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The Experts below are selected from a list of 54 Experts worldwide ranked by ideXlab platform
S. Murakami – 1st expert on this subject based on the ideXlab platform
SEROLOGICAL STUDY OF RADIATION HAZARD. II. THE EFFECT OF X-RAY TO PASSIVE SKIN ALLERGY, 2020Co-Authors: S. MurakamiAbstract:
White albumin, dissolved in potassium alum solution in a concentration of 1.5 mg/ml was used as antigen, and was injected into the ear vein of a rabbit every other day for 12 times. The whole blood was removed on the 7th day following the last injection, and the separated blood serum was kept in an ice box after the addition of merzonin in the proportion of 1: 10000. The irradiated guinea pigs were injected with the rabbit’s serum and were injected again with various concentrations of antigen into the abdominal skin after 24 hr. The skin reaction was examined a day later. After sensitization, 1.5 ml of 0.5% Evans blue solution per kg in weight was injected and immediately 0.1 ml of 1.0, 0.1, 0.01, and 0.001% of antigen was injected subcutaneous in the abdomen, 30 min after which the state of skin reaction was studied. Arthus Phenomenon was mostly inhibited on the 7th day after 200 r of x irradiation, and was gradually recovered and showed slightly increased tendency on the 28th day. The area of skin reaction in Arthus Phenomenon was minimum on the day following 200 r and showed increased tendency on the 28th day. After 400more » r the Arthus Phenomenon was mostly inhibited on the 7th day and the area of skin reaction became almost absent. Arthus Phenomenon indicated by the Evans blue method showed a maximum area of skin reaction on the 7th day after 200 r, which was diffusely infiltrated with an unsharp margin and then gradually became small and sharply demarcated on the 28th day. The histological changes of the skin in the guinea pig following 200 r were slight with atrophy of the epithelium and no other changes seen. (Absts. Japan. Med., 1: No. 7, 1960.)« less
Hideyo Yamaguchi – 2nd expert on this subject based on the ideXlab platform
suppressive effects of lanoconazole on Arthus Phenomenon in vivo and on production and functions of tnf in vitroNippon Ishinkin Gakkai Zasshi, 2000Co-Authors: Masayasu Mitsuya, Kayoko Wada, Hiroko Ishibashi, Shigeru Tansho, Hideyo YamaguchiAbstract:
抗真菌剤ラノコナゾール(LCZ)の抗炎症作用をin vivoとin vitro実験で検討した.卵白アルブミンで感作されたウサギでアルツス現象を惹起し,1および2%に含むLCZクリーム剤を反応局所へ塗布し,反応惹起開始から炎症の終了まで肉眼的に観察した.抗原を注入した局所の浮腫,紅斑,出血および壊死の反応サイズを測定した結果,2%LCZ剤塗布が出血抑制効果を示すことが解った.一方,炎症性サイトカインであるTNFの産生とその機能に対するLCZの効果をin vitro実験で検討した.LCZは腹腔マクロファージのTNF産生を20μg/mlで抑制し,ヒト末梢血の好中球の粘着反応を100μg/mlで抑制した.さらに,LCZはTNFによるL-929繊維芽細胞増殖抑制作用を0.05μg/mlで抑制した.このことはLCZが極めて低濃度でサイトカインによる細胞毒性から繊維芽細胞を防護する可能性を示唆する.以上の結果はLCZが炎症反応に対する抑制効果をもつことを示すとともに,その作用が細胞保護効果と関連している可能性を示唆している.
V. A. Frolov – 3rd expert on this subject based on the ideXlab platform
Parameters of hemostasis and blood lysosomal enzyme activity in allergic necrotizing inflammation against the background of suppression and stimulation of immune processesBulletin of Experimental Biology and Medicine, 1997Co-Authors: A. M. Avanesov, G. A. Drozdova, G. M. Drogova, A. V. Pasechnik, V. A. FrolovAbstract:
Changes in the hemostasis system are experimentally shown in rabbits with modeled allergic inflammation (Arthus Phenomenon) of the maxilla. Suppression of immune processes has an adverse effect on this system, while immunostimulation improves hemostatic parameters. Immunosuppression impairs lysosomal mechanisms of inflammation, while stimulation of the immune system normalizes these mechanisms.