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Sudhakar Pipavath - One of the best experts on this subject based on the ideXlab platform.
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imaging of occupational lung disease
Radiologic Clinics of North America, 2016Co-Authors: Jay Champlin, Rachael Edwards, Sudhakar PipavathAbstract:Occupational lung Diseases span a variety of pulmonary disorders caused by inhalation of dusts or chemical antigens in a vocational setting. Included in these are the classic mineral pneumoconioses of silicosis, coal worker's pneumoconiosis, and Asbestos-Related Diseases as well as many immune-mediated and airway-centric Diseases, and new and emerging disorders. Although some of these have characteristic imaging appearances, a multidisciplinary approach with focus on occupational exposure history is essential to proper diagnosis.
Maria Camila Rodriguez - One of the best experts on this subject based on the ideXlab platform.
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an asbestos contaminated town in the vicinity of an asbestos cement facility the case study of sibate colombia
Environmental Research, 2019Co-Authors: Juan Pablo Ramosbonilla, Pietro Comba, Roberto Pasetto, Maria Fernanda Celygarcia, Margarita Giraldo, Benedetto Terracini, Daniela Marsili, Valeria Ascoli, Benjamin Lysaniuk, Maria Camila RodriguezAbstract:Abstract Introduction The asbestos industry began operations in Colombia in 1942, with an asbestos-cement facility located in the municipality of Sibate. In recent years residents from Sibate have been complaining about what they consider is an unusually large number of people diagnosed with Asbestos-Related Diseases in the town. A study to analyze the situation of Sibate started in 2015, to verify if the number of asbestos related Diseases being diagnosed were higher than expected, and to identify potential asbestos exposure sources in the town. Methods A health and socioeconomic survey was implemented door-to-door to identify potential Asbestos-Related Diseases. Several self-reported mesothelioma cases were identified, and for confirmation purposes, copies of the medical record with the histopathology report were obtained. A panel of six physicians analyzed the medical records. Information of validated cases was used to estimate the male and female age-adjusted incidence rate for Sibate. Based on reports of the existence of potential asbestos-contaminated landfills, topographic maps, a digital elevation model, and current satellite images were crossed using a geographic information system to identify potential landfilled areas, and soils samples were collected in some of these areas. Results A total of 355 surveys were completed, and 29 self-reported mesothelioma cases were identified. Twenty-five of these cases have been persons who had lived at some moment of their lives in Sibate. It was possible to obtain copies of the medical diagnosis for 17 cases. Of these, the panel of physicians classified 15 cases as certain pleural mesothelioma, one as probable, and one as not mesothelioma. Based on this information, the estimated age-adjusted incidence rate of mesothelioma in Sibate was 3.1 × 105 persons-year for males and 1.6 × 105 persons-year for females. These rates are high in comparison to those reported in other cities, regions, and countries of the world. Using geographic information systems, landfilled zones in the urban area of Sibate were identified, on top of which a school and different sports facilities were built. The analysis of four soil samples collected in landfilled zones, confirmed the existence of an underground layer of friable and non-friable asbestos. Conclusion The collected evidence suggests the presence of a malignant pleural mesothelioma cluster in Sibate.
Jean-claude Pairon - One of the best experts on this subject based on the ideXlab platform.
