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Asthma in Adults

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Francine Kauffmann – One of the best experts on this subject based on the ideXlab platform.

  • CD14 and toll-like receptor gene polymorphisms, country living, and Asthma in Adults.
    American Journal of Respiratory and Critical Care Medicine, 2009
    Co-Authors: Lidwien Smit, Valérie Siroux, Emmanuelle Bouzigon, Marie-pierre Oryszczyn, Mark Lathrop, Florence Desmenais, Francine Kauffmann

    Abstract:

    RATIONALE: It has been shown that country living protects against Asthma, which may be explained by microbial exposures. OBJECTIVES: To study whether single nucleotide polymorphisms (SNPs) in CD14 and Toll-like receptor (TLR) 2, TLR4 and TLR9 genes are associated with Asthma in Adults, and whether these SNPs modify associations between country living and Asthma. METHODS: Twenty-five SNPs in CD14, TLR2, TLR4, and TLR9 genes were genotyped in adult subjects from the French Epidemiological study on the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy (EGEA). We conducted a case-control analysis on unrelated subjects (239 with Asthma and 596 without Asthma), and a family-based association test (FBAT) in 192 families ascertained through probands with Asthma. MEASUREMENTS AND MAin RESULTS: The TLR2/+596 C allele was associated with an increased risk for Asthma in both case-control and family-based analyses (under a dominant model, odds ratio [OR] 1.91 and 95% confidence interval [CI] 1.34-2.72, P = 0.0003; Z statistics from FBAT = 2.48, P = 0.01). in skin prick test (SPT) positive subjects, the CD14/-260 C allele was negatively associated with Asthma (additive model, OR 0.66; CI 0.48-0.91). Significant gene-environment interactions between variation in CD14 and TLR genes and country living during childhood were found for ten SNPs. in SPT positive subjects carrying CD14/-260 CC, country living protected against Asthma (OR, 0.32; 95% CI, 0.12-0.85), whereas country living was not associated with Asthma in subjects who were atopic and carrying CD14/-260 T (OR, 1.11; 95% CI, 0.65-1.90) (gene-environment interaction, P < 0.05). CONCLUSIONS: TLR2 and CD14 SNPs were associated with Asthma and atopic Asthma respectively. in addition, CD14, TLR2, TLR4, and TLR9 SNPs modified associations between country living and Asthma.

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  • CD14 and toll-like receptor gene polymorphisms, country living, and Asthma in Adults.
    American journal of respiratory and critical care medicine, 2008
    Co-Authors: Lidwien A.m. Smit, Valérie Siroux, Emmanuelle Bouzigon, Marie-pierre Oryszczyn, Mark Lathrop, Florence Demenais, Francine Kauffmann

    Abstract:

    Rationale: It has been shown that country living protects against Asthma, which may be explained by microbial exposures.Objectives: To study whether single nucleotide polymorphisms (SNPs) in CD14 and Toll-like receptor (TLR) 2, TLR4 and TLR9 genes are associated with Asthma in Adults, and whether these SNPs modify associations between country living and Asthma.Methods: Twenty-five SNPs in CD14, TLR2, TLR4, and TLR9 genes were genotyped in adult subjects from the French Epidemiological study on the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy (EGEA). We conducted a case-control analysis on unrelated subjects (239 with Asthma and 596 without Asthma), and a family-based association test (FBAT) in 192 families ascertained through probands with Asthma.Measurements and Main Results: The TLR2/+596 C allele was associated with an increased risk for Asthma in both case-control and family-based analyses (under a dominant model, odds ratio [OR] 1.91 and 95% confidence interval [CI] 1….

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Valérie Siroux – One of the best experts on this subject based on the ideXlab platform.

