The Experts below are selected from a list of 309 Experts worldwide ranked by ideXlab platform
Eric S. Fraga - One of the best experts on this subject based on the ideXlab platform.
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Enhancing Automated Process design with cognitive agents, distributed software components and web repositories
Engineering Optimization, 2007Co-Authors: Id Stalker, Eric S. FragaAbstract:A novel problem-solving environment for Automated Process design, which integrates cognitive agents, web repositories and distributed software components with an existing Automated Process design tool, is presented. It is shown how the approach offers the potential for significant improvements in two key aspects of design, namely, problem formulation and innovation. Note that by improving the quality of the solutions space, the approach directly supports optimization.
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Enhancing Automated Process design with cognitive agents, distributed software components and web repositories
2004Co-Authors: Id Stalker, Eric S. FragaAbstract:We present a novel problem solving environment for Automated Process design, integrating cognitive agents, web repositories and distributed software components with an existing Automated Process design tool. The approach is portable and addresses two key aspects of design: problem formulation and innovation. We model problem formulation and implement the resulting strategy through a pair of cognitive agents. The agents are situated within a larger framework which provides access to a wealth of resources. The approach supports innovation in design by freeing the designer to focus on creative aspects.
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Interactivity and Automated Process design
Chemical Engineering & Technology, 2003Co-Authors: Eric S. Fraga, Kefeng Wang, Abdellah SalhiAbstract:Automated Process design tools are often based on the use of optimization to identify the best Process flowsheet, typically in the early stages of design. Due to the non-linear models that are frequently required, the resulting optimization problem is difficult to solve. Difficulties arise both in identifying good initial solutions and in finding the global optimum. In some cases, even feasible initial points can be difficult to find. Furthermore, the objective function and the feasible search space may be non-convex. As a result, automation alone can be insufficient for the solution of difficult Process design problems. The engineer can, and arguably should, be involved in the Process of design, and tools that encourage this direct involvement are desirable. In early design, exploration of alternatives can be useful. Jacaranda is a system for Automated design [1]. It is based on the use of discrete programming, in conjunction with implicit enumeration and branch and bound techniques, to solve Process design problems with complex models. Jacaranda has been designed to support interactivity to ensure the maximum effectiveness from the combination of the computer and the engineer [2]. The aim is to allow the engineer to perform the tasks that a human can do best while ensuring that the computationally complex and repetitive steps are undertaken by the Automated design tool. In this context, Jacaranda provides visualization and data mining support for the engineer [3,4]. Examples demonstrating the potential of an interactive Automated design approach are presented. These include heat integrated separation sequence synthesis, reaction/separation with environmental issues, and a Process optimization problem with small feasible regions. Interactivity is used to support an iterative refinement approach to Process synthesis or to target optimization procedures to improve the quality of the solutions obtained. Visualization is shown to be a key underpinning technology, which also aids the engineer in understanding the results obtained by Automated design tools
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Engineer computer interaction for Automated Process design in COGents
Computer Aided Chemical Engineering, 2003Co-Authors: Id Stalker, R.a. Stalker Firth, Eric S. FragaAbstract:Abstract We identify those interaction issues necessary to foster creativity in Automated Process design. We apply the key distinctions of Engineer Computer Interaction ( Stalker & Smith 2002 ) to ensure that these are included in the development of a Process design agent within the COGents framework ( Braunschweig et al. 2002, COGents n.d. ). The formalism is used to develop a blueprint for interactivity between a designer and a design agent which fosters creativity in design.
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Incorporation of dynamic behaviour in an Automated Process synthesis system
Computers & Chemical Engineering, 2000Co-Authors: Eric S. Fraga, J Hagemann, A.d. Estrada-villagrana, I.d.l. BogleAbstract:Abstract Incorporating non-economic criteria into an Automated Process synthesis procedure enables an engineer to prune, more easily and more effectively, the large design space early in the design Process. Although existing synthesis procedures are based on the use of steady state modelling, issues such as operability and flexibility are best handled through the use of dynamic models. This paper describes a discrete programming approach, implemented in the Jacaranda synthesis tool, incorporating dynamic modelling for the generation of Process designs, which meet specified criteria for operability or flexibility. Particular attention is given to implementation issues, including especially how to incorporate dynamic modelling efficiently in an Automated environment. An example of the design of separation sequences with good start-up and feed disturbance behaviour is presented.
Lauren Ambrogio - One of the best experts on this subject based on the ideXlab platform.
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a scalable fully Automated Process for construction of sequence ready human exome targeted capture libraries
Genome Biology, 2011Co-Authors: Sheila Fisher, Andrew Barry, Justin Abreu, Brian Minie, Jillian Nolan, Toni Delorey, Geneva Young, Timothy Fennell, Alexander Allen, Lauren AmbrogioAbstract:Genome targeting methods enable cost-effective capture of specific subsets of the genome for sequencing. We present here an Automated, highly scalable method for carrying out the Solution Hybrid Selection capture approach that provides a dramatic increase in scale and throughput of sequence-ready libraries produced. Significant Process improvements and a series of in-Process quality control checkpoints are also added. These Process improvements can also be used in a manual version of the protocol.
Andrew Barry - One of the best experts on this subject based on the ideXlab platform.
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a scalable fully Automated Process for construction of sequence ready human exome targeted capture libraries
Genome Biology, 2011Co-Authors: Sheila Fisher, Andrew Barry, Justin Abreu, Brian Minie, Jillian Nolan, Toni Delorey, Geneva Young, Timothy Fennell, Alexander Allen, Lauren AmbrogioAbstract:Genome targeting methods enable cost-effective capture of specific subsets of the genome for sequencing. We present here an Automated, highly scalable method for carrying out the Solution Hybrid Selection capture approach that provides a dramatic increase in scale and throughput of sequence-ready libraries produced. Significant Process improvements and a series of in-Process quality control checkpoints are also added. These Process improvements can also be used in a manual version of the protocol.
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a scalable fully Automated Process for construction of sequence ready barcoded libraries for 454
Genome Biology, 2010Co-Authors: Niall J Lennon, Robert E Lintner, Scott Anderson, Pablo Alvarez, Andrew Barry, William Brockman, Riza M Daza, Rachel L Erlich, Georgia Giannoukos, Lisa GreenAbstract:We present an Automated, high throughput library construction Process for 454 technology. Sample handling errors and cross-contamination are minimized via end-to-end barcoding of plasticware, along with molecular DNA barcoding of constructs. Automation-friendly magnetic bead-based size selection and cleanup steps have been devised, eliminating major bottlenecks and significant sources of error. Using this methodology, one technician can create 96 sequence-ready 454 libraries in 2 days, a dramatic improvement over the standard method.
Lisa Green - One of the best experts on this subject based on the ideXlab platform.
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a scalable fully Automated Process for construction of sequence ready barcoded libraries for 454
Genome Biology, 2010Co-Authors: Niall J Lennon, Robert E Lintner, Scott Anderson, Pablo Alvarez, Andrew Barry, William Brockman, Riza M Daza, Rachel L Erlich, Georgia Giannoukos, Lisa GreenAbstract:We present an Automated, high throughput library construction Process for 454 technology. Sample handling errors and cross-contamination are minimized via end-to-end barcoding of plasticware, along with molecular DNA barcoding of constructs. Automation-friendly magnetic bead-based size selection and cleanup steps have been devised, eliminating major bottlenecks and significant sources of error. Using this methodology, one technician can create 96 sequence-ready 454 libraries in 2 days, a dramatic improvement over the standard method.
Michael T. Flavin - One of the best experts on this subject based on the ideXlab platform.
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Automated Process Research and the Optimization of the Synthesis of 4(5)-(3-Pyridyl)imidazole
Organic Process Research & Development, 2001Co-Authors: Eric W. Kirchhoff, Denise R. Anderson, Songlei Zhang, And Constance S. Cassidy, Michael T. FlavinAbstract:Automated Process development technology was applied to the synthesis of 4(5)-(3-pyridyl)imidazole. This method utilizes Automated liquid handling equipment coupled with statistically designed protocols for rapid Process optimization. Two experimental sets were carried out based on a three-level factorial and central composite designs to optimise the product yield. The central composite design was repeated on one-fifth the scale to test the capabilities of the Automated equipment. The reaction variables investigated were temperature and stoichiometry of formamide. The optimum in situ yield of 4(5)-(3-pyridyl)imidazole was found to be at 160 °C and 9 equiv of formamide. The results from the Automated technology can be applied to larger-scale synthesis of the desired compound.
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Automated Process Research. An Example of Accelerated Optimization of the Friedel−Crafts Acylation Reaction, a Key Step for the Synthesis of Anti-HIV (+)-Calanolide A
Organic Process Research & Development, 2000Co-Authors: Jintao Zhang, Eric W. Kirchhoff, David E. Zembower, Nancy Jimenez, Prabir Sen, Michael T. FlavinAbstract:An Automated Process research approach to reaction optimization was developed. Chemical Process research can be greatly accelerated by coupling Automated synthesis equipment with statistical design of experiments (DoE). With the use of an Automated Process approach, multiple experiments can be performed in parallel on an Automated platform, and multiple parameters that may influence Process performance can be examined within one set of experiments generated from statistical design. We have successfully applied an Automated Process research approach to optimize the Friedel−Crafts acylation reaction that was used in our total synthesis of (+)-calanolide A, a potential anti-HIV agent currently in clinical trials. The in situ yield for a coumarin product was successfully optimized, increasing from 70% to 97% by HPLC analysis.
