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Antti M Kiviniemi - One of the best experts on this subject based on the ideXlab platform.
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effect of polycystic ovary syndrome on cardiac Autonomic Function at a late fertile age a prospective northern finland birth cohort 1966 study
BMJ Open, 2019Co-Authors: Antti M Kiviniemi, Mikko P Tulppo, Katri Puukka, Merimaija Ollila, Elisabet Stenervictorin, Juha S TapanainenAbstract:Objectives Previous studies of women in their 20s and 30s have reported impaired Autonomic Function in women with polycystic ovary syndrome (PCOS). We aimed to study, for the first time, whether PCOS is associated with impaired cardiac Autonomic Function independent of metabolic and hormonal status in their late reproductive years. Design A prospective Northern Finland Birth Cohort 1966 (NFBC1966) study including 5889 women born in 1966 and followed through the age of 46. At that age, n=3706/5123 women (72%) answered the postal questionnaires and n=3280/5123 women (64%) participated in the clinical examination. Setting General community. Participants The sample included women presenting both irregular menses (oligomenorrhoea or amenorrhoea) and hirsutism at age 31 (n=125) or with formally diagnosed PCOS by age 46 (n=181) and women without PCOS symptoms or diagnosis (n=1577). Primary and secondary outcome measures Heart rate variability parameters: the root mean square of successive R-R differences (rMSSD), spectral power densities (LF: low frequency and HF: high frequency) and baroreflex sensitivity (BRS). Results We found that parasympathetic activity (assessed by rMSSD: 19.5 (12.4; 31.9) vs 24.3 (16.1; 34.8) ms, p=0.004 and HF: 172 (75; 399) vs 261 (112; 565) ms2, p=0.002) and BRS (6.13±3.12 vs 6.99±3.52 ms/mm Hg, p=0.036) were lower in women with PCOS compared with the controls. However, in the multivariate regression analysis, PCOS, body mass index and the free androgen index did not significantly associate with rMSSD, whereas blood pressure, insulin resistance and triglycerides did. Conclusions We report here for the first time that late reproductive-aged women with PCOS display impaired cardiac Autonomic Function manifested as decreased vagal activity. Metabolic status, rather than hyperandrogenaemia and PCOS per se, was the strongest contributing factor. Given the link between cardiac morbidity and impaired Autonomic Function, the findings underline the importance of screening and treating metabolic abnormalities early on in women with PCOS.
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cardiac Autonomic Function in adults born preterm
The Journal of Pediatrics, 2019Co-Authors: Antti M Kiviniemi, Marjo-riitta Järvelin, Risto Karvonen, Marika Sipola, Marjaana Tikanmaki, Johan G Eriksson, Mikko P TulppoAbstract:Objective To evaluate cardiac Autonomic Function in adults born preterm. Study design We studied the association between prematurity and cardiac Autonomic Function using heart rate variability measurements in 600 adults (mean age of 23.3 years) from a geographically based cohort in Northern Finland. There were 117 young adults born early preterm ( Results Compared with controls, the mean difference in root mean square of successive differences (indicating cardiac vagal activity) was −12.0% (95% CI −22.2%, −0.5%, adjusted for sex, age, source cohort, and season P = .04) for the early preterm group and −7.8% (−16.8%, 2.0%, P = .12) for the late preterm group. Mean differences with controls in low frequency power (indicating cardiac vagal activity, including some sympathetic- and baroreflex-mediated effects) were −13.6% (−26.7%, 1.8%, P = .08) for the early preterm group and −16.4% (−27.0%, −4.3%, P = .01) for the late preterm group. Mean differences in high frequency power (quantifying cardiac vagal modulation in respiratory frequency) were −19.2% (−36.6%, 2.9%, P = .09) for the early preterm group and −13.8% (−29.4%, 5.3%, P = .15) for the late preterm group. Differences were attenuated when controlled for body mass index and physical activity. Conclusions Our results suggest altered Autonomic regulatory control in adults born preterm, including those born late preterm. Altered Autonomic regulatory control may contribute to increased cardiovascular risk in adults born preterm.
