The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Mingfu Wang - One of the best experts on this subject based on the ideXlab platform.
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chemoprevention of colorectal cancer by artocarpin a dietary phytochemical from Artocarpus heterophyllus
Journal of Agricultural and Food Chemistry, 2017Co-Authors: Guochuan Sun, Zongping Zheng, Mingfu Wang, Meehyun Lee, Soouk Kang, Zigang Dong, Wei ChenAbstract:Artocarpus heterophyllus is an evergreen tree distributed in tropical regions, and its fruit (jackfruit) is well-known as the world’s largest tree-borne fruit. Although A. heterophyllus has been widely used in folk medicines against inflammation, its potential in cancer chemoprevention remains unclear. Herein we identified artocarpin from A. heterophyllus as a promising colorectal cancer chemopreventive agent by targeting Akt kinase. Phenotypically, artocarpin exhibited selective cytotoxicity against human colon cancer cells. Artocarpin impaired the anchorage-independent growth capability, suppressed colon cancer cell growth, and induced a G1 phase cell cycle arrest which was followed by apoptotic as well as autophagic cell death. Mechanistic studies revealed that artocarpin directly targeted Akt 1 and 2 kinase activity evidenced by in vitro kinase assay, ex vivo binding assay as well as Akt downstream cellular signal transduction. Importantly, oral administration of artocarpin attenuated colitis-associat...
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characterization of antiproliferative activity constituents from Artocarpus heterophyllus
Journal of Agricultural and Food Chemistry, 2014Co-Authors: Zongping Zheng, Chuan Qin, Shuang Zhang, Yingying Lin, Guobin Xie, Mingfu Wang, Jie ChenAbstract:Artocarpus heterophyllus is an evergreen fruit tree cultivated in many tropical regions. Previous studies have shown that some of its compositions exhibited potential tyrosinase inhibition activities. This study indentified 8 new phenolic compounds, artoheterophyllins E–J (1–6), 4-geranyl-2′,3,4′,5-tetrahydroxy-cis-stilbene (7), and 5-methoxymorican M (8) and 2 new natural compounds (9 and 10), 2,3-dihydro-5,7-dihydroxy-2-(2-hydroxy-4-methoxyphenyl)-4H-benzopyran-4-one and 6-[(1S,2S)-1,2-dihydroxy-3-methylbutyl]-2-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-3-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one, together with 23 known compounds (11–33), from the ethanol extract of the wood of A. heterophyllus. The structures of the eight new compounds (1–8) and two new natural compounds were established by extensive 1D- and 2D-NMR experiments. The anticancer effects of the isolated compounds were examined in MCF-7, H460, and SMMC-7721 human cancer cell lines by MTT assay. Compounds 5, 11, 12, and 30 significantly ...
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chemical components and tyrosinase inhibitors from the twigs of Artocarpus heterophyllus
Journal of Agricultural and Food Chemistry, 2009Co-Authors: Zongping Zheng, Sibao Chen, Shiyun Wang, Xiachang Wang, Kawing Cheng, Dajiang Yang, Mingfu WangAbstract:An HPLC method was developed and validated to compare the chemical profiles and tyrosinase inhibitors in the woods, twigs, roots, and leaves of Artocarpus heterophyllus . Five active tyrosinase inhibitors including dihydromorin, steppogenin, norartocarpetin, artocarpanone, and artocarpesin were used as marker compounds in this HPLC method. It was discovered that the chemical profiles of A. heterophyllus twigs and woods are quite different. Systematic chromatographic methods were further applied to purify the chemicals in the twigs of A. heterophyllus. Four new phenolic compounds, including one isoprenylated 2-arylbenzofuran derivative, artoheterophyllin A (1), and three isoprenylated flavonoids, artoheterophyllin B (2), artoheterophyllin C (3), and artoheterophyllin D (4), together with 16 known compounds, were isolated from the ethanol extract of the twigs of A. heterophyllus. The structures of compounds 1-4 were elucidated by spectroscopic analysis. However, the four new compounds did not show significant inhibitory activities against mushroom tyrosinase compared to kojic acid. It was found that similar compounds, such as norartocarpetin and artocarpesin in the twigs and woods of A. heterophyllus, contributed to their tyrosinase inhibitory activity.
