The Experts below are selected from a list of 1614 Experts worldwide ranked by ideXlab platform
Patrick J. Walsh - One of the best experts on this subject based on the ideXlab platform.
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Asymmetric Allylation of ketones and subsequent tandem reactions catalyzed by a novel polymer supported titanium binolate complex
ChemInform, 2014Co-Authors: Jagjit S. Yadav, Patrick J. Walsh, Gretchen R. Stanton, Xinyuan Fan, Jerome R. Robinson, Eric J. Schelter, Miquel A. PericàsAbstract:The title catalyst allows successful heterogeneous catalysis for the challenging Asymmetric Allylation of a diverse range of ketones.
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Asymmetric Allylation of Ketones and Subsequent Tandem Reactions Catalyzed by a Novel Polymer-Supported Titanium—BINOLate Complex.
ChemInform, 2014Co-Authors: Jagjit S. Yadav, Patrick J. Walsh, Gretchen R. Stanton, Xinyuan Fan, Jerome R. Robinson, Eric J. Schelter, Miquel A. PericàsAbstract:The title catalyst allows successful heterogeneous catalysis for the challenging Asymmetric Allylation of a diverse range of ketones.
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Asymmetric Allylation of ketones and subsequent tandem reactions catalyzed by a novel polymer supported titanium binolate complex
Chemistry: A European Journal, 2014Co-Authors: Jagjit S. Yadav, Patrick J. Walsh, Gretchen R. Stanton, Xinyuan Fan, Jerome R. Robinson, Eric J. Schelter, Miquel A. PericàsAbstract:By using a novel, simple, and convenient synthetic route, enantiopure 6-ethynyl-BINOL (BINOL = 1,1-binaphthol) was synthesized and anchored to an azidomethylpolystyrene resin through a copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction. The polystyrene (PS)-supported BINOL ligand was converted into its diisopropoxytitanium derivative in situ and used as a heterogeneous catalyst in the Asymmetric Allylation of ketones. The catalyst showed good activity and excellent enantioselectivity, typically matching the results obtained in the corresponding homogeneous reaction. The Allylation reaction mixture could be submitted to epoxidation by simple treatment with tert-butyl hydroperoxide (TBHP), and the tandem Asymmetric Allylation epoxidation process led to a highly enantioenriched epoxy alcohol with two adjacent quaternary centers as a single diastereomer. A tandem Asymmetric Allylation/Pauson-Khand reaction was also performed, involving simple treatment of the Allylation reaction mixture with Co2(CO)8/N-methyl morpholine N-oxide. This cascade process resulted in the formation of two diastereomeric tricyclic enones in high yields and enantioselectivities.
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Asymmetric Allylation of Ketones and Subsequent Tandem Reactions Catalyzed by a Novel Polymer‐Supported Titanium–BINOLate Complex
Chemistry (Weinheim an der Bergstrasse Germany), 2014Co-Authors: Jagjit S. Yadav, Patrick J. Walsh, Gretchen R. Stanton, Xinyuan Fan, Jerome R. Robinson, Eric J. Schelter, Miquel A. PericàsAbstract:By using a novel, simple, and convenient synthetic route, enantiopure 6-ethynyl-BINOL (BINOL = 1,1-binaphthol) was synthesized and anchored to an azidomethylpolystyrene resin through a copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction. The polystyrene (PS)-supported BINOL ligand was converted into its diisopropoxytitanium derivative in situ and used as a heterogeneous catalyst in the Asymmetric Allylation of ketones. The catalyst showed good activity and excellent enantioselectivity, typically matching the results obtained in the corresponding homogeneous reaction. The Allylation reaction mixture could be submitted to epoxidation by simple treatment with tert-butyl hydroperoxide (TBHP), and the tandem Asymmetric Allylation epoxidation process led to a highly enantioenriched epoxy alcohol with two adjacent quaternary centers as a single diastereomer. A tandem Asymmetric Allylation/Pauson-Khand reaction was also performed, involving simple treatment of the Allylation reaction mixture with Co2(CO)8/N-methyl morpholine N-oxide. This cascade process resulted in the formation of two diastereomeric tricyclic enones in high yields and enantioselectivities.
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Highly concentrated catalytic Asymmetric Allylation of ketones.
