Atractylodes

14,000,000 Leading Edge Experts on the ideXlab platform

Scan Science and Technology

Contact Leading Edge Experts & Companies

Scan Science and Technology

Contact Leading Edge Experts & Companies

The Experts below are selected from a list of 4389 Experts worldwide ranked by ideXlab platform

Xuebo Hu - One of the best experts on this subject based on the ideXlab platform.

  • the transcript profile of a traditional chinese medicine Atractylodes lancea revealing its sesquiterpenoid biosynthesis of the major active components
    PLOS ONE, 2016
    Co-Authors: Shakeel Ahmed, Chuansong Zhan, Yanyan Yang, Xuekui Wang, Tewu Yang, Zeying Zhao, Qiyun Zhang, Xiaohua Li, Xuebo Hu
    Abstract:

    Atractylodes lancea (Thunb.) DC., named “Cangzhu” in China, which belongs to the Asteraceae family. In some countries of Southeast Asia (China, Thailand, Korea, Japan etc.) its rhizome, commonly called rhizoma atractylodis, is used to treat many diseases as it contains a variety of sesquiterpenoids and other components of medicinal importance. Despite its medicinal value, the information of the sesquiterpenoid biosynthesis is largely unknown. In this study, we investigated the transcriptome analysis of different tissues of non-model plant A. lancea by using short read sequencing technology (Illumina). We found 62,352 high quality unigenes with an average sequence length of 913 bp in the transcripts of A. Lancea. Among these, 43,049 (69.04%), 30,264 (48.53%), 26,233 (42.07%), 17,881 (28.67%) and 29,057(46.60%) unigenes showed significant similarity (E-value<1e-5) to known proteins in Nr, KEGG, SWISS-PROT, GO, and COG databases, respectively. Of the total 62,352 unigenes, 43,049 (Nr Database) open reading frames were predicted. On the basis of different bioinformatics tools we identify all the enzymes that take part in the terpenoid biosynthesis as well as five different known sesquiterpenoids via cytosolic mevalonic acid (MVA) pathway and plastidal methylerythritol phosphate (MEP) pathways. In our study, 6, 864 Simple Sequence Repeats (SSRs) were also found as great potential markers in A. lancea. This transcriptomic resource of A. lancea provides a great contribution in advancement of research for this specific medicinal plant and more specifically for the gene mining of different classes of terpenoids and other chemical compounds that have medicinal as well as economic importance.

Juiwei Liang - One of the best experts on this subject based on the ideXlab platform.

  • sesquiterpenoids from Atractylodes macrocephala act as farnesoid x receptor and progesterone receptor modulators
    Bioorganic & Medicinal Chemistry Letters, 2012
    Co-Authors: Chiajui Tsai, Juiwei Liang
    Abstract:

    Two sesquiterpenoids, atractylenolide II and III, were isolated and identified from Atractylodes macrocephala (Asteraceae) to be subsequently evaluated for their activity against farnesoid X receptor (FXR) and progesterone receptor (PR) by transient transfection reporter assays. These sesquiterpenoids did not exert significant agonistic effect but antagonized the activity of chenodeoxycholic acid (CDCA), an endogenous FXR agonist, for FXR driven SHP promoter transactivation. Additionally, they transactivated CYP7A1 gene promoter activity by antagonizing FXR. Apart from acting as a FXR antagonist, atractylenolide III also showed agonistic activity against PR. All these results demonstrated that atractylenolide II and III are the active components of Atractylodes macrocephala to exert specific pharmacologic effects.

Shakeel Ahmed - One of the best experts on this subject based on the ideXlab platform.

  • the transcript profile of a traditional chinese medicine Atractylodes lancea revealing its sesquiterpenoid biosynthesis of the major active components
    PLOS ONE, 2016
    Co-Authors: Shakeel Ahmed, Chuansong Zhan, Yanyan Yang, Xuekui Wang, Tewu Yang, Zeying Zhao, Qiyun Zhang, Xiaohua Li, Xuebo Hu
    Abstract:

