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William B. Kelly - One of the best experts on this subject based on the ideXlab platform.
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On the dynamic performance of the Abbott Safeset blood-conserving Arterial Line system.
Journal of Clinical Monitoring and Computing, 1999Co-Authors: Russell P. Woda, Roger Dzwonczyk, Cheryl Buyama, Brad L. Bernacki, William B. KellyAbstract:Objective. Critically ill patients frequently have indwelling Arterial Lines placed during their Intensive Care Unit stay. The Lines are used to monitor blood pressure continuously, administer drugs and to draw blood for a variety of physiologic tests. Several blood-conserving Arterial Line systems have been developed to eliminate the need to discard blood in the process of obtaining undiluted and uncontaminated blood samples. The purpose of this study was to evaluate the dynamic performance of one such system – the Abbott Clinical Care System Safeset™ blood conserving Arterial Line system – in comparison to a conventional Arterial Line system. Methods. We studied ninety-nine patients who had indwelling Arterial Lines placed during surgery and who were admitted to our Surgical Intensive Care Unit (SICU). The patients were randomly placed into one of two groups. The control group received a conventional indwelling Arterial Line system; the experimental group received the Abbott Safeset™ system. We measured the damping coefficient and resonant frequency daily in order to evaluate and compare the dynamic performance of the two systems. We also measured discard volumes (in the control group) and blood sample sizes during the patients’ stays in the SICU. Results. The two patient groups were similar in regards to demographics and baseLine clinical characteristics. A median 3 ml of blood per draw and 17.5 ml of blood per patient was discarded in purging the conventional Arterial Line system while, by design, no blood was discarded with the experimental system. There was no difference between the two groups with regard to damping coefficient. Both systems were underdamped. However, the conventional Arterial Line system had a significantly higher resonant frequency (16.7 Hz) compared to the Safeset™ system (12.5 Hz). Conclusions. Because the Abbott Safeset™ blood-conserving Arterial Line system is underdamped and has a lower resonant frequency compared to the traditional Arterial system, it may overestimate systolic blood pressure, particularly in patients with high heart rates.
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On the dynamic performance of the Abbott Safeset blood-conserving Arterial Line system.
Journal of clinical monitoring and computing, 1999Co-Authors: Russell P. Woda, Roger Dzwonczyk, Cheryl Buyama, Brad L. Bernacki, William B. KellyAbstract:Critically ill patients frequently have indwelling Arterial Lines placed during their Intensive Care Unit stay. The Lines are used to monitor blood pressure continuously, administer drugs and to draw blood for a variety of physiologic tests. Several blood-conserving Arterial Line systems have been developed to eliminate the need to discard blood in the process of obtaining undiluted and uncontaminated blood samples. The purpose of this study was to evaluate the dynamic performance of one such system the Abbott Clinical Care System Safeset blood conserving Arterial Line system - in comparison to a conventional Arterial Line system. We studied ninety-nine patients who had indwelling Arterial Lines placed during surgery and who were admitted to our Surgical Intensive Care Unit (SICU). The patients were randomly placed into one of two groups. The control group received a conventional indwelling Arterial Line system; the experimental group received the Abbott Safeset system. We measured the damping coefficient and resonant frequency daily in order to evaluate and compare the dynamic performance of the two systems. We also measured discard volumes (in the control group) and blood sample sizes during the patients' stays in the SICU. The two patient groups were similar in regards to demographics and baseLine clinical characteristics. A median 3 ml of blood per draw and 17.5 ml of blood per patient was discarded in purging the conventional Arterial Line system while, by design, no blood was discarded with the experimental system. There was no difference between the two groups with regard to damping coefficient. Both systems were underdamped. However, the conventional Arterial Line system had a significantly higher resonant frequency (16.7 Hz) compared to the Safeset system (12.5 Hz). Because the Abbott Safeset blood-conserving Arterial Line system is underdamped and has a lower resonant frequency compared to the traditional Arterial system, it may overestimate systolic blood pressure, particularly in patients with high heart rates.
