The Experts below are selected from a list of 40869 Experts worldwide ranked by ideXlab platform
Koichi Kusakawa - One of the best experts on this subject based on the ideXlab platform.
-
biological monitoring of human exposure to neonicotinoids using urine samples and neonicotinoid excretion kinetics
PLOS ONE, 2016Co-Authors: Kouji H Harada, Keiko Tanaka, Hiroko Sakamoto, Mie Imanaka, Tamon Niisoe, Toshiaki Hitomi, Hatasu Kobayashi, Hiroko Okuda, Sumiko Inoue, Koichi KusakawaAbstract:Background Neonicotinoids, which are novel pesticides, have entered into usage around the world because they are selectively toxic to arthropods and relatively non-toxic to vertebrates. It has been suggested that several neonicotinoids cause neurodevelopmental toxicity in mammals. The aim was to establish the relationship between oral Intake and urinary excretion of neonicotinoids by humans to facilitate biological monitoring, and to estimate dietary neonicotinoid Intakes by Japanese adults. Methodology/Principal Findings Deuterium-labeled neonicotinoid (acetamiprid, clothianidin, dinotefuran, and imidacloprid) microdoses were orally ingested by nine healthy adults, and 24 h pooled urine samples were collected for 4 consecutive days after dosing. The excretion kinetics were modeled using one- and two-compartment models, then validated in a non-deuterium-labeled neonicotinoid microdose study involving 12 healthy adults. Increased urinary concentrations of labeled neonicotinoids were observed after dosing. Clothianidin was recovered unchanged within 3 days, and most dinotefuran was recovered unchanged within 1 day. Around 10% of the imidacloprid dose was excreted unchanged. Most of the acetamiprid was metabolized to desmethyl-acetamiprid. Spot urine samples from 373 Japanese adults were analyzed for neonicotinoids, and Daily Intakes were estimated. The estimated Average Daily Intake of these neonicotinoids was 0.53–3.66 μg/day. The highest Intake of any of the neonicotinoids in the study population was 64.5 μg/day for dinotefuran, and this was <1% of the acceptable Daily Intake.
-
Biological Monitoring of human exposure to neonicotinoids using urine samples, and neonicotinoid excretion kinetics
PloS one, 2016Co-Authors: Kouji H Harada, Keiko Tanaka, Hiroko Sakamoto, Mie Imanaka, Tamon Niisoe, Toshiaki Hitomi, Hatasu Kobayashi, Hiroko Okuda, Sumiko Inoue, Koichi KusakawaAbstract:Background Neonicotinoids, which are novel pesticides, have entered into usage around the world because they are selectively toxic to arthropods and relatively non-toxic to vertebrates. It has been suggested that several neonicotinoids cause neurodevelopmental toxicity in mammals. The aim was to establish the relationship between oral Intake and urinary excretion of neonicotinoids by humans to facilitate biological monitoring, and to estimate dietary neonicotinoid Intakes by Japanese adults. Methodology/Principal Findings Deuterium-labeled neonicotinoid (acetamiprid, clothianidin, dinotefuran, and imidacloprid) microdoses were orally ingested by nine healthy adults, and 24 h pooled urine samples were collected for 4 consecutive days after dosing. The excretion kinetics were modeled using one- and two-compartment models, then validated in a non-deuterium-labeled neonicotinoid microdose study involving 12 healthy adults. Increased urinary concentrations of labeled neonicotinoids were observed after dosing. Clothianidin was recovered unchanged within 3 days, and most dinotefuran was recovered unchanged within 1 day. Around 10% of the imidacloprid dose was excreted unchanged. Most of the acetamiprid was metabolized to desmethyl-acetamiprid. Spot urine samples from 373 Japanese adults were analyzed for neonicotinoids, and Daily Intakes were estimated. The estimated Average Daily Intake of these neonicotinoids was 0.53–3.66 μg/day. The highest Intake of any of the neonicotinoids in the study population was 64.5 μg/day for dinotefuran, and this was
Jean Woo - One of the best experts on this subject based on the ideXlab platform.
-
synthetic colourings of some snack foods consumed by primary school children aged 8 9 years in hong kong
Food Additives & Contaminants Part B-surveillance, 2011Co-Authors: Kris Yuet Wan Lok, Y W Chung, Iris F. F. Benzie, Jean WooAbstract:An HPLC method with photodiode array detection was used for the quantification of 11 synthetic dyes in 87 snack food products commonly consumed by children in Hong Kong, China. Dietary exposure to synthetic colours was estimated using food-frequency questionnaire data obtained from 142 primary school children aged 8–9 years in three districts of Hong Kong. Dietary exposure to synthetic colours for an Average primary school student was considerably lower than the threshold for acceptable Daily Intake (ADI) for their ages, except for sunset yellow FCF. Data obtained showed that the Average Daily Intake of sunset yellow FCF (E110) was 51% over the ADI threshold in 9-year-old boys. The higher Intakes of sunset yellow FCF were mainly due to the high consumption of soft drinks and desserts such as jellies, which have high concentrations of this synthetic colour additive.
