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Mike H. Baums - One of the best experts on this subject based on the ideXlab platform.
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Nicotine consumption may lead to Aseptic Loosening in proximal mega-prosthetic femoral replacement
Journal of Orthopaedics and Traumatology, 2017Co-Authors: Philip Johannes Felix Leute, Isabel Hoffmann, Ahmed Hammad, Stefan Lakemeier, Hans-michael Klinger, Mike H. BaumsAbstract:Background Aseptic Loosening after total hip arthroplasty is likely related to nicotine ingestion. However, Aseptic Loosening as a direct consequence of smoking habits has not been described with regard to proximal mega-prosthetic femoral replacement. The aim of the present study was to evaluate the association between nicotine consumption and Aseptic Loosening rates after proximal mega-prosthetic femoral replacement. Materials and methods A consecutive series of patients who received mega-prosthetic replacement of the proximal femur at our hospital between 2005 and 2015 were included. Their files were reviewed and evaluated for the influence of smoking on Aseptic Loosening rates. All living patients were invited to complete a functional follow-up assessment at our clinic. Results Twenty-six patients with 27 prostheses were included. Five patients were active smokers, and 21 patients were non-smokers. Aseptic Loosening was observed in three patients in the smoking group, whereas none of the non-smokers developed Aseptic Loosening. Fisher’s exact test showed a relationship between nicotine consumption and Aseptic Loosening of the prostheses ( p = 0.003). Conclusions Smoking increases the likelihood of Aseptic Loosening after proximal mega-prosthetic femoral replacement. Level of evidence Level 4 according to Oxford Centre of Evidence-Based Medicine 2011.
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Nicotine consumption may lead to Aseptic Loosening in proximal mega-prosthetic femoral replacement
Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology, 2016Co-Authors: Philip Johannes Felix Leute, Isabel Hoffmann, Ahmed Hammad, Stefan Lakemeier, Hans-michael Klinger, Mike H. BaumsAbstract:Aseptic Loosening after total hip arthroplasty is likely related to nicotine ingestion. However, Aseptic Loosening as a direct consequence of smoking habits has not been described with regard to proximal mega-prosthetic femoral replacement. The aim of the present study was to evaluate the association between nicotine consumption and Aseptic Loosening rates after proximal mega-prosthetic femoral replacement. A consecutive series of patients who received mega-prosthetic replacement of the proximal femur at our hospital between 2005 and 2015 were included. Their files were reviewed and evaluated for the influence of smoking on Aseptic Loosening rates. All living patients were invited to complete a functional follow-up assessment at our clinic. Twenty-six patients with 27 prostheses were included. Five patients were active smokers, and 21 patients were non-smokers. Aseptic Loosening was observed in three patients in the smoking group, whereas none of the non-smokers developed Aseptic Loosening. Fisher’s exact test showed a relationship between nicotine consumption and Aseptic Loosening of the prostheses (p = 0.003). Smoking increases the likelihood of Aseptic Loosening after proximal mega-prosthetic femoral replacement. Level 4 according to Oxford Centre of Evidence-Based Medicine 2011.
Martin Tötsch - One of the best experts on this subject based on the ideXlab platform.
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Adiponectin attenuates osteolysis in Aseptic Loosening of total hip replacements
Acta biomaterialia, 2013Co-Authors: Stefan Landgraeber, Martin Tötsch, S. Putz, Martin Schlattjan, Lars P. Bechmann, Florian Grabellus, Gero Hilken, Marcus Jäger, Ali CanbayAbstract:Joint replacements have a longer durability in patients with high serum levels of adiponectin (APN) than in patients with low levels. We aimed to characterize the unknown pathophysiological effects of APN on wear particle-induced inflammation, apoptosis and osteolysis. Immunohistochemistry was performed to detect APN, its receptors and apoptosis in patients with and without Aseptic Loosening. Additionally, APN knockout mouse studies and pharmacological intervention of APN were performed in an established calvarial mouse model. Osteolysis and inflammation were quantified by histomorphometry and microcomputed tomography, apoptosis by immunohistochemistry and TUNEL assay. In a cell culture model, human monocyte-derived macrophages were incubated with or without metal wear debris particles and partially treated with APN. Expression of APN, AdipoR1 and calreticulin in specimens from patients with Aseptic Loosening were significantly higher than in patients without Aseptic Loosening. Administration of APN in mice significantly reduced wear particle-induced inflammation, osteolysis and the number of caspase-3-positive macrophages. The cell culture model showed that APN leads to significantly lower values of TNF-α. These findings support a prominent role of APN in the development of particle-induced osteolysis and APN may be therapeutically useful in patients with Aseptic Loosening.
