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Jerilynn C Prior - One of the best experts on this subject based on the ideXlab platform.
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fluid retention over the menstrual cycle 1 year data from the prospective ovulation cohort
Obstetrics and Gynecology International, 2011Co-Authors: Colin P White, Yvette M Vigna, Christine L Hitchcock, Jerilynn C PriorAbstract:We report menstrual and mid-cycle patterns of self-reported “fluid retention” in 765 menstrual cycles in 62 healthy women. Self-reported “fluid retention,” commonly described as bloating, is one element of the clinical assessment and diagnosis of premenstrual symptoms. These daily diary data were collected as part of an observational prospective one-year study of bone changes in healthy women of differing exercise characteristics. Ovulation was documented by quantitative Basal Temperature analysis, and serum estradiol and progesterone levels were available from initial and final cycles. Fluid retention scores (on a 0–4 scale) peaked on the first day of menstrual flow (mean ± SE : ), were lowest during the mid-follicular period, and gradually increased from to over the 11 days surrounding ovulation. Mid-cycle, but not premenstrual, fluid scores tended to be lower in anovulatory cycles (ANOVA ), and scores were higher around menstruation than at midcycle (). Neither estradiol nor progesterone levels were significantly associated with fluid retention scores. The peak day of average fluid retention was the first day of flow. There were no significant differences in women's self-perceived fluid retention between ovulatory and anovulatory cycles.
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detecting evidence of luteal activity by least squares quantitative Basal Temperature analysis against urinary progesterone metabolites and the effect of wake time variability
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2009Co-Authors: Jennifer L Bedford, Jerilynn C Prior, Christine L Hitchcock, Susan I. BarrAbstract:Objective: To assess computerised least-squares analysis of quantitative Basal Temperature (LS-BT) against urinary pregnanediol glucuronide (PdG) as an indirect measure of ovulation, and to evaluate the stability of LS-QBT to wake-time variation. Study design: Cross-sectional study of 40 healthy, normal-weight, regularly menstruating women aged 19–34. Participants recorded Basal Temperature and collected first void urine daily for one complete menstrual cycle. Evidence of luteal activity (ELA), an indirect ovulation indicator, was assessed using Kassam’s PdG algorithm, which identifies a sustained 3-day PdG rise, and the LS-QBT algorithm, by determining whether the Temperature curve is significantly biphasic. Cycles were classified as ELA+ or ELA. We explored the need to pre-screen for wake-time variations by repeating the analysis using: (A) all recorded Temperatures, (B) wake-time adjusted Temperatures, (C) Temperatures within 2 h of average wake-time, and (D) expert reviewed Temperatures. Results: Relative to PdG, classification of cycles as ELA+ was 35 of 36 for LS-QBT methods A and B, 33 of 34 (method C) and 30 of 31 (method D). Classification of cycles as ELA was 1 of 4 (methods A and B) and 0 of 3 (methods C and D). Positive predictive value was 92% for methods A–C and 91% for method D. Negative predictive value was 50% for methods A and B and 0% for methods C and D. Overall accuracy was 90% for methods A and B, 89% for method C and 88% for method D. The day of a significant Temperature increase by LS-QBT and the first day of a sustained PdG rise were correlated (r = 0.803, 0.741, 0.651, 0.747 for methods A–D, respectively, all p < 0.001). Conclusion: LS-QBT showed excellent detection of ELA+ cycles (sensitivity, positive predictive value) but poor detection of ELA cycles (specificity, negative predictive value) relative to urinary PdG. Correlations between the methods and overall accuracy were good and similar for all analyses. Findings suggest that LS-QBT is robust to wake-time variability and that expert interpretation is unnecessary. This method shows promise for use as an epidemiological tool to document cyclic progesterone increase. Further validation relative to daily transvaginal ultrasound is required.
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Cyclicity of breast tenderness and night-time vasomotor symptoms in mid-life women: information collected using the Daily Perimenopause Diary.