    Atractylodes lancea (Thunb.) DC., named “Cangzhu” in China, which belongs to the Asteraceae family. In some countries of Southeast Asia (China, Thailand, Korea, Japan etc.) its rhizome, commonly called rhizoma atractylodis, is used to treat many diseases as it contains a variety of sesquiterpenoids and other components of medicinal importance. Despite its medicinal value, the information of the sesquiterpenoid biosynthesis is largely unknown. In this study, we investigated the transcriptome analysis of different tissues of non-model plant A. lancea by using short read sequencing technology (Illumina). We found 62,352 high quality unigenes with an average sequence length of 913 bp in the transcripts of A. Lancea. Among these, 43,049 (69.04%), 30,264 (48.53%), 26,233 (42.07%), 17,881 (28.67%) and 29,057(46.60%) unigenes showed significant similarity (E-value<1e-5) to known proteins in Nr, KEGG, SWISS-PROT, GO, and COG databases, respectively. Of the total 62,352 unigenes, 43,049 (Nr Database) open reading frames were predicted. On the basis of different bioinformatics tools we identify all the enzymes that take part in the terpenoid biosynthesis as well as five different known sesquiterpenoids via cytosolic mevalonic acid (MVA) pathway and plastidal methylerythritol phosphate (MEP) pathways. In our study, 6, 864 Simple Sequence Repeats (SSRs) were also found as great potential markers in A. lancea. This transcriptomic resource of A. lancea provides a great contribution in advancement of research for this specific medicinal plant and more specifically for the gene mining of different classes of terpenoids and other chemical compounds that have medicinal as well as economic importance.

Lin-zhen Jiang - One of the best experts on this subject based on the ideXlab platform.

  • The changes of processing method and theoretical pharmacodynamic analysis of largehead Atractylodes rhizome
    Chinese journal of medical history, 2020
    Co-Authors: Huan An, Xiao-yin Li, Ai-wen Zhuang, Na-ni Wang, Lin-zhen Jiang
    Abstract:

    Largehead Atractylodes rhizome, known as "the first essential medicine for invigorating qi and strengthening spleen" , is one of the most commonly used Chinese materia medica. According to the different clinical treatment requirements, largehead Atractylodes rhizome can be processed into a variety types of products, such as raw, fried with earth, stir-frying with bran, and deep-fried largehead Atractylodes rhizome. The processing quality is of great significance to ensure the efficacy, drug safety and improve the preparation process. Through the detailed research on the processing methods of largehead Atractylodes rhizome in ancient books, modern documents and norms, this study clarifies the history and evolution of the processing technology of largehead Atractylodes rhizome in ancient and modern times, and summarizes the internal laws and external factors of the processing technology changes by combining the processing technology differences, materials addition and theoretical analysis of pharmacodynamics. It not only saves the tedious and repeated steps, but also improves and optimizes the efficacy and quality of the preparation, and gets standardization and unification in the follow-up practice, which provides a reference for the research and development of the processing technology of largehead Atractylodes rhizome and other Chinese materia medica. Key words: largehead Atractylodes rhizome; Chinese medicinal processing; materia medica

  • The changes of processing method and theoretical pharmacodynamic analysis of largehead Atractylodes rhizome
    Zhonghua yi shi za zhi (Beijing China : 1980), 2020
    Co-Authors: Huan An, Xiao-yin Li, Ai-wen Zhuang, Na-ni Wang, Lin-zhen Jiang
    Abstract:

    Largehead Atractylodes rhizome, known as "the first essential medicine for invigorating qi and strengthening spleen" , is one of the most commonly used Chinese materia medica. According to the different clinical treatment requirements, largehead Atractylodes rhizome can be processed into a variety types of products, such as raw, fried with earth, stir-frying with bran, and deep-fried largehead Atractylodes rhizome. The processing quality is of great significance to ensure the efficacy, drug safety and improve the preparation process. Through the detailed research on the processing methods of largehead Atractylodes rhizome in ancient books, modern documents and norms, this study clarifies the history and evolution of the processing technology of largehead Atractylodes rhizome in ancient and modern times, and summarizes the internal laws and external factors of the processing technology changes by combining the processing technology differences, materials addition and theoretical analysis of pharmacodynamics. It not only saves the tedious and repeated steps, but also improves and optimizes the efficacy and quality of the preparation, and gets standardization and unification in the follow-up practice, which provides a reference for the research and development of the processing technology of largehead Atractylodes rhizome and other Chinese materia medica.

Chiajui Tsai - One of the best experts on this subject based on the ideXlab platform.

  • sesquiterpenoids from Atractylodes macrocephala act as farnesoid x receptor and progesterone receptor modulators
    Bioorganic & Medicinal Chemistry Letters, 2012
    Co-Authors: Chiajui Tsai, Juiwei Liang
    Abstract:

    Two sesquiterpenoids, atractylenolide II and III, were isolated and identified from Atractylodes macrocephala (Asteraceae) to be subsequently evaluated for their activity against farnesoid X receptor (FXR) and progesterone receptor (PR) by transient transfection reporter assays. These sesquiterpenoids did not exert significant agonistic effect but antagonized the activity of chenodeoxycholic acid (CDCA), an endogenous FXR agonist, for FXR driven SHP promoter transactivation. Additionally, they transactivated CYP7A1 gene promoter activity by antagonizing FXR. Apart from acting as a FXR antagonist, atractylenolide III also showed agonistic activity against PR. All these results demonstrated that atractylenolide II and III are the active components of Atractylodes macrocephala to exert specific pharmacologic effects.