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S Baumgart - One of the best experts on this subject based on the ideXlab platform.

  • Atrial Natriuretic Factor and postnatal diuresis in respiratory distress syndrome.
    Archives of disease in childhood, 1991
    Co-Authors: H J Rozycki, S Baumgart
    Abstract:

    To find out if Atrial Natriuretic Factor plays a part in the control of urine output during the initiation alone or throughout postnatal diuresis in neonates with respiratory distress syndrome, Atrial Natriuretic Factor concentrations and clinical and renal variables were measured prospectively three times during the first three days of life in 13 premature infants. Atrial Natriuretic Factor concentrations rose significantly between the first and second sample times as did the urine output and output:input ratio. By the time that the third sample was taken, Atrial Natriuretic Factor concentration had decreased significantly since the second sample had been taken, while urine flow was maintained. All subjects initiated a spontaneous diuresis that was related to the second concentration of Atrial Natriuretic Factor. With partial correlation analysis a significant relationship was shown between the concentration of Atrial Natriuretic Factor and the maintenance of urine output throughout the study period. Individual hormone concentrations did not, however, correlate with simultaneous renal variables. Changes in the concentrations of Atrial Natriuretic Factor coincided with initiation of spontaneous diuresis in babies with respiratory distress syndrome, and may have a role in the complex mechanisms that maintain this diuresis.

L D Platt - One of the best experts on this subject based on the ideXlab platform.

  • Effect of pregnancy on the vasodepressor response to Atrial Natriuretic Factor.
    American journal of obstetrics and gynecology, 1993
    Co-Authors: L C Castro, R J Allen, C P Arora, C J Hobel, L D Platt
    Abstract:

    We attempted to determine whether pregnancy alters the vasodepressor response to both physiologic and pharmacologic infusions of Atrial Natriuretic Factor 99-126. Ten virgin and 10 pregnant (17 +/- 1 days of gestation) conscious, unrestrained Sprague-Dawley rats with chronic indwelling vascular catheters were studied. Mean arterial pressure and heart rate were measured in response to steady-state infusions of either saline solution or increasing concentrations of Atrial Natriuretic Factor (range 5 to 2560 ng.kg-1.min-1). Basal mean arterial pressure was significantly lower in pregnant rats than in virgin rats (89 +/- 3 vs 97 +/- 2 mm Hg, p < 0.02). Atrial Natriuretic Factor induced significant dose-dependent decreases in mean arterial pressure and heart rate in virgin and pregnant rats (p < 0.001). The hypotensive effects of Atrial Natriuretic Factor were blunted in the pregnant rats only in response to the highest concentrations of Atrial Natriuretic Factor administered (-27 +/- 3 mm Hg in pregnant rats vs -43 +/- 3 mm Hg in virgin rats, p < 0.005). The vasodepressor response to physiologic infusions of Atrial Natriuretic Factor was not affected by pregnancy status. However, pharmacologic infusions of Atrial Natriuretic Factor resulted in a blunted vasodepressor response in the pregnant animals. This may be due to alterations in vascular Atrial Natriuretic Factor receptors, changes in the clearance rate of Atrial Natriuretic Factor, or the modulating effects of other vasoactive hormones.

  • Effect of pregnancy on the vasodepressor response to Atrial Natriuretic Factor.
    American Journal of Obstetrics and Gynecology, 1993
    Co-Authors: L C Castro, R J Allen, C J Hobel, Chander Arora, L D Platt
    Abstract:

    OBJECTIVE: We attempted to determine whether pregnancy alters the vasodepressor response to both physiologic and pharmacologic infusions of Atrial Natriuretic Factor 99-126. STUDY DESIGN: Ten virgin and 10 pregnant (17 ± 1 days of gestation) conscious, unrestrained Sprague-Dawley rats with chronic indwelling vascular catheters were studied. Mean arterial pressure and heart rate were measured in response to steady-state infusions of either saline solution or increasing concentrations of Atrial Natriuretic Factor (range 5 to 2560 ng · kg -1 · min -1 ). RESULTS: Basal mean arterial pressure was significantly lower in pregnant rats than in virgin rats (89 ± 3 vs 97 ± 2 mm Hg, p p p CONCLUSIONS: The vasodepressor response to physiologic infusions of Atrial Natriuretic Factor was not affected by pregnancy status. However, pharmacologic infusions of Atrial Natriuretic Factor resulted in a blunted vasodepressor response in the pregnant animals. This may be due to alterations in vascular Atrial Natriuretic Factor receptors, changes in the clearance rate of Atrial Natriuretic Factor, or the modulating effects of other vasoactive hormones.

H J Rozycki - One of the best experts on this subject based on the ideXlab platform.

