The Experts below are selected from a list of 303 Experts worldwide ranked by ideXlab platform
Joseph M. Mylotte - One of the best experts on this subject based on the ideXlab platform.
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Relationships Between Periodontal Disease and Bacterial Pneumonia.
Journal of Periodontology, 1996Co-Authors: Frank A. Scannapieco, Joseph M. MylotteAbstract:Bacterial Pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. The continuing emergence of antibiotic-resistant bacteria (e.g., penicillin-resistant pneumococci) suggests that Bacterial Pneumonia will assume increasing importance in the coming years. Thus, knowledge of the pathogenesis of, and risk factors for, Bacterial Pneumonia is critical to the development of strategies for prevention and treatment of these infections. Bacterial Pneumonia in adults is the result of aspiration of oropharyngeal flora into the lower respiratory tract and failure of host defense mechanisms to eliminate the contaminating bacteria, which multiply in the lung and cause infection. It is recognized that community-acquired Pneumonia and lung abscesses can be the result of infection by anaerobic bacteria; dental plaque would seem to be a logical source of these bacteria, especially in patients with periodontal disease. It is also possible that patients with high risk for Pneumonia, such as hospitalized patients and nursing home residents, are likely to pay less attention to personal hygiene than healthy patients. One important dimension of this personal neglect may be diminished attention to oral hygiene. Poor oral hygiene and periodontal disease may promote oropharyngeal colonization by potential respiratory pathogens (PRPs) including Enterobacteriaceae (Klebsiella Pneumoniae, Escherichia coli, Enterobacter species, etc.), Pseudomonas aeruginosa, and Staphylococcus aureus. This paper provides the rationale for the development of this hypothesis especially as it pertains to mechanically ventilated intensive care unit patients and nursing home residents, two patient groups with a high risk for Bacterial Pneumonia.
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Relationships Between Periodontal Disease and Bacterial Pneumonia.
Journal of periodontology, 1996Co-Authors: Frank A. Scannapieco, Joseph M. MylotteAbstract:Bacterial Pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. The continuing emergence of antibiotic-resistant bacteria (e.g., penicillin-resistant pneumococci) suggests that Bacterial Pneumonia will assume increasing importance in the coming years. Thus, knowledge of the pathogenesis of, and risk factors for, Bacterial Pneumonia is critical to the development of strategies for prevention and treatment of these infections. Bacterial Pneumonia in adults is the result of aspiration of oropharyngeal flora into the lower respiratory tract and failure of host defense mechanisms to eliminate the contaminating bacteria, which multiply in the lung and cause infection. It is recognized that community-acquired Pneumonia and lung abscesses can be the result of infection by anaerobic bacteria; dental plaque would seem to be a logical source of these bacteria, especially in patients with periodontal disease. It is also possible that patients with high risk for Pneumonia, such as hospitalized patients and nursing home residents, are likely to pay less attention to personal hygiene than healthy patients. One important dimension of this personal neglect may be diminished attention to oral hygiene. Poor oral hygiene and periodontal disease may promote oropharyngeal colonization by potential respiratory pathogens (PRPs) including Enterobacteriaceae (Klebsiella Pneumoniae, Escherichia coli, Enterobacter species, etc.), Pseudomonas aeruginosa, and Staphylococcus aureus. This paper provides the rationale for the development of this hypothesis especially as it pertains to mechanically ventilated intensive care unit patients and nursing home residents, two patient groups with a high risk for Bacterial Pneumonia. J Periodontol 1996;67:1114-1122.
Frank A. Scannapieco - One of the best experts on this subject based on the ideXlab platform.
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Relationships Between Periodontal Disease and Bacterial Pneumonia.
Journal of Periodontology, 1996Co-Authors: Frank A. Scannapieco, Joseph M. MylotteAbstract:Bacterial Pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. The continuing emergence of antibiotic-resistant bacteria (e.g., penicillin-resistant pneumococci) suggests that Bacterial Pneumonia will assume increasing importance in the coming years. Thus, knowledge of the pathogenesis of, and risk factors for, Bacterial Pneumonia is critical to the development of strategies for prevention and treatment of these infections. Bacterial Pneumonia in adults is the result of aspiration of oropharyngeal flora into the lower respiratory tract and failure of host defense mechanisms to eliminate the contaminating bacteria, which multiply in the lung and cause infection. It is recognized that community-acquired Pneumonia and lung abscesses can be the result of infection by anaerobic bacteria; dental plaque would seem to be a logical source of these bacteria, especially in patients with periodontal disease. It is also possible that patients with high risk for Pneumonia, such as hospitalized patients and nursing home residents, are likely to pay less attention to personal hygiene than healthy patients. One important dimension of this personal neglect may be diminished attention to oral hygiene. Poor oral hygiene and periodontal disease may promote oropharyngeal colonization by potential respiratory pathogens (PRPs) including Enterobacteriaceae (Klebsiella Pneumoniae, Escherichia coli, Enterobacter species, etc.), Pseudomonas aeruginosa, and Staphylococcus aureus. This paper provides the rationale for the development of this hypothesis especially as it pertains to mechanically ventilated intensive care unit patients and nursing home residents, two patient groups with a high risk for Bacterial Pneumonia.
