The Experts below are selected from a list of 2493 Experts worldwide ranked by ideXlab platform
Chin-hsiao Tseng - One of the best experts on this subject based on the ideXlab platform.
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epidemiologic evidence of diabetogenic effect of arsenic
Toxicology Letters, 2002Co-Authors: Chin-hsiao Tseng, Chingping Tseng, Hung Yi Chiou, Yu Mei Hsueh, Choon Khim Chong, Chienjen ChenAbstract:It is Well documented that arsenic can lead to skin lesions, atherosclerotic diseases and cancers. The association between arsenic exposure and diabetes mellitus is a relatively new finding. Up to now, there are six epidemiologic reports linking diabetes mellitus with arsenic exposure from environmental and occupational sources. Two reports in Taiwan carried out in the blackfoot disease-hyperendemic villages, one cross-sectional and one prospective follow-up of the same cohort, indicate that arsenic exposure from drinking Artesian Well water is associated with prevalence and incidence of diabetes mellitus in a dose-responsive pattern. The observation of the relation between arsenic exposure and diabetes mellitus is further supported by studies carried out in Sweden and Bangladesh. In Sweden, case-control analyses of death records of copper smelters and glass workers revealed a trend of increasing diabetes mellitus with increasing arsenic exposure from inhalation. In Bangladesh, prevalence of diabetes mellitus among arsenic-exposed subjects with keratosis was about five times higher than unexposed subjects. Increasing trends of diabetes mellitus with indices of arsenic exposure in drinking water seems to be independent of the presence of skin lesions associated with arsenic exposure. Although these studies consistently show an association between arsenic exposure and diabetes mellitus, the weak study designs of cross-sectional or case-control, the use of glucosuria or diabetes death as diagnostic criteria and the lack of adjustment for possible confounders in some studies, are major limitations that may reduce the strength of the evidence.
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Dose-response relationship between peripheral vascular disease and ingested inorganic arsenic among residents in blackfoot disease endemic villages in Taiwan.
Atherosclerosis, 1996Co-Authors: Chin-hsiao Tseng, C.-k. Chong, C J Chen, T.-y. TaiAbstract:The purpose of this study was to examine the correlation between previous arsenic exposure and peripheral vascular disease after stopping consumption of high-arsenic Artesian Well water for more than two decades in blackfoot disease endemic villages in Taiwan. A total of 582 adults (263 men and 319 women, aged 52.6 +/- 10.6 years) living in these villages underwent Doppler ultrasound measurement of systolic pressures on bilateral ankle (posterior tibial and dorsal pedal) and brachial arteries and estimation for long-term arsenic exposure. The diagnosis of peripheral vascular disease was based on an ankle-brachial index (the ratio between ankle and brachial systolic pressures) or = 20.0 mg/l-years, respectively, compared with those who were not exposed. This study suggests a close relation between long-term arsenic exposure and peripheral vascular disease in blackfoot disease endemic villages in Taiwan after stopping consumption of Artesian Well water.
T.-y. Tai - One of the best experts on this subject based on the ideXlab platform.
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Dose-response relationship between peripheral vascular disease and ingested inorganic arsenic among residents in blackfoot disease endemic villages in Taiwan.
Atherosclerosis, 1996Co-Authors: Chin-hsiao Tseng, C.-k. Chong, C J Chen, T.-y. TaiAbstract:The purpose of this study was to examine the correlation between previous arsenic exposure and peripheral vascular disease after stopping consumption of high-arsenic Artesian Well water for more than two decades in blackfoot disease endemic villages in Taiwan. A total of 582 adults (263 men and 319 women, aged 52.6 +/- 10.6 years) living in these villages underwent Doppler ultrasound measurement of systolic pressures on bilateral ankle (posterior tibial and dorsal pedal) and brachial arteries and estimation for long-term arsenic exposure. The diagnosis of peripheral vascular disease was based on an ankle-brachial index (the ratio between ankle and brachial systolic pressures) or = 20.0 mg/l-years, respectively, compared with those who were not exposed. This study suggests a close relation between long-term arsenic exposure and peripheral vascular disease in blackfoot disease endemic villages in Taiwan after stopping consumption of Artesian Well water.
Chienjen Chen - One of the best experts on this subject based on the ideXlab platform.