Climacteric, 2003Co-Authors: G. E. Hale, Yvette M Vigna, Christine L Hitchcock, L. A. Williams, Jerilynn C PriorAbstract:Objective: The purpose was to explore cyclicity of breast tenderness and vasomotor symptoms in menstruating mid-life women using the Daily Perimenopause Diary. Methods: Untreated mid-life women from a convenience sample completed the Daily Perimenopause Diary for clinical (n = 14) or research (n = 10) assessments. Breast tenderness, sleep disturbance and day and night vasomotor intensity were rated on a 0-4 scale with vasomotor number as a count. Daily oral Temperature data were analyzed using the Quantitative Basal Temperature algorithm to assess ovulation and estimate luteal phase length. Analysis of variance tested cyclicity using the mean of three 3-day windows (during flow, at mid-cycle and premenstrually). Results: Ninety-eight complete flow-to-flow diaries (from 24 women, mean age 47 years, cycle length 27 ± 6.4 (standard deviation) days) were available, with quantitative Temperature data for 60 cycles in 16 women. Of assessed cycles, 90% were ovulatory; 25% had luteal phases < 10 days. Breast tend...
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Medroxyprogesterone increases Basal Temperature: a placebo-controlled crossover trial in postmenopausal women*
Fertility and sterility, 1995Co-Authors: Jerilynn C Prior, Yvette M Vigna, Donald W. Mckay, Susan I. BarrAbstract:Objective To assess whether Temperature is increased by medroxyprogesterone (MPA) and thus whether Basal Temperature records could be used to determine ovulation during cyclic MPA therapy. Design A 2-month double-blind placebo-controlled crossover trial in which oral Basal Temperature was measured daily. Setting Normal human volunteers in an academic medical environment. Subjects Eleven postmenopausal women not taking gonadal hormones. Intervention Medroxyprogesterone acetate (10 mg/d) or placebo, calendar days 16 to 25, with crossover. Main Outcome Measures Comparison of mean Temperature days 17 to 26 during MPA versus placebo; comparison of differences between Temperatures days 7 to 16 and 17 to 26 in MPA versus placebo months; and analysis for a significant monthly thermal shift. Results The mean Temperatures during MPA treatment averaged 0.27°C higher than during the placebo phase and showed a significant change from pretreatment to "treatment" phases during MPA but not during placebo cycles. Eight of the MPA and one of the placebo cycles showed a shift from lower to higher Temperatures days 16 to 25. Conclusion Medroxyprogesterone acetate has a physiological progesterone-like thermal effect. Therefore Basal Temperature data cannot reliably indicate ovulation during cyclic MPA administration.
Isabelle Lagroye - One of the best experts on this subject based on the ideXlab platform.
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Effects of radiofrequency field exposure on proteotoxic-induced and heat-induced HSF1 response in live cells using the bioluminescence resonance energy transfer technique
Cell Stress and Chaperones, 2020Co-Authors: Emmanuelle Poque, Hermanus J. Ruigrok, Delia Arnaud-cormos, Denis Habauzit, Yann Chappe, Catherine Martin, Florence Poulletier De Gannes, Annabelle Hurtier, Andre Garenne, Isabelle LagroyeAbstract:As of today, only acute effects of RF fields have been confirmed to represent a potential health hazard and they are attributed to non-specific heating (≥ 1 °C) under high-level exposure. Yet, the possibility that environmental RF impact living matter in the absence of Temperature elevation needs further investigation. Since HSF1 is both a thermosensor and the master regulator of heat-shock stress response in eukaryotes, it remains to assess HSF1 activation in live cells under exposure to low-level RF signals. We thus measured Basal, Temperature-induced, and chemically induced HSF1 trimerization, a mandatory step on the cascade of HSF1 activation, under RF exposure to continuous wave (CW), Global System for Mobile (GSM), and Wi-Fi-modulated 1800 MHz signals, using a bioluminescence resonance energy transfer technique (BRET) probe. Our results show that, as expected, HSF1 is heat-activated by acute exposure of transiently transfected HEK293T cells to a CW RF field at a specific absorption rate of 24 W/kg for 30 min. However, we found no evidence of HSF1 activation under the same RF exposure condition when the cell culture medium Temperature was fixed. We also found no experimental evidence that, at a fixed Temperature, chronic RF exposure for 24 h at a SAR of 1.5 and 6 W/kg altered the potency or the maximal capability of the proteasome inhibitor MG132 to activate HSF1, whatever signal used. We only found that RF exposure to CW signals (1.5 and 6 W/kg) and GSM signals (1.5 W/kg) for 24 h marginally decreased Basal HSF1 activity.