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Senescence in cells in Aseptic Loosening after total hip replacement.
Acta biomaterialia, 2010Co-Authors: Stefan Landgraeber, U. Quint, Tim Classen, Martin TötschAbstract:Abstract Particle-induced osteolysis is a major cause of Aseptic Loosening after total joint replacement. The purpose of the current study was to evaluate cellular senescence of macrophages and giant cells in patients with Aseptic hip Loosening by determination of SA-β-Gal (SA-β-galactosidase), a reliable and frequently used indicator of cellular senescence. The level of senescence in capsule and interface membranes was significantly higher in patients with Aseptic Loosening in comparison to specimens from patients without Aseptic Loosening. Using Spearman’s rank correlation, we found that the expression of SA-β-Gal in giant cells ( p = 0.002) and macrophages ( p = 0.050) in the interface membranes correlates significantly with the degree of polyethylene debris. We speculate that the induction of DNA damage by wear particles is responsible for premature senescence. Consequently, we conclude that the form of senescence observed in this study is a “stress-induced senescence”.
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ERCC1 expression in Aseptic Loosening after total hip replacement
Journal of biomedical materials research. Part A, 2010Co-Authors: Stefan Landgraeber, Marius Von Knoch, Franz Löer, Alexander Wegner, Michael Tsokos, Kurt Werner Schmid, Martin TötschAbstract:Particle-induced osteolysis is a major cause of Aseptic Loosening after total joint replacement. The purpose of the current study was to evaluate the DNA damage repair capacity of macrophages in patients with Aseptic hip Loosening by determination of ERCC1. Moreover, we wanted to elucidate if the potency of the DNA-repair mechanisms correlates with the survival of joint implants. For this purpose we compared the immunohistochemical ERCC1 expression in capsules and interface membranes of patients with Loosening of a hip replacement in the first 10 years after implantation with those in patients with late Loosening. In analogy with ERCC1 studies on cancer in humans we calculated the semi-quantitative H-score by multiplying the staining intensity with the proportion score of positive stained macrophages. The level of ERCC1 reaction in the specimens taken from patients with early Aseptic Loosening (mean H-score 0.57) was clearly lower in comparison with those from patients undergoing exchange hip arthroplasty later than 10 years after surgery (mean H-score 2.24). We determined an H-score for ERCC1 expression of 1 as a cutoff point giving a sensitivity and specificity of 100% for identification of early Aseptic Loosening after less than 10 years. In summary, lower levels of ERCC1 were found in patients with early Aseptic Loosening compared to patients with Aseptic Loosening later than 10 years.
Philip Johannes Felix Leute - One of the best experts on this subject based on the ideXlab platform.
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Nicotine consumption may lead to Aseptic Loosening in proximal mega-prosthetic femoral replacement
Journal of Orthopaedics and Traumatology, 2017Co-Authors: Philip Johannes Felix Leute, Isabel Hoffmann, Ahmed Hammad, Stefan Lakemeier, Hans-michael Klinger, Mike H. BaumsAbstract:Background Aseptic Loosening after total hip arthroplasty is likely related to nicotine ingestion. However, Aseptic Loosening as a direct consequence of smoking habits has not been described with regard to proximal mega-prosthetic femoral replacement. The aim of the present study was to evaluate the association between nicotine consumption and Aseptic Loosening rates after proximal mega-prosthetic femoral replacement. Materials and methods A consecutive series of patients who received mega-prosthetic replacement of the proximal femur at our hospital between 2005 and 2015 were included. Their files were reviewed and evaluated for the influence of smoking on Aseptic Loosening rates. All living patients were invited to complete a functional follow-up assessment at our clinic. Results Twenty-six patients with 27 prostheses were included. Five patients were active smokers, and 21 patients were non-smokers. Aseptic Loosening was observed in three patients in the smoking group, whereas none of the non-smokers developed Aseptic Loosening. Fisher’s exact test showed a relationship between nicotine consumption and Aseptic Loosening of the prostheses ( p = 0.003). Conclusions Smoking increases the likelihood of Aseptic Loosening after proximal mega-prosthetic femoral replacement. Level of evidence Level 4 according to Oxford Centre of Evidence-Based Medicine 2011.