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Anxious and depressive symptoms in the French Asbestos-Related Diseases Cohort: risk factors and self-perception of risk
The European Journal of Public Health, 2016Co-Authors: Ibrahim Mounchetrou Njoya, Jean-claude Pairon, Christophe Paris, Jérôme Dinet, Amandine Luc, Joëlle Lighezzolo-alnot, Isabelle ThaonAbstract:Background: Asbestos is known to be an independent risk factor for lung and pleural cancers. However, to date, little attention has been paid to the psychological effects of asbestos exposure among exposed subjects. The objectives of this study were to estimate the prevalence of anxious and depressive symptoms among >2000 French participants of the Asbestos-Related Diseases Cohort (ARDCO), 6 years after their inclusion, to identify the risk factors associated with those anxious and depressive symptoms and to evaluate the impact of the asbestos-risk perception. Methods: The ARDCO was constituted in four regions of France between October 2003 and December 2005, by including former asbestos workers. Between 2011 and 2012, participants of the ARDCO program were invited to undergo another chest CT scan 6 years after the previous scan. Participants were asked to complete questionnaires including asbestos exposure assessment, Hospital Anxiety and Depression Scale (HADS), asbestos-risk perception and self-perception of Asbestos-Related Diseases. Results: Among the 2225 participants, 2210 fully completed questionnaires were collected and analyzed. The prevalence of symptoms of probable anxiety and probable depression was 19.7% and 9.9%, respectively. The risk of anxious and depressive symptoms was independently associated with self-perception of the intensity of asbestos exposure, asbestos-risk perception and self-perception of Asbestos-Related Diseases. Conclusion: The results obtained in this large study confirm that previously asbestos-exposed subjects are likely to develop anxious and depressive symptoms. Finally, implications related to the prevention of anxiety and depression among asbestos-exposed workers is discussed.
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Asbestos-Related Diseases in automobile mechanics.
Annals of Occupational Hygiene, 2012Co-Authors: Jacques Ameille, Catherine Atassi, Manuela Vasile, Dominique Mompoint, Lounis Hamzi, Mireille Matrat, Robert Garnier, Nicole Rosenberg, Alexis Descatha, Jean-claude PaironAbstract:UNLABELLED: Purpose: Automobile mechanics have been exposed to asbestos in the past, mainly due to the presence of chrysotile asbestos in brakes and clutches. Despite the large number of automobile mechanics, little is known about the non-malignant respiratory Diseases observed in this population. The aim of this retrospective multicenter study was to analyse the frequency of pleural and parenchymal abnormalities on high-resolution computed tomography (HRCT) in a population of automobile mechanics. METHODS: The study population consisted of 103 automobile mechanics with no other source of occupational exposure to asbestos, referred to three occupational health departments in the Paris area for systematic screening of Asbestos-Related Diseases. All subjects were examined by HRCT and all images were reviewed separately by two independent readers; who in the case of disagreement discussed until they reached agreement. Multiple logistic regression models were constructed to investigate factors associated with pleural plaques. RESULTS: Pleural plaques were observed in five cases (4.9%) and interstitial abnormalities consistent with asbestosis were observed in one case. After adjustment for age, smoking status, and a history of non-Asbestos-Related respiratory Diseases, multiple logistic regression models showed a significant association between the duration of exposure to asbestos and pleural plaques. CONCLUSIONS: The asbestos exposure experienced by automobile mechanics may lead to pleural plaques. The low prevalence of non-malignant Asbestos-Related Diseases, using a very sensitive diagnostic tool, is in favor of a low cumulative exposure to asbestos in this population of workers.
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Asbestos-Related Diseases in Automobile Mechanics
The Annals of Occupational Hygiene, 2011Co-Authors: Jacques Ameille, Catherine Atassi, Manuela Vasile, Dominique Mompoint, Lounis Hamzi, Mireille Matrat, Robert Garnier, Nicole Rosenberg, Alexis Descatha, Jean-claude PaironAbstract:Purpose: Automobile mechanics have been exposed to asbestos in the past, mainly due to the presence of chrysotile asbestos in brakes and clutches. Despite the large number of automobile mechanics, little is known about the non-malignant respiratory Diseases observed in this population. The aim of this retrospective multicenter study was to analyse the frequency of pleural and parenchymal abnormalities on high-resolution computed tomography (HRCT) in a population of automobile mechanics. Methods: The study population consisted of 103 automobile mechanics with no other source of occupational exposure to asbestos, referred to three occupational health departments in the Paris area for systematic screening of Asbestos-Related Diseases. All subjects were examined by HRCTand all images were reviewed separately by two independent readers; who in the case of disagreement discussed until they reached agreement. Multiple logistic regression models were constructed to investigate factors associated with pleural plaques. Results: Pleural plaques were observed in five cases (4.9%) and interstitial abnormalities consistent with asbestosis were observed in one case. After adjustment for age, smoking status, and a history of non-Asbestos-Related respiratory Diseases, multiple logistic regression models showed a significant association between the duration of exposure to asbestos and pleural plaques. Conclusions: The asbestos exposure experienced by automobile mechanics may lead to pleural plaques. The low prevalence of non-malignant Asbestos-Related Diseases, using a very sensitive diagnostic tool, is in favor of a low cumulative exposure to asbestos in this population of workers.
