Basal Dendrite

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Tracy S Tran - One of the best experts on this subject based on the ideXlab platform.

  • correction corrigendum autism spectrum disorder susceptibility gene taok2 affects Basal Dendrite formation in the neocortex
    Nature Neuroscience, 2014
    Co-Authors: Froylan Calderon De Anda, Ana Lucia Rosario, Tracy S Tran, Omer Durak, Johannes Gräff, Konstantinos Meletis, Damien Rei, Takahiro Soda, Ram Madabhushi, David D. Ginty
    Abstract:

    Nat. Neurosci. 15, 1022–1031 (2012); published online 10 June 2012; corrected after print 9 July 2012 In the version of this article initially published, the scale bar length for Figure 7d was not given. The bar represents 10 μm. The error has been corrected in the HTML and PDF versions of the article.

  • Corrigendum: Autism spectrum disorder susceptibility gene TAOK2 affects Basal Dendrite formation in the neocortex
    Nature Neuroscience, 2014
    Co-Authors: Froylan Calderon De Anda, Ana Lucia Rosario, Tracy S Tran, Omer Durak, Johannes Gräff, Konstantinos Meletis, Damien Rei, Takahiro Soda, Ram Madabhushi, David D. Ginty
    Abstract:

    Corrigendum: Autism spectrum disorder susceptibility gene TAOK2 affects Basal Dendrite formation in the neocortex

  • autism spectrum disorder susceptibility gene taok2 affects Basal Dendrite formation in the neocortex
    Nature Neuroscience, 2012
    Co-Authors: Froylan Calderon De Anda, Ana Lucia Rosario, Tracy S Tran, Omer Durak
    Abstract:

    How neurons develop their morphology is an important question in neurobiology. Here we describe a new pathway that specifically affects the formation of Basal Dendrites and axonal projections in cortical pyramidal neurons. We report that thousand-and-one-amino acid 2 kinase (TAOK2), also known as TAO2, is essential for Dendrite morphogenesis. TAOK2 downregulation impairs Basal Dendrite formation in vivo without affecting apical Dendrites. Moreover, TAOK2 interacts with Neuropilin 1 (Nrp1), a receptor protein that binds the secreted guidance cue Semaphorin 3A (Sema3A). TAOK2 overexpression restores Dendrite formation in cultured cortical neurons from Nrp1(Sema-) mice, which express Nrp1 receptors incapable of binding Sema3A. TAOK2 overexpression also ameliorates the Basal Dendrite impairment resulting from Nrp1 downregulation in vivo. Finally, Sema3A and TAOK2 modulate the formation of Basal Dendrites through the activation of the c-Jun N-terminal kinase (JNK). These results delineate a pathway whereby Sema3A and Nrp1 transduce signals through TAOK2 and JNK to regulate Basal Dendrite development in cortical neurons.

Froylan Calderon De Anda - One of the best experts on this subject based on the ideXlab platform.

  • correction corrigendum autism spectrum disorder susceptibility gene taok2 affects Basal Dendrite formation in the neocortex
    Nature Neuroscience, 2014
    Co-Authors: Froylan Calderon De Anda, Ana Lucia Rosario, Tracy S Tran, Omer Durak, Johannes Gräff, Konstantinos Meletis, Damien Rei, Takahiro Soda, Ram Madabhushi, David D. Ginty
    Abstract:

    Nat. Neurosci. 15, 1022–1031 (2012); published online 10 June 2012; corrected after print 9 July 2012 In the version of this article initially published, the scale bar length for Figure 7d was not given. The bar represents 10 μm. The error has been corrected in the HTML and PDF versions of the article.

  • Corrigendum: Autism spectrum disorder susceptibility gene TAOK2 affects Basal Dendrite formation in the neocortex
    Nature Neuroscience, 2014
    Co-Authors: Froylan Calderon De Anda, Ana Lucia Rosario, Tracy S Tran, Omer Durak, Johannes Gräff, Konstantinos Meletis, Damien Rei, Takahiro Soda, Ram Madabhushi, David D. Ginty
    Abstract:

    Corrigendum: Autism spectrum disorder susceptibility gene TAOK2 affects Basal Dendrite formation in the neocortex

  • autism spectrum disorder susceptibility gene taok2 affects Basal Dendrite formation in the neocortex
    Nature Neuroscience, 2012
    Co-Authors: Froylan Calderon De Anda, Ana Lucia Rosario, Tracy S Tran, Omer Durak
    Abstract:

    How neurons develop their morphology is an important question in neurobiology. Here we describe a new pathway that specifically affects the formation of Basal Dendrites and axonal projections in cortical pyramidal neurons. We report that thousand-and-one-amino acid 2 kinase (TAOK2), also known as TAO2, is essential for Dendrite morphogenesis. TAOK2 downregulation impairs Basal Dendrite formation in vivo without affecting apical Dendrites. Moreover, TAOK2 interacts with Neuropilin 1 (Nrp1), a receptor protein that binds the secreted guidance cue Semaphorin 3A (Sema3A). TAOK2 overexpression restores Dendrite formation in cultured cortical neurons from Nrp1(Sema-) mice, which express Nrp1 receptors incapable of binding Sema3A. TAOK2 overexpression also ameliorates the Basal Dendrite impairment resulting from Nrp1 downregulation in vivo. Finally, Sema3A and TAOK2 modulate the formation of Basal Dendrites through the activation of the c-Jun N-terminal kinase (JNK). These results delineate a pathway whereby Sema3A and Nrp1 transduce signals through TAOK2 and JNK to regulate Basal Dendrite development in cortical neurons.

