The Experts below are selected from a list of 71577 Experts worldwide ranked by ideXlab platform
Grace Y Yi - One of the best experts on this subject based on the ideXlab platform.
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estimation of the basic reproduction number average incubation time Asymptomatic Infection rate and case fatality rate for covid 19 meta analysis and sensitivity analysis
Journal of Medical Virology, 2020Co-Authors: Wenqing He, Grace Y YiAbstract:The coronavirus disease-2019 (COVID-19) has been found to be caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, comprehensive knowledge of COVID-19 remains incomplete and many important features are still unknown. This manuscript conducts a meta-analysis and a sensitivity study to answer the questions: What is the basic reproduction number? How long is the incubation time of the disease on average? What portion of Infections are Asymptomatic? And ultimately, what is the case fatality rate? Our studies estimate the basic reproduction number to be 3.15 with the 95% CI (2.41-3.90), the average incubation time to be 5.08 days with the 95% CI (4.77-5.39) (in day), the Asymptomatic Infection rate to be 46% with the 95% CI (18.48%-73.60%), and the case fatality rate to be 2.72% with 95% CI (1.29%-4.16%) where Asymptomatic Infections are accounted for.
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estimation of the basic reproduction number average incubation time Asymptomatic Infection rate and case fatality rate for covid 19 meta analysis and sensitivity analysis
medRxiv, 2020Co-Authors: Wenqing He, Grace Y YiAbstract:The coronavirus disease 2019 (COVID-19) has been found to be caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, comprehensive knowledge of COVID-19 remains incomplete and many important features are still unknown. This manuscripts conduct a meta-analysis and a sensitivity study to answer the questions: What is the basic reproduction number? How long is the incubation time of the disease on average? What portion of Infections are Asymptomatic? And ultimately, what is the case fatality rate? Our studies estimate the basic reproduction number to be 3.15 with the 95% interval (2.41, 3.90), the average incubation time to be 5.08 days with the 95% confidence interval (4.77, 5.39) (in day), the Asymptomatic Infection rate to be 46% with the 95% confidence interval (18.48%, 73.60%), and the case fatality rate to be 2.72% with 95% confidence interval (1.29%, 4.16%) where Asymptomatic Infections are accounted for.
Michael Klompas - One of the best experts on this subject based on the ideXlab platform.
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presymptomatic transmission of sars cov 2 amongst residents and staff at a skilled nursing facility results of real time pcr and serologic testing
Clinical Infectious Diseases, 2020Co-Authors: Scott A Goldberg, Michael Klompas, Jochen Lennerz, Eden Mark, Virginia M Pierce, Ryan W Thompson, Charles T Pu, Lauren L Ritterhouse, Anand S DigheAbstract:High rates of Asymptomatic Infection suggest benefits to routine testing in congregate care settings. SARS-CoV-2 screening was undertaken in a single nursing facility without a known case of COVID-19, demonstrating an 85% prevalence among residents and 37% among staff. Serology was not helpful in identifying Infections.
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universal sars cov 2 testing on admission to the labor and delivery unit low prevalence among Asymptomatic obstetric patients
Infection Control and Hospital Epidemiology, 2020Co-Authors: Ilona T Goldfarb, Khady Diouf, William H Barth, Julian N Robinson, Daniel H Katz, Katherine E Gregory, Andrea L Ciaranello, Sigal Yawetz, Erica S Shenoy, Michael KlompasAbstract:This article seeks to report on the prevalence of Asymptomatic SARS-CoV-2 in women presenting to the labor and delivery units in Boston, another high-prevalence community in the United States The 4 major hospitals affiliated with Mass General Brigham Health provide maternity care to ~14,750 women per year Over 18 days of universal testing on the labor and delivery units, 763 women were admitted and 757 (99 2%) were tested Of those, 139 had symptoms possibly consistent with COVID-19 Of symptomatic women, 11 of 139 (7 9%) tested positive Among Asymptomatic women, 9 of 618 (1 5%) tested positive Thus, 9 of 20 patients positive for SARS-CoV-2 at admission (45%) had no symptoms of COVID-19 at presentation The percentage of Asymptomatic women who tested positive varied by hospital: 2 7% and 1 5% in the 2 academic hospitals, 1 8% and 0 6% in the 2 community hospitals Across the 4 hospitals, none of the positive Asymptomatic women developed COVID-19 symptoms during the delivery hospitalization and all 9 newborns tested negative for SARS-CoV-2 In a large healthcare system in metropolitan Boston, the study identified a low prevalence of COVID-19 Infection among Asymptomatic pregnant women presenting for admission to the labor and delivery units The incidence of Asymptomatic Infection amongst women admitted to the labor and delivery units in greater Boston was substantially lower than that of New York City despite similar case counts per capita Notably, the 1%-2% incidence of Asymptomatic Infection in our population more closely mirrors Asymptomatic Infection rates in other areas Several theories may explain the lower prevalence of Asymptomatic Infection in Boston compared to New York City: (1) we began testing >30 days after physical distancing orders were placed by the state and hence were sampling at a time with declining community transmission, the overall population density of greater Boston is lower than New York City, perhaps leading to less community-based transmission, and some New York hospitals transiently stopped or considered stopping birth partners from attending deliveries, which could have led to some women underreporting symptoms
Wenqing He - One of the best experts on this subject based on the ideXlab platform.