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ONTHEDYNAMICPERFORMANCEOFTHE ABBOTT SAFESET 2 BLOOD-CONSERVINGArterialLine SYSTEM
1999Co-Authors: Roger Dzwonczyk, Cheryl Buyama, Brad L. Bernacki, William B. KellyAbstract:Objective. Critically ill patients frequently have indwelling Arterial Lines placed during their Intensive Care Unit stay. The Lines are used to monitor blood pressure continuously, administer drugs and to draw blood for a variety of physiologic tests. Several blood-conserving Arterial Line systems have been developed to eliminate the need to discard blood in the process of obtaining undiluted and uncontaminated blood samples. The purpose of this study was to evaluate the dynamic performance of one such system ^ the Abbott Clinical Care System Safeset 2 blood conserving Arterial Line system ^ in comparison to a conventional Arterial Line system. Methods.We studied ninety-nine patients who had indwelling Arterial Lines placed during surgery and who were admitted to our Surgical Intensive Care Unit (SICU). The patients were randomly placed into one of two groups. The control group received a conventional indwelling Arterial Line system; the experimental group received the Abbott Safeset 2 system. We measured the damping coe⁄cient and resonant frequency daily in order to evaluate and compare the dynamic performance of the two systems. We also measured discard volumes (in the control group) and blood sample sizes during the patients' stays in the SICU. Results. The two patient groups were similar in regards to demographics and baseLine clinical characteristics. A median 3 ml of blood per draw and 17.5 ml of blood per patient was discarded in purging the conventional Arterial Line system while, by design, no blood was discarded with the experimental system. There was no diierence between the two groups with regard to damping coe⁄cient. Both systems were underdamped. How- ever, the conventional Arterial Line system had a signi¢cantly higher resonant frequency (16.7Hz) compared to the Safeset 2 system (12.5 Hz). Conclusions. Because the Abbott Safeset 2 blood-conserving Arterial Line system is underdamped and has a lower resonant frequency compared to the traditional Arterial system, it may overestimate systolic blood pressure, particularly in patients with high heart rates.
Tara Cochrane - One of the best experts on this subject based on the ideXlab platform.
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Arterial Line versus venous Line administration of low molecular weight heparin enoxaparin for prevention of thrombosis in the extracorporeal blood circuit of patients on haemodialysis or haemodiafiltration a randomized cross over trial
Nephrology, 2016Co-Authors: Jagadeesh Kurtkoti, Bhadran Bose, Balaji Hiremagalur, Jing Sun, Tara CochraneAbstract:Study Objective: The objective of the study is to compare the anti-factor Xa (AXa) level in the blood, after Arterial and venous Line administration of equivalent doses of enoxaparin for prevention of thrombosis in the extracorporeal blood circuit.Design: The design of the study is a dual centre, prospective, open-labelled randomized crossover, 7 weeks trial.Setting: The setting of the study is on a patient on long-term haemodialysis (HD) or haemodiafiltration (HDF) using high-flux membrane.Participant: There were eight patients on HD and eight on HDF.Intervention: Participants were randomly assigned to receive enoxaparin either through the Arterial Line or venous Line of extracorporeal blood circuit for an initial study interval of 2 weeks, followed by 2 weeks of alternate route administration. During the run-in period of 1 week and the follow-up period of 2 weeks, enoxaparin was administered through the Arterial Line.Outcomes: The primary outcome measure was to compare AXa blood level 4 h after enoxaparin administration. The secondary outcome measures were manual compression time to stop bleeding from arteriovenous fistula, extracorporeal circuit clotting and systemic bleeding episodes.Results: The mean AXa blood level, 4 h after venous circuit administration (0.58 +/- 0.21 (HD), 0.82 +/- 0.29 (HDF)) of enoxaparin, was significantly greater than that after Arterial administration of enoxaparin (0.39 +/- 0.25 (HD), 0.39 +/- 0.14 (HDF) U/mL), (P<0.001).Conclusion: In patients on HD or HDF, venous Line administration of enoxaparin achieves greater 4 h blood AXa level compared with Arterial Line administration of equivalent dose. Based on this, we suggest a 25% or 50% reduction in the dose of venous Line enoxaparin, compared with the dose administered through Arterial Line in patients receiving either HD or HDF, respectively.