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Relationships Between Periodontal Disease and Bacterial Pneumonia.
Journal of periodontology, 1996Co-Authors: Frank A. Scannapieco, Joseph M. MylotteAbstract:Bacterial Pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. The continuing emergence of antibiotic-resistant bacteria (e.g., penicillin-resistant pneumococci) suggests that Bacterial Pneumonia will assume increasing importance in the coming years. Thus, knowledge of the pathogenesis of, and risk factors for, Bacterial Pneumonia is critical to the development of strategies for prevention and treatment of these infections. Bacterial Pneumonia in adults is the result of aspiration of oropharyngeal flora into the lower respiratory tract and failure of host defense mechanisms to eliminate the contaminating bacteria, which multiply in the lung and cause infection. It is recognized that community-acquired Pneumonia and lung abscesses can be the result of infection by anaerobic bacteria; dental plaque would seem to be a logical source of these bacteria, especially in patients with periodontal disease. It is also possible that patients with high risk for Pneumonia, such as hospitalized patients and nursing home residents, are likely to pay less attention to personal hygiene than healthy patients. One important dimension of this personal neglect may be diminished attention to oral hygiene. Poor oral hygiene and periodontal disease may promote oropharyngeal colonization by potential respiratory pathogens (PRPs) including Enterobacteriaceae (Klebsiella Pneumoniae, Escherichia coli, Enterobacter species, etc.), Pseudomonas aeruginosa, and Staphylococcus aureus. This paper provides the rationale for the development of this hypothesis especially as it pertains to mechanically ventilated intensive care unit patients and nursing home residents, two patient groups with a high risk for Bacterial Pneumonia. J Periodontol 1996;67:1114-1122.
Jane C. Deng - One of the best experts on this subject based on the ideXlab platform.
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Postviral Complications: Bacterial Pneumonia.
Clinics in chest medicine, 2016Co-Authors: Jason E. Prasso, Jane C. DengAbstract:Secondary Bacterial Pneumonia after viral respiratory infection remains a significant source of morbidity and mortality. Susceptibility is mediated by a variety of viral and Bacterial factors, and complex interactions with the host immune system. Prevention and treatment strategies are limited to influenza vaccination and antibiotics/antivirals respectively. Novel approaches to identifying the individuals with influenza who are at increased risk for secondary Bacterial Pneumonias are urgently needed. Given the threat of further pandemics and the heightened prevalence of these viruses, more research into the immunologic mechanisms of this disease is warranted with the hope of discovering new potential therapies.
Kristin Highland - One of the best experts on this subject based on the ideXlab platform.
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Recognition and management of respiratory co-infection and secondary Bacterial Pneumonia in patients with COVID-19.
Cleveland Clinic journal of medicine, 2020Co-Authors: Fatima Adhi, Kristin HighlandAbstract:In COVID-19, respiratory infection with SARS-CoV-2 plus another virus (viral co-infection) or with SARS-CoV-2 plus a Bacterial pathogen (combined viral and Bacterial Pneumonia) has been described. Secondary Bacterial Pneumonia can follow the initial phase of viral respiratory infection or occur during the recovery phase. No obvious pattern or guidelines exist for viral co-infection, combined viral and Bacterial Pneumonia, or secondary Bacterial Pneumonia in COVID-19. Based on existing clinical data and experience with similar viruses such as influenza and SARS-CoV, the management approach in COVID-19 should, ideally, take into consideration the overall presentation and the trajectory of illness.
Jonathan A Mccullers - One of the best experts on this subject based on the ideXlab platform.
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influenza virus neuraminidase contributes to secondary Bacterial Pneumonia
The Journal of Infectious Diseases, 2005Co-Authors: Ville T Peltola, Gopal K Murti, Jonathan A MccullersAbstract:Secondary Bacterial Pneumonia is a common cause of death during influenza epidemics. We hypothesized that virus-specific factors could contribute to differences in annual excess mortality. Recombinant influenza viruses with neuraminidases from representative strains from the past 50 years were created and characterized. The specific level of their neuraminidase activity correlated with their ability to support secondary Bacterial Pneumonia. Recombinant viruses with neuraminidases from 1957 and 1997 influenza strains had the highest level of activity, whereas a virus with the neuraminidase from a 1968 strain had the lowest level of activity. The high level of activity of the neuraminidase from the 1957 strain, compared with that of other neuraminidases, more strongly supported the adherence of Streptococcus Pneumoniae and the development of secondary Bacterial Pneumonia in a mouse model. These data lend support to our hypothesis that the influenza virus neuraminidase contributes to secondary Bacterial Pneumonia and subsequent excess mortality.