The Experts below are selected from a list of 76206 Experts worldwide ranked by ideXlab platform
Lea Maria Zanini Maciel - One of the best experts on this subject based on the ideXlab platform.
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hypothalamic pituitary axis and peripheral tissue responses to trh stimulation and liothyronine suppression tests in normal subjects evaluated by current methods
Thyroid, 2008Co-Authors: Gustavo Leopoldo Rodrigues Dare, Margaret De Castro, Lea Maria Zanini MacielAbstract:Objective: To reevaluate the responses of thyrotropin-releasing hormone (TRH) stimulation test in Baseline Condition as well as after the administration of graded supraphysiological doses of liothyronine (L-T3) in normal subjects. Design: To assess various parameters related to the hypothalamic-pituitary axis and peripheral tissue responses to L-T3 in 22 normal individuals (median age: 30.5 years). Subjects were submitted to an intravenous TRH test at Baseline Condition and also to the oral administration of sequential and graded doses of L-T3 (50, 100, and 200 μg/day), each given over 3 days, at an outpatient clinic. Blood samples were obtained for thyrotropin (TSH) and prolactin (PRL) at basal and then 15, 30, and 60 minutes after the TRH injection. Effects of L-T3 administration on cholesterol, creatine kinase, retinol, ferritin, and sex hormone–binding globulin (SHBG) were also measured at basal and after the oral administration of L-T3. Main outcome: TRH administration resulted in an increase of 4- t...
Antti Revonsuo - One of the best experts on this subject based on the ideXlab platform.
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cortex functional connectivity as a neurophysiological correlate of hypnosis an eeg case study
Neuropsychologia, 2007Co-Authors: Andrew A Fingelkurts, Sakari Kallio, Antti RevonsuoAbstract:Cortex functional connectivity associated with hypnosis was investigated in a single highly hypnotizable subject in a normal Baseline Condition and under neutral hypnosis during two sessions separated by a year. After the hypnotic induction, but without further suggestions as compared to the Baseline Condition, all studied parameters of local and remote functional connectivity were significantly changed. The significant differences between hypnosis and the Baseline Condition were observable (to different extent) in five studied independent frequency bands (delta, theta, alpha, beta, and gamma). The results were consistent and stable after 1 year. Based on these findings we conclude that alteration in functional connectivity of the brain may be regarded as a neuronal correlate of hypnosis (at least in very highly hypnotizable subjects) in which separate cognitive modules and subsystems may be temporarily incapable of communicating with each other normally.
Gustavo Leopoldo Rodrigues Dare - One of the best experts on this subject based on the ideXlab platform.
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hypothalamic pituitary axis and peripheral tissue responses to trh stimulation and liothyronine suppression tests in normal subjects evaluated by current methods
Thyroid, 2008Co-Authors: Gustavo Leopoldo Rodrigues Dare, Margaret De Castro, Lea Maria Zanini MacielAbstract:Objective: To reevaluate the responses of thyrotropin-releasing hormone (TRH) stimulation test in Baseline Condition as well as after the administration of graded supraphysiological doses of liothyronine (L-T3) in normal subjects. Design: To assess various parameters related to the hypothalamic-pituitary axis and peripheral tissue responses to L-T3 in 22 normal individuals (median age: 30.5 years). Subjects were submitted to an intravenous TRH test at Baseline Condition and also to the oral administration of sequential and graded doses of L-T3 (50, 100, and 200 μg/day), each given over 3 days, at an outpatient clinic. Blood samples were obtained for thyrotropin (TSH) and prolactin (PRL) at basal and then 15, 30, and 60 minutes after the TRH injection. Effects of L-T3 administration on cholesterol, creatine kinase, retinol, ferritin, and sex hormone–binding globulin (SHBG) were also measured at basal and after the oral administration of L-T3. Main outcome: TRH administration resulted in an increase of 4- t...
Ellen Poliakoff - One of the best experts on this subject based on the ideXlab platform.
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object affordance and spatial compatibility effects in parkinson s disease
Cortex, 2011Co-Authors: Adam Galpin, Jeremy P R Dick, Steven P Tipper, Ellen PoliakoffAbstract:Movement in Parkinson’s disease (PD) is strongly influenced by sensory stimuli. Here, we investigated two features of visual stimuli known to affect response times in healthy individuals; the spatial location of an object (the spatial effect) and its action-relevance (the ‘affordance’ effect). Poliakoff et al. (2007) found that while PD patients show normal spatial effects, they do notshow an additional affordance effect. Hereweinvestigatedwhether these effects are driven by facilitation or inhibition, and whether the affordance effect emerges over a longer time-course in PD. Participants (24 PD and 24 controls) viewed either a lateralise door handle (affordance Condition), a lateralised abstract stimulus (spatial Condition), or a centrally presented Baseline stimulus (Baseline Condition), and responded to a colour change in the stimulus occurring after 0 msec, 500 msec or 1000 msec. The colour change indicated whether to respond with the left or right hand, which were either spatially compatible or incompatible with the lateralised stimulus orientation in the affordance and spatial Conditions. The Baseline Condition allowed us to assess whether compatibility effects were driven by facilitation of the compatible response or inhibition of the incompatible response. The results indicate that stimulus orientation elicited faster responses from the nearest hand. For controls, the affordance effect was stronger and driven by facilitation, whilst the spatial Condition was driven by inhibition. In contrast, the affordance and spatialcompatibility effects did not differ between Conditions in the PD group and both were driven by facilitation. This suggests that the PD group responded as if all stimuli were actionrelevant, and may have implications for understanding the cueing of movement in PD.
Margaret De Castro - One of the best experts on this subject based on the ideXlab platform.
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hypothalamic pituitary axis and peripheral tissue responses to trh stimulation and liothyronine suppression tests in normal subjects evaluated by current methods
Thyroid, 2008Co-Authors: Gustavo Leopoldo Rodrigues Dare, Margaret De Castro, Lea Maria Zanini MacielAbstract:Objective: To reevaluate the responses of thyrotropin-releasing hormone (TRH) stimulation test in Baseline Condition as well as after the administration of graded supraphysiological doses of liothyronine (L-T3) in normal subjects. Design: To assess various parameters related to the hypothalamic-pituitary axis and peripheral tissue responses to L-T3 in 22 normal individuals (median age: 30.5 years). Subjects were submitted to an intravenous TRH test at Baseline Condition and also to the oral administration of sequential and graded doses of L-T3 (50, 100, and 200 μg/day), each given over 3 days, at an outpatient clinic. Blood samples were obtained for thyrotropin (TSH) and prolactin (PRL) at basal and then 15, 30, and 60 minutes after the TRH injection. Effects of L-T3 administration on cholesterol, creatine kinase, retinol, ferritin, and sex hormone–binding globulin (SHBG) were also measured at basal and after the oral administration of L-T3. Main outcome: TRH administration resulted in an increase of 4- t...
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Hypothalamic-pituitary axis and peripheral tissue responses to TRH stimulation and Liothyronine suppression tests in normal subjects evaluated by current methods
MARY ANN LIEBERT INC, 2008Co-Authors: Dare, Gustavo Leopoldo Rodrigues, Margaret De Castro, Maciel, Lea Maria ZaniniAbstract:Objective: To reevaluate the responses of thyrotropin-releasing hormone ( TRH) stimulation test in Baseline Condition as well as after the administration of graded supraphysiological doses of liothyronine ( L- T-3) in normal subjects. Design: To assess various parameters related to the hypothalamic-pituitary axis and peripheral tissue responses to L- T-3 in 22 normal individuals ( median age: 30.