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Fitness, Fatness, Physical Activity, and Autonomic Function in Midlife
Medicine and science in sports and exercise, 2017Co-Authors: Antti M Kiviniemi, Mikko P Tulppo, Nelli Perkiömäki, Juha Auvinen, Maisa Niemelä, Tuija Tammelin, Katri Puukka, Aimo Ruokonen, Sirkka Keinänen-kiukaanniemi, Marjo-riitta JärvelinAbstract:ABSTRACTPurposeAlthough low cardiorespiratory fitness (CRF), physical inactivity, and obesity are associated with impaired Autonomic Function, they are also extensively interrelated. The present study aimed to assess the extent to which they contribute to Autonomic Function independently of each oth
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lifelong physical activity and cardiovascular Autonomic Function in midlife
Medicine and Science in Sports and Exercise, 2016Co-Authors: Antti M Kiviniemi, Mikko P Tulppo, Nelli Perkiömäki, Juha Auvinen, Tuija Tammelin, Marjo-riitta Järvelin, Sauli Herrala, Arto J Hautala, Riikka Ahola, Raija KorpelainenAbstract:Purpose Physical activity (PA) associates with cardiovascular Autonomic Function, but the relationship with lifelong PA is unclear. We hypothesized that lifelong PA would associate with cardiovascular Autonomic Function in midlife. Methods At the age of 46 yr, the subjects of the prospective Northern Finland Birth Cohort 1966 were invited to examinations where vagally mediated heart rate variability (root mean square of the successive differences in RRi [rMSSD]) and cross-spectral baroreflex sensitivity (BRS) were analyzed from 3-min recordings of ECG and blood pressure in seated and standing positions. Three lifelong PA trajectory groups (active, semiactive, and inactive) were formed according to their self-reported frequencies of participation in PA at the ages of 14, 31, and 46 yr. Finally, 1283 men and 1779 women without cardiorespiratory diseases and diabetes had complete data on lifelong PA, covariates, and rMSSD, and 662 men and 807 women for BRS. Results In both sexes and measurement conditions, the active (P Conclusion Higher lifelong PA was associated with better cardiovascular Autonomic Function in midlife. In women, this effect was independent, but in men, it seemed to be mediated by the other lifestyle and cardiometabolic factors.
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cardiac Autonomic Function and high intensity interval training in middle age men
Medicine and Science in Sports and Exercise, 2014Co-Authors: Antti M Kiviniemi, Mikko P Tulppo, Joonas J Eskelinen, Anna M Savolainen, Jukka Kapanen, Ilkka Heinonen, Heikki V Huikuri, Jarna C Hannukainen, Kari K KalliokoskiAbstract:ABSTRACTPurposeThe effects of short-term high-intensity interval training (HIT) on cardiac Autonomic Function are unclear. The present study assessed cardiac Autonomic adaptations to short-term HIT in comparison with aerobic endurance training (AET).MethodsTwenty-six healthy middle-age sedentary men
Mikko P Tulppo - One of the best experts on this subject based on the ideXlab platform.