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Arterial Line versus venous Line administration of low molecular weight heparin, enoxaparin for prevention of thrombosis in the extracorporeal blood circuit of patients on haemodialysis or haemodiafiltration: A randomized cross‐over trial
Nephrology (Carlton Vic.), 2016Co-Authors: Jagadeesh Kurtkoti, Bhadran Bose, Balaji Hiremagalur, Jing Sun, Tara CochraneAbstract:Study Objective: The objective of the study is to compare the anti-factor Xa (AXa) level in the blood, after Arterial and venous Line administration of equivalent doses of enoxaparin for prevention of thrombosis in the extracorporeal blood circuit.Design: The design of the study is a dual centre, prospective, open-labelled randomized crossover, 7 weeks trial.Setting: The setting of the study is on a patient on long-term haemodialysis (HD) or haemodiafiltration (HDF) using high-flux membrane.Participant: There were eight patients on HD and eight on HDF.Intervention: Participants were randomly assigned to receive enoxaparin either through the Arterial Line or venous Line of extracorporeal blood circuit for an initial study interval of 2 weeks, followed by 2 weeks of alternate route administration. During the run-in period of 1 week and the follow-up period of 2 weeks, enoxaparin was administered through the Arterial Line.Outcomes: The primary outcome measure was to compare AXa blood level 4 h after enoxaparin administration. The secondary outcome measures were manual compression time to stop bleeding from arteriovenous fistula, extracorporeal circuit clotting and systemic bleeding episodes.Results: The mean AXa blood level, 4 h after venous circuit administration (0.58 +/- 0.21 (HD), 0.82 +/- 0.29 (HDF)) of enoxaparin, was significantly greater than that after Arterial administration of enoxaparin (0.39 +/- 0.25 (HD), 0.39 +/- 0.14 (HDF) U/mL), (P
Brian R. Davidson - One of the best experts on this subject based on the ideXlab platform.
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Acute limb ischemia caused by femoral Arterial Line induces remote liver injury in a rabbit model of liver ischemia/reperfusion injury.
Angiology, 2009Co-Authors: Georgios K. Glantzounis, H Sheth, Cecil S. Thompson, T.s. Hafez, Sanjeev Kanoria, Viniyendra Pamecha, Susan E. Davies, Dimitri P. Mikhailidis, Alexander M. Seifalian, Brian R. DavidsonAbstract:Femoral Arterial Lines are used for continuous monitoring of Arterial blood pressure in experimental studies. However, placement of a catheter in the femoral artery could produce acute limb ischemia with associated systemic effects. The aim of this study was to investigate the effect of femoral Arterial Line insertion on liver function, in a rabbit liver lobar ischemia-reperfusion (I/R) model. Four groups of animals (n = 6 each) were studied: groups 1 and 2 (sham) underwent laparotomy but no liver ischemia. In groups 3 and 4 (I/R), liver lobar ischemia was induced for 60 minutes followed by 7 hours of reperfusion. In groups 1 and 3, the Arterial Line was placed in the femoral artery whereas in groups 2 and 4 in the ear artery. Liver function was assessed by serum alanine aminotransferase (ALT) activity, bile flow, plasma lactate levels, and histology. Results are expressed as mean ± SEM. Alanine aminotransferase activity and lactate levels were significantly higher in the I/R femoral Line group compared w...
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acute limb ischemia caused by femoral Arterial Line induces remote liver injury in a rabbit model of liver ischemia reperfusion injury
Angiology, 2009Co-Authors: Georgios K. Glantzounis, H Sheth, Cecil S. Thompson, T.s. Hafez, Sanjeev Kanoria, Viniyendra Pamecha, Susan E. Davies, Dimitri P. Mikhailidis, Alexander M. Seifalian, Brian R. DavidsonAbstract:Femoral Arterial Lines are used for continuous monitoring of Arterial blood pressure in experimental studies. However, placement of a catheter in the femoral artery could produce acute limb ischemia with associated systemic effects. The aim of this study was to investigate the effect of femoral Arterial Line insertion on liver function, in a rabbit liver lobar ischemia-reperfusion (I/R) model. Four groups of animals (n = 6 each) were studied: groups 1 and 2 (sham) underwent laparotomy but no liver ischemia. In groups 3 and 4 (I/R), liver lobar ischemia was induced for 60 minutes followed by 7 hours of reperfusion. In groups 1 and 3, the Arterial Line was placed in the femoral artery whereas in groups 2 and 4 in the ear artery. Liver function was assessed by serum alanine aminotransferase (ALT) activity, bile flow, plasma lactate levels, and histology. Results are expressed as mean ± SEM. Alanine aminotransferase activity and lactate levels were significantly higher in the I/R femoral Line group compared w...