-
synthetic colourings of some snack foods consumed by primary school children aged 8 9 years in hong kong
Food Additives & Contaminants Part B-surveillance, 2011Co-Authors: Kris Yuet Wan Lok, Y W Chung, Iris F. F. Benzie, Jean WooAbstract:An HPLC method with photodiode array detection was used for the quantification of 11 synthetic dyes in 87 snack food products commonly consumed by children in Hong Kong, China. Dietary exposure to synthetic colours was estimated using food-frequency questionnaire data obtained from 142 primary school children aged 8–9 years in three districts of Hong Kong. Dietary exposure to synthetic colours for an Average primary school student was considerably lower than the threshold for acceptable Daily Intake (ADI) for their ages, except for sunset yellow FCF. Data obtained showed that the Average Daily Intake of sunset yellow FCF (E110) was 51% over the ADI threshold in 9-year-old boys. The higher Intakes of sunset yellow FCF were mainly due to the high consumption of soft drinks and desserts such as jellies, which have high concentrations of this synthetic colour additive.
Ravagli L Ceroni - One of the best experts on this subject based on the ideXlab platform.
-
alcohol use is a risk factor for a first generalized tonic clonic seizure the alc e alcohol and epilepsy study group
Neurology, 1997Co-Authors: M Leone, Ettore Beghi, E Bottacchi, E Morgando, R Mutani, R Cremo, G Amedeo, M Gianelli, Ravagli L CeroniAbstract:We performed a multicenter case-control study to estimate whether chronic alcoholism and alcohol consumption are risk factors for developing a first generalized tonic-clonic seizure (GTCS). We studied 237 first-seizure patients (158 men, 79 women) matched to 474 hospital controls for center, sex, age (+/-5 years), and weekday of the seizure. The risk of first GTCS in alcoholics was greater than in non-alcoholics for men (odds ratio, 6.8; 95% confidence limits, 3.6-13.0) and women (6.8, 1.6-32.6). The odds ratio (both sexes) was 1.2 (0.8-1.8) for an Average Daily Intake of absolute alcohol of 1 to 25 g/day and rose with the amount of alcohol consumed Daily: 1.3 (0.8-2.1) for 26 to 50 g/day, 3.0 (1.7-5.4) for 51 to 100 g/day, 7.9 (2.9-21.9) for 101 to 200 g/day, and 16.6 (1.9-373.4) for >200 g/day. Our study provides evidence of a powerful association between alcohol use, alcoholism, and the first GTCS.
-
alcohol use is a risk factor for a first generalized tonic clonic seizure
Neurology, 1997Co-Authors: M Leone, Ettore Beghi, E Bottacchi, E Morgando, R Mutani, R Cremo, G Amedeo, M Gianelli, Ravagli L CeroniAbstract:We performed a multicenter case-control study to estimate whether chronic alcoholism and alcohol consumption are risk factors for developing a first generalized tonic-clonic seizure (GTCS). We studied 237 first-seizure patients (158 men, 79 women) matched to 474 hospital controls for center, sex, age (+/-5 years), and weekday of the seizure. The risk of first GTCS in alcoholics was greater than in non-alcoholics for men (odds ratio, 6.8; 95% confidence limits, 3.6-13.0) and women (6.8, 1.6-32.6). The odds ratio (both sexes) was 1.2 (0.8-1.8) for an Average Daily Intake of absolute alcohol of 1 to 25 g/day and rose with the amount of alcohol consumed Daily: 1.3 (0.8-2.1) for 26 to 50 g/day, 3.0 (1.7-5.4) for 51 to 100 g/day, 7.9 (2.9-21.9) for 101 to 200 g/day, and 16.6 (1.9-373.4) for >200 g/day. Our study provides evidence of a powerful association between alcohol use, alcoholism, and the first GTCS.
Wouter Hendrikus Hendriks - One of the best experts on this subject based on the ideXlab platform.
-
Quantitation of Maillard reaction products in commercially available pet foods
Journal of Agricultural and Food Chemistry, 2014Co-Authors: Charlotte Van Rooijen, Lucille Alexander, Guido Bosch, A.f.b. Van Der Poel, Peter A. Wierenga, Wouter Hendrikus HendriksAbstract:During processing of pet food, the Maillard reaction occurs, which reduces the bioavailability of essential amino acids such as lysine and results in the formation of advanced Maillard reaction products (MRPs). The aim of this study was to quantitate MRPs (fructoselysine (FL), carboxymethyllysine (CML), hydroxymethylfurfural (HMF)) and the cross-link lysinoalanine (LAL) in commercial pet foods. Sixty-seven extruded, canned, and pelleted dog and cat foods for growth and maintenance were analyzed using UPLC-MS. Canned pet foods contained on Average the most FL, CML, and HMF (4534, 37, and 1417 mg/kg dry matter, respectively) followed by pelleted and extruded foods. Average Daily Intake (mg/kg body weight(0.75)) of HMF is 122 times higher for dogs and 38 times higher for cats than Average Intake for adult humans. As commercial pet foods are most often the only source of food for dogs and cats, future research focus should be on the bioavailability and long-term health implications of MRP consumption by dogs and cats.