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effect of polycystic ovary syndrome on cardiac Autonomic Function at a late fertile age a prospective northern finland birth cohort 1966 study
BMJ Open, 2019Co-Authors: Antti M Kiviniemi, Mikko P Tulppo, Katri Puukka, Merimaija Ollila, Elisabet Stenervictorin, Juha S TapanainenAbstract:Objectives Previous studies of women in their 20s and 30s have reported impaired Autonomic Function in women with polycystic ovary syndrome (PCOS). We aimed to study, for the first time, whether PCOS is associated with impaired cardiac Autonomic Function independent of metabolic and hormonal status in their late reproductive years. Design A prospective Northern Finland Birth Cohort 1966 (NFBC1966) study including 5889 women born in 1966 and followed through the age of 46. At that age, n=3706/5123 women (72%) answered the postal questionnaires and n=3280/5123 women (64%) participated in the clinical examination. Setting General community. Participants The sample included women presenting both irregular menses (oligomenorrhoea or amenorrhoea) and hirsutism at age 31 (n=125) or with formally diagnosed PCOS by age 46 (n=181) and women without PCOS symptoms or diagnosis (n=1577). Primary and secondary outcome measures Heart rate variability parameters: the root mean square of successive R-R differences (rMSSD), spectral power densities (LF: low frequency and HF: high frequency) and baroreflex sensitivity (BRS). Results We found that parasympathetic activity (assessed by rMSSD: 19.5 (12.4; 31.9) vs 24.3 (16.1; 34.8) ms, p=0.004 and HF: 172 (75; 399) vs 261 (112; 565) ms2, p=0.002) and BRS (6.13±3.12 vs 6.99±3.52 ms/mm Hg, p=0.036) were lower in women with PCOS compared with the controls. However, in the multivariate regression analysis, PCOS, body mass index and the free androgen index did not significantly associate with rMSSD, whereas blood pressure, insulin resistance and triglycerides did. Conclusions We report here for the first time that late reproductive-aged women with PCOS display impaired cardiac Autonomic Function manifested as decreased vagal activity. Metabolic status, rather than hyperandrogenaemia and PCOS per se, was the strongest contributing factor. Given the link between cardiac morbidity and impaired Autonomic Function, the findings underline the importance of screening and treating metabolic abnormalities early on in women with PCOS.
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cardiac Autonomic Function in adults born preterm
The Journal of Pediatrics, 2019Co-Authors: Antti M Kiviniemi, Marjo-riitta Järvelin, Risto Karvonen, Marika Sipola, Marjaana Tikanmaki, Johan G Eriksson, Mikko P TulppoAbstract:Objective To evaluate cardiac Autonomic Function in adults born preterm. Study design We studied the association between prematurity and cardiac Autonomic Function using heart rate variability measurements in 600 adults (mean age of 23.3 years) from a geographically based cohort in Northern Finland. There were 117 young adults born early preterm ( Results Compared with controls, the mean difference in root mean square of successive differences (indicating cardiac vagal activity) was −12.0% (95% CI −22.2%, −0.5%, adjusted for sex, age, source cohort, and season P = .04) for the early preterm group and −7.8% (−16.8%, 2.0%, P = .12) for the late preterm group. Mean differences with controls in low frequency power (indicating cardiac vagal activity, including some sympathetic- and baroreflex-mediated effects) were −13.6% (−26.7%, 1.8%, P = .08) for the early preterm group and −16.4% (−27.0%, −4.3%, P = .01) for the late preterm group. Mean differences in high frequency power (quantifying cardiac vagal modulation in respiratory frequency) were −19.2% (−36.6%, 2.9%, P = .09) for the early preterm group and −13.8% (−29.4%, 5.3%, P = .15) for the late preterm group. Differences were attenuated when controlled for body mass index and physical activity. Conclusions Our results suggest altered Autonomic regulatory control in adults born preterm, including those born late preterm. Altered Autonomic regulatory control may contribute to increased cardiovascular risk in adults born preterm.