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isolation of tyrosinase inhibitors from Artocarpus heterophyllus and use of its extract as antibrowning agent
Molecular Nutrition & Food Research, 2008Co-Authors: Zongping Zheng, Kawing Cheng, Mingfu WangAbstract:A new furanoflavone, 7-(2,4-dihydroxyphenyl)-4-hydroxy-2-(2-hydroxy propan-2-yl)-2, 3-dihydrofuro(3, 2-g)chromen-5-one (artocarpfuranol, 1), together with 14 known compounds, dihydromorin (2), steppogenin (3), norartocarpetin (4), artocarpanone (5), artocarpesin (6), artocarpin (7), cycloartocarpin (8), cycloartocarpesin (9), artocarpetin (10), brosimone I (11), cudraflavone B (12), carpachromene (13), isoartocarpesin (14), and cyanomaclurin (15) were isolated from the wood of Artocarpus heterophyllus. Their structures were identified by interpretation of MS,( 1)H-NMR,( 13)C-NMR, HMQC, and HMBC spectroscopic data. Among them, compounds 1-6 and 14 showed strong mushroom tyrosinase inhibitory activity with IC(50) values lower than 50 microM, more potent than kojic acid (IC(50) = 71.6 microM), a well-known tyrosinase inhibitor. In addition, extract of A. heterophyllus was evaluated for its antibrowning effect on fresh-cut apple slices. It was discovered that fresh-cut apple slices treated by dipping in solution of 0.03 or 0.05% of A. heterophyllus extract with 0.5% ascorbic acid did not undergo any substantial browning reaction after storage at room temperature for 24 h. The antibrowning effect was significantly better than samples treated with the extract (0.03 or 0.05%) or ascorbic acid (0.5%) alone. The results provide preliminary evidence supporting the potential of this natural extract as antibrowning agent in food systems.
Zongping Zheng - One of the best experts on this subject based on the ideXlab platform.
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chemoprevention of colorectal cancer by artocarpin a dietary phytochemical from Artocarpus heterophyllus
Journal of Agricultural and Food Chemistry, 2017Co-Authors: Guochuan Sun, Zongping Zheng, Mingfu Wang, Meehyun Lee, Soouk Kang, Zigang Dong, Wei ChenAbstract:Artocarpus heterophyllus is an evergreen tree distributed in tropical regions, and its fruit (jackfruit) is well-known as the world’s largest tree-borne fruit. Although A. heterophyllus has been widely used in folk medicines against inflammation, its potential in cancer chemoprevention remains unclear. Herein we identified artocarpin from A. heterophyllus as a promising colorectal cancer chemopreventive agent by targeting Akt kinase. Phenotypically, artocarpin exhibited selective cytotoxicity against human colon cancer cells. Artocarpin impaired the anchorage-independent growth capability, suppressed colon cancer cell growth, and induced a G1 phase cell cycle arrest which was followed by apoptotic as well as autophagic cell death. Mechanistic studies revealed that artocarpin directly targeted Akt 1 and 2 kinase activity evidenced by in vitro kinase assay, ex vivo binding assay as well as Akt downstream cellular signal transduction. Importantly, oral administration of artocarpin attenuated colitis-associat...
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characterization of antiproliferative activity constituents from Artocarpus heterophyllus
Journal of Agricultural and Food Chemistry, 2014Co-Authors: Zongping Zheng, Chuan Qin, Shuang Zhang, Yingying Lin, Guobin Xie, Mingfu Wang, Jie ChenAbstract:Artocarpus heterophyllus is an evergreen fruit tree cultivated in many tropical regions. Previous studies have shown that some of its compositions exhibited potential tyrosinase inhibition activities. This study indentified 8 new phenolic compounds, artoheterophyllins E–J (1–6), 4-geranyl-2′,3,4′,5-tetrahydroxy-cis-stilbene (7), and 5-methoxymorican M (8) and 2 new natural compounds (9 and 10), 2,3-dihydro-5,7-dihydroxy-2-(2-hydroxy-4-methoxyphenyl)-4H-benzopyran-4-one and 6-[(1S,2S)-1,2-dihydroxy-3-methylbutyl]-2-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-3-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one, together with 23 known compounds (11–33), from the ethanol extract of the wood of A. heterophyllus. The structures of the eight new compounds (1–8) and two new natural compounds were established by extensive 1D- and 2D-NMR experiments. The anticancer effects of the isolated compounds were examined in MCF-7, H460, and SMMC-7721 human cancer cell lines by MTT assay. Compounds 5, 11, 12, and 30 significantly ...