  • Atrial Natriuretic Factor and postnatal diuresis in respiratory distress syndrome.
    Archives of disease in childhood, 1991
    Co-Authors: H J Rozycki, S Baumgart
    Abstract:

    To find out if Atrial Natriuretic Factor plays a part in the control of urine output during the initiation alone or throughout postnatal diuresis in neonates with respiratory distress syndrome, Atrial Natriuretic Factor concentrations and clinical and renal variables were measured prospectively three times during the first three days of life in 13 premature infants. Atrial Natriuretic Factor concentrations rose significantly between the first and second sample times as did the urine output and output:input ratio. By the time that the third sample was taken, Atrial Natriuretic Factor concentration had decreased significantly since the second sample had been taken, while urine flow was maintained. All subjects initiated a spontaneous diuresis that was related to the second concentration of Atrial Natriuretic Factor. With partial correlation analysis a significant relationship was shown between the concentration of Atrial Natriuretic Factor and the maintenance of urine output throughout the study period. Individual hormone concentrations did not, however, correlate with simultaneous renal variables. Changes in the concentrations of Atrial Natriuretic Factor coincided with initiation of spontaneous diuresis in babies with respiratory distress syndrome, and may have a role in the complex mechanisms that maintain this diuresis.

L C Castro - One of the best experts on this subject based on the ideXlab platform.

  • Effect of pregnancy on the vasodepressor response to Atrial Natriuretic Factor.
    American journal of obstetrics and gynecology, 1993
    Co-Authors: L C Castro, R J Allen, C P Arora, C J Hobel, L D Platt
    Abstract:

    We attempted to determine whether pregnancy alters the vasodepressor response to both physiologic and pharmacologic infusions of Atrial Natriuretic Factor 99-126. Ten virgin and 10 pregnant (17 +/- 1 days of gestation) conscious, unrestrained Sprague-Dawley rats with chronic indwelling vascular catheters were studied. Mean arterial pressure and heart rate were measured in response to steady-state infusions of either saline solution or increasing concentrations of Atrial Natriuretic Factor (range 5 to 2560 ng.kg-1.min-1). Basal mean arterial pressure was significantly lower in pregnant rats than in virgin rats (89 +/- 3 vs 97 +/- 2 mm Hg, p < 0.02). Atrial Natriuretic Factor induced significant dose-dependent decreases in mean arterial pressure and heart rate in virgin and pregnant rats (p < 0.001). The hypotensive effects of Atrial Natriuretic Factor were blunted in the pregnant rats only in response to the highest concentrations of Atrial Natriuretic Factor administered (-27 +/- 3 mm Hg in pregnant rats vs -43 +/- 3 mm Hg in virgin rats, p < 0.005). The vasodepressor response to physiologic infusions of Atrial Natriuretic Factor was not affected by pregnancy status. However, pharmacologic infusions of Atrial Natriuretic Factor resulted in a blunted vasodepressor response in the pregnant animals. This may be due to alterations in vascular Atrial Natriuretic Factor receptors, changes in the clearance rate of Atrial Natriuretic Factor, or the modulating effects of other vasoactive hormones.

  • Effect of pregnancy on the vasodepressor response to Atrial Natriuretic Factor.
    American Journal of Obstetrics and Gynecology, 1993
    Co-Authors: L C Castro, R J Allen, C J Hobel, Chander Arora, L D Platt
    Abstract:

    OBJECTIVE: We attempted to determine whether pregnancy alters the vasodepressor response to both physiologic and pharmacologic infusions of Atrial Natriuretic Factor 99-126. STUDY DESIGN: Ten virgin and 10 pregnant (17 ± 1 days of gestation) conscious, unrestrained Sprague-Dawley rats with chronic indwelling vascular catheters were studied. Mean arterial pressure and heart rate were measured in response to steady-state infusions of either saline solution or increasing concentrations of Atrial Natriuretic Factor (range 5 to 2560 ng · kg -1 · min -1 ). RESULTS: Basal mean arterial pressure was significantly lower in pregnant rats than in virgin rats (89 ± 3 vs 97 ± 2 mm Hg, p p p CONCLUSIONS: The vasodepressor response to physiologic infusions of Atrial Natriuretic Factor was not affected by pregnancy status. However, pharmacologic infusions of Atrial Natriuretic Factor resulted in a blunted vasodepressor response in the pregnant animals. This may be due to alterations in vascular Atrial Natriuretic Factor receptors, changes in the clearance rate of Atrial Natriuretic Factor, or the modulating effects of other vasoactive hormones.

James A Nathanson - One of the best experts on this subject based on the ideXlab platform.

  • Atrial Natriuretic Factor and salt wasting after aneurysmal subarachnoid hemorrhage
    Stroke, 1991
    Co-Authors: Eelco F M Wijdicks, Allan H Ropper, E J Hunnicutt, G S Richardson, James A Nathanson
    Abstract:

    The causes of volume depletion and hyponatremia after subarachnoid hemorrhage are not fully understood but may be in part due to natriuresis or "cerebral salt wasting." Because previous studies using infrequent hormone sampling have given inconsistent results, we determined if elevations in Atrial Natriuretic Factor concentrations preceded negative sodium and fluid balances.We measured diurnal Atrial Natriuretic Factor and vasopressin concentrations and sodium balance for 5 days in 14 consecutive patients after aneurysmal subarachnoid hemorrhage.Plasma concentrations of Atrial Natriuretic Factor on admission were elevated in subarachnoid hemorrhage patients (mean +/- SD 106 +/- 59 pg/ml) compared with acutely ill controls (39 +/- 30 pg/ml). In eight patients, high peak concentrations of Atrial Natriuretic Factor, greater than 300 pg/ml or a twofold increase above baseline, were followed by natriuresis and a negative sodium balance. Three patients, two of whom became hyponatremic, developed cerebral infarc...