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electrocardiogram ecg abnormality among residents in arseniasis endemic and non endemic areas of southwestern taiwan a study of gene gene and gene environment interactions
2012Co-Authors: Yatang Liao, Chienjen Chen, Wei Chen, Hsiaoyen Chen, Shuli WangAbstract:Natural occurrence of arsenic in groundwater is found in the Americas, European, Western Africa, and Asia including Taiwan, Japan, southern Thailand and China where in some areas, drinking water supplies are primarily based on groundwater resources 2. For general population in southwestern coast Taiwan, the major arsenic exposure resource is the ingestion of arsenic contaminated groundwater. The residents have used high-arsenic contaminated Well water for drinking and cooking for many decades since early 1910s. The tap water supply system was implemented in the early 1960s, however Artesian Well water has not been used for drinking or cooking until mid-1970s 3. Because arsenic toxicity operates in a highly nonlinear manner and different levels of exposure measurements applied result in large discrepancy across studies and made it difficult to come up a reliable dose-response relationship for arsenic hazard. There is a long-standing observation of individual variability in susceptibility to arsenic toxicity 4 and this variation may be partly due to differences in age and sex distribution across areas, and also individual arsenic metabolism capabilities 5,6. Inter-individual differences in the speciation and amounts of arsenic metabolites have been reported among subjects chronically exposed to arsenic 7 and significant genetic determinants of arsenic metabolism was supported by epidemiological study 8. Toenail and hair arsenic has been reported to provided an integrated measure of internal arsenic exposure 9. However epidemiologic studies showed that external contamination lead to overestimation of internal dose and urinary arsenic concentration seems to be a better marker than concentrations in drinking water10. Growing epidemiological evidence also suggests that some factors such as age, sex and genetic susceptibility are related to its metabolism and can be important predictors for arsenic-related health hazard 11,12.
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epidemiologic evidence of diabetogenic effect of arsenic
Toxicology Letters, 2002Co-Authors: Chin-hsiao Tseng, Chingping Tseng, Hung Yi Chiou, Yu Mei Hsueh, Choon Khim Chong, Chienjen ChenAbstract:It is Well documented that arsenic can lead to skin lesions, atherosclerotic diseases and cancers. The association between arsenic exposure and diabetes mellitus is a relatively new finding. Up to now, there are six epidemiologic reports linking diabetes mellitus with arsenic exposure from environmental and occupational sources. Two reports in Taiwan carried out in the blackfoot disease-hyperendemic villages, one cross-sectional and one prospective follow-up of the same cohort, indicate that arsenic exposure from drinking Artesian Well water is associated with prevalence and incidence of diabetes mellitus in a dose-responsive pattern. The observation of the relation between arsenic exposure and diabetes mellitus is further supported by studies carried out in Sweden and Bangladesh. In Sweden, case-control analyses of death records of copper smelters and glass workers revealed a trend of increasing diabetes mellitus with increasing arsenic exposure from inhalation. In Bangladesh, prevalence of diabetes mellitus among arsenic-exposed subjects with keratosis was about five times higher than unexposed subjects. Increasing trends of diabetes mellitus with indices of arsenic exposure in drinking water seems to be independent of the presence of skin lesions associated with arsenic exposure. Although these studies consistently show an association between arsenic exposure and diabetes mellitus, the weak study designs of cross-sectional or case-control, the use of glucosuria or diabetes death as diagnostic criteria and the lack of adjustment for possible confounders in some studies, are major limitations that may reduce the strength of the evidence.
Tseng Chin-hsiao - One of the best experts on this subject based on the ideXlab platform.
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Cardiovascular Disease in Arsenic-Exposed Subjects Living in the Arseniasis-Hyperendemic Areas in Taiwan
2009Co-Authors: Tseng Chin-hsiaoAbstract:There are two arsenic exposure endemic areas in Taiwan, one confined to the southwestern coast and the other to the northeastern coast. Blackfoot disease is an endemic peripheral vascular disease leading to gangrenous change of the foot and the lower extremity, which was found to be confined to the southwestern coast of Taiwan for approximately a century. A series of epidemiologic studies since mid-twentieth century suggest arsenic exposure from drinking Artesian Well water as a major cause of the disease . More recent studies carried out over the past decades confirmed the association between arsenic exposure and peripheral vascular disease in a dose-responsive pattern. Furthermore, the other clinical manifestations related to the cardiovascular system including diabetes mellitus, hypertension, ischemic heart disease, cerebral infarction and mortality from cardiovascular disease were also highly associated with arsenic exposure in the endemic areas. Studies also suggest the presence of subclinical arterial insufficiency and microcirculatory defects in seemingly normal subjects living in the blackfoot disease hyperendemic villages and that lower serum antioxidant levels of alpha- and beta- carotene are associated with a higher risk of arsenic-related ischemic heart disease. More recent studies suggest that the risk of peripheral vascular disease and hypertension is associated with the individual incapability to completely methylate inorganic arsenic