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Effects of radiofrequency field exposure on proteotoxic-induced and heat-induced HSF1 response in live cells using the bioluminescence resonance energy transfer technique
Cell Stress and Chaperones, 2020Co-Authors: Emmanuelle Poque, Hermanus J. Ruigrok, Delia Arnaud-cormos, Denis Habauzit, Yann Chappe, Catherine Martin, Florence Poulletier De Gannes, Annabelle Hurtier, Andre Garenne, Isabelle LagroyeAbstract:As of today, only acute effects of RF fields have been confirmed to represent a potential health hazard and they are attributed to non-specific heating (>= 1 degrees C) under high-level exposure. Yet, the possibility that environmental RF impact living matter in the absence of Temperature elevation needs further investigation. Since HSF1 is both a thermosensor and the master regulator of heat-shock stress response in eukaryotes, it remains to assess HSF1 activation in live cells under exposure to low-level RF signals. We thus measured Basal, Temperature-induced, and chemically induced HSF1 trimerization, a mandatory step on the cascade of HSF1 activation, under RF exposure to continuous wave (CW), Global System for Mobile (GSM), and Wi-Fi-modulated 1800 MHz signals, using a bioluminescence resonance energy transfer technique (BRET) probe. Our results show that, as expected, HSF1 is heat-activated by acute exposure of transiently transfected HEK293T cells to a CW RF field at a specific absorption rate of 24 W/kg for 30 min. However, we found no evidence of HSF1 activation under the same RF exposure condition when the cell culture medium Temperature was fixed. We also found no experimental evidence that, at a fixed Temperature, chronic RF exposure for 24 h at a SAR of 1.5 and 6 W/kg altered the potency or the maximal capability of the proteasome inhibitor MG132 to activate HSF1, whatever signal used. We only found that RF exposure to CW signals (1.5 and 6 W/kg) and GSM signals (1.5 W/kg) for 24 h marginally decreased Basal HSF1 activity.
Philippe Huybrechts - One of the best experts on this subject based on the ideXlab platform.
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Basal Temperature conditions of the Greenland ice sheet during the glacial cycles
Annals of Glaciology, 1996Co-Authors: Philippe HuybrechtsAbstract:A high-resolution, three-dimensional thermomechanical ice-sheet model, which includes isostasy, the possibility of ice sheet expansion on the continentalshelf and refined climatic parameterisations, was used to investigate the Basal thermal regime of the Greenland ice sheet. The thermodynamic calculations takeinto account the usual terms of heat flow within the ice, a thermal active bedrock layer in transient situations, and all of the effects associated with changes inice thickness and flow pattern. Basal Temperature conditions are documented with respect to glacial-interglacial shifts in climatic boundary conditions, both insteady state as during simulations over the last two glacial cycles using the GRIP d180 record. It is found that the Basal Temperature field shows a largesensitivity in steady state experiments, but that during a glacial cycle, Basal Temperature variations are strongly damped, in particular in central areas. Acomparison has been made with measured data from deep ice cores and implications are discussed.
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Formation and disintegration of the Antarctic ice sheet
Annals of Glaciology, 1994Co-Authors: Philippe HuybrechtsAbstract:A model of the Antarctic ice sheet has been used to simulate the ice sheet in warmer climates, in order to investigate what kind of ice-sheet geometries one can reasonably expect under what kind of climatic conditions and to discover which physical mechanisms may be involved to explain them. The results of these experiments reveal the considerable stability of; in particular, the East Antarctic ice sheet. It would require a Temperature rise of between 17 and 20 K above present levels to remove this ice sheet from the subglacial basins in the interior of the continent and of 25 K to melt down the Antarctic ice sheet completely. For a Temperature rise below 5 K, the model actually predicts a larger Antarctic ice sheet than today as a result of increased snowfall, whereas the west Antarctic ice sheet was round not to survive Temperatures more than 8–10 K above present values. Furthermore, Basal Temperature conditions in these experiments point to the problems involved in raising the base of the ice sheet to the pressure-melting point over the large areas necessary to consider the possibility of sliding instability. These results bear on a lively debate regarding the late Cenozoic glacial history of Antarctica. Particularly, based on these findings, it is difficult to reconcile a highly variable East Antarctic ice sheet until the Pliocene with modest warming recorded in, for instance, the deep-sea records for the late Neogene.
