The Experts below are selected from a list of 36 Experts worldwide ranked by ideXlab platform
Yan Zhao - One of the best experts on this subject based on the ideXlab platform.
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7-Alkyl Indole Synthesis via a Convenient Formation/Alkylation of Lithionitrobenzenes and an Improved Bartoli Reaction
Synlett, 2002Co-Authors: Michael C. Pirrung, Michael Wedel, Yan ZhaoAbstract:A more convenient and efficient method for metalation/ alkylation of nitrobenzenes to give 2-substituted nitrobenzenes was developed. Their conversion to 7-alkylindoles using the Bartoli Reaction with vinyl magnesium bromide was performed with an improved protocol.
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7 alkyl indole synthesis via a convenient formation alkylation of lithionitrobenzenes and an improved Bartoli Reaction
Synlett, 2002Co-Authors: Michael C. Pirrung, Michael Wedel, Yan ZhaoAbstract:A more convenient and efficient method for metalation/ alkylation of nitrobenzenes to give 2-substituted nitrobenzenes was developed. Their conversion to 7-alkylindoles using the Bartoli Reaction with vinyl magnesium bromide was performed with an improved protocol.
Michael C. Pirrung - One of the best experts on this subject based on the ideXlab platform.
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7-Alkyl Indole Synthesis via a Convenient Formation/Alkylation of Lithionitrobenzenes and an Improved Bartoli Reaction
Synlett, 2002Co-Authors: Michael C. Pirrung, Michael Wedel, Yan ZhaoAbstract:A more convenient and efficient method for metalation/ alkylation of nitrobenzenes to give 2-substituted nitrobenzenes was developed. Their conversion to 7-alkylindoles using the Bartoli Reaction with vinyl magnesium bromide was performed with an improved protocol.
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7 alkyl indole synthesis via a convenient formation alkylation of lithionitrobenzenes and an improved Bartoli Reaction
Synlett, 2002Co-Authors: Michael C. Pirrung, Michael Wedel, Yan ZhaoAbstract:A more convenient and efficient method for metalation/ alkylation of nitrobenzenes to give 2-substituted nitrobenzenes was developed. Their conversion to 7-alkylindoles using the Bartoli Reaction with vinyl magnesium bromide was performed with an improved protocol.
Michael Wedel - One of the best experts on this subject based on the ideXlab platform.
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7-Alkyl Indole Synthesis via a Convenient Formation/Alkylation of Lithionitrobenzenes and an Improved Bartoli Reaction
Synlett, 2002Co-Authors: Michael C. Pirrung, Michael Wedel, Yan ZhaoAbstract:A more convenient and efficient method for metalation/ alkylation of nitrobenzenes to give 2-substituted nitrobenzenes was developed. Their conversion to 7-alkylindoles using the Bartoli Reaction with vinyl magnesium bromide was performed with an improved protocol.
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7 alkyl indole synthesis via a convenient formation alkylation of lithionitrobenzenes and an improved Bartoli Reaction
Synlett, 2002Co-Authors: Michael C. Pirrung, Michael Wedel, Yan ZhaoAbstract:A more convenient and efficient method for metalation/ alkylation of nitrobenzenes to give 2-substituted nitrobenzenes was developed. Their conversion to 7-alkylindoles using the Bartoli Reaction with vinyl magnesium bromide was performed with an improved protocol.
Swen Hoelder - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of Amino-Substituted Indoles Using the Bartoli Reaction.
ChemInform, 2012Co-Authors: Laura Wylie, Paolo Innocenti, Daniel K. Whelligan, Swen HoelderAbstract:Nitroanilines are used for the first time as substrates in the Bartoli Reaction, providing a new method for preparation of aminoindoles.
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Synthesis of amino-substituted indoles using the Bartoli Reaction
Organic & biomolecular chemistry, 2012Co-Authors: Laura Wylie, Paolo Innocenti, Daniel K. Whelligan, Swen HoelderAbstract:We report herein the concise preparation of a range of functionalised aminoindoles via a new application of the Bartoli Reaction. Scope and limitations of the methodology have been extensively studied to reveal the importance of protecting groups and substitution patterns. The use of amino substituted nitroanilines for the Bartoli Reaction is to our knowledge unprecedented. Our work thus represents a novel entry into substituted aminoindoles which are relevant building blocks for both the fine chemical and pharmaceutical industry.
Monica Nardi - One of the best experts on this subject based on the ideXlab platform.
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Applications of Bartoli indole synthesis
Chemical Society Reviews, 2014Co-Authors: Giuseppe Bartoli, Renato Dalpozzo, Monica NardiAbstract:In 1989, the Reaction of vinyl magnesium halides with ortho-substituted nitroarenes leading to indoles was discovered. This Reaction is now frequently reported as the “Bartoli Reaction” or the “Bartoli indole synthesis” (BIS). It has rapidly become the shortest and most flexible route to 7-substituted indoles, because the classical indole syntheses generally fail in their preparation. The flexibility of the Bartoli Reaction is great as it can be extended to heteroaromatic nitro derivatives and can be run on solid support. This review will focus on the use of the Bartoli indole synthesis as the key step in preparations of complex indoles, which appeared in the literature in the last few years.