Organic letters, 2007Co-Authors: Alfred J. Wooten, Jeung Gon Kim, Patrick J. WalshAbstract:We report the catalytic Asymmetric Allylation of ketones under highly concentrated reaction conditions with a catalyst generated from titanium tetraisopropoxide and BINOL (1:2 ratio) in the presence of isopropanol. This catalyst promotes the addition of tetraallylstannane to a variety of ketones to produce tertiary homoallylic alcohols in excellent yield (80–99%) with high enantioselectivities (79–95%). The resulting homoallylic alcohols can also be epoxidized in situ using tert-butyl hydroperoxide (TBHP) to afford cyclic epoxy alcohols in high yield (84–87%).
Miquel A. Pericàs - One of the best experts on this subject based on the ideXlab platform.
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Asymmetric Allylation of ketones and subsequent tandem reactions catalyzed by a novel polymer supported titanium binolate complex
ChemInform, 2014Co-Authors: Jagjit S. Yadav, Patrick J. Walsh, Gretchen R. Stanton, Xinyuan Fan, Jerome R. Robinson, Eric J. Schelter, Miquel A. PericàsAbstract:The title catalyst allows successful heterogeneous catalysis for the challenging Asymmetric Allylation of a diverse range of ketones.
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Asymmetric Allylation of Ketones and Subsequent Tandem Reactions Catalyzed by a Novel Polymer-Supported Titanium—BINOLate Complex.
ChemInform, 2014Co-Authors: Jagjit S. Yadav, Patrick J. Walsh, Gretchen R. Stanton, Xinyuan Fan, Jerome R. Robinson, Eric J. Schelter, Miquel A. PericàsAbstract:The title catalyst allows successful heterogeneous catalysis for the challenging Asymmetric Allylation of a diverse range of ketones.
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Asymmetric Allylation of ketones and subsequent tandem reactions catalyzed by a novel polymer supported titanium binolate complex
Chemistry: A European Journal, 2014Co-Authors: Jagjit S. Yadav, Patrick J. Walsh, Gretchen R. Stanton, Xinyuan Fan, Jerome R. Robinson, Eric J. Schelter, Miquel A. PericàsAbstract:By using a novel, simple, and convenient synthetic route, enantiopure 6-ethynyl-BINOL (BINOL = 1,1-binaphthol) was synthesized and anchored to an azidomethylpolystyrene resin through a copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction. The polystyrene (PS)-supported BINOL ligand was converted into its diisopropoxytitanium derivative in situ and used as a heterogeneous catalyst in the Asymmetric Allylation of ketones. The catalyst showed good activity and excellent enantioselectivity, typically matching the results obtained in the corresponding homogeneous reaction. The Allylation reaction mixture could be submitted to epoxidation by simple treatment with tert-butyl hydroperoxide (TBHP), and the tandem Asymmetric Allylation epoxidation process led to a highly enantioenriched epoxy alcohol with two adjacent quaternary centers as a single diastereomer. A tandem Asymmetric Allylation/Pauson-Khand reaction was also performed, involving simple treatment of the Allylation reaction mixture with Co2(CO)8/N-methyl morpholine N-oxide. This cascade process resulted in the formation of two diastereomeric tricyclic enones in high yields and enantioselectivities.
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Asymmetric Allylation of Ketones and Subsequent Tandem Reactions Catalyzed by a Novel Polymer‐Supported Titanium–BINOLate Complex
Chemistry (Weinheim an der Bergstrasse Germany), 2014Co-Authors: Jagjit S. Yadav, Patrick J. Walsh, Gretchen R. Stanton, Xinyuan Fan, Jerome R. Robinson, Eric J. Schelter, Miquel A. PericàsAbstract:By using a novel, simple, and convenient synthetic route, enantiopure 6-ethynyl-BINOL (BINOL = 1,1-binaphthol) was synthesized and anchored to an azidomethylpolystyrene resin through a copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction. The polystyrene (PS)-supported BINOL ligand was converted into its diisopropoxytitanium derivative in situ and used as a heterogeneous catalyst in the Asymmetric Allylation of ketones. The catalyst showed good activity and excellent enantioselectivity, typically matching the results obtained in the corresponding homogeneous reaction. The Allylation reaction mixture could be submitted to epoxidation by simple treatment with tert-butyl hydroperoxide (TBHP), and the tandem Asymmetric Allylation epoxidation process led to a highly enantioenriched epoxy alcohol with two adjacent quaternary centers as a single diastereomer. A tandem Asymmetric Allylation/Pauson-Khand reaction was also performed, involving simple treatment of the Allylation reaction mixture with Co2(CO)8/N-methyl morpholine N-oxide. This cascade process resulted in the formation of two diastereomeric tricyclic enones in high yields and enantioselectivities.