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Formation and disintegration of the Antarctic ice sheet
Annals of Glaciology, 1994Co-Authors: Philippe HuybrechtsAbstract:A model of the Antarctic ice sheet has been used to simulate the ice sheet in warmer climates, in order to investigate what kind of ice sheet geometries one canreasonably expect under what kind of climatic conditions and to find out which physical mechanisms may be involved to explain them. The results of theseexperiments reveal the large stability of, in particular, the East Antarctic ice sheet. It would require a Temperature rise of between 17 and 20K above presentlevels to remove this ice sheet from the subglacial basins in the interior of the continent and of 25K to melt the Antarctic ice sheet completely down. For aTemperature rise below 5K, the model actually predicts a larger Antarctic ice sheet than today as a result of increased snowfall, whereas the West Antarctic icesheet was found not to survive Temperatures more than 8-10K above present values. Furthermore, Basal Temperature conditions in these experiments point tothe problems involved to raise the base to the pressure melting point over the large areas necessary to consider the possibility of sliding instability. Theseresults bear on a lively debate regarding the Late Cenozoic glacial history of Antarctica. In particular, based on these findings it appears difficult to reconcile ahighly variable East Antarctic ice sheet up to the Pliocene with the modest warmings recorded in, for instance, the deep sea records for the Late Neogene.
Emmanuelle Poque - One of the best experts on this subject based on the ideXlab platform.
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Effects of radiofrequency field exposure on proteotoxic-induced and heat-induced HSF1 response in live cells using the bioluminescence resonance energy transfer technique
Cell Stress and Chaperones, 2020Co-Authors: Emmanuelle Poque, Hermanus J. Ruigrok, Delia Arnaud-cormos, Denis Habauzit, Yann Chappe, Catherine Martin, Florence Poulletier De Gannes, Annabelle Hurtier, Andre Garenne, Isabelle LagroyeAbstract:As of today, only acute effects of RF fields have been confirmed to represent a potential health hazard and they are attributed to non-specific heating (≥ 1 °C) under high-level exposure. Yet, the possibility that environmental RF impact living matter in the absence of Temperature elevation needs further investigation. Since HSF1 is both a thermosensor and the master regulator of heat-shock stress response in eukaryotes, it remains to assess HSF1 activation in live cells under exposure to low-level RF signals. We thus measured Basal, Temperature-induced, and chemically induced HSF1 trimerization, a mandatory step on the cascade of HSF1 activation, under RF exposure to continuous wave (CW), Global System for Mobile (GSM), and Wi-Fi-modulated 1800 MHz signals, using a bioluminescence resonance energy transfer technique (BRET) probe. Our results show that, as expected, HSF1 is heat-activated by acute exposure of transiently transfected HEK293T cells to a CW RF field at a specific absorption rate of 24 W/kg for 30 min. However, we found no evidence of HSF1 activation under the same RF exposure condition when the cell culture medium Temperature was fixed. We also found no experimental evidence that, at a fixed Temperature, chronic RF exposure for 24 h at a SAR of 1.5 and 6 W/kg altered the potency or the maximal capability of the proteasome inhibitor MG132 to activate HSF1, whatever signal used. We only found that RF exposure to CW signals (1.5 and 6 W/kg) and GSM signals (1.5 W/kg) for 24 h marginally decreased Basal HSF1 activity.
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Effects of radiofrequency field exposure on proteotoxic-induced and heat-induced HSF1 response in live cells using the bioluminescence resonance energy transfer technique
Cell Stress and Chaperones, 2020Co-Authors: Emmanuelle Poque, Hermanus J. Ruigrok, Delia Arnaud-cormos, Denis Habauzit, Yann Chappe, Catherine Martin, Florence Poulletier De Gannes, Annabelle Hurtier, Andre Garenne, Isabelle LagroyeAbstract:As of today, only acute effects of RF fields have been confirmed to represent a potential health hazard and they are attributed to non-specific heating (>= 1 degrees C) under high-level exposure. Yet, the possibility that environmental RF impact living matter in the absence of Temperature elevation needs further investigation. Since HSF1 is both a thermosensor and the master regulator of heat-shock stress response in eukaryotes, it remains to assess HSF1 activation in live cells under exposure to low-level RF signals. We thus measured Basal, Temperature-induced, and chemically induced HSF1 trimerization, a mandatory step on the cascade of HSF1 activation, under RF exposure to continuous wave (CW), Global System for Mobile (GSM), and Wi-Fi-modulated 1800 MHz signals, using a bioluminescence resonance energy transfer technique (BRET) probe. Our results show that, as expected, HSF1 is heat-activated by acute exposure of transiently transfected HEK293T cells to a CW RF field at a specific absorption rate of 24 W/kg for 30 min. However, we found no evidence of HSF1 activation under the same RF exposure condition when the cell culture medium Temperature was fixed. We also found no experimental evidence that, at a fixed Temperature, chronic RF exposure for 24 h at a SAR of 1.5 and 6 W/kg altered the potency or the maximal capability of the proteasome inhibitor MG132 to activate HSF1, whatever signal used. We only found that RF exposure to CW signals (1.5 and 6 W/kg) and GSM signals (1.5 W/kg) for 24 h marginally decreased Basal HSF1 activity.
