. From these receptors the 5-HT1D subtype exhibited the highest pKi with 7.98 in the prediction model. From the other ergotalkaloids, agroclavine and festuclavine also seemed to be highly affine to the 5-HT1D-receptor with pKi>8. In general, the ergotalkaloids of Argyreia nervosa seem to prefer serotonin and dopamine receptors (pKi>7). However, with exception of ergometrine/ergometrinine only for 5-HT3A, and histamine H2 and H4 no affinities were predicted. Compared to LSD, LSA exhibited lower binding affinities in the in vitro binding assays for all tested receptor subtypes. However, with a pKi of 7.99, 7.56, and 7.21 a clear affinity for 5-HT1A, 5-HT2, and α2 could be demonstrated. For DA receptor subtypes and the α1-receptor the pKi ranged from 6.05 to 6.85. Conclusion Since the psychedelic activity of LSA in the recent human study was weak and although LSA from Argyreia nervosa is often considered as natural exchange for LSD, LSA should not be regarded as LSD-like psychedelic drug. However, vegetative side effects and psychotropic effects may be triggered by serotonin or dopamine receptor subtypes.
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variable adverse effects in subjects after ingestion of equal doses of Argyreia nervosa seeds
Forensic Science International, 2012Co-Authors: Christian Kremer, Alexander Paulke, Cora Wunder, Stefan W ToennesAbstract:As the new drug Spice hit the market in 2006 and was a hot topic in the media, the general issue of legal highs has been brought to the attention of a large number of (young) people. One of these so called legal highs are the seeds of Argyreia nervosa, also known as Hawaiian Baby Woodrose, which contains the psychotropic alkaloid lysergic acid amide (LSA). A study was designed to assess how driving ability is affected by Argyreia nervosa. However, the study could not be continued due to severe adverse effects in 3 of 4 subjects, such as cardiovascular dysregulation in two and a psychosis like state in one subject. All of the participants recovered completely within 9h after ingestion. Despite body normalized doses interindividually highly differing reactions in type and intensity were observed. Furthermore, fluctuating alkaloid contents in seeds and multi-drug intoxications make the use of this legal high far more dangerous than commonly believed.