The Experts below are selected from a list of 225 Experts worldwide ranked by ideXlab platform
Bernhard H. Lauterburg - One of the best experts on this subject based on the ideXlab platform.
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Stimulation of respiration by Methylene blue in rat liver mitochondria
FEBS letters, 1997Co-Authors: Theresa Visarius, Jörg W. Stucki, Bernhard H. LauterburgAbstract:The effect of Methylene blue on isolated rat liver mitochondria in the presence and absence of chloroacetaldehyde was investigated. Fatty acid oxidation was inhibited by chloroacetaldehyde and subsequently stimulated by Methylene blue. Assessment of tightly coupled mitochondria revealed decreasing respiratory control ratios induced by increasing concentrations of Methylene blue and Methylene blue provoked mitochondrial swelling. In uncoupled mitochondria, Methylene blue promoted a concentration-dependent stimulation of respiration. These findings provide evidence that Methylene blue, the redox dye currently used as an antidote for encephalopathy associated with alkylating chemotherapy, uncouples oxidative phosphorylation and acts as an electron transfer mediator to stimulate mitochondrial respiration.
Theresa Visarius - One of the best experts on this subject based on the ideXlab platform.
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Stimulation of respiration by Methylene blue in rat liver mitochondria
FEBS letters, 1997Co-Authors: Theresa Visarius, Jörg W. Stucki, Bernhard H. LauterburgAbstract:The effect of Methylene blue on isolated rat liver mitochondria in the presence and absence of chloroacetaldehyde was investigated. Fatty acid oxidation was inhibited by chloroacetaldehyde and subsequently stimulated by Methylene blue. Assessment of tightly coupled mitochondria revealed decreasing respiratory control ratios induced by increasing concentrations of Methylene blue and Methylene blue provoked mitochondrial swelling. In uncoupled mitochondria, Methylene blue promoted a concentration-dependent stimulation of respiration. These findings provide evidence that Methylene blue, the redox dye currently used as an antidote for encephalopathy associated with alkylating chemotherapy, uncouples oxidative phosphorylation and acts as an electron transfer mediator to stimulate mitochondrial respiration.
Jörg W. Stucki - One of the best experts on this subject based on the ideXlab platform.
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Stimulation of respiration by Methylene blue in rat liver mitochondria
FEBS letters, 1997Co-Authors: Theresa Visarius, Jörg W. Stucki, Bernhard H. LauterburgAbstract:The effect of Methylene blue on isolated rat liver mitochondria in the presence and absence of chloroacetaldehyde was investigated. Fatty acid oxidation was inhibited by chloroacetaldehyde and subsequently stimulated by Methylene blue. Assessment of tightly coupled mitochondria revealed decreasing respiratory control ratios induced by increasing concentrations of Methylene blue and Methylene blue provoked mitochondrial swelling. In uncoupled mitochondria, Methylene blue promoted a concentration-dependent stimulation of respiration. These findings provide evidence that Methylene blue, the redox dye currently used as an antidote for encephalopathy associated with alkylating chemotherapy, uncouples oxidative phosphorylation and acts as an electron transfer mediator to stimulate mitochondrial respiration.
Cherkupally Sanjeeva Reddy - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and Biological Study of Novel Methylene-bis-chalcones and Substituted Methylene-bis-pyrimidines/pyrimidinones.
ChemInform, 2008Co-Authors: Adki Nagaraj, Cherkupally Sanjeeva ReddyAbstract:A series of novel Methylene-bis-chalcones was prepared by the reaction of 5,5′-Methylene-bis-salicylaldehyde with different acetophenones, subsequent treatment of Methylene-bis-chalcones with urea/thiourea gave the corresponding Methylene-bis-pyrimidinones/Methylene-bis-mercaptopyrimidines in good yields. Characterization of the new compounds has been done by means of IR, 1H NMR, MS and elemental analysis. The antibacterial, antitubercular and antifungal activity of the compounds has also been evaluated.
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Synthesis and biological study of novel Methylene‐bis‐chalcones and substituted Methylene‐bis‐pyrimidines/pyrimidinones
Journal of Heterocyclic Chemistry, 2007Co-Authors: Adki Nagaraj, Cherkupally Sanjeeva ReddyAbstract:A series of novel Methylene-bis-chalcones was prepared by the reaction of 5,5′-Methylene-bis-salicylaldehyde with different acetophenones, subsequent treatment of Methylene-bis-chalcones with urea/thiourea gave the corresponding Methylene-bis-pyrimidinones/Methylene-bis-mercaptopyrimidines in good yields. Characterization of the new compounds has been done by means of IR, 1H NMR, MS and elemental analysis. The antibacterial, antitubercular and antifungal activity of the compounds has also been evaluated.
Nathaniel A. Lynd - One of the best experts on this subject based on the ideXlab platform.
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Poly[(ethylene oxide)-co-(Methylene ethylene oxide)]: A hydrolytically degradable poly(ethylene oxide) platform
ACS macro letters, 2012Co-Authors: Pontus Lundberg, Bongjae F. Lee, Sebastiaan A. Van Den Berg, Eric D. Pressly, Annabelle Lee, Craig J. Hawker, Nathaniel A. LyndAbstract:A facile method for imparting hydrolytic degradability to poly(ethylene oxide) (PEO), compatible with current PEGylation strategies, is presented. By incorporating Methylene ethylene oxide (MEO) units into the parent PEO backbone, complete degradation was defined by the molar incorporation of MEO, and the structure of the degradation byproducts was consistent with an acid-catalyzed vinyl-ether hydrolysis mechanism. The hydrolytic degradation of poly[(ethylene oxide)-co-(Methylene ethylene oxide)] was pH-sensitive, with degradation at pH 5 being significantly faster than at pH 7.4 at 37 °C in PBS buffer, while long-term stability could be obtained in either the solid-state or at pH 7.4 at 6 °C.