-
Quantitation of Maillard Reaction Products in Commercially Available Pet Foods
2014Co-Authors: Charlotte Van Rooijen, Lucille Alexander, Guido Bosch, A.f.b. Van Der Poel, Peter A. Wierenga, Wouter Hendrikus HendriksAbstract:During processing of pet food, the Maillard reaction occurs, which reduces the bioavailability of essential amino acids such as lysine and results in the formation of advanced Maillard reaction products (MRPs). The aim of this study was to quantitate MRPs (fructoselysine (FL), carboxymethyllysine (CML), hydroxymethylfurfural (HMF)) and the cross-link lysinoalanine (LAL) in commercial pet foods. Sixty-seven extruded, canned, and pelleted dog and cat foods for growth and maintenance were analyzed using UPLC-MS. Canned pet foods contained on Average the most FL, CML, and HMF (4534, 37, and 1417 mg/kg dry matter, respectively) followed by pelleted and extruded foods. Average Daily Intake (mg/kg body weight0.75) of HMF is 122 times higher for dogs and 38 times higher for cats than Average Intake for adult humans. As commercial pet foods are most often the only source of food for dogs and cats, future research focus should be on the bioavailability and long-term health implications of MRP consumption by dogs and cats
Kouji H Harada - One of the best experts on this subject based on the ideXlab platform.
-
biological monitoring of human exposure to neonicotinoids using urine samples and neonicotinoid excretion kinetics
PLOS ONE, 2016Co-Authors: Kouji H Harada, Keiko Tanaka, Hiroko Sakamoto, Mie Imanaka, Tamon Niisoe, Toshiaki Hitomi, Hatasu Kobayashi, Hiroko Okuda, Sumiko Inoue, Koichi KusakawaAbstract:Background Neonicotinoids, which are novel pesticides, have entered into usage around the world because they are selectively toxic to arthropods and relatively non-toxic to vertebrates. It has been suggested that several neonicotinoids cause neurodevelopmental toxicity in mammals. The aim was to establish the relationship between oral Intake and urinary excretion of neonicotinoids by humans to facilitate biological monitoring, and to estimate dietary neonicotinoid Intakes by Japanese adults. Methodology/Principal Findings Deuterium-labeled neonicotinoid (acetamiprid, clothianidin, dinotefuran, and imidacloprid) microdoses were orally ingested by nine healthy adults, and 24 h pooled urine samples were collected for 4 consecutive days after dosing. The excretion kinetics were modeled using one- and two-compartment models, then validated in a non-deuterium-labeled neonicotinoid microdose study involving 12 healthy adults. Increased urinary concentrations of labeled neonicotinoids were observed after dosing. Clothianidin was recovered unchanged within 3 days, and most dinotefuran was recovered unchanged within 1 day. Around 10% of the imidacloprid dose was excreted unchanged. Most of the acetamiprid was metabolized to desmethyl-acetamiprid. Spot urine samples from 373 Japanese adults were analyzed for neonicotinoids, and Daily Intakes were estimated. The estimated Average Daily Intake of these neonicotinoids was 0.53–3.66 μg/day. The highest Intake of any of the neonicotinoids in the study population was 64.5 μg/day for dinotefuran, and this was <1% of the acceptable Daily Intake.
-
Biological Monitoring of human exposure to neonicotinoids using urine samples, and neonicotinoid excretion kinetics
PloS one, 2016Co-Authors: Kouji H Harada, Keiko Tanaka, Hiroko Sakamoto, Mie Imanaka, Tamon Niisoe, Toshiaki Hitomi, Hatasu Kobayashi, Hiroko Okuda, Sumiko Inoue, Koichi KusakawaAbstract:Background Neonicotinoids, which are novel pesticides, have entered into usage around the world because they are selectively toxic to arthropods and relatively non-toxic to vertebrates. It has been suggested that several neonicotinoids cause neurodevelopmental toxicity in mammals. The aim was to establish the relationship between oral Intake and urinary excretion of neonicotinoids by humans to facilitate biological monitoring, and to estimate dietary neonicotinoid Intakes by Japanese adults. Methodology/Principal Findings Deuterium-labeled neonicotinoid (acetamiprid, clothianidin, dinotefuran, and imidacloprid) microdoses were orally ingested by nine healthy adults, and 24 h pooled urine samples were collected for 4 consecutive days after dosing. The excretion kinetics were modeled using one- and two-compartment models, then validated in a non-deuterium-labeled neonicotinoid microdose study involving 12 healthy adults. Increased urinary concentrations of labeled neonicotinoids were observed after dosing. Clothianidin was recovered unchanged within 3 days, and most dinotefuran was recovered unchanged within 1 day. Around 10% of the imidacloprid dose was excreted unchanged. Most of the acetamiprid was metabolized to desmethyl-acetamiprid. Spot urine samples from 373 Japanese adults were analyzed for neonicotinoids, and Daily Intakes were estimated. The estimated Average Daily Intake of these neonicotinoids was 0.53–3.66 μg/day. The highest Intake of any of the neonicotinoids in the study population was 64.5 μg/day for dinotefuran, and this was