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chemical components and tyrosinase inhibitors from the twigs of Artocarpus heterophyllus
Journal of Agricultural and Food Chemistry, 2009Co-Authors: Zongping Zheng, Sibao Chen, Shiyun Wang, Xiachang Wang, Kawing Cheng, Dajiang Yang, Mingfu WangAbstract:An HPLC method was developed and validated to compare the chemical profiles and tyrosinase inhibitors in the woods, twigs, roots, and leaves of Artocarpus heterophyllus . Five active tyrosinase inhibitors including dihydromorin, steppogenin, norartocarpetin, artocarpanone, and artocarpesin were used as marker compounds in this HPLC method. It was discovered that the chemical profiles of A. heterophyllus twigs and woods are quite different. Systematic chromatographic methods were further applied to purify the chemicals in the twigs of A. heterophyllus. Four new phenolic compounds, including one isoprenylated 2-arylbenzofuran derivative, artoheterophyllin A (1), and three isoprenylated flavonoids, artoheterophyllin B (2), artoheterophyllin C (3), and artoheterophyllin D (4), together with 16 known compounds, were isolated from the ethanol extract of the twigs of A. heterophyllus. The structures of compounds 1-4 were elucidated by spectroscopic analysis. However, the four new compounds did not show significant inhibitory activities against mushroom tyrosinase compared to kojic acid. It was found that similar compounds, such as norartocarpetin and artocarpesin in the twigs and woods of A. heterophyllus, contributed to their tyrosinase inhibitory activity.
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isolation of tyrosinase inhibitors from Artocarpus heterophyllus and use of its extract as antibrowning agent
Molecular Nutrition & Food Research, 2008Co-Authors: Zongping Zheng, Kawing Cheng, Mingfu WangAbstract:A new furanoflavone, 7-(2,4-dihydroxyphenyl)-4-hydroxy-2-(2-hydroxy propan-2-yl)-2, 3-dihydrofuro(3, 2-g)chromen-5-one (artocarpfuranol, 1), together with 14 known compounds, dihydromorin (2), steppogenin (3), norartocarpetin (4), artocarpanone (5), artocarpesin (6), artocarpin (7), cycloartocarpin (8), cycloartocarpesin (9), artocarpetin (10), brosimone I (11), cudraflavone B (12), carpachromene (13), isoartocarpesin (14), and cyanomaclurin (15) were isolated from the wood of Artocarpus heterophyllus. Their structures were identified by interpretation of MS,( 1)H-NMR,( 13)C-NMR, HMQC, and HMBC spectroscopic data. Among them, compounds 1-6 and 14 showed strong mushroom tyrosinase inhibitory activity with IC(50) values lower than 50 microM, more potent than kojic acid (IC(50) = 71.6 microM), a well-known tyrosinase inhibitor. In addition, extract of A. heterophyllus was evaluated for its antibrowning effect on fresh-cut apple slices. It was discovered that fresh-cut apple slices treated by dipping in solution of 0.03 or 0.05% of A. heterophyllus extract with 0.5% ascorbic acid did not undergo any substantial browning reaction after storage at room temperature for 24 h. The antibrowning effect was significantly better than samples treated with the extract (0.03 or 0.05%) or ascorbic acid (0.5%) alone. The results provide preliminary evidence supporting the potential of this natural extract as antibrowning agent in food systems.
L Prakash - One of the best experts on this subject based on the ideXlab platform.
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physicochemical properties of flour and isolated starch from jackfruit seeds Artocarpus heterophyllus lam
RGUHS Journal of Pharmaceutical Sciences, 2011Co-Authors: T Menaka, G Nagaraja, D B Yogesh, U Sunil S Kumar, L PrakashAbstract:A B S T R A C T Jackfruit (Artocarpus heterophyllus Lam.) is one the most significant evergreen trees grown in Asia. The objective of this study was to compare physicochemical properties of jackfruit seed flour and starch, starch was isolated from jackfruit seeds and purified. The jackfruit seed flour and starch were subjected to checkout the parameters like organoleptic characteristics, chemical analysis, limit test physico-chemical analysis and micromeritic properties. The chemical composition of seed flour was carbohydrates, polysaccharides, proteins, steroids and amyloses and content of jackfruit seed starch was carbohydrates, polysaccharides and amyloses. Limit test for chlorides, iron and sulphates was passing. The moisture content of starch was more than that of flours. The pH of starch was shows 6.51 and pH of flour was 6.78. The starch was characterized by using scanning electron microscopy method. The shape of the starch was found to be smooth and o spherical shaped and size of starch was 6.2mm. Gelatinization and pasting characteristics of starch shows at 65-70 C. Swelling index was 5.96 and 8.03 (g/g) for seed flour and purified starch respectively. Microbial growth was absent in seeds flour and isolated jackfruit starch respectively. Micromeritic properties of seeds flour and isolated jackfruit starch showed good.