Yishuang Zhao - One of the best experts on this subject based on the ideXlab platform.
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copper catalyzed Asymmetric Allylation of chiral n tert butanesulfinyl imines dual stereocontrol with nearly perfect diastereoselectivity
ChemInform, 2015Co-Authors: Yishuang Zhao, Ping TianAbstract:A BINOL-derived phosphoramidite ligand is successfully applied in the copper-catalyzed Asymmetric Allylation of chiral N-tert-butanesulfinyl aldimines (I) and ketimines (IV) leading to homoallylic amines with high diastereoselectivity.
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Copper‐Catalyzed Asymmetric Allylation of Chiral N‐tert‐Butanesulfinyl Imines: Dual Stereocontrol with Nearly Perfect Diastereoselectivity.
ChemInform, 2015Co-Authors: Yishuang Zhao, Ping Tian, Qiang Liu, Jing-chao Tao, Guo‐qiang LinAbstract:A BINOL-derived phosphoramidite ligand is successfully applied in the copper-catalyzed Asymmetric Allylation of chiral N-tert-butanesulfinyl aldimines (I) and ketimines (IV) leading to homoallylic amines with high diastereoselectivity.
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copper catalyzed Asymmetric Allylation of chiral n tert butanesulfinyl imines dual stereocontrol with nearly perfect diastereoselectivity
Organic and Biomolecular Chemistry, 2015Co-Authors: Yishuang Zhao, Ping TianAbstract:Copper-catalyzed Asymmetric Allylation of chiral N-tert-butanesulfinyl imines has been described. Dual stereocontrol, through the combination of a chiral auxiliary and a chiral copper complex, has played an important role in achieving the nearly perfect diastereoselectivities (all dr > 99:1), especially for ketimine substrates.
Pablo Barrio - One of the best experts on this subject based on the ideXlab platform.
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Asymmetric Allylation rcm mediated synthesis of fluorinated benzo fused bicyclic homoallylic amines as dihydronaphthalene derivatives
Journal of Organic Chemistry, 2016Co-Authors: Daniel M Sedgwick, Pablo Barrio, Antonio Simon, Raquel Roman, Santos FusteroAbstract:Enantiomerically enriched fluorinated benzo-fused bicyclic homoallylic amines have been synthesized through an Asymmetric Allylation/ring closing metathesis (RCM) sequence. This sequence has been carried out using α-trifluoromethylstyrene derivatives as key intermediates, synthesized by microwave radiation. The great deactivating effect exerted by such substituents has been brought to light by a comparative study.
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Asymmetric Allylation/RCM-Mediated Synthesis of Fluorinated Benzo-Fused Bicyclic Homoallylic Amines As Dihydronaphthalene Derivatives
The Journal of organic chemistry, 2016Co-Authors: Daniel M Sedgwick, Pablo Barrio, Antonio Simon, Raquel Roman, Santos FusteroAbstract:Enantiomerically enriched fluorinated benzo-fused bicyclic homoallylic amines have been synthesized through an Asymmetric Allylation/ring closing metathesis (RCM) sequence. This sequence has been carried out using α-trifluoromethylstyrene derivatives as key intermediates, synthesized by microwave radiation. The great deactivating effect exerted by such substituents has been brought to light by a comparative study.
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Asymmetric Allylation pauson khand reaction a simple entry to polycyclic amines application to the synthesis of aminosteroid analogues
Organic Letters, 2014Co-Authors: Santos Fustero, Ruben Lazaro, Nuria Aiguabella, Antoni Riera, Antonio Simonfuentes, Pablo BarrioAbstract:Asymmetric Allylation of o-iodoarylsulfinylimines has been achieved in high diastereoselectivities. The thus-obtained o-iodoarylhomoallylic sulfinamides participate in a subsequent Sonogashira coupling followed by a diastereoselective intramolecular Pauson–Khand reaction. In this way, tricyclic amines showing a unique benzo-fused indenyl backbone were obtained. The methodology has been applied to the synthesis of amino steroid analogues.
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Asymmetric Allylation/Pauson–Khand Reaction: A Simple Entry to Polycyclic Amines. Application to the Synthesis of Aminosteroid Analogues
Organic letters, 2014Co-Authors: Santos Fustero, Ruben Lazaro, Nuria Aiguabella, Antoni Riera, Antonio Simón-fuentes, Pablo BarrioAbstract:Asymmetric Allylation of o-iodoarylsulfinylimines has been achieved in high diastereoselectivities. The thus-obtained o-iodoarylhomoallylic sulfinamides participate in a subsequent Sonogashira coupling followed by a diastereoselective intramolecular Pauson–Khand reaction. In this way, tricyclic amines showing a unique benzo-fused indenyl backbone were obtained. The methodology has been applied to the synthesis of amino steroid analogues.