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Fitness, Fatness, Physical Activity, and Autonomic Function in Midlife
Medicine and science in sports and exercise, 2017Co-Authors: Antti M Kiviniemi, Mikko P Tulppo, Nelli Perkiömäki, Juha Auvinen, Maisa Niemelä, Tuija Tammelin, Katri Puukka, Aimo Ruokonen, Sirkka Keinänen-kiukaanniemi, Marjo-riitta JärvelinAbstract:ABSTRACTPurposeAlthough low cardiorespiratory fitness (CRF), physical inactivity, and obesity are associated with impaired Autonomic Function, they are also extensively interrelated. The present study aimed to assess the extent to which they contribute to Autonomic Function independently of each oth
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lifelong physical activity and cardiovascular Autonomic Function in midlife
Medicine and Science in Sports and Exercise, 2016Co-Authors: Antti M Kiviniemi, Mikko P Tulppo, Nelli Perkiömäki, Juha Auvinen, Tuija Tammelin, Marjo-riitta Järvelin, Sauli Herrala, Arto J Hautala, Riikka Ahola, Raija KorpelainenAbstract:Purpose Physical activity (PA) associates with cardiovascular Autonomic Function, but the relationship with lifelong PA is unclear. We hypothesized that lifelong PA would associate with cardiovascular Autonomic Function in midlife. Methods At the age of 46 yr, the subjects of the prospective Northern Finland Birth Cohort 1966 were invited to examinations where vagally mediated heart rate variability (root mean square of the successive differences in RRi [rMSSD]) and cross-spectral baroreflex sensitivity (BRS) were analyzed from 3-min recordings of ECG and blood pressure in seated and standing positions. Three lifelong PA trajectory groups (active, semiactive, and inactive) were formed according to their self-reported frequencies of participation in PA at the ages of 14, 31, and 46 yr. Finally, 1283 men and 1779 women without cardiorespiratory diseases and diabetes had complete data on lifelong PA, covariates, and rMSSD, and 662 men and 807 women for BRS. Results In both sexes and measurement conditions, the active (P Conclusion Higher lifelong PA was associated with better cardiovascular Autonomic Function in midlife. In women, this effect was independent, but in men, it seemed to be mediated by the other lifestyle and cardiometabolic factors.
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cardiac Autonomic Function and high intensity interval training in middle age men
Medicine and Science in Sports and Exercise, 2014Co-Authors: Antti M Kiviniemi, Mikko P Tulppo, Joonas J Eskelinen, Anna M Savolainen, Jukka Kapanen, Ilkka Heinonen, Heikki V Huikuri, Jarna C Hannukainen, Kari K KalliokoskiAbstract:ABSTRACTPurposeThe effects of short-term high-intensity interval training (HIT) on cardiac Autonomic Function are unclear. The present study assessed cardiac Autonomic adaptations to short-term HIT in comparison with aerobic endurance training (AET).MethodsTwenty-six healthy middle-age sedentary men
Richard L Verrier - One of the best experts on this subject based on the ideXlab platform.
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vagus nerve stimulation provides multiyear improvements in Autonomic Function and cardiac electrical stability in the anthem hf study
Journal of Cardiac Failure, 2021Co-Authors: Bruce D Nearing, I S Anand, Imad Libbus, Lorenzo A Dicarlo, Bruce H Kenknight, Richard L VerrierAbstract:ABSTRACT Background Patients with heart failure with reduced left ventricular ejection fraction (LVEF) (HFrEF) experience long-term deterioration of Autonomic Function and cardiac electrical stability linked to increased mortality risk. The Autonomic Neural Regulation Therapy to Enhance Myocardial Function in Heart Failure (ANTHEM-HF) trial reported improved heart rate variability (HRV) and heart rate turbulence (HRT) and reduced T-wave alternans (TWA) after 12 months of vagus nerve stimulation (VNS). We investigated whether the benefits of chronic VNS persist in the long term. Methods and Results Effects of chronic VNS on heart rate, HRV, HRT, TWA, R-wave and T-wave heterogeneity (RWH, TWH), and nonsustained ventricular tachycardia (NSVT) incidence were evaluated in all ANTHEM-HF patients with ambulatory ECG data at 24 and 36 months (n = 25). Autonomic markers improved significantly at 24 and 36 months compared to baseline [heart rate, square root of the mean squared differences of successive normal-to-normal intervals (rMSSD), standard deviation of the normal-to-normal intervals (SDNN), HF-HRV, HRT slope, P Conclusion In symptomatic patients with HFrEF, chronic VNS appears to confer wide-ranging, persistent improvements in Autonomic tone (HRV), baroreceptor sensitivity (HRT), and cardiac electrical stability (TWA, RWH, TWH).