Fuad Jubran - One of the best experts on this subject based on the ideXlab platform.
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Evaluation of a new blood-conserving Arterial Line system for patients in intensive care units.
Critical care medicine, 1993Co-Authors: Mitchell J. Silver, Hala Jubran, Susan Stein, Thomas D. Mcsweeney, Fuad JubranAbstract:OBJECTIVE: To evaluate blood samples obtained from a new blood-conserving Arterial Line system for the presence of hemodilution or heparin contamination. DESIGN: Prospective, clinical trial. SETTING: A coronary intensive care unit in a tertiary-care teaching hospital. PATIENTS: Cardiovascular patients in whom invasive Arterial blood pressure monitoring was indicated. INTERVENTIONS: Paired blood samples were obtained from a conventional Arterial Line system and a new blood-conserving Arterial Line system for the measurement of hematocrit and partial thromboplastin time, and compared to evaluate for the presence of either hemodilution or heparin contamination. MEASUREMENTS AND MAIN RESULTS: A Bland-Altman bias analysis of the variability between the two blood draw methods was performed. The analysis indicated that a) a randomly determined partial thromboplastin time obtained from the blood-conserving Arterial Line would lie between 3.32 and -5.11 of the partial thromboplastin time taken from the conventional Arterial Line value with 95% confidence; and b) a randomly determined hematocrit obtained from the blood-conserving Arterial Line would lie between 1.97 and -1.85 of the hematocrit taken from the conventional Arterial Line value with 95% confidence. CONCLUSIONS: We concluded that a) blood samples obtained with the blood-conserving Arterial Line demonstrate no evidence of hemodilution or heparin contamination; b) the blood-conserving Arterial Line provides blood samples without the need for an initial volume of blood to be discarded; c) the blood-conserving Arterial Line provides a means for blood conservation in the intensive care setting.
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Reduction of Blood Loss From Diagnostic Sampling in Critically III Patients Using a Blood-Conserving Arterial Line System
Chest, 1993Co-Authors: Mitchell J. Silver, Fuad Jubran, Lisa A. Gragg, James K. StollerAbstract:Study objective To demonstrate the utility of a new blood-conserving Arterial Line system in reducing blood loss associated with blood drawing in the critical care setting. Design Prospective, randomized, crossover comparison between two Arterial Line systems. Setting Medical intensive care unit (ICU); tertiary care teaching institution. Patients Thirty-one patients who required invasive Arterial blood pressure monitoring throughout their ICU course. Interventions For ICU days 1 to 2, patients were randomized to receive either a conventional Arterial Line system or a new blood-conserving Arterial Line system. On ICU days 3 to 7, patients with a conventional Arterial Line were crossed over to the blood-conserving Arterial Line, and vice versa. Laboratory blood volumes, mixed discard volumes, and blood discard volumes were then recorded to document how much blood loss is associated with each aspect of the blood sampling process. Results The mean total volume of blood sent to the laboratory for testing was 257.4 ml. As a result of "clearing the Line" over the 7-day period, patients with the conventional Arterial Line system lost a mean volume of 340.2 ml of blood mixed with heparinized saLine solution more than patients with the blood-conserving Arterial Line. In terms of the blood component of the blood-heparinized saLine solution mixture, use of the conventional Arterial Line was associated with an average of 156.8 ml more blood discarded than with the blood-conserving Arterial Line. Conclusion The new blood-conserving Arterial Line system provides a simple and effective method for reducing blood loss related to diagnostic sampling in the critical care setting.