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Nicotine consumption may lead to Aseptic Loosening in proximal mega-prosthetic femoral replacement
Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology, 2016Co-Authors: Philip Johannes Felix Leute, Isabel Hoffmann, Ahmed Hammad, Stefan Lakemeier, Hans-michael Klinger, Mike H. BaumsAbstract:Aseptic Loosening after total hip arthroplasty is likely related to nicotine ingestion. However, Aseptic Loosening as a direct consequence of smoking habits has not been described with regard to proximal mega-prosthetic femoral replacement. The aim of the present study was to evaluate the association between nicotine consumption and Aseptic Loosening rates after proximal mega-prosthetic femoral replacement. A consecutive series of patients who received mega-prosthetic replacement of the proximal femur at our hospital between 2005 and 2015 were included. Their files were reviewed and evaluated for the influence of smoking on Aseptic Loosening rates. All living patients were invited to complete a functional follow-up assessment at our clinic. Twenty-six patients with 27 prostheses were included. Five patients were active smokers, and 21 patients were non-smokers. Aseptic Loosening was observed in three patients in the smoking group, whereas none of the non-smokers developed Aseptic Loosening. Fisher’s exact test showed a relationship between nicotine consumption and Aseptic Loosening of the prostheses (p = 0.003). Smoking increases the likelihood of Aseptic Loosening after proximal mega-prosthetic femoral replacement. Level 4 according to Oxford Centre of Evidence-Based Medicine 2011.
Stefan Landgraeber - One of the best experts on this subject based on the ideXlab platform.
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Adiponectin attenuates osteolysis in Aseptic Loosening of total hip replacements
Acta biomaterialia, 2013Co-Authors: Stefan Landgraeber, Martin Tötsch, S. Putz, Martin Schlattjan, Lars P. Bechmann, Florian Grabellus, Gero Hilken, Marcus Jäger, Ali CanbayAbstract:Joint replacements have a longer durability in patients with high serum levels of adiponectin (APN) than in patients with low levels. We aimed to characterize the unknown pathophysiological effects of APN on wear particle-induced inflammation, apoptosis and osteolysis. Immunohistochemistry was performed to detect APN, its receptors and apoptosis in patients with and without Aseptic Loosening. Additionally, APN knockout mouse studies and pharmacological intervention of APN were performed in an established calvarial mouse model. Osteolysis and inflammation were quantified by histomorphometry and microcomputed tomography, apoptosis by immunohistochemistry and TUNEL assay. In a cell culture model, human monocyte-derived macrophages were incubated with or without metal wear debris particles and partially treated with APN. Expression of APN, AdipoR1 and calreticulin in specimens from patients with Aseptic Loosening were significantly higher than in patients without Aseptic Loosening. Administration of APN in mice significantly reduced wear particle-induced inflammation, osteolysis and the number of caspase-3-positive macrophages. The cell culture model showed that APN leads to significantly lower values of TNF-α. These findings support a prominent role of APN in the development of particle-induced osteolysis and APN may be therapeutically useful in patients with Aseptic Loosening.
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Senescence in cells in Aseptic Loosening after total hip replacement.
Acta biomaterialia, 2010Co-Authors: Stefan Landgraeber, U. Quint, Tim Classen, Martin TötschAbstract:Abstract Particle-induced osteolysis is a major cause of Aseptic Loosening after total joint replacement. The purpose of the current study was to evaluate cellular senescence of macrophages and giant cells in patients with Aseptic hip Loosening by determination of SA-β-Gal (SA-β-galactosidase), a reliable and frequently used indicator of cellular senescence. The level of senescence in capsule and interface membranes was significantly higher in patients with Aseptic Loosening in comparison to specimens from patients without Aseptic Loosening. Using Spearman’s rank correlation, we found that the expression of SA-β-Gal in giant cells ( p = 0.002) and macrophages ( p = 0.050) in the interface membranes correlates significantly with the degree of polyethylene debris. We speculate that the induction of DNA damage by wear particles is responsible for premature senescence. Consequently, we conclude that the form of senescence observed in this study is a “stress-induced senescence”.