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Asymmetric Allylation ring closing metathesis one pot synthesis of benzo fused cyclic homoallylic amines application to the formal synthesis of sertraline derivatives
ChemInform, 2013Co-Authors: Santos Fustero, Ruben Lazaro, Lidia Herrera, Elsa Rodriguez, Natalia Mateu, Pablo BarrioAbstract:A stepwise process consisting of Asymmetric Allylation of imines of type (I) and following ring-closing metathesis of the resulting dienes (III) is developed to synthesize cyclic homoallylic amines.
Santos Fustero - One of the best experts on this subject based on the ideXlab platform.
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Asymmetric Allylation rcm mediated synthesis of fluorinated benzo fused bicyclic homoallylic amines as dihydronaphthalene derivatives
Journal of Organic Chemistry, 2016Co-Authors: Daniel M Sedgwick, Pablo Barrio, Antonio Simon, Raquel Roman, Santos FusteroAbstract:Enantiomerically enriched fluorinated benzo-fused bicyclic homoallylic amines have been synthesized through an Asymmetric Allylation/ring closing metathesis (RCM) sequence. This sequence has been carried out using α-trifluoromethylstyrene derivatives as key intermediates, synthesized by microwave radiation. The great deactivating effect exerted by such substituents has been brought to light by a comparative study.
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Asymmetric Allylation/RCM-Mediated Synthesis of Fluorinated Benzo-Fused Bicyclic Homoallylic Amines As Dihydronaphthalene Derivatives
The Journal of organic chemistry, 2016Co-Authors: Daniel M Sedgwick, Pablo Barrio, Antonio Simon, Raquel Roman, Santos FusteroAbstract:Enantiomerically enriched fluorinated benzo-fused bicyclic homoallylic amines have been synthesized through an Asymmetric Allylation/ring closing metathesis (RCM) sequence. This sequence has been carried out using α-trifluoromethylstyrene derivatives as key intermediates, synthesized by microwave radiation. The great deactivating effect exerted by such substituents has been brought to light by a comparative study.
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Asymmetric Allylation pauson khand reaction a simple entry to polycyclic amines application to the synthesis of aminosteroid analogues
Organic Letters, 2014Co-Authors: Santos Fustero, Ruben Lazaro, Nuria Aiguabella, Antoni Riera, Antonio Simonfuentes, Pablo BarrioAbstract:Asymmetric Allylation of o-iodoarylsulfinylimines has been achieved in high diastereoselectivities. The thus-obtained o-iodoarylhomoallylic sulfinamides participate in a subsequent Sonogashira coupling followed by a diastereoselective intramolecular Pauson–Khand reaction. In this way, tricyclic amines showing a unique benzo-fused indenyl backbone were obtained. The methodology has been applied to the synthesis of amino steroid analogues.
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Asymmetric Allylation/Pauson–Khand Reaction: A Simple Entry to Polycyclic Amines. Application to the Synthesis of Aminosteroid Analogues
Organic letters, 2014Co-Authors: Santos Fustero, Ruben Lazaro, Nuria Aiguabella, Antoni Riera, Antonio Simón-fuentes, Pablo BarrioAbstract:Asymmetric Allylation of o-iodoarylsulfinylimines has been achieved in high diastereoselectivities. The thus-obtained o-iodoarylhomoallylic sulfinamides participate in a subsequent Sonogashira coupling followed by a diastereoselective intramolecular Pauson–Khand reaction. In this way, tricyclic amines showing a unique benzo-fused indenyl backbone were obtained. The methodology has been applied to the synthesis of amino steroid analogues.
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Asymmetric Allylation ring closing metathesis one pot synthesis of benzo fused cyclic homoallylic amines application to the formal synthesis of sertraline derivatives
ChemInform, 2013Co-Authors: Santos Fustero, Ruben Lazaro, Lidia Herrera, Elsa Rodriguez, Natalia Mateu, Pablo BarrioAbstract:A stepwise process consisting of Asymmetric Allylation of imines of type (I) and following ring-closing metathesis of the resulting dienes (III) is developed to synthesize cyclic homoallylic amines.
