The Experts below are selected from a list of 76176 Experts worldwide ranked by ideXlab platform
Sohan Singh Hayreh - One of the best experts on this subject based on the ideXlab platform.
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central retinal Artery Occlusion
Indian Journal of Ophthalmology, 2018Co-Authors: Sohan Singh HayrehAbstract:Central retinal Artery Occlusion (CRAO) has been known as a clinical entity since 1859, when von Graefe [1] first described CRAO due to embolism. After that, Schweigger [2] in 1984 described it on ophthalmoscopy. A voluminous literature has accumulated on its various aspects. It presents with classical clinical findings: a dramatic, marked visual loss in the involved eye, with typical fundus findings.
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central retinal vein Occlusion associated with cilioretinal Artery Occlusion
Retina-the Journal of Retinal and Vitreous Diseases, 2008Co-Authors: Sohan Singh Hayreh, Lynn FraterrigoAbstract:Purpose:To describe the clinical characteristics and pathogenesis of central retinal vein Occlusion (CRVO) associated with cilioretinal Artery Occlusion (CLRAO).Methods:The study included 38 patients (38 eyes) who had CRVO associated with CLRAO and were seen in our clinic from 1974 to 1999. At their
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optic disk and retinal nerve fiber layer damage after transient central retinal Artery Occlusion an experimental study in rhesus monkeys
American Journal of Ophthalmology, 2000Co-Authors: Sohan Singh HayrehAbstract:Abstract PURPOSE: To evaluate the retinal tolerance time to acute ischemic insult in middle-aged or elderly rhesus monkeys with pre-existing atherosclerosis and arterial hypertension. METHODS: In 39 eyes of 39 middle-aged and elderly rhesus monkeys with a mean age of 19.5 ± 2.8 years, Occlusion of the central retinal Artery was produced by temporary clamping of the central retinal Artery at its site of entry into the dural sheath of the optic nerve for 97 to 300 minutes. Stereoscopic color fundus photography and fluorescein fundus angiography were performed before central retinal Artery Occlusion and serially thereafter. Retinal nerve fiber layer damage and optic disk changes were assessed by comparing morphometric evaluation of the color fundus photographs taken before central retinal Artery Occlusion and color fundus photographs taken at the end of the study. RESULTS: There was a significant correlation between duration of central retinal Artery Occlusion and decreased visibility of retinal nerve fiber layer ( P = .018) and increasing optic disk pallor ( P = .014), and a trend between residual retinal circulation and decreased visibility of retinal nerve fiber layer ( P = .085) and optic disk pallor ( P = .162). However, there was a marked interindividual variation between the length of central retinal Artery Occlusion and degree of increased optic disk pallor and decreased visibility of the retinal nerve fiber layer, even among eyes with similar duration of central retinal Artery Occlusion. Complete or almost total optic nerve atrophy and nerve fiber damage were present in all eyes in which the duration of central retinal Artery Occlusion was 240 minutes or more. CONCLUSIONS: The findings of this study, compared with our previous study in young healthy rhesus monkeys, indicate that in middle-aged or elderly atherosclerotic and arterial hypertensive rhesus monkeys, central retinal Artery Occlusion for less than 100 minutes produced no apparent morphometric evidence of optic nerve damage; however, central retinal Artery Occlusion of 105 minutes but less than 240 minutes produced a variable degree of damage; central retinal Artery Occlusion for 240 minutes or more produced total or almost total optic nerve atrophy and nerve fiber damage.
John C. Meadows - One of the best experts on this subject based on the ideXlab platform.