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Pleural plaques and asbestosis: Dose- and time-response relationships based on HRCT data
European Respiratory Journal, 2009Co-Authors: C Paris, Jacques Ameille, Jean-claude Pairon, S. Thierry, P. Brochard, M. Letourneux, E. Schorle, A. Stoufflet, F. Conso, B. AubertAbstract:Most studies on Asbestos-Related Diseases are based on chest radiographs, and dose-response relationships are still controversial. The aim of this study was to describe the most relevant parameters of asbestos exposure linked to pleural plaques and asbestosis diagnosed by high-resolution computed tomography (HRCT). A large screening programme including systematic HRCT examinations was organised from 2003 to 2005 in France for formerly asbestos-exposed workers. The time since first exposure (TSFE), level, duration and cumulative exposure to asbestos were used in adjusted unconditional logistic regression to model the relationships of the two Diseases. Analysis of a population of 5,545 subjects demonstrated that TSFE (p
Pietro Comba - One of the best experts on this subject based on the ideXlab platform.
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occupational cohort study of asbestos cement workers in a contaminated site in sicily italy
Epidemiologia e prevenzione, 2020Co-Authors: Lucia Fazzo, Achille Cernigliaro, Marco De Santis, Giancarlo Quattrone, Caterina Bruno, Amerigo Zona, Rosario Tumino, Giuseppe Cascone, Salvatore Scondotto, Pietro CombaAbstract:OBJECTIVES to analyse the Asbestos-Related Diseases risk among the former workers of Sacelit asbestos-cement plant, operating in San Filippo del Mela (Sicily: 1958- 1993). DESIGN cohort study. SETTING AND PARTICIPANTS 228 subjects were employed in Sacelit from 1958 to 1993. Due to the available observation periods, the analyses of the different outcomes were performed for the subjects alive at the beginning of the respective follow up periods: mortality (1986-2018) was analysed for 204 subjects (177 men, 27 women), hospitalization (2001-2016) for 164 workers (139 men, 25 women) and the incidence of mesothelioma (1998-2016) was estimated for 178 subjects (153 men, 25 women). MAIN OUTCOMES MEASURES mortality (Standardized Mortality Ratio: SMR) and hospitalization (Standardized Hospitalization Ratio: SHR) from specific Diseases were analysed. Incidence (Standardized Incidence Ratio: SIR) of mesothelioma cases was detected, also. SMR (1986-2014), SHR (2001-2016) and SIR (1998-2016), with 95% Confidence Intervals, were computed with respect to the regional rates, with STATA11. RESULTS in the men cohort, mortality from lung (17 cases, SMR 2.83) and pleural cancers (5 cases, SMR 30) and from asbestosis (15 cases, SMR 1,930) was in excess. The risk of hospitalization was in excess, in both genders, from lung cancer (men: 6 cases, SHR 4.1; women: 2 cases, SHR 8.6) and asbestosis (men: 17 cases, SHR 1,304; women: 6 cases, SHR 2,455). The incidence of mesothelioma was in excess in men (5 cases, SIR 23.9); no female cases of mesothelioma were observed. CONCLUSIONS a high occurrence of Asbestos-Related Diseases in the cohort, particularly among men, was observed. The excess of hospitalization from asbestosis and lung cancer was highlighted also in women. The prosecution of the on-going health surveillance plan is particularly appropriated.