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estimation of the basic reproduction number average incubation time Asymptomatic Infection rate and case fatality rate for covid 19 meta analysis and sensitivity analysis
Journal of Medical Virology, 2020Co-Authors: Wenqing He, Grace Y YiAbstract:The coronavirus disease-2019 (COVID-19) has been found to be caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, comprehensive knowledge of COVID-19 remains incomplete and many important features are still unknown. This manuscript conducts a meta-analysis and a sensitivity study to answer the questions: What is the basic reproduction number? How long is the incubation time of the disease on average? What portion of Infections are Asymptomatic? And ultimately, what is the case fatality rate? Our studies estimate the basic reproduction number to be 3.15 with the 95% CI (2.41-3.90), the average incubation time to be 5.08 days with the 95% CI (4.77-5.39) (in day), the Asymptomatic Infection rate to be 46% with the 95% CI (18.48%-73.60%), and the case fatality rate to be 2.72% with 95% CI (1.29%-4.16%) where Asymptomatic Infections are accounted for.
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estimation of the basic reproduction number average incubation time Asymptomatic Infection rate and case fatality rate for covid 19 meta analysis and sensitivity analysis
medRxiv, 2020Co-Authors: Wenqing He, Grace Y YiAbstract:The coronavirus disease 2019 (COVID-19) has been found to be caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, comprehensive knowledge of COVID-19 remains incomplete and many important features are still unknown. This manuscripts conduct a meta-analysis and a sensitivity study to answer the questions: What is the basic reproduction number? How long is the incubation time of the disease on average? What portion of Infections are Asymptomatic? And ultimately, what is the case fatality rate? Our studies estimate the basic reproduction number to be 3.15 with the 95% interval (2.41, 3.90), the average incubation time to be 5.08 days with the 95% confidence interval (4.77, 5.39) (in day), the Asymptomatic Infection rate to be 46% with the 95% confidence interval (18.48%, 73.60%), and the case fatality rate to be 2.72% with 95% confidence interval (1.29%, 4.16%) where Asymptomatic Infections are accounted for.
Anand S Dighe - One of the best experts on this subject based on the ideXlab platform.
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presymptomatic transmission of sars cov 2 amongst residents and staff at a skilled nursing facility results of real time pcr and serologic testing
Clinical Infectious Diseases, 2020Co-Authors: Scott A Goldberg, Michael Klompas, Jochen Lennerz, Eden Mark, Virginia M Pierce, Ryan W Thompson, Charles T Pu, Lauren L Ritterhouse, Anand S DigheAbstract:High rates of Asymptomatic Infection suggest benefits to routine testing in congregate care settings. SARS-CoV-2 screening was undertaken in a single nursing facility without a known case of COVID-19, demonstrating an 85% prevalence among residents and 37% among staff. Serology was not helpful in identifying Infections.
Xi Zhang - One of the best experts on this subject based on the ideXlab platform.
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comparative replication and immune activation profiles of sars cov 2 and sars cov in human lungs an ex vivo study with implications for the pathogenesis of covid 19
Clinical Infectious Diseases, 2020Co-Authors: Hin Chu, Jasper F W Chan, Yixin Wang, Terrence Tsztai Yuen, Yue Chai, Yuxin Hou, Huiping Shuai, Dong Yang, Xiner Huang, Xi ZhangAbstract:BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging coronavirus that has resulted in more than 2 000 000 laboratory-confirmed cases including over 145 000 deaths. Although SARS-CoV-2 and SARS-CoV share a number of common clinical manifestations, SARS-CoV-2 appears to be highly efficient in person-to-person transmission and frequently causes Asymptomatic or presymptomatic Infections. However, the underlying mechanisms that confer these viral characteristics of high transmissibility and Asymptomatic Infection remain incompletely understood. METHODS: We comprehensively investigated the replication, cell tropism, and immune activation profile of SARS-CoV-2 Infection in human lung tissues with SARS-CoV included as a comparison. RESULTS: SARS-CoV-2 infected and replicated in human lung tissues more efficiently than SARS-CoV. Within the 48-hour interval, SARS-CoV-2 generated 3.20-fold more infectious virus particles than did SARS-CoV from the infected lung tissues (P < .024). SARS-CoV-2 and SARS-CoV were similar in cell tropism, with both targeting types I and II pneumocytes and alveolar macrophages. Importantly, despite the more efficient virus replication, SARS-CoV-2 did not significantly induce types I, II, or III interferons in the infected human lung tissues. In addition, while SARS-CoV Infection upregulated the expression of 11 out of 13 (84.62%) representative proinflammatory cytokines/chemokines, SARS-CoV-2 Infection only upregulated 5 of these 13 (38.46%) key inflammatory mediators despite replicating more efficiently. CONCLUSIONS: Our study provides the first quantitative data on the comparative replication capacity and immune activation profile of SARS-CoV-2 and SARS-CoV Infection in human lung tissues. Our results provide important insights into the pathogenesis, high transmissibility, and Asymptomatic Infection of SARS-CoV-2.