Omer Durak - One of the best experts on this subject based on the ideXlab platform.

  • correction corrigendum autism spectrum disorder susceptibility gene taok2 affects Basal Dendrite formation in the neocortex
    Nature Neuroscience, 2014
    Co-Authors: Froylan Calderon De Anda, Ana Lucia Rosario, Tracy S Tran, Omer Durak, Johannes Gräff, Konstantinos Meletis, Damien Rei, Takahiro Soda, Ram Madabhushi, David D. Ginty
    Abstract:

    Nat. Neurosci. 15, 1022–1031 (2012); published online 10 June 2012; corrected after print 9 July 2012 In the version of this article initially published, the scale bar length for Figure 7d was not given. The bar represents 10 μm. The error has been corrected in the HTML and PDF versions of the article.

  • Corrigendum: Autism spectrum disorder susceptibility gene TAOK2 affects Basal Dendrite formation in the neocortex
    Nature Neuroscience, 2014
    Co-Authors: Froylan Calderon De Anda, Ana Lucia Rosario, Tracy S Tran, Omer Durak, Johannes Gräff, Konstantinos Meletis, Damien Rei, Takahiro Soda, Ram Madabhushi, David D. Ginty
    Abstract:

    Corrigendum: Autism spectrum disorder susceptibility gene TAOK2 affects Basal Dendrite formation in the neocortex

  • autism spectrum disorder susceptibility gene taok2 affects Basal Dendrite formation in the neocortex
    Nature Neuroscience, 2012
    Co-Authors: Froylan Calderon De Anda, Ana Lucia Rosario, Tracy S Tran, Omer Durak
    Abstract:

    How neurons develop their morphology is an important question in neurobiology. Here we describe a new pathway that specifically affects the formation of Basal Dendrites and axonal projections in cortical pyramidal neurons. We report that thousand-and-one-amino acid 2 kinase (TAOK2), also known as TAO2, is essential for Dendrite morphogenesis. TAOK2 downregulation impairs Basal Dendrite formation in vivo without affecting apical Dendrites. Moreover, TAOK2 interacts with Neuropilin 1 (Nrp1), a receptor protein that binds the secreted guidance cue Semaphorin 3A (Sema3A). TAOK2 overexpression restores Dendrite formation in cultured cortical neurons from Nrp1(Sema-) mice, which express Nrp1 receptors incapable of binding Sema3A. TAOK2 overexpression also ameliorates the Basal Dendrite impairment resulting from Nrp1 downregulation in vivo. Finally, Sema3A and TAOK2 modulate the formation of Basal Dendrites through the activation of the c-Jun N-terminal kinase (JNK). These results delineate a pathway whereby Sema3A and Nrp1 transduce signals through TAOK2 and JNK to regulate Basal Dendrite development in cortical neurons.

Ana Lucia Rosario - One of the best experts on this subject based on the ideXlab platform.

  • correction corrigendum autism spectrum disorder susceptibility gene taok2 affects Basal Dendrite formation in the neocortex
    Nature Neuroscience, 2014
    Co-Authors: Froylan Calderon De Anda, Ana Lucia Rosario, Tracy S Tran, Omer Durak, Johannes Gräff, Konstantinos Meletis, Damien Rei, Takahiro Soda, Ram Madabhushi, David D. Ginty
    Abstract:

    Nat. Neurosci. 15, 1022–1031 (2012); published online 10 June 2012; corrected after print 9 July 2012 In the version of this article initially published, the scale bar length for Figure 7d was not given. The bar represents 10 μm. The error has been corrected in the HTML and PDF versions of the article.

  • Corrigendum: Autism spectrum disorder susceptibility gene TAOK2 affects Basal Dendrite formation in the neocortex
    Nature Neuroscience, 2014
    Co-Authors: Froylan Calderon De Anda, Ana Lucia Rosario, Tracy S Tran, Omer Durak, Johannes Gräff, Konstantinos Meletis, Damien Rei, Takahiro Soda, Ram Madabhushi, David D. Ginty
    Abstract:

    Corrigendum: Autism spectrum disorder susceptibility gene TAOK2 affects Basal Dendrite formation in the neocortex

  • autism spectrum disorder susceptibility gene taok2 affects Basal Dendrite formation in the neocortex
    Nature Neuroscience, 2012
    Co-Authors: Froylan Calderon De Anda, Ana Lucia Rosario, Tracy S Tran, Omer Durak
    Abstract:

    How neurons develop their morphology is an important question in neurobiology. Here we describe a new pathway that specifically affects the formation of Basal Dendrites and axonal projections in cortical pyramidal neurons. We report that thousand-and-one-amino acid 2 kinase (TAOK2), also known as TAO2, is essential for Dendrite morphogenesis. TAOK2 downregulation impairs Basal Dendrite formation in vivo without affecting apical Dendrites. Moreover, TAOK2 interacts with Neuropilin 1 (Nrp1), a receptor protein that binds the secreted guidance cue Semaphorin 3A (Sema3A). TAOK2 overexpression restores Dendrite formation in cultured cortical neurons from Nrp1(Sema-) mice, which express Nrp1 receptors incapable of binding Sema3A. TAOK2 overexpression also ameliorates the Basal Dendrite impairment resulting from Nrp1 downregulation in vivo. Finally, Sema3A and TAOK2 modulate the formation of Basal Dendrites through the activation of the c-Jun N-terminal kinase (JNK). These results delineate a pathway whereby Sema3A and Nrp1 transduce signals through TAOK2 and JNK to regulate Basal Dendrite development in cortical neurons.

David D. Ginty - One of the best experts on this subject based on the ideXlab platform.

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