The Experts below are selected from a list of 570 Experts worldwide ranked by ideXlab platform
Mallikharjuna Rao Lambu - One of the best experts on this subject based on the ideXlab platform.
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Diastereoselective synthesis of highly functionalized cis-1-oxadecalines via 6-endo-tet-cyclizations of 2-C-branched sugars
RSC Advances, 2020Co-Authors: Mallikharjuna Rao Lambu, Debaraj MukherjeeAbstract:Zinc mediated Barbier Reaction of 4-chloro-2-eno-C-allyl pyranoside with aryl aldehydes provided benzylic alcoholic products which underwent FeCl3 catalyzed highly stereoselective 6-endo-tet cyclization giving access to functionalized cis-1-oxadecalins at room temperature.
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Diastereoselective Synthesis of Highly Functionalized cis-1-Oxadecalines via 6-endo-tet-Cyclizations of 2-C-Branched Sugars.
ChemInform, 2015Co-Authors: Mallikharjuna Rao Lambu, Debaraj MukherjeeAbstract:The title compounds (IV) are obtained via zinc mediated Barbier Reaction of pyranosides (I) with aryl aldehydes followed by FeCl3 catalyzed highly stereoselective 6-endo-tet cyclization.
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synthesis of c spiro glycoconjugates from sugar lactones via zinc mediated Barbier Reaction
RSC Advances, 2014Co-Authors: Mallikharjuna Rao Lambu, Altaf Hussain, Deepak Sharma, Syed Khalid Yousuf, Baldev Singh, Anil K Tripathi, Debaraj MukherjeeAbstract:Anomeric gem-diallylation, mono-β-crotylation and mono-β-propargylation of sugar 1,5 and 1,4 lactones have been achieved under Barbier Reaction conditions using Zn powder and a catalytic amount of TMSCl as an activator. Ring closing olefin metathesis of the synthesized gem-diallyl derivatives furnished C-spiro cyclopentene glycosides. Finally, the cyclopentene rings were converted into carbohydrate based tricyclic morpholine fused triazole glycoconjugates as potential SGLT2 inhibitors.
Yoshimaro Kobayashi - One of the best experts on this subject based on the ideXlab platform.
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Diastereoselective synthesis and optical resolution of 3,4-substituted tetrahydroisoquinolin-4-ols
Tetrahedron, 1993Co-Authors: Masaru Kihara, Minoru Kashimoto, Yoshimaro Kobayashi, Motoki Ikeuchi, Kaori Jinno, Yoshimitsu NagaoAbstract:Abstract Trans -3,4-substituted 1,2,3,4-tetrahydroisoquinolin-4-ols were prepared diastereoselectively by an insertion Reaction with zerovalent nickel and by Barbier Reaction with butyllithium of N -(2-iodobenzyl)phenacylamines. The isoquinolin-4-ols were resolved by means of HPLC method and the absolute configurations were determined.
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a convenient synthesis of 4 substituted 1 2 3 4 tetrahydroisoquinolin 4 ols by a novel intramolecular Barbier Reaction and by an insertion Reaction Reaction scope and limitations
Tetrahedron, 1992Co-Authors: Masaru Kihara, Minoru Kashimoto, Yoshimaro KobayashiAbstract:Abstract 4-Substituted 1,2,3,4-tetrahydroisoquinolin-4-ols were prepared from N -(2-iodobenzyl)phenacylamines by an intramolecular Barbier Reaction with butyllithium and by an insertion Reaction with zerovalent nickel. The scope and limitations of these Reactions were discussed.
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A new intramolecular Barbier Reaction of N-(2-iodobenzyl)phenacylamines: A convenient synthesis of 1,2,3,4-tetrahydroisoquinomn-4-ols
Tetrahedron Letters, 1990Co-Authors: Masaru Kihara, Minoru Kashimoto, Yoshimaro Kobayashi, Shigeru KobayashiAbstract:Abstract 4-Phenyl-1,2,3,4-tetrahydroisoquinolin-4-ols were prepared by an intramolecular Barbier Reaction of N-(2-iodobenzyl)phenacylamines with butyllithium in good yields.
Bo Ram Park - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of indenoindene-fused α-methylene-γ-butyrolactones via a tandem intra- and intermolecular Friedel–Crafts Reaction
Tetrahedron Letters, 2011Co-Authors: Bo Ram ParkAbstract:Abstract An efficient synthesis of indenoindene-fused α-methylene-γ-butyrolactones was carried out via a tandem intra- and intermolecular Friedel–Crafts Reaction from the spiro-lactone, which can be easily prepared from ninhydrin by indium-mediated Barbier Reaction of cinnamyl bromide.
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an efficient synthesis of α methylene γ butyrolactones from baylis hillman adducts via an in mediated Barbier Reaction and stereoselective lactonization under meso2cl et3n conditions
Tetrahedron Letters, 2010Co-Authors: Bo Ram ParkAbstract:Abstract An efficient synthesis of trans -α-methylene-γ-butyrolactones is disclosed from syn -homoallylic alcohols via the intramolecular mesylate displacement Reaction promoted by nearby ester group under the influence of MsCl/Et 3 N. syn -Homoallylic alcohols were prepared via the In-mediated Barbier Reaction of the bromides of Baylis–Hillman adducts.
