The Experts below are selected from a list of 225351 Experts worldwide ranked by ideXlab platform
Adriano Aguzzi - One of the best experts on this subject based on the ideXlab platform.
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B lymphocyte-restricted expression of prion protein does not enable prion replication in prion protein knockout mice
Proceedings of the National Academy of Sciences of the United States of America, 2001Co-Authors: Fabio Montrasio, Alex J. Raeber, Christian A. J. Vosshenrich, Juliane Proft, Antonio Cozzio, Michael A. Klein, Thomas Rulicke, Daniela Rossi, Eckhard Flechsig, Adriano AguzziAbstract:Prion replication in Spleen and neuroinvasion after i.p. inoculation of mice is impaired in forms of immunodeficiency where mature B lymphocytes are lacking. In Spleens of wild-type mice, infectivity is associated with B and T lymphocytes and stroma but not with circulating lymphocytes. We generated transgenic prion protein knockout mice overexpressing prion protein in B lymphocytes and found that they failed to accumulate prions in Spleen after i.p. inoculation. We conclude that splenic B lymphocytes are not prion-replication competent and that they acquire prions from other cells, most likely follicular dendritic cells with which they closely associate and whose maturation depends on them.
Gro Linno Willemoe - One of the best experts on this subject based on the ideXlab platform.
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intrapancreatic accessory Spleen mimicking malignant tumor three case reports
Acta radiologica short reports, 2019Co-Authors: Maria Zurek Munkmadsen, Kristine Zakarian, Peter Oturai, Carsten Palnaes Hansen, Birgitte Federspiel, Eva Fallentin, Gro Linno WillemoeAbstract:Intrapancreatic hypervascular lesions may represent metastases, neuroendocrine tumors, or intrapancreatic accessory Spleens. The benign intrapancreatic accessory Spleen can be difficult to separate from a malignant neuroendocrine tumor or metastasis. We report three cases of pancreatic lesions that underwent pancreatic surgery due to suspicion of malignancy on imaging; all cases were histologically intrapancreatic accessory Spleens. Our cases point to the importance of performing single-photon emission computed tomography with heat-damaged Tc-99m-pertechnetate labelled erythrocytes to identify splenic tissue, even though small lesions can show a false-negative result.
Fabio Montrasio - One of the best experts on this subject based on the ideXlab platform.
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B lymphocyte-restricted expression of prion protein does not enable prion replication in prion protein knockout mice
Proceedings of the National Academy of Sciences of the United States of America, 2001Co-Authors: Fabio Montrasio, Alex J. Raeber, Christian A. J. Vosshenrich, Juliane Proft, Antonio Cozzio, Michael A. Klein, Thomas Rulicke, Daniela Rossi, Eckhard Flechsig, Adriano AguzziAbstract:Prion replication in Spleen and neuroinvasion after i.p. inoculation of mice is impaired in forms of immunodeficiency where mature B lymphocytes are lacking. In Spleens of wild-type mice, infectivity is associated with B and T lymphocytes and stroma but not with circulating lymphocytes. We generated transgenic prion protein knockout mice overexpressing prion protein in B lymphocytes and found that they failed to accumulate prions in Spleen after i.p. inoculation. We conclude that splenic B lymphocytes are not prion-replication competent and that they acquire prions from other cells, most likely follicular dendritic cells with which they closely associate and whose maturation depends on them.
Byung Ihn Choi - One of the best experts on this subject based on the ideXlab platform.
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intrapancreatic accessory Spleen findings on mr imaging ct us and scintigraphy and the pathologic analysis
Korean Journal of Radiology, 2008Co-Authors: Se Hyung Kim, Jae Young Lee, Joon Koo Han, Jeong Min Lee, Kyunghee C. Cho, Kyoung Won Kim, Byung Ihn ChoiAbstract:Although the tail of the pancreas is the second most common site of an accessory Spleen, intrapancreatic accessory Spleen (IPAS) has rarely been noted radiologically. However, as the imaging techniques have recently advanced, IPAS will be more frequently detected as an incidental pancreatic nodule on CT or MRI. Because accessory Spleens usually pose no clinical problems, it is important to characterize accessory Spleens as noninvasively as possible. An IPAS has similar characteristics to those of the Spleen on the precontrast and contrast-enhanced images of all the imaging modalities. In particular, inhomogeneous enhancement of an IPAS in its early phases may be a diagnostic clue. Superparamagnetic iron oxide (SPIO)-enhanced MRI and Levovist-enhanced US, and the mechanisms of which are theoretically similar to that of Tc-99m scintigraphy, can be used as alternative tools to confirm the diagnosis of IPAS. An IPAS shows a significant signal drop similar to the Spleen on the SPIO-enhanced T2 or T2*-weighted imaging and prolonged enhancement on the delayed hepatosplenic phase of contrast-enhanced US. We review and illustrate the differential points between IPAS and hypervascular pancreatic tumors in this manuscript.
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contrast enhanced sonography of intrapancreatic accessory Spleen in six patients
American Journal of Roentgenology, 2007Co-Authors: Se Hyung Kim, Jae Young Lee, Joon Koo Han, Jeong Min Lee, Byung Ihn ChoiAbstract:OBJECTIVE. The purpose of this article is to describe the characteristic findings of intrapancreatic accessory Spleen over time on contrast-enhanced sonography.CONCLUSION. On contrast-enhanced sonography, intrapancreatic accessory Spleens showed a characteristic inhomogeneous enhancement on the early vascular phase, enhancement similar to the main Spleen during the postvascular phases, and prolonged enhancement on the delayed hepatosplenic phase.
Motoshi Nishiura - One of the best experts on this subject based on the ideXlab platform.
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intrapancreatic accessory Spleen mimicking endocrine tumor of the pancreas case report and review of the literature
Journal of Gastrointestinal Surgery, 2008Co-Authors: Shuichiro Uchiyama, Masahide Hiyoshi, Jiro Ohuchida, Naoya Imamura, Motoaki Nagano, Hideki Hidaka, Kenji Yorita, Yutaka Akiyama, Kazuo Chijiiwa, Motoshi NishiuraAbstract:Accessory Spleen is an anomaly that is observed in about 10% of individuals by the autopsy study, and most accessory Spleens are located close to the splenic hilum. Although accessory Spleen is a frequently encountered entity, intrapancreatic accessory Spleen (IPAS) is rarely recognized radiologically and is sometimes mistaken for another type of pancreatic neoplasm. Only 10 IPAS cases surgically resected as solid pancreatic mass have been reported in the English literature. We herein report a case of IPAS mimicking an endocrine tumor of the pancreas and review of the literature.