Russell P. Woda - One of the best experts on this subject based on the ideXlab platform.
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On the dynamic performance of the Abbott Safeset blood-conserving Arterial Line system.
Journal of Clinical Monitoring and Computing, 1999Co-Authors: Russell P. Woda, Roger Dzwonczyk, Cheryl Buyama, Brad L. Bernacki, William B. KellyAbstract:Objective. Critically ill patients frequently have indwelling Arterial Lines placed during their Intensive Care Unit stay. The Lines are used to monitor blood pressure continuously, administer drugs and to draw blood for a variety of physiologic tests. Several blood-conserving Arterial Line systems have been developed to eliminate the need to discard blood in the process of obtaining undiluted and uncontaminated blood samples. The purpose of this study was to evaluate the dynamic performance of one such system – the Abbott Clinical Care System Safeset™ blood conserving Arterial Line system – in comparison to a conventional Arterial Line system. Methods. We studied ninety-nine patients who had indwelling Arterial Lines placed during surgery and who were admitted to our Surgical Intensive Care Unit (SICU). The patients were randomly placed into one of two groups. The control group received a conventional indwelling Arterial Line system; the experimental group received the Abbott Safeset™ system. We measured the damping coefficient and resonant frequency daily in order to evaluate and compare the dynamic performance of the two systems. We also measured discard volumes (in the control group) and blood sample sizes during the patients’ stays in the SICU. Results. The two patient groups were similar in regards to demographics and baseLine clinical characteristics. A median 3 ml of blood per draw and 17.5 ml of blood per patient was discarded in purging the conventional Arterial Line system while, by design, no blood was discarded with the experimental system. There was no difference between the two groups with regard to damping coefficient. Both systems were underdamped. However, the conventional Arterial Line system had a significantly higher resonant frequency (16.7 Hz) compared to the Safeset™ system (12.5 Hz). Conclusions. Because the Abbott Safeset™ blood-conserving Arterial Line system is underdamped and has a lower resonant frequency compared to the traditional Arterial system, it may overestimate systolic blood pressure, particularly in patients with high heart rates.
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On the dynamic performance of the Abbott Safeset blood-conserving Arterial Line system.
Journal of clinical monitoring and computing, 1999Co-Authors: Russell P. Woda, Roger Dzwonczyk, Cheryl Buyama, Brad L. Bernacki, William B. KellyAbstract:Critically ill patients frequently have indwelling Arterial Lines placed during their Intensive Care Unit stay. The Lines are used to monitor blood pressure continuously, administer drugs and to draw blood for a variety of physiologic tests. Several blood-conserving Arterial Line systems have been developed to eliminate the need to discard blood in the process of obtaining undiluted and uncontaminated blood samples. The purpose of this study was to evaluate the dynamic performance of one such system the Abbott Clinical Care System Safeset blood conserving Arterial Line system - in comparison to a conventional Arterial Line system. We studied ninety-nine patients who had indwelling Arterial Lines placed during surgery and who were admitted to our Surgical Intensive Care Unit (SICU). The patients were randomly placed into one of two groups. The control group received a conventional indwelling Arterial Line system; the experimental group received the Abbott Safeset system. We measured the damping coefficient and resonant frequency daily in order to evaluate and compare the dynamic performance of the two systems. We also measured discard volumes (in the control group) and blood sample sizes during the patients' stays in the SICU. The two patient groups were similar in regards to demographics and baseLine clinical characteristics. A median 3 ml of blood per draw and 17.5 ml of blood per patient was discarded in purging the conventional Arterial Line system while, by design, no blood was discarded with the experimental system. There was no difference between the two groups with regard to damping coefficient. Both systems were underdamped. However, the conventional Arterial Line system had a significantly higher resonant frequency (16.7 Hz) compared to the Safeset system (12.5 Hz). Because the Abbott Safeset blood-conserving Arterial Line system is underdamped and has a lower resonant frequency compared to the traditional Arterial system, it may overestimate systolic blood pressure, particularly in patients with high heart rates.