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ERCC1 expression in Aseptic Loosening after total hip replacement
Journal of biomedical materials research. Part A, 2010Co-Authors: Stefan Landgraeber, Marius Von Knoch, Franz Löer, Alexander Wegner, Michael Tsokos, Kurt Werner Schmid, Martin TötschAbstract:Particle-induced osteolysis is a major cause of Aseptic Loosening after total joint replacement. The purpose of the current study was to evaluate the DNA damage repair capacity of macrophages in patients with Aseptic hip Loosening by determination of ERCC1. Moreover, we wanted to elucidate if the potency of the DNA-repair mechanisms correlates with the survival of joint implants. For this purpose we compared the immunohistochemical ERCC1 expression in capsules and interface membranes of patients with Loosening of a hip replacement in the first 10 years after implantation with those in patients with late Loosening. In analogy with ERCC1 studies on cancer in humans we calculated the semi-quantitative H-score by multiplying the staining intensity with the proportion score of positive stained macrophages. The level of ERCC1 reaction in the specimens taken from patients with early Aseptic Loosening (mean H-score 0.57) was clearly lower in comparison with those from patients undergoing exchange hip arthroplasty later than 10 years after surgery (mean H-score 2.24). We determined an H-score for ERCC1 expression of 1 as a cutoff point giving a sensitivity and specificity of 100% for identification of early Aseptic Loosening after less than 10 years. In summary, lower levels of ERCC1 were found in patients with early Aseptic Loosening compared to patients with Aseptic Loosening later than 10 years.
Stefan Lakemeier - One of the best experts on this subject based on the ideXlab platform.
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Nicotine consumption may lead to Aseptic Loosening in proximal mega-prosthetic femoral replacement
Journal of Orthopaedics and Traumatology, 2017Co-Authors: Philip Johannes Felix Leute, Isabel Hoffmann, Ahmed Hammad, Stefan Lakemeier, Hans-michael Klinger, Mike H. BaumsAbstract:Background Aseptic Loosening after total hip arthroplasty is likely related to nicotine ingestion. However, Aseptic Loosening as a direct consequence of smoking habits has not been described with regard to proximal mega-prosthetic femoral replacement. The aim of the present study was to evaluate the association between nicotine consumption and Aseptic Loosening rates after proximal mega-prosthetic femoral replacement. Materials and methods A consecutive series of patients who received mega-prosthetic replacement of the proximal femur at our hospital between 2005 and 2015 were included. Their files were reviewed and evaluated for the influence of smoking on Aseptic Loosening rates. All living patients were invited to complete a functional follow-up assessment at our clinic. Results Twenty-six patients with 27 prostheses were included. Five patients were active smokers, and 21 patients were non-smokers. Aseptic Loosening was observed in three patients in the smoking group, whereas none of the non-smokers developed Aseptic Loosening. Fisher’s exact test showed a relationship between nicotine consumption and Aseptic Loosening of the prostheses ( p = 0.003). Conclusions Smoking increases the likelihood of Aseptic Loosening after proximal mega-prosthetic femoral replacement. Level of evidence Level 4 according to Oxford Centre of Evidence-Based Medicine 2011.
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Nicotine consumption may lead to Aseptic Loosening in proximal mega-prosthetic femoral replacement
Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology, 2016Co-Authors: Philip Johannes Felix Leute, Isabel Hoffmann, Ahmed Hammad, Stefan Lakemeier, Hans-michael Klinger, Mike H. BaumsAbstract:Aseptic Loosening after total hip arthroplasty is likely related to nicotine ingestion. However, Aseptic Loosening as a direct consequence of smoking habits has not been described with regard to proximal mega-prosthetic femoral replacement. The aim of the present study was to evaluate the association between nicotine consumption and Aseptic Loosening rates after proximal mega-prosthetic femoral replacement. A consecutive series of patients who received mega-prosthetic replacement of the proximal femur at our hospital between 2005 and 2015 were included. Their files were reviewed and evaluated for the influence of smoking on Aseptic Loosening rates. All living patients were invited to complete a functional follow-up assessment at our clinic. Twenty-six patients with 27 prostheses were included. Five patients were active smokers, and 21 patients were non-smokers. Aseptic Loosening was observed in three patients in the smoking group, whereas none of the non-smokers developed Aseptic Loosening. Fisher’s exact test showed a relationship between nicotine consumption and Aseptic Loosening of the prostheses (p = 0.003). Smoking increases the likelihood of Aseptic Loosening after proximal mega-prosthetic femoral replacement. Level 4 according to Oxford Centre of Evidence-Based Medicine 2011.
