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Christos Reppas – One of the best experts on this subject based on the ideXlab platform.

  • degradation kinetics of metronidazole and olsalazine by bacteria in Ascending Colon and in feces of healthy adults
    International Journal of Pharmaceutics, 2011
    Co-Authors: Maria Vertzoni, Konstantinos Goumas, Bertil Abrahamsson, Anders Carlsson, Christos Reppas

    Abstract:

    PURPOSE To compare the degradation kinetics of metronidazole and olsalazine by the bacteria of Ascending Colon and the bacteria of feces of healthy adults. METHODS Contents of the Ascending Colon of seven healthy adults were collected under conditions simulating the bioavailability/bioequivalence studies in the fasted and in the fed states on a crossover basis. Material from the contents of the Ascending Colon was prepared by ultracentrifuging and diluting the precipitate with a volume of normal saline equivalent to that of the supernatant. Fecal material was prepared from feces of three healthy adults collected at two occasions that were separated by at least 6 months. Ex vivo drug degradation kinetics were evaluated under anaerobic conditions. RESULTS Mean half-lives of metronidazole degradation in material from the contents of the Ascending Colon collected in the fasted state and in fecal material were 16.1 and 2.4 min, respectively (p<0.001). The corresponding numbers for olsalazine were 57.8 and 9.2 min, respectively (p<0.001). Both compounds were stable in material from the contents of Ascending Colon collected in the fed state. CONCLUSIONS Compared with data in fecal material, degradation of metronidazole and olsalazine in material from the contents of the Ascending Colon is significantly slower and it becomes non-significant during the arrival of fresh food remnants in the region.

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  • Degradation kinetics of metronidazole and olsalazine by bacteria in Ascending Colon and in feces of healthy adults.
    International journal of pharmaceutics, 2011
    Co-Authors: Maria Vertzoni, Konstantinos Goumas, Bertil Abrahamsson, Anders Carlsson, Christos Reppas

    Abstract:

    To compare the degradation kinetics of metronidazole and olsalazine by the bacteria of Ascending Colon and the bacteria of feces of healthy adults.
    Contents of the Ascending Colon of seven healthy adults were collected under conditions simulating the bioavailability/bioequivalence studies in the fasted and in the fed states on a crossover basis. Material from the contents of the Ascending Colon was prepared by ultracentrifuging and diluting the precipitate with a volume of normal saline equivalent to that of the supernatant. Fecal material was prepared from feces of three healthy adults collected at two occasions that were separated by at least 6 months. Ex vivo drug degradation kinetics were evaluated under anaerobic conditions.
    Mean half-lives of metronidazole degradation in material from the contents of the Ascending Colon collected in the fasted state and in fecal material were 16.1 and 2.4 min, respectively (p<0.001). The corresponding numbers for olsalazine were 57.8 and 9.2 min, respectively (p<0.001). Both compounds were stable in material from the contents of Ascending Colon collected in the fed state.
    Compared with data in fecal material, degradation of metronidazole and olsalazine in material from the contents of the Ascending Colon is significantly slower and it becomes non-significant during the arrival of fresh food remnants in the region.
    Copyright © 2011 Elsevier B.V. All rights reserved.

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  • Degradation kinetics of metronidazole and olsalazine by bacteria in Ascending Colon and in feces of healthy adults.
    International Journal of Pharmaceutics, 2011
    Co-Authors: Maria Vertzoni, Konstantinos Goumas, Bertil Abrahamsson, Anders Carlsson, Christos Reppas

    Abstract:

    PURPOSE To compare the degradation kinetics of metronidazole and olsalazine by the bacteria of Ascending Colon and the bacteria of feces of healthy adults. METHODS Contents of the Ascending Colon of seven healthy adults were collected under conditions simulating the bioavailability/bioequivalence studies in the fasted and in the fed states on a crossover basis. Material from the contents of the Ascending Colon was prepared by ultracentrifuging and diluting the precipitate with a volume of normal saline equivalent to that of the supernatant. Fecal material was prepared from feces of three healthy adults collected at two occasions that were separated by at least 6 months. Ex vivo drug degradation kinetics were evaluated under anaerobic conditions. RESULTS Mean half-lives of metronidazole degradation in material from the contents of the Ascending Colon collected in the fasted state and in fecal material were 16.1 and 2.4 min, respectively (p

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Isaac Levy – One of the best experts on this subject based on the ideXlab platform.