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vagus nerve stimulation provides multiyear improvements in Autonomic Function and cardiac electrical stability in the anthem hf study
Journal of Cardiac Failure, 2021Co-Authors: Bruce D Nearing, I S Anand, Imad Libbus, Lorenzo A Dicarlo, Bruce H Kenknight, Richard L VerrierAbstract:BACKGROUND Patients with heart failure with reduced left ventricular ejection fraction (LVEF) (HFrEF) experience long-term deterioration of Autonomic Function and cardiac electrical stability linked to increased mortality risk. The Autonomic Neural Regulation Therapy to Enhance Myocardial Function in Heart Failure (ANTHEM-HF) trial reported improved heart rate variability (HRV) and heart rate turbulence (HRT) and reduced T-wave alternans (TWA) after 12 months of vagus nerve stimulation (VNS). We investigated whether the benefits of chronic VNS persist in the long term. METHODS AND RESULTS Effects of chronic VNS on heart rate, HRV, HRT, TWA, R-wave and T-wave heterogeneity (RWH, TWH), and nonsustained ventricular tachycardia (NSVT) incidence were evaluated in all ANTHEM-HF patients with ambulatory ECG data at 24 and 36 months (n = 25). Autonomic markers improved significantly at 24 and 36 months compared to baseline [heart rate, square root of the mean squared differences of successive normal-to-normal intervals (rMSSD), standard deviation of the normal-to-normal intervals (SDNN), HF-HRV, HRT slope, P < 0.05]. Peak TWA levels remained reduced at 24 and 36 months (P < 0.0001). Reductions in RWH and TWH at 6 and 12 months persisted at 24 and 36 months (P < 0.01). NSVT decreased at 12, 24, and 36 months (P < 0.025). No sudden cardiac deaths, ventricular fibrillation, or sustained ventricular tachycardia occurred. CONCLUSION In symptomatic patients with HFrEF, chronic VNS appears to confer wide-ranging, persistent improvements in Autonomic tone (HRV), baroreceptor sensitivity (HRT), and cardiac electrical stability (TWA, RWH, TWH).
Katri Puukka - One of the best experts on this subject based on the ideXlab platform.
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effect of polycystic ovary syndrome on cardiac Autonomic Function at a late fertile age a prospective northern finland birth cohort 1966 study
BMJ Open, 2019Co-Authors: Antti M Kiviniemi, Mikko P Tulppo, Katri Puukka, Merimaija Ollila, Elisabet Stenervictorin, Juha S TapanainenAbstract:Objectives Previous studies of women in their 20s and 30s have reported impaired Autonomic Function in women with polycystic ovary syndrome (PCOS). We aimed to study, for the first time, whether PCOS is associated with impaired cardiac Autonomic Function independent of metabolic and hormonal status in their late reproductive years. Design A prospective Northern Finland Birth Cohort 1966 (NFBC1966) study including 5889 women born in 1966 and followed through the age of 46. At that age, n=3706/5123 women (72%) answered the postal questionnaires and n=3280/5123 women (64%) participated in the clinical examination. Setting General community. Participants The sample included women presenting both irregular menses (oligomenorrhoea or amenorrhoea) and hirsutism at age 31 (n=125) or with formally diagnosed PCOS by age 46 (n=181) and women without PCOS symptoms or diagnosis (n=1577). Primary and secondary outcome measures Heart rate variability parameters: the root mean square of successive R-R differences (rMSSD), spectral power densities (LF: low frequency and HF: high frequency) and baroreflex sensitivity (BRS). Results We found that parasympathetic activity (assessed by rMSSD: 19.5 (12.4; 31.9) vs 24.3 (16.1; 34.8) ms, p=0.004 and HF: 172 (75; 399) vs 261 (112; 565) ms2, p=0.002) and BRS (6.13±3.12 vs 6.99±3.52 ms/mm Hg, p=0.036) were lower in women with PCOS compared with the controls. However, in the multivariate regression analysis, PCOS, body mass index and the free androgen index did not significantly associate with rMSSD, whereas blood pressure, insulin resistance and triglycerides did. Conclusions We report here for the first time that late reproductive-aged women with PCOS display impaired cardiac Autonomic Function manifested as decreased vagal activity. Metabolic status, rather than hyperandrogenaemia and PCOS per se, was the strongest contributing factor. Given the link between cardiac morbidity and impaired Autonomic Function, the findings underline the importance of screening and treating metabolic abnormalities early on in women with PCOS.
