Bacterial Sinusitis - Explore the Science & Experts | ideXlab

Scan Science and Technology

Contact Leading Edge Experts & Companies

Bacterial Sinusitis

The Experts below are selected from a list of 1413 Experts worldwide ranked by ideXlab platform

Ellen R. Wald – 1st expert on this subject based on the ideXlab platform

  • antibiotic recommendations for acute otitis media and acute Bacterial Sinusitis conundrum no more
    Pediatric Infectious Disease Journal, 2018
    Co-Authors: Ellen R. Wald, Gregory P. Demuri

    Abstract:

    There has been a substantial change in the prevalence and microbiologic characteristics of cases of acute otitis media secondary to the widespread use of pneumococcal conjugate vaccines. Current trends in nasopharyngeal colonization and the microbiology of acute otitis media support a change in the recommendation for antibiotic management of acute otitis media and acute Bacterial Sinusitis in children.

  • Microbiology of Acute, Subacute, and Chronic RhinoSinusitis in Children
    Diseases of the Sinuses, 2014
    Co-Authors: Gregory P. Demuri, Ellen R. Wald

    Abstract:

    Acute, subacute, and chronic rhinoSinusitis may involve an infectious etiology. Knowledge of the microbiology of Sinusitis is necessary because it impacts the choice of antibiotic therapy. The sinus aspirate is the most reliable source of microbiological data in Sinusitis in children. However, sinus aspirates are rarely done in cases of patients with rhinoSinusitis; the last time one was done in a child was in 1984. When they are done, sinus aspirate studies of children showed the presence of Streptococcus pneumoniae (S. pneumoniae), Haemophilus influenzae, and Moraxella catarrhalis (M. catarrhalis). Unlike sinus aspirates, nasopharyngeal and middle meatal cultures are not reliable in determining the bacteriology of children with acute Sinusitis. The observation of an increase in the proportion of cases of acute otitis media caused by H. influenzae may reflect that in acute Sinusitis as well. Staphylococcus aureus does not play a significant role in uncomplicated acute Bacterial Sinusitis. The microbiology of acute otitis media can be used as a surrogate for that of acute Bacterial Sinusitis in children. In contrast to bacteria, the contribution of viruses to the pathogenesis of acute Bacterial Sinusitis has not been studied systematically. The pathogenesis of chronic Sinusitis may be related to Bacterial biofilms as a stimulant of chronic inflammation.

  • are nasopharyngeal cultures useful in diagnosis of acute Bacterial Sinusitis in children
    Clinical Pediatrics, 2013
    Co-Authors: Nader Shaikh, Alejandro Hoberman, Kathleen D Colborn, Diana H Kearney, Jong H Jeong, Marcia Kurslasky, Karen A Barbadora, Adelbert Bowen, Lynda L Flom, Ellen R. Wald

    Abstract:

    The diagnosis of acute Bacterial Sinusitis can be challenging because symptoms of acute Sinusitis and an upper respiratory tract infection (URI) overlap. A rapid test, if accurate in differentiating Sinusitis from URI, could be helpful in the diagnostic process. We examined the utility of nasopharyngeal cultures in identifying the subgroup of children with a clinical diagnosis of acute Sinusitis who are least likely to benefit from antimicrobial therapy (those with completely normal sinus radiographs). Nasopharyngeal swabs were collected from 204 children meeting a priori clinical criteria for acute Sinusitis. All children had sinus X-rays at the time of diagnosis. To determine if negative nasopharyngeal culture results could reliably identify the subgroup of children with normal radiographs, we calculated negative predictive values and negative likelihood ratios. Absence of pathogens in the nasopharynx was not helpful in identifying this low-risk subgroup.

Jay Piccirillo – 2nd expert on this subject based on the ideXlab platform

  • psychometric evaluation of the sinonasal outcome test 16 and activity impairment assessment in acute Bacterial Sinusitis
    Otolaryngology-Head and Neck Surgery, 2013
    Co-Authors: N. Quadri, Andrew Lloyd, Karen N. Keating, Beenish Nafees, Jay Piccirillo, D. Wild

    Abstract:

    ObjectiveTo validate the Sinonasal Outcome Test-16 and Activity Impairment Assessment in patients with acute Bacterial Sinusitis.Study DesignData were used from a phase III clinical trial designed to evaluate the efficacy and safety of moxifloxacin 400 mg once daily for 5 consecutive days in the treatment of acute Bacterial Sinusitis. The psychometric properties and factor structure of the 2 measures were assessed.SettingParticipants were given the measures to self-complete using either a telephone voice response system or a paper-and-pencil format.Subjects and MethodsThree hundred seventy-four patients with acute Bacterial Sinusitis were used in the analysis. Patients received either a placebo or 400 mg moxifloxacin once daily. Patients were then reviewed at test of cure and follow-up. All analyses were conducted on a combined sample of placebo and active treatment patients.ResultsThe Sinonasal Outcome Test-16 was associated with minimal missing data at baseline but a higher proportion by test of cure. T…

  • Psychometric evaluation of the Sinonasal Outcome Test-16 and activity impairment assessment in acute Bacterial Sinusitis.
    Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2013
    Co-Authors: N. Quadri, Andrew Lloyd, Karen N. Keating, Beenish Nafees, Jay Piccirillo, D. Wild