  • Mucinous Cystadenoma of the Ascending Colon: a Novel Presentation
    Scandinavian journal of gastroenterology, 2003
    Co-Authors: R. Shaco‐levy, V. Tsodikov, Isaac Levy

    Abstract:

    Mucinous cystadenomas usually occur in the appendix, ovaries and pancreas. This is the first report to describe mucinous cystadenoma of the Ascending Colon. A 32-year-old female presented with abdominal pain. Radiographic studies demonstrated a space-occupying lesion in the Ascending Colon associated with intussusception. Right colectomy revealed a cystic mass within the Ascending Colon that contained thick mucin and was lined by mucin-producing columnar epithelium. Clinical and pathologic features with a brief review of the literature are presented.

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Maria Vertzoni – One of the best experts on this subject based on the ideXlab platform.

  • degradation kinetics of metronidazole and olsalazine by bacteria in Ascending Colon and in feces of healthy adults
    International Journal of Pharmaceutics, 2011
    Co-Authors: Maria Vertzoni, Konstantinos Goumas, Bertil Abrahamsson, Anders Carlsson, Christos Reppas

    Abstract:

    PURPOSE To compare the degradation kinetics of metronidazole and olsalazine by the bacteria of Ascending Colon and the bacteria of feces of healthy adults. METHODS Contents of the Ascending Colon of seven healthy adults were collected under conditions simulating the bioavailability/bioequivalence studies in the fasted and in the fed states on a crossover basis. Material from the contents of the Ascending Colon was prepared by ultracentrifuging and diluting the precipitate with a volume of normal saline equivalent to that of the supernatant. Fecal material was prepared from feces of three healthy adults collected at two occasions that were separated by at least 6 months. Ex vivo drug degradation kinetics were evaluated under anaerobic conditions. RESULTS Mean half-lives of metronidazole degradation in material from the contents of the Ascending Colon collected in the fasted state and in fecal material were 16.1 and 2.4 min, respectively (p<0.001). The corresponding numbers for olsalazine were 57.8 and 9.2 min, respectively (p<0.001). Both compounds were stable in material from the contents of Ascending Colon collected in the fed state. CONCLUSIONS Compared with data in fecal material, degradation of metronidazole and olsalazine in material from the contents of the Ascending Colon is significantly slower and it becomes non-significant during the arrival of fresh food remnants in the region.

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  • Degradation kinetics of metronidazole and olsalazine by bacteria in Ascending Colon and in feces of healthy adults.
    International journal of pharmaceutics, 2011
    Co-Authors: Maria Vertzoni, Konstantinos Goumas, Bertil Abrahamsson, Anders Carlsson, Christos Reppas

    Abstract:

    To compare the degradation kinetics of metronidazole and olsalazine by the bacteria of Ascending Colon and the bacteria of feces of healthy adults.
    Contents of the Ascending Colon of seven healthy adults were collected under conditions simulating the bioavailability/bioequivalence studies in the fasted and in the fed states on a crossover basis. Material from the contents of the Ascending Colon was prepared by ultracentrifuging and diluting the precipitate with a volume of normal saline equivalent to that of the supernatant. Fecal material was prepared from feces of three healthy adults collected at two occasions that were separated by at least 6 months. Ex vivo drug degradation kinetics were evaluated under anaerobic conditions.
    Mean half-lives of metronidazole degradation in material from the contents of the Ascending Colon collected in the fasted state and in fecal material were 16.1 and 2.4 min, respectively (p<0.001). The corresponding numbers for olsalazine were 57.8 and 9.2 min, respectively (p<0.001). Both compounds were stable in material from the contents of Ascending Colon collected in the fed state.
    Compared with data in fecal material, degradation of metronidazole and olsalazine in material from the contents of the Ascending Colon is significantly slower and it becomes non-significant during the arrival of fresh food remnants in the region.
    Copyright © 2011 Elsevier B.V. All rights reserved.

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  • Degradation kinetics of metronidazole and olsalazine by bacteria in Ascending Colon and in feces of healthy adults.
    International Journal of Pharmaceutics, 2011
    Co-Authors: Maria Vertzoni, Konstantinos Goumas, Bertil Abrahamsson, Anders Carlsson, Christos Reppas

    Abstract:

    PURPOSE To compare the degradation kinetics of metronidazole and olsalazine by the bacteria of Ascending Colon and the bacteria of feces of healthy adults. METHODS Contents of the Ascending Colon of seven healthy adults were collected under conditions simulating the bioavailability/bioequivalence studies in the fasted and in the fed states on a crossover basis. Material from the contents of the Ascending Colon was prepared by ultracentrifuging and diluting the precipitate with a volume of normal saline equivalent to that of the supernatant. Fecal material was prepared from feces of three healthy adults collected at two occasions that were separated by at least 6 months. Ex vivo drug degradation kinetics were evaluated under anaerobic conditions. RESULTS Mean half-lives of metronidazole degradation in material from the contents of the Ascending Colon collected in the fasted state and in fecal material were 16.1 and 2.4 min, respectively (p

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