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Fitness, Fatness, Physical Activity, and Autonomic Function in Midlife
Medicine and science in sports and exercise, 2017Co-Authors: Antti M Kiviniemi, Mikko P Tulppo, Nelli Perkiömäki, Juha Auvinen, Maisa Niemelä, Tuija Tammelin, Katri Puukka, Aimo Ruokonen, Sirkka Keinänen-kiukaanniemi, Marjo-riitta JärvelinAbstract:ABSTRACTPurposeAlthough low cardiorespiratory fitness (CRF), physical inactivity, and obesity are associated with impaired Autonomic Function, they are also extensively interrelated. The present study aimed to assess the extent to which they contribute to Autonomic Function independently of each oth
Merimaija Ollila - One of the best experts on this subject based on the ideXlab platform.
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effect of polycystic ovary syndrome on cardiac Autonomic Function at a late fertile age a prospective northern finland birth cohort 1966 study
BMJ Open, 2019Co-Authors: Antti M Kiviniemi, Mikko P Tulppo, Katri Puukka, Merimaija Ollila, Elisabet Stenervictorin, Juha S TapanainenAbstract:Objectives Previous studies of women in their 20s and 30s have reported impaired Autonomic Function in women with polycystic ovary syndrome (PCOS). We aimed to study, for the first time, whether PCOS is associated with impaired cardiac Autonomic Function independent of metabolic and hormonal status in their late reproductive years. Design A prospective Northern Finland Birth Cohort 1966 (NFBC1966) study including 5889 women born in 1966 and followed through the age of 46. At that age, n=3706/5123 women (72%) answered the postal questionnaires and n=3280/5123 women (64%) participated in the clinical examination. Setting General community. Participants The sample included women presenting both irregular menses (oligomenorrhoea or amenorrhoea) and hirsutism at age 31 (n=125) or with formally diagnosed PCOS by age 46 (n=181) and women without PCOS symptoms or diagnosis (n=1577). Primary and secondary outcome measures Heart rate variability parameters: the root mean square of successive R-R differences (rMSSD), spectral power densities (LF: low frequency and HF: high frequency) and baroreflex sensitivity (BRS). Results We found that parasympathetic activity (assessed by rMSSD: 19.5 (12.4; 31.9) vs 24.3 (16.1; 34.8) ms, p=0.004 and HF: 172 (75; 399) vs 261 (112; 565) ms2, p=0.002) and BRS (6.13±3.12 vs 6.99±3.52 ms/mm Hg, p=0.036) were lower in women with PCOS compared with the controls. However, in the multivariate regression analysis, PCOS, body mass index and the free androgen index did not significantly associate with rMSSD, whereas blood pressure, insulin resistance and triglycerides did. Conclusions We report here for the first time that late reproductive-aged women with PCOS display impaired cardiac Autonomic Function manifested as decreased vagal activity. Metabolic status, rather than hyperandrogenaemia and PCOS per se, was the strongest contributing factor. Given the link between cardiac morbidity and impaired Autonomic Function, the findings underline the importance of screening and treating metabolic abnormalities early on in women with PCOS.