    Abstract:

    OBJECTIVE: To validate the Sinonasal Outcome Test-16 and Activity Impairment Assessment in patients with acute Bacterial Sinusitis.\n\nSTUDY DESIGN: Data were used from a phase III clinical trial designed to evaluate the efficacy and safety of moxifloxacin 400 mg once daily for 5 consecutive days in the treatment of acute Bacterial Sinusitis. The psychometric properties and factor structure of the 2 measures were assessed.\n\nSETTING: Participants were given the measures to self-complete using either a telephone voice response system or a paper-and-pencil format.\n\nSUBJECTS AND METHODS: Three hundred seventy-four patients with acute Bacterial Sinusitis were used in the analysis. Patients received either a placebo or 400 mg moxifloxacin once daily. Patients were then reviewed at test of cure and follow-up. All analyses were conducted on a combined sample of placebo and active treatment patients.\n\nRESULTS: The Sinonasal Outcome Test-16 was associated with minimal missing data at baseline but a higher proportion by test of cure. There was no evidence of floor or ceiling effects and no significant skew. The Activity Impairment Assessment also had low missing data at baseline and no obvious floor or ceiling effects, but the data were not normally distributed. Both measures had good internal consistency. Convergent and divergent validity as well as sensitivity and the minimally important difference are also reported.\n\nCONCLUSION: The measures both have good psychometric properties and are suitable for use with patients with acute Bacterial Sinusitis. Both instruments are sensitive. The minimal important difference estimates for the Sinonasal Outcome Test-16 are quite high but are similar to estimates reported previously.

  • acute Bacterial Sinusitis
    The New England Journal of Medicine, 2004
    Co-Authors: Jay Piccirillo

    Abstract:

    A 43-year-old man has a two-week history of nasal congestion, postnasal drip, and fatigue. He has used an over-the-counter nasal decongestant and acetaminophen, without relief. During the past few days, facial pain and pressure have developed and have not responded to decongestants. In addition, his nasal discharge has turned from clear to yellow. How should he be treated?

D. Wild – 3rd expert on this subject based on the ideXlab platform

  • psychometric evaluation of the sinonasal outcome test 16 and activity impairment assessment in acute Bacterial Sinusitis
    Otolaryngology-Head and Neck Surgery, 2013
    Co-Authors: N. Quadri, Andrew Lloyd, Karen N. Keating, Beenish Nafees, Jay Piccirillo, D. Wild

    Abstract:

    ObjectiveTo validate the Sinonasal Outcome Test-16 and Activity Impairment Assessment in patients with acute Bacterial Sinusitis.Study DesignData were used from a phase III clinical trial designed to evaluate the efficacy and safety of moxifloxacin 400 mg once daily for 5 consecutive days in the treatment of acute Bacterial Sinusitis. The psychometric properties and factor structure of the 2 measures were assessed.SettingParticipants were given the measures to self-complete using either a telephone voice response system or a paper-and-pencil format.Subjects and MethodsThree hundred seventy-four patients with acute Bacterial Sinusitis were used in the analysis. Patients received either a placebo or 400 mg moxifloxacin once daily. Patients were then reviewed at test of cure and follow-up. All analyses were conducted on a combined sample of placebo and active treatment patients.ResultsThe Sinonasal Outcome Test-16 was associated with minimal missing data at baseline but a higher proportion by test of cure. T…

  • Psychometric evaluation of the Sinonasal Outcome Test-16 and activity impairment assessment in acute Bacterial Sinusitis.
    Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2013
    Co-Authors: N. Quadri, Andrew Lloyd, Karen N. Keating, Beenish Nafees, Jay Piccirillo, D. Wild

    Abstract:

    OBJECTIVE: To validate the Sinonasal Outcome Test-16 and Activity Impairment Assessment in patients with acute Bacterial Sinusitis.\n\nSTUDY DESIGN: Data were used from a phase III clinical trial designed to evaluate the efficacy and safety of moxifloxacin 400 mg once daily for 5 consecutive days in the treatment of acute Bacterial Sinusitis. The psychometric properties and factor structure of the 2 measures were assessed.\n\nSETTING: Participants were given the measures to self-complete using either a telephone voice response system or a paper-and-pencil format.\n\nSUBJECTS AND METHODS: Three hundred seventy-four patients with acute Bacterial Sinusitis were used in the analysis. Patients received either a placebo or 400 mg moxifloxacin once daily. Patients were then reviewed at test of cure and follow-up. All analyses were conducted on a combined sample of placebo and active treatment patients.\n\nRESULTS: The Sinonasal Outcome Test-16 was associated with minimal missing data at baseline but a higher proportion by test of cure. There was no evidence of floor or ceiling effects and no significant skew. The Activity Impairment Assessment also had low missing data at baseline and no obvious floor or ceiling effects, but the data were not normally distributed. Both measures had good internal consistency. Convergent and divergent validity as well as sensitivity and the minimally important difference are also reported.\n\nCONCLUSION: The measures both have good psychometric properties and are suitable for use with patients with acute Bacterial Sinusitis. Both instruments are sensitive. The minimal important difference estimates for the Sinonasal Outcome Test-16 are quite high but are similar to estimates reported previously.