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Epidemiologic Evidence of Diabetogenic Effect of Arsenic
2008Co-Authors: Tseng Chin-hsiaoAbstract:It is Well documented that arsenic can lead to skin lesions, atherosclerotic diseases and cancers. The association between arsenic exposure and diabetes mellitus is a relatively new finding. Up to now, there are six epidemiologic reports linking diabetes mellitus with arsenic exposure from environmental and occupational sources. Two reports in Taiwan carried out in the blackfoot disease- hyperendemic villages, one cross-sectional and one prospective follow-up of the same cohort, indicate that arsenic exposure from drinking Artesian Well water is associated with prevalence and incidence of diabetes mellitus in a dose-responsive pattern. The observation of the relation between arsenic exposure and diabetes mellitus is further supported by studies carried out in Sweden and Bangladesh. In Sweden, case-control analyses of death records of copper smelters and glass workers revealed a trend of increasing diabetes mellitus with increasing arsenic exposure from inhalation. In Bangladesh, prevalence of diabetes mellitus among arsenic-exposed subjects with keratosis was about five times higher than unexposed subjects. Increasing trends of diabetes mellitus with indices of arsenic exposure in drinking water seems to be independent of the presence of skin lesions associated with arsenic exposure. Although these studies consistently show an association between arsenic exposure and diabetes mellitus, the weak study designs of cross-sectional or case- control, the use of glucosuria or diabetes death as diagnostic criteria and the lack of adjustment for possible confounders in some studies, are major limitations that may reduce the strength of the evidence. (C) 2002 Elsevier Science Ireland Ltd . All rights reserved
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Long-Term Arsenic Exposure and Ischemic Heart Disease in Arseniasis- Hyperendemic Villages in Taiwan
2008Co-Authors: Tseng Chin-hsiaoAbstract:The association between long-term arsenic exposure and peripheral vascular disease has been Well documented in our previous epidemiologic studies. The purpose of this study was to evaluate whether long-term arsenic exposure could be associated with ischemic heart disease (IHD). A total of 462 subjects living in the blackfoot disease-hyperendemic villages along the southwestern coast of Taiwan and characterized by long- term arsenic exposure from drinking Artesian Well water was studied. The subjects were recruited from an epidemiologic cohort who participated in a health examination. IHD was diagnosed by coding the resting electrocardiograms with the Minnesota code. History of arsenic exposure was estimated through information obtained from a personal interview according to a structured questionnaire and the arsenic content in Artesian Well water of the villages. Cumulative arsenic exposure (CAE) was calculated as the sum of the products multiplying the arsenic concentration in Artesian Well water (mg/l) by the duration of drinking the water (years) in consecutive periods of living in the different villages. Among the subjects, 78 cases (16.9%) were diagnosed as having IHD. The prevalence rates of IHD for the age groups of 30-39, 40-49, 50-59 , and greater than or equal to 60 years were 4.9, 7.5, 16.8, and 30.7%, respectively (P < 0.001). For those with CAE of 0, 0.1-14.9 and greater than or equal to 15 mg/l- years, the prevalence rates of IHD were 5.2, 10. 9 and 24. No , respectively (P < 0.001). The odds ratios (95%) confidence intervals) for IHD were 1.60 (0.48, 5.34), and 3.60 (1.11, 11.65), respectively, for those with CAE of 0.1-14.9 and greater than or equal to 15.0 mg/l-years, when compared with those lacking drinking water exposure to arsenic after multivariate adjustment. It is concluded that IHD in the arseniasis-hyperendemic villages in Taiwan was associated with long-term arsenic exposure. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved
C.-k. Chong - One of the best experts on this subject based on the ideXlab platform.
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Dose-response relationship between peripheral vascular disease and ingested inorganic arsenic among residents in blackfoot disease endemic villages in Taiwan.
Atherosclerosis, 1996Co-Authors: Chin-hsiao Tseng, C.-k. Chong, C J Chen, T.-y. TaiAbstract:The purpose of this study was to examine the correlation between previous arsenic exposure and peripheral vascular disease after stopping consumption of high-arsenic Artesian Well water for more than two decades in blackfoot disease endemic villages in Taiwan. A total of 582 adults (263 men and 319 women, aged 52.6 +/- 10.6 years) living in these villages underwent Doppler ultrasound measurement of systolic pressures on bilateral ankle (posterior tibial and dorsal pedal) and brachial arteries and estimation for long-term arsenic exposure. The diagnosis of peripheral vascular disease was based on an ankle-brachial index (the ratio between ankle and brachial systolic pressures) or = 20.0 mg/l-years, respectively, compared with those who were not exposed. This study suggests a close relation between long-term arsenic exposure and peripheral vascular disease in blackfoot disease endemic villages in Taiwan after stopping consumption of Artesian Well water.
