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Aureobasidium pullulans

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Giuseppe Criseo – 1st expert on this subject based on the ideXlab platform

  • disseminated nosocomial fungal infection by Aureobasidium pullulans var melanigenum a case report
    Journal of Clinical Microbiology, 2003
    Co-Authors: Giuseppe Bolignano, Giuseppe Criseo


    We report on a rare case of disseminated nosocomial fungal infection due to Aureobasidium pullulans var. melanigenum in a severely traumatized patient. Repeated blood and urine cultures yielded multicellular filamentous hyphal structures of varying size accompanied by budding yeast-like-cells of ellipsoidal morphology. The patient became asymptomatic after fluconazole therapy.

Haoshuai Li – 2nd expert on this subject based on the ideXlab platform

  • optimization of medium and cultivation conditions for alkaline protease production by the marine yeast Aureobasidium pullulans
    Bioresource Technology, 2007
    Co-Authors: Peng Wang, Haoshuai Li


    Abstract A yeast strain, Aureobasidium pullulans , which could produce the high yield of protease was isolated from sediment of saltern in Qingdao, China. Maximum production of enzyme (623.1 U/mg protein; 7.2 U/ml) was obtained in a medium containing 2.5 g soluble starch and 2.0 g NaNO 3 , 100 ml seawater, initial pH 6.0, after fermentation at 24.5 °C for 30 h. The protease had the highest activity at pH 9.0 and 45 °C.

Deanna A Sutton – 3rd expert on this subject based on the ideXlab platform

  • in vitro activities of eight antifungal drugs against 104 environmental and clinical isolates of Aureobasidium pullulans
    Antimicrobial Agents and Chemotherapy, 2014
    Co-Authors: Javad M Najafzadeh, Deanna A Sutton, Saradeghi M Keisari, Hossein Zarrinfar, Sybren G De Hoog, Anuradha Chowdhary, Jacques F Meis


    Aureobasidium pullulans is an unusual agent of phaeohyphomycosis. The in vitro activities of antifungals against 104 isolates of Aureobasidium pullulans var. pullulans and A. pullulans var. melanigenum revealed low MIC90s of amphotericin B, posaconazole, and itraconazole. However, they were resistant to fluconazole (≥64 μg/ml) and had high MICs of voriconazole, isavuconazole, caspofungin, and micafungin.

  • Aureobasidium pullulans var melanigenum fungemia in a pediatric patient
    Medical Mycology, 2011
    Co-Authors: Kileen L Mershonshier, Deanna A Sutton, Sybren G De Hoog, Jaime G Deville, Shirley Delair, Annette W Fothergill, Brian L Wickes, Michael A Lewinski


    This report describes a chronically ill child who presented with high fever and was diagnosed with catheter-related sepsis. Aureobasidium pullulans variety melanigenum, a dematiaceous fungus that rarely causes opportunistic infections, was recovered from multiple blood cultures. Antifungal susceptibilities were performed and the minimum inhibitory concentration (MIC) for fluconazole was 64 mg/l, suggestive of fluconazole resistance. The patient made a full recovery after removal of the catheter line and treatment with liposomal amphotericin B. This is the first case report of an elevated in vitro fluconazole MIC of an A. pullulans isolate and only the third case of successful treatment of A. pullulans fungemia.