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An efficient synthesis of α-methylene-γ-butyrolactones from Baylis–Hillman adducts via an In-mediated Barbier Reaction and stereoselective lactonization under MeSO2Cl/Et3N conditions
Tetrahedron Letters, 2010Co-Authors: Bo Ram ParkAbstract:Abstract An efficient synthesis of trans -α-methylene-γ-butyrolactones is disclosed from syn -homoallylic alcohols via the intramolecular mesylate displacement Reaction promoted by nearby ester group under the influence of MsCl/Et 3 N. syn -Homoallylic alcohols were prepared via the In-mediated Barbier Reaction of the bromides of Baylis–Hillman adducts.
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facile synthesis of benzofulvene derivatives from baylis hillman adducts in mediated Barbier Reaction combined with pd 0 catalyzed intramolecular heck elimination cascade
ChemInform, 2010Co-Authors: Bo Ram ParkAbstract:Precursors (V), (VIII), and (XI), derived from Baylis—Hillman adducts via bromination, Barbier Reaction with aldehydes and acetylation, are subjected to Pd-catalyzed conditions A) or B).
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Facile Synthesis of Benzofulvene Derivatives from Baylis—Hillman Adducts: In‐Mediated Barbier Reaction Combined with Pd(0)‐Catalyzed Intramolecular Heck‐Elimination Cascade.
ChemInform, 2010Co-Authors: Bo Ram ParkAbstract:Precursors (V), (VIII), and (XI), derived from Baylis—Hillman adducts via bromination, Barbier Reaction with aldehydes and acetylation, are subjected to Pd-catalyzed conditions A) or B).
Masaru Kihara - One of the best experts on this subject based on the ideXlab platform.
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Diastereoselective synthesis and optical resolution of 3,4-substituted tetrahydroisoquinolin-4-ols
Tetrahedron, 1993Co-Authors: Masaru Kihara, Minoru Kashimoto, Yoshimaro Kobayashi, Motoki Ikeuchi, Kaori Jinno, Yoshimitsu NagaoAbstract:Abstract Trans -3,4-substituted 1,2,3,4-tetrahydroisoquinolin-4-ols were prepared diastereoselectively by an insertion Reaction with zerovalent nickel and by Barbier Reaction with butyllithium of N -(2-iodobenzyl)phenacylamines. The isoquinolin-4-ols were resolved by means of HPLC method and the absolute configurations were determined.
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a convenient synthesis of 4 substituted 1 2 3 4 tetrahydroisoquinolin 4 ols by a novel intramolecular Barbier Reaction and by an insertion Reaction Reaction scope and limitations
Tetrahedron, 1992Co-Authors: Masaru Kihara, Minoru Kashimoto, Yoshimaro KobayashiAbstract:Abstract 4-Substituted 1,2,3,4-tetrahydroisoquinolin-4-ols were prepared from N -(2-iodobenzyl)phenacylamines by an intramolecular Barbier Reaction with butyllithium and by an insertion Reaction with zerovalent nickel. The scope and limitations of these Reactions were discussed.
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A new intramolecular Barbier Reaction of N-(2-iodobenzyl)phenacylamines: A convenient synthesis of 1,2,3,4-tetrahydroisoquinomn-4-ols
Tetrahedron Letters, 1990Co-Authors: Masaru Kihara, Minoru Kashimoto, Yoshimaro Kobayashi, Shigeru KobayashiAbstract:Abstract 4-Phenyl-1,2,3,4-tetrahydroisoquinolin-4-ols were prepared by an intramolecular Barbier Reaction of N-(2-iodobenzyl)phenacylamines with butyllithium in good yields.
Debaraj Mukherjee - One of the best experts on this subject based on the ideXlab platform.
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Diastereoselective synthesis of highly functionalized cis-1-oxadecalines via 6-endo-tet-cyclizations of 2-C-branched sugars
RSC Advances, 2020Co-Authors: Mallikharjuna Rao Lambu, Debaraj MukherjeeAbstract:Zinc mediated Barbier Reaction of 4-chloro-2-eno-C-allyl pyranoside with aryl aldehydes provided benzylic alcoholic products which underwent FeCl3 catalyzed highly stereoselective 6-endo-tet cyclization giving access to functionalized cis-1-oxadecalins at room temperature.
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Diastereoselective Synthesis of Highly Functionalized cis-1-Oxadecalines via 6-endo-tet-Cyclizations of 2-C-Branched Sugars.
ChemInform, 2015Co-Authors: Mallikharjuna Rao Lambu, Debaraj MukherjeeAbstract:The title compounds (IV) are obtained via zinc mediated Barbier Reaction of pyranosides (I) with aryl aldehydes followed by FeCl3 catalyzed highly stereoselective 6-endo-tet cyclization.
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synthesis of c spiro glycoconjugates from sugar lactones via zinc mediated Barbier Reaction
RSC Advances, 2014Co-Authors: Mallikharjuna Rao Lambu, Altaf Hussain, Deepak Sharma, Syed Khalid Yousuf, Baldev Singh, Anil K Tripathi, Debaraj MukherjeeAbstract:Anomeric gem-diallylation, mono-β-crotylation and mono-β-propargylation of sugar 1,5 and 1,4 lactones have been achieved under Barbier Reaction conditions using Zn powder and a catalytic amount of TMSCl as an activator. Ring closing olefin metathesis of the synthesized gem-diallyl derivatives furnished C-spiro cyclopentene glycosides. Finally, the cyclopentene rings were converted into carbohydrate based tricyclic morpholine fused triazole glycoconjugates as potential SGLT2 inhibitors.