  • Outdoor air pollution, exhaled 8-isoprostane and current Asthma in Adults: the EGEA study
    European Respiratory Journal, 2018
    Co-Authors: Anaïs Havet, Bénédicte Jacquemin, Farid Zerimech, Margaux Sanchez, Valérie Siroux, Nicole Le Moual, Bert Brunekreef, Morgane Stempfelet, Nino Künzli, Régis Matran

    Abstract:

    Associations between outdoor air pollution and Asthma in Adults are still scarce, and the underlying biological mechanisms are poorly understood. Our aim was to study the associations between 1) long-term exposure to outdoor air pollution and current Asthma, 2) exhaled 8-isoprostane (8-iso; a biomarker related to oxidative stress) and current Asthma, and 3) outdoor air pollution and exhaled 8-iso.Cross-sectional analyses were conducted in 608 Adults (39% with current Asthma) from the first follow-up of the French case-control and family study on Asthma (EGEA; the Epidemiological study of the Genetic and Environmental factors of Asthma). Data on nitrogen dioxide, nitrogen oxides, particulate matter with a diameter ≤10 and ≤2.5 µm (PM10 and PM2.5), road traffic, and ozone (O3) were from ESCAPE (European Study of Cohorts for Air Pollution Effects) and IFEN (French institute for the Environment) assessments. Models took account of city and familial dependence.The risk of current Asthma increased with traffic intensity (adjusted (a)OR 1.09 (95% CI 1.00-1.18) per 5000 vehicles per day), with O3 exposure (aOR 2.04 (95% CI 1.27-3.29) per 10 µg·m-3) and with exhaled 8-iso concentration (aOR 1.50 (95% CI 1.06-2.12) per 1 pg·mL-1). Among participants without Asthma, exhaled 8-iso concentration increased with PM2.5 exposure (adjusted (a)β 0.23 (95% CI 0.005-0.46) per 5 µg·m-3), and decreased with O3 and O3-summer exposures (aβ -0.20 (95% CI -0.39- -0.01) and aβ -0.52 (95% CI -0.77- -0.26) per 10 µg·m-3, respectively).Our results add new insights into a potential role of oxidative stress in the associations between outdoor air pollution and Asthma in Adults.

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  • CD14 and toll-like receptor gene polymorphisms, country living, and Asthma in Adults.
    American Journal of Respiratory and Critical Care Medicine, 2009
    Co-Authors: Lidwien Smit, Valérie Siroux, Emmanuelle Bouzigon, Marie-pierre Oryszczyn, Mark Lathrop, Florence Desmenais, Francine Kauffmann

    Abstract:

    RATIONALE: It has been shown that country living protects against Asthma, which may be explained by microbial exposures. OBJECTIVES: To study whether single nucleotide polymorphisms (SNPs) in CD14 and Toll-like receptor (TLR) 2, TLR4 and TLR9 genes are associated with Asthma in Adults, and whether these SNPs modify associations between country living and Asthma. METHODS: Twenty-five SNPs in CD14, TLR2, TLR4, and TLR9 genes were genotyped in adult subjects from the French Epidemiological study on the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy (EGEA). We conducted a case-control analysis on unrelated subjects (239 with Asthma and 596 without Asthma), and a family-based association test (FBAT) in 192 families ascertained through probands with Asthma. MEASUREMENTS AND MAin RESULTS: The TLR2/+596 C allele was associated with an increased risk for Asthma in both case-control and family-based analyses (under a dominant model, odds ratio [OR] 1.91 and 95% confidence interval [CI] 1.34-2.72, P = 0.0003; Z statistics from FBAT = 2.48, P = 0.01). in skin prick test (SPT) positive subjects, the CD14/-260 C allele was negatively associated with Asthma (additive model, OR 0.66; CI 0.48-0.91). Significant gene-environment interactions between variation in CD14 and TLR genes and country living during childhood were found for ten SNPs. in SPT positive subjects carrying CD14/-260 CC, country living protected against Asthma (OR, 0.32; 95% CI, 0.12-0.85), whereas country living was not associated with Asthma in subjects who were atopic and carrying CD14/-260 T (OR, 1.11; 95% CI, 0.65-1.90) (gene-environment interaction, P < 0.05). CONCLUSIONS: TLR2 and CD14 SNPs were associated with Asthma and atopic Asthma respectively. in addition, CD14, TLR2, TLR4, and TLR9 SNPs modified associations between country living and Asthma.

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  • CD14 and toll-like receptor gene polymorphisms, country living, and Asthma in Adults.
    American journal of respiratory and critical care medicine, 2008
    Co-Authors: Lidwien A.m. Smit, Valérie Siroux, Emmanuelle Bouzigon, Marie-pierre Oryszczyn, Mark Lathrop, Florence Demenais, Francine Kauffmann

    Abstract:

    Rationale: It has been shown that country living protects against Asthma, which may be explained by microbial exposures.Objectives: To study whether single nucleotide polymorphisms (SNPs) in CD14 and Toll-like receptor (TLR) 2, TLR4 and TLR9 genes are associated with Asthma in Adults, and whether these SNPs modify associations between country living and Asthma.Methods: Twenty-five SNPs in CD14, TLR2, TLR4, and TLR9 genes were genotyped in adult subjects from the French Epidemiological study on the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy (EGEA). We conducted a case-control analysis on unrelated subjects (239 with Asthma and 596 without Asthma), and a family-based association test (FBAT) in 192 families ascertained through probands with Asthma.Measurements and Main Results: The TLR2/+596 C allele was associated with an increased risk for Asthma in both case-control and family-based analyses (under a dominant model, odds ratio [OR] 1.91 and 95% confidence interval [CI] 1….

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Marie-pierre Oryszczyn – One of the best experts on this subject based on the ideXlab platform.

  • CD14 and toll-like receptor gene polymorphisms, country living, and Asthma in Adults.
    American Journal of Respiratory and Critical Care Medicine, 2009
    Co-Authors: Lidwien Smit, Valérie Siroux, Emmanuelle Bouzigon, Marie-pierre Oryszczyn, Mark Lathrop, Florence Desmenais, Francine Kauffmann

    Abstract:

    RATIONALE: It has been shown that country living protects against Asthma, which may be explained by microbial exposures. OBJECTIVES: To study whether single nucleotide polymorphisms (SNPs) in CD14 and Toll-like receptor (TLR) 2, TLR4 and TLR9 genes are associated with Asthma in Adults, and whether these SNPs modify associations between country living and Asthma. METHODS: Twenty-five SNPs in CD14, TLR2, TLR4, and TLR9 genes were genotyped in adult subjects from the French Epidemiological study on the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy (EGEA). We conducted a case-control analysis on unrelated subjects (239 with Asthma and 596 without Asthma), and a family-based association test (FBAT) in 192 families ascertained through probands with Asthma. MEASUREMENTS AND MAin RESULTS: The TLR2/+596 C allele was associated with an increased risk for Asthma in both case-control and family-based analyses (under a dominant model, odds ratio [OR] 1.91 and 95% confidence interval [CI] 1.34-2.72, P = 0.0003; Z statistics from FBAT = 2.48, P = 0.01). in skin prick test (SPT) positive subjects, the CD14/-260 C allele was negatively associated with Asthma (additive model, OR 0.66; CI 0.48-0.91). Significant gene-environment interactions between variation in CD14 and TLR genes and country living during childhood were found for ten SNPs. in SPT positive subjects carrying CD14/-260 CC, country living protected against Asthma (OR, 0.32; 95% CI, 0.12-0.85), whereas country living was not associated with Asthma in subjects who were atopic and carrying CD14/-260 T (OR, 1.11; 95% CI, 0.65-1.90) (gene-environment interaction, P < 0.05). CONCLUSIONS: TLR2 and CD14 SNPs were associated with Asthma and atopic Asthma respectively. in addition, CD14, TLR2, TLR4, and TLR9 SNPs modified associations between country living and Asthma.

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  • CD14 and toll-like receptor gene polymorphisms, country living, and Asthma in Adults.
    American journal of respiratory and critical care medicine, 2008
    Co-Authors: Lidwien A.m. Smit, Valérie Siroux, Emmanuelle Bouzigon, Marie-pierre Oryszczyn, Mark Lathrop, Florence Demenais, Francine Kauffmann

    Abstract:

    Rationale: It has been shown that country living protects against Asthma, which may be explained by microbial exposures.Objectives: To study whether single nucleotide polymorphisms (SNPs) in CD14 and Toll-like receptor (TLR) 2, TLR4 and TLR9 genes are associated with Asthma in Adults, and whether these SNPs modify associations between country living and Asthma.Methods: Twenty-five SNPs in CD14, TLR2, TLR4, and TLR9 genes were genotyped in adult subjects from the French Epidemiological study on the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy (EGEA). We conducted a case-control analysis on unrelated subjects (239 with Asthma and 596 without Asthma), and a family-based association test (FBAT) in 192 families ascertained through probands with Asthma.Measurements and Main Results: The TLR2/+596 C allele was associated with an increased risk for Asthma in both case-control and family-based analyses (under a dominant model, odds ratio [OR] 1.91 and 95% confidence interval [CI] 1….

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