Susan I. Barr - One of the best experts on this subject based on the ideXlab platform.
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detecting evidence of luteal activity by least squares quantitative Basal Temperature analysis against urinary progesterone metabolites and the effect of wake time variability
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2009Co-Authors: Jennifer L Bedford, Jerilynn C Prior, Christine L Hitchcock, Susan I. BarrAbstract:Objective: To assess computerised least-squares analysis of quantitative Basal Temperature (LS-BT) against urinary pregnanediol glucuronide (PdG) as an indirect measure of ovulation, and to evaluate the stability of LS-QBT to wake-time variation. Study design: Cross-sectional study of 40 healthy, normal-weight, regularly menstruating women aged 19–34. Participants recorded Basal Temperature and collected first void urine daily for one complete menstrual cycle. Evidence of luteal activity (ELA), an indirect ovulation indicator, was assessed using Kassam’s PdG algorithm, which identifies a sustained 3-day PdG rise, and the LS-QBT algorithm, by determining whether the Temperature curve is significantly biphasic. Cycles were classified as ELA+ or ELA. We explored the need to pre-screen for wake-time variations by repeating the analysis using: (A) all recorded Temperatures, (B) wake-time adjusted Temperatures, (C) Temperatures within 2 h of average wake-time, and (D) expert reviewed Temperatures. Results: Relative to PdG, classification of cycles as ELA+ was 35 of 36 for LS-QBT methods A and B, 33 of 34 (method C) and 30 of 31 (method D). Classification of cycles as ELA was 1 of 4 (methods A and B) and 0 of 3 (methods C and D). Positive predictive value was 92% for methods A–C and 91% for method D. Negative predictive value was 50% for methods A and B and 0% for methods C and D. Overall accuracy was 90% for methods A and B, 89% for method C and 88% for method D. The day of a significant Temperature increase by LS-QBT and the first day of a sustained PdG rise were correlated (r = 0.803, 0.741, 0.651, 0.747 for methods A–D, respectively, all p < 0.001). Conclusion: LS-QBT showed excellent detection of ELA+ cycles (sensitivity, positive predictive value) but poor detection of ELA cycles (specificity, negative predictive value) relative to urinary PdG. Correlations between the methods and overall accuracy were good and similar for all analyses. Findings suggest that LS-QBT is robust to wake-time variability and that expert interpretation is unnecessary. This method shows promise for use as an epidemiological tool to document cyclic progesterone increase. Further validation relative to daily transvaginal ultrasound is required.
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Medroxyprogesterone increases Basal Temperature: a placebo-controlled crossover trial in postmenopausal women*
Fertility and sterility, 1995Co-Authors: Jerilynn C Prior, Yvette M Vigna, Donald W. Mckay, Susan I. BarrAbstract:Objective To assess whether Temperature is increased by medroxyprogesterone (MPA) and thus whether Basal Temperature records could be used to determine ovulation during cyclic MPA therapy. Design A 2-month double-blind placebo-controlled crossover trial in which oral Basal Temperature was measured daily. Setting Normal human volunteers in an academic medical environment. Subjects Eleven postmenopausal women not taking gonadal hormones. Intervention Medroxyprogesterone acetate (10 mg/d) or placebo, calendar days 16 to 25, with crossover. Main Outcome Measures Comparison of mean Temperature days 17 to 26 during MPA versus placebo; comparison of differences between Temperatures days 7 to 16 and 17 to 26 in MPA versus placebo months; and analysis for a significant monthly thermal shift. Results The mean Temperatures during MPA treatment averaged 0.27°C higher than during the placebo phase and showed a significant change from pretreatment to "treatment" phases during MPA but not during placebo cycles. Eight of the MPA and one of the placebo cycles showed a shift from lower to higher Temperatures days 16 to 25. Conclusion Medroxyprogesterone acetate has a physiological progesterone-like thermal effect. Therefore Basal Temperature data cannot reliably indicate ovulation during cyclic MPA administration.
