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Christos Reppas - One of the best experts on this subject based on the ideXlab platform.
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degradation kinetics of metronidazole and olsalazine by bacteria in Ascending Colon and in feces of healthy adults
International Journal of Pharmaceutics, 2011Co-Authors: Maria Vertzoni, Konstantinos Goumas, Bertil Abrahamsson, Anders Carlsson, Christos ReppasAbstract:PURPOSE To compare the degradation kinetics of metronidazole and olsalazine by the bacteria of Ascending Colon and the bacteria of feces of healthy adults. METHODS Contents of the Ascending Colon of seven healthy adults were collected under conditions simulating the bioavailability/bioequivalence studies in the fasted and in the fed states on a crossover basis. Material from the contents of the Ascending Colon was prepared by ultracentrifuging and diluting the precipitate with a volume of normal saline equivalent to that of the supernatant. Fecal material was prepared from feces of three healthy adults collected at two occasions that were separated by at least 6 months. Ex vivo drug degradation kinetics were evaluated under anaerobic conditions. RESULTS Mean half-lives of metronidazole degradation in material from the contents of the Ascending Colon collected in the fasted state and in fecal material were 16.1 and 2.4 min, respectively (p<0.001). The corresponding numbers for olsalazine were 57.8 and 9.2 min, respectively (p<0.001). Both compounds were stable in material from the contents of Ascending Colon collected in the fed state. CONCLUSIONS Compared with data in fecal material, degradation of metronidazole and olsalazine in material from the contents of the Ascending Colon is significantly slower and it becomes non-significant during the arrival of fresh food remnants in the region.
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Degradation kinetics of metronidazole and olsalazine by bacteria in Ascending Colon and in feces of healthy adults.
International journal of pharmaceutics, 2011Co-Authors: Maria Vertzoni, Konstantinos Goumas, Bertil Abrahamsson, Anders Carlsson, Christos ReppasAbstract:To compare the degradation kinetics of metronidazole and olsalazine by the bacteria of Ascending Colon and the bacteria of feces of healthy adults. Contents of the Ascending Colon of seven healthy adults were collected under conditions simulating the bioavailability/bioequivalence studies in the fasted and in the fed states on a crossover basis. Material from the contents of the Ascending Colon was prepared by ultracentrifuging and diluting the precipitate with a volume of normal saline equivalent to that of the supernatant. Fecal material was prepared from feces of three healthy adults collected at two occasions that were separated by at least 6 months. Ex vivo drug degradation kinetics were evaluated under anaerobic conditions. Mean half-lives of metronidazole degradation in material from the contents of the Ascending Colon collected in the fasted state and in fecal material were 16.1 and 2.4 min, respectively (p<0.001). The corresponding numbers for olsalazine were 57.8 and 9.2 min, respectively (p<0.001). Both compounds were stable in material from the contents of Ascending Colon collected in the fed state. Compared with data in fecal material, degradation of metronidazole and olsalazine in material from the contents of the Ascending Colon is significantly slower and it becomes non-significant during the arrival of fresh food remnants in the region. Copyright © 2011 Elsevier B.V. All rights reserved.
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Degradation kinetics of metronidazole and olsalazine by bacteria in Ascending Colon and in feces of healthy adults.
International Journal of Pharmaceutics, 2011Co-Authors: Maria Vertzoni, Konstantinos Goumas, Bertil Abrahamsson, Anders Carlsson, Christos ReppasAbstract:PURPOSE To compare the degradation kinetics of metronidazole and olsalazine by the bacteria of Ascending Colon and the bacteria of feces of healthy adults. METHODS Contents of the Ascending Colon of seven healthy adults were collected under conditions simulating the bioavailability/bioequivalence studies in the fasted and in the fed states on a crossover basis. Material from the contents of the Ascending Colon was prepared by ultracentrifuging and diluting the precipitate with a volume of normal saline equivalent to that of the supernatant. Fecal material was prepared from feces of three healthy adults collected at two occasions that were separated by at least 6 months. Ex vivo drug degradation kinetics were evaluated under anaerobic conditions. RESULTS Mean half-lives of metronidazole degradation in material from the contents of the Ascending Colon collected in the fasted state and in fecal material were 16.1 and 2.4 min, respectively (p
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Characterization of the Ascending Colon fluids in ulcerative colitis.
Pharmaceutical research, 2010Co-Authors: Maria Vertzoni, Konstantinos Goumas, Erik Söderlind, Bertil Abrahamsson, Jennifer B. Dressman, Androniki Poulou, Christos ReppasAbstract:Purpose To characterize the fluid composition in Ascending Colon of fasted adults with ulcerative colitis in relapse and in remission with a view to predicting variations on dosage form performance in the lower inflamed gut.
Isaac Levy - One of the best experts on this subject based on the ideXlab platform.
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Mucinous Cystadenoma of the Ascending Colon: a Novel Presentation
Scandinavian journal of gastroenterology, 2003Co-Authors: R. Shaco‐levy, V. Tsodikov, Isaac LevyAbstract:Mucinous cystadenomas usually occur in the appendix, ovaries and pancreas. This is the first report to describe mucinous cystadenoma of the Ascending Colon. A 32-year-old female presented with abdominal pain. Radiographic studies demonstrated a space-occupying lesion in the Ascending Colon associated with intussusception. Right colectomy revealed a cystic mass within the Ascending Colon that contained thick mucin and was lined by mucin-producing columnar epithelium. Clinical and pathologic features with a brief review of the literature are presented.
Maria Vertzoni - One of the best experts on this subject based on the ideXlab platform.
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degradation kinetics of metronidazole and olsalazine by bacteria in Ascending Colon and in feces of healthy adults
International Journal of Pharmaceutics, 2011Co-Authors: Maria Vertzoni, Konstantinos Goumas, Bertil Abrahamsson, Anders Carlsson, Christos ReppasAbstract:PURPOSE To compare the degradation kinetics of metronidazole and olsalazine by the bacteria of Ascending Colon and the bacteria of feces of healthy adults. METHODS Contents of the Ascending Colon of seven healthy adults were collected under conditions simulating the bioavailability/bioequivalence studies in the fasted and in the fed states on a crossover basis. Material from the contents of the Ascending Colon was prepared by ultracentrifuging and diluting the precipitate with a volume of normal saline equivalent to that of the supernatant. Fecal material was prepared from feces of three healthy adults collected at two occasions that were separated by at least 6 months. Ex vivo drug degradation kinetics were evaluated under anaerobic conditions. RESULTS Mean half-lives of metronidazole degradation in material from the contents of the Ascending Colon collected in the fasted state and in fecal material were 16.1 and 2.4 min, respectively (p<0.001). The corresponding numbers for olsalazine were 57.8 and 9.2 min, respectively (p<0.001). Both compounds were stable in material from the contents of Ascending Colon collected in the fed state. CONCLUSIONS Compared with data in fecal material, degradation of metronidazole and olsalazine in material from the contents of the Ascending Colon is significantly slower and it becomes non-significant during the arrival of fresh food remnants in the region.
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Degradation kinetics of metronidazole and olsalazine by bacteria in Ascending Colon and in feces of healthy adults.
International journal of pharmaceutics, 2011Co-Authors: Maria Vertzoni, Konstantinos Goumas, Bertil Abrahamsson, Anders Carlsson, Christos ReppasAbstract:To compare the degradation kinetics of metronidazole and olsalazine by the bacteria of Ascending Colon and the bacteria of feces of healthy adults. Contents of the Ascending Colon of seven healthy adults were collected under conditions simulating the bioavailability/bioequivalence studies in the fasted and in the fed states on a crossover basis. Material from the contents of the Ascending Colon was prepared by ultracentrifuging and diluting the precipitate with a volume of normal saline equivalent to that of the supernatant. Fecal material was prepared from feces of three healthy adults collected at two occasions that were separated by at least 6 months. Ex vivo drug degradation kinetics were evaluated under anaerobic conditions. Mean half-lives of metronidazole degradation in material from the contents of the Ascending Colon collected in the fasted state and in fecal material were 16.1 and 2.4 min, respectively (p<0.001). The corresponding numbers for olsalazine were 57.8 and 9.2 min, respectively (p<0.001). Both compounds were stable in material from the contents of Ascending Colon collected in the fed state. Compared with data in fecal material, degradation of metronidazole and olsalazine in material from the contents of the Ascending Colon is significantly slower and it becomes non-significant during the arrival of fresh food remnants in the region. Copyright © 2011 Elsevier B.V. All rights reserved.
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Degradation kinetics of metronidazole and olsalazine by bacteria in Ascending Colon and in feces of healthy adults.
International Journal of Pharmaceutics, 2011Co-Authors: Maria Vertzoni, Konstantinos Goumas, Bertil Abrahamsson, Anders Carlsson, Christos ReppasAbstract:PURPOSE To compare the degradation kinetics of metronidazole and olsalazine by the bacteria of Ascending Colon and the bacteria of feces of healthy adults. METHODS Contents of the Ascending Colon of seven healthy adults were collected under conditions simulating the bioavailability/bioequivalence studies in the fasted and in the fed states on a crossover basis. Material from the contents of the Ascending Colon was prepared by ultracentrifuging and diluting the precipitate with a volume of normal saline equivalent to that of the supernatant. Fecal material was prepared from feces of three healthy adults collected at two occasions that were separated by at least 6 months. Ex vivo drug degradation kinetics were evaluated under anaerobic conditions. RESULTS Mean half-lives of metronidazole degradation in material from the contents of the Ascending Colon collected in the fasted state and in fecal material were 16.1 and 2.4 min, respectively (p
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Characterization of the Ascending Colon fluids in ulcerative colitis.
Pharmaceutical research, 2010Co-Authors: Maria Vertzoni, Konstantinos Goumas, Erik Söderlind, Bertil Abrahamsson, Jennifer B. Dressman, Androniki Poulou, Christos ReppasAbstract:Purpose To characterize the fluid composition in Ascending Colon of fasted adults with ulcerative colitis in relapse and in remission with a view to predicting variations on dosage form performance in the lower inflamed gut.
David R. Grant - One of the best experts on this subject based on the ideXlab platform.
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Transplantation Of Segmental Rat Intestinal Grafts Including The Ileocecal Valve And The Ascending Colon
Transplantation, 1994Co-Authors: R. Black, Tetsuo Hashimoto, Robert Zhong, Ronald J. Behme, Bertha Garcia, John Duff, David R. GrantAbstract:Extrinsic denervation and lymphatic disruption impair nutrient absorption after small bowel transplantation. The present study was undertaken to determine whether adding the ileocecal valve with or without the Ascending Colon would improve the function of a segmental intestinal graft. Five groups of Lewis rats (n = 10/group) were studied. Group I had a sham laparotomy. Groups II, III, IV, and V had the native jejunum, ileum, and cecum replaced with a graft. Inbred Lewis rats were used as isogeneic donors for the transplants to avoid the confounding effect of graft rejection. Group II had the entire jejunum and ileum transplanted. Group III had 20 cm of terminal ileum transplanted. Group IV had 20 cm of the terminal ileum including the ileocecal valve transplanted. Group V had 20 cm of the terminal ileum, the ileocecal valve, and the Ascending Colon transplanted. The terminal ileum-transplanted and terminal ileum/ileocecal valve-transplanted groups lost more than 25% of their preoperative weight by the end of the second postoperative week; most of these animals were killed because of inanition. In contrast, the sham laparotomy, jejunum/ileum-transplanted, and Ascending Colon-transplanted groups remained healthy until completion of the study on the 28th postoperative day. The Ascending Colon-transplanted group had slower intestinal transit and less bacterial contamination of the terminal ileum compared with the terminal ileum-transplanted and terminal ileum/ileocecal valve-transplanted groups (P < 0.05). Transplantation of the Ascending Colon and the ileocecal valve significantly improves the function of segmental small bowel isografts in rats. These data suggest that adding a Colonic segment may be a simple method to improve the function of short-segment cadaveric and living-related intestinal grafts in humans.
Zhang Shaozeng - One of the best experts on this subject based on the ideXlab platform.
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Continent ileal ceacal- Ascending Colon urinary reservoir.
Journal of Modern Urology, 2001Co-Authors: Zhang ShaozengAbstract:Objective To evaluate the procedure of continent ileal ceacai Ascending Colon urinary diversion-Methods From Oct. 1996 to Oct.2000, continent ileal ceacal Ascending Colon urinary diversion was performed in 23 patients with bladder cancer following radical cystectomy. Results 23 cases have been followed up and have reliable continence in all. The capacity of the reservoir was 300 ml to 550 ml with maximum pressure of 40 cmH2O ,self catheriating were carried out every 4 to 5 hours. No hyperchlorernic metablic acidosis occ-cured in the patients. Conclusions Cantient ileal ceacal Ascending was Colon urinarg reserveir believed to be an ideal form of urinary diversion and there was few complications and can impreve quality life of postcystectomy patients.