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an asbestos contaminated town in the vicinity of an asbestos cement facility the case study of sibate colombia
Environmental Research, 2019Co-Authors: Juan Pablo Ramosbonilla, Pietro Comba, Roberto Pasetto, Maria Fernanda Celygarcia, Margarita Giraldo, Benedetto Terracini, Daniela Marsili, Valeria Ascoli, Benjamin Lysaniuk, Maria Camila RodriguezAbstract:Abstract Introduction The asbestos industry began operations in Colombia in 1942, with an asbestos-cement facility located in the municipality of Sibate. In recent years residents from Sibate have been complaining about what they consider is an unusually large number of people diagnosed with Asbestos-Related Diseases in the town. A study to analyze the situation of Sibate started in 2015, to verify if the number of asbestos related Diseases being diagnosed were higher than expected, and to identify potential asbestos exposure sources in the town. Methods A health and socioeconomic survey was implemented door-to-door to identify potential Asbestos-Related Diseases. Several self-reported mesothelioma cases were identified, and for confirmation purposes, copies of the medical record with the histopathology report were obtained. A panel of six physicians analyzed the medical records. Information of validated cases was used to estimate the male and female age-adjusted incidence rate for Sibate. Based on reports of the existence of potential asbestos-contaminated landfills, topographic maps, a digital elevation model, and current satellite images were crossed using a geographic information system to identify potential landfilled areas, and soils samples were collected in some of these areas. Results A total of 355 surveys were completed, and 29 self-reported mesothelioma cases were identified. Twenty-five of these cases have been persons who had lived at some moment of their lives in Sibate. It was possible to obtain copies of the medical diagnosis for 17 cases. Of these, the panel of physicians classified 15 cases as certain pleural mesothelioma, one as probable, and one as not mesothelioma. Based on this information, the estimated age-adjusted incidence rate of mesothelioma in Sibate was 3.1 × 105 persons-year for males and 1.6 × 105 persons-year for females. These rates are high in comparison to those reported in other cities, regions, and countries of the world. Using geographic information systems, landfilled zones in the urban area of Sibate were identified, on top of which a school and different sports facilities were built. The analysis of four soil samples collected in landfilled zones, confirmed the existence of an underground layer of friable and non-friable asbestos. Conclusion The collected evidence suggests the presence of a malignant pleural mesothelioma cluster in Sibate.
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Asbestos related Diseases in Italy: an integrated approach to identify unexpected professional or environmental exposure risks at municipal level.
International Archives of Occupational and Environmental Health, 2007Co-Authors: Alessandro Marinaccio, Roberto Pasetto, Alberto Scarselli, Alessandra Binazzi, Pierluigi Altavista, Stefano Belli, Marina Mastrantonio, Raffaella Uccelli, Pietro CombaAbstract:Purpose Past intensive use of asbestos has implied severe public health consequences. Spatial distribution of deaths from malignant mesothelioma and of compensated cases for asbestos related Diseases in Italy were compared to identify unexpected sources of asbestos exposure.
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Asbestos-Related Diseases in Italy: epidemiologic evidences and public health issues.
International Journal of Occupational and Environmental Health, 2005Co-Authors: Pietro Comba, Enzo Merler, Roberto PasettoAbstract:Epidemiologic information about Asbestos-Related Diseases in Italy, derived from mortality data, epidemiologic surveillance, and analytical studies, is presented. These systems evidence exposures to asbestos and relative risks for populations exposed in work environments and also in the general environment, and provide objective data to identify sources of exposure and for risk management. Limitations and perspectives of Italian studies are considered, and public health issues evaluated: the risk for migrants, social security aspects, and Asbestos-Related disease in the courts. Although asbestos use was banned in 1992, information and risk communication efforts should be implemented to empower affected individuals and communities and to pursue equitable allocation of resources for primary prevention and health surveillance.
Jay Champlin - One of the best experts on this subject based on the ideXlab platform.
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imaging of occupational lung disease
Radiologic Clinics of North America, 2016Co-Authors: Jay Champlin, Rachael Edwards, Sudhakar PipavathAbstract:Occupational lung Diseases span a variety of pulmonary disorders caused by inhalation of dusts or chemical antigens in a vocational setting. Included in these are the classic mineral pneumoconioses of silicosis, coal worker's pneumoconiosis, and Asbestos-Related Diseases as well as many immune-mediated and airway-centric Diseases, and new and emerging disorders. Although some of these have characteristic imaging appearances, a multidisciplinary approach with focus on occupational exposure history is essential to proper diagnosis.