Ryuichiro Kondo - One of the best experts on this subject based on the ideXlab platform.
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3 prenyl luteolin a new prenylated flavone with melanin biosynthesis inhibitory activity from wood of Artocarpus heterophyllus
Fitoterapia, 2010Co-Authors: Enos Tangke Arung, Kuniyoshi Shimizu, Hiroyuki Tanaka, Ryuichiro KondoAbstract:In our efforts to find new whitening agent from natural resources, we focused on wood of Artocarpus heterophyllus which shows anti-melanogenesis activity. By activity-guided fractionation of A. heterophyllus wood extract, a new prenylated flavonoid, 3-prenyl luteolin (1) was isolated. The IC(50) of mushroom tyrosinase inhibitory activity of 1 was 76.3 microM. The results of the comparison with that of luteolin showed the prenyl substituent at C-3 position of 1 play an important role for revealing tyrosinase inhibition. In melanin formation inhibition on B16 melanoma cells, IC(50) of 1 was 56.7 microM with less cytotoxicity.
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isoprenoid substituted flavonoids from wood of Artocarpus heterophyllus on b16 melanoma cells cytotoxicity and structural criteria
Fitoterapia, 2010Co-Authors: Enos Tangke Arung, Kuniyoshi Shimizu, Keisuke Yoshikawa, Ryuichiro KondoAbstract:Abstract As a result of cytotoxicity-guided fractionation, nine flavonoids, artocarpin (1), cudraflavone C (2), 6-prenylapigenin (3), kuwanon C (4), norartocarpin (5), albanin A (6), cudraflavone B (7), brosimone I (8) and artocarpanone (9) were identified from the methanol extract of the wood of Artocarpus heterophyllus , known commonly as Nangka in Indonesia. A structure–activity investigation of the effect of these isolated compounds (1–9) and structurally related compounds on B16 melanoma cells indicated that isoprenoid moiety substitutions in flavonoids enhance their cytotoxicity, and that the position of attachment and the number of isoprenoid-substituent moieties per molecule influence flavonoid cytotoxicity.
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structure activity relationship of prenyl substituted polyphenols from Artocarpus heterophyllus as inhibitors of melanin biosynthesis in cultured melanoma cells
Chemistry & Biodiversity, 2007Co-Authors: Enos Tangke Arung, Kuniyoshi Shimizu, Ryuichiro KondoAbstract:A series of prenylated, flavone-based polyphenols, compounds 1-8, were isolated from the wood of Artocarpus heterophyllus. These compounds, which have previously been shown not to inhibit tyrosinase activity, were found to be active inhibitors of the in vivo melanin biosynthesis in B16 melanoma cells, with little or no cytotoxicity. To clarify the structural requirement for inhibition, some structure-activity relationships were studied, in comparison with related compounds lacking prenyl side chains. Our experiments indicate that both prenyl and OH groups, as well as the type of substitution pattern, are crucial for the inhibition of melanin production in B16 melanoma cells.
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inhibitory effect of artocarpanone from Artocarpus heterophyllus on melanin biosynthesis
Biological & Pharmaceutical Bulletin, 2006Co-Authors: Enos Tangke Arung, Kuniyoshi Shimizu, Ryuichiro KondoAbstract:In our previous efforts to find new tyrosinase inhibitory materials, we investigated 44 Indonesian medicinal plants belonging to 24 families. Among those plants, the extract of Artocarpus heterophyllus was one of the strongest inhibitors of tyrosinase activity. By activity-guided fractionation of A. heterophyllus wood extract, we isolated artocarpanone, which inhibited both mushroom tyrosinase activity and melanin production in B16 melanoma cells. This compound is a strong candidate as a remedy for hyperpigmentation in human skin.