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THE AMNESIC SYNDROME OF POSTERIOR CEREBRAL Artery Occlusion
Acta Neurologica Scandinavica, 2009Co-Authors: D. Frank Benson, C. David Marsden, John C. MeadowsAbstract:Ten patients who suffered an acute onset of amnesia associated with either unilateral or bilateral visual field defects are described. Clinical evaluation pointed to infarction in the posterior cerebral Artery territory in each case. The posterior cerebral Artery supplies medial temporal structures (including hippocampus), and infarction in this region is presumably responsible for the amnesia. Amnesia occurring as a symptom of a stroke was thus strongly linked to posterior cerebral Artery Occlusion. Amnesia is usually said to require bilateral lesions but four cases in the present series appeared to have unilateral (left-sided) Occlusion. There are several reports in the literature of amnesia following either left posterior cerebral Artery Occlusion or left temporal lobectomy. The question of unilateral vs. bilateral damage in the genesis of amnesic states is discussed in relation to this left-sided preponderance and in the context of the common origin of both posterior cerebral arteries. From present evidence it is concluded that lesions confined to the left side may cause temporary amnesia, but that the evidence for permanent amnesia is inconclusive.
Erich Hofmann - One of the best experts on this subject based on the ideXlab platform.
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collateral vessels in proximal middle cerebral Artery Occlusion the endostroke study
Radiology, 2015Co-Authors: Oliver C Singer, Joachim Berkefeld, Christian H Nolte, Georg Bohner, Arno Reich, Martin Wiesmann, Klaus Groeschel, Stephan Boor, Tobias Neumannhaefelin, Erich HofmannAbstract:In patients with proximal middle cerebral Artery Occlusion undergoing endovascular stroke treatment, collateral vessels are a pivotal factor in determining reperfusion success, final infarct size, and clinical outcome.
Randall T Higashida - One of the best experts on this subject based on the ideXlab platform.
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endovascular embolectomy of acute basilar Artery Occlusion
Neurology, 2003Co-Authors: D Binder, Audrey Fosterbarber, Reza Malek, Wade S Smith, Randall T HigashidaAbstract:Acute basilar Artery Occlusion has a mortality rate approaching 90%. The authors describe a case of acute basilar Artery Occlusion managed successfully with endovascular embolectomy. A 31-year-old man sought treatment for confusion, dysarthria, and right-sided weakness. He soon became unresponsive and was found to have a vertebral Artery dissection and an associated basilar Artery embolism. The dissection was managed with endovascular stenting, and the basilar Artery embolus was removed with a clot retriever at 7 hours. The patient recovered without neurologic deficit.
Hiroshi Yao - One of the best experts on this subject based on the ideXlab platform.
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ampa receptor antagonist ym90k reduces infarct volume in thrombotic distal middle cerebral Artery Occlusion in spontaneously hypertensive rats
Brain Research, 1997Co-Authors: Hiroshi Yao, Setsuro Ibayashi, Hiroshi Nakane, Hong Cai, Hideyuki Uchimura, Masatoshi FujishimaAbstract:We examined the effects of a potent and selective antagonist of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) subtype of glutamate receptor, YM90K, on brain infarction using a newly developed stroke model of thrombotic distal middle cerebral Artery Occlusion. Male spontaneously hypertensive rats (5–7 months old) were subjected to photochemically-induced distal middle cerebral Artery Occlusion as previously described [Stroke 26 (1996) 333–336]. Intravenous infusion of YM90K (n=8) (5 mg/kg per h for 1 h) or the same amount of vehicle (n=8) (alkaline saline) was started 5 min after distal middle cerebral Artery Occlusion. Penumbral cerebral blood flow was determined with laser-Doppler flowmetry. Three days after the ischemic insult, brains were stained with 2,3,5-triphenyltetrazolium cholride and infarct volumes were determined. One hour infusion of YM90K significantly reduced infarct volume by 34% (93±23 mm3 in control group vs. 61±25 mm3 in YM90K-treated group, P=0.017). There were no significant differences in the degrees of cerebral blood flow reduction after distal middle cerebral Artery Occlusion between the YM90K treated and control groups. YM90K reduces infarct volume in experimental ischemia produced by photothrombotic distal middle cerebral Artery Occlusion in rats. The present results demonstrated beneficial effects of AMPA receptor blockade on acute ischemic stroke.