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inhibitory effect of isoprenoid substituted flavonoids isolated from Artocarpus heterophyllus on melanin biosynthesis
Planta Medica, 2006Co-Authors: Enos Tangke Arung, Kuniyoshi Shimizu, Ryuichiro KondoAbstract:: Isoprenoid-substituted flavonoids were isolated from the wood of Artocarpus heterophyllus by means of activity-guided fractionation. Artocarpin (1), cudraflavone C (2), 6-prenylapigenin (3), kuwanon C (4), norartocarpin (5) and albanin A (6) inhibited melanin biosynthesis in B16 melanoma cells without inhibiting tyrosinase. A structure-activity investigation indicated that the presence of the isoprenoid-substituted moiety enhanced the inhibitory activity on melanin production in B16 melanoma cells.
Kawing Cheng - One of the best experts on this subject based on the ideXlab platform.
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chemical components and tyrosinase inhibitors from the twigs of Artocarpus heterophyllus
Journal of Agricultural and Food Chemistry, 2009Co-Authors: Zongping Zheng, Sibao Chen, Shiyun Wang, Xiachang Wang, Kawing Cheng, Dajiang Yang, Mingfu WangAbstract:An HPLC method was developed and validated to compare the chemical profiles and tyrosinase inhibitors in the woods, twigs, roots, and leaves of Artocarpus heterophyllus . Five active tyrosinase inhibitors including dihydromorin, steppogenin, norartocarpetin, artocarpanone, and artocarpesin were used as marker compounds in this HPLC method. It was discovered that the chemical profiles of A. heterophyllus twigs and woods are quite different. Systematic chromatographic methods were further applied to purify the chemicals in the twigs of A. heterophyllus. Four new phenolic compounds, including one isoprenylated 2-arylbenzofuran derivative, artoheterophyllin A (1), and three isoprenylated flavonoids, artoheterophyllin B (2), artoheterophyllin C (3), and artoheterophyllin D (4), together with 16 known compounds, were isolated from the ethanol extract of the twigs of A. heterophyllus. The structures of compounds 1-4 were elucidated by spectroscopic analysis. However, the four new compounds did not show significant inhibitory activities against mushroom tyrosinase compared to kojic acid. It was found that similar compounds, such as norartocarpetin and artocarpesin in the twigs and woods of A. heterophyllus, contributed to their tyrosinase inhibitory activity.
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isolation of tyrosinase inhibitors from Artocarpus heterophyllus and use of its extract as antibrowning agent
Molecular Nutrition & Food Research, 2008Co-Authors: Zongping Zheng, Kawing Cheng, Mingfu WangAbstract:A new furanoflavone, 7-(2,4-dihydroxyphenyl)-4-hydroxy-2-(2-hydroxy propan-2-yl)-2, 3-dihydrofuro(3, 2-g)chromen-5-one (artocarpfuranol, 1), together with 14 known compounds, dihydromorin (2), steppogenin (3), norartocarpetin (4), artocarpanone (5), artocarpesin (6), artocarpin (7), cycloartocarpin (8), cycloartocarpesin (9), artocarpetin (10), brosimone I (11), cudraflavone B (12), carpachromene (13), isoartocarpesin (14), and cyanomaclurin (15) were isolated from the wood of Artocarpus heterophyllus. Their structures were identified by interpretation of MS,( 1)H-NMR,( 13)C-NMR, HMQC, and HMBC spectroscopic data. Among them, compounds 1-6 and 14 showed strong mushroom tyrosinase inhibitory activity with IC(50) values lower than 50 microM, more potent than kojic acid (IC(50) = 71.6 microM), a well-known tyrosinase inhibitor. In addition, extract of A. heterophyllus was evaluated for its antibrowning effect on fresh-cut apple slices. It was discovered that fresh-cut apple slices treated by dipping in solution of 0.03 or 0.05% of A. heterophyllus extract with 0.5% ascorbic acid did not undergo any substantial browning reaction after storage at room temperature for 24 h. The antibrowning effect was significantly better than samples treated with the extract (0.03 or 0.05%) or ascorbic acid (0.5%) alone. The results provide preliminary evidence supporting the potential of this natural extract as antibrowning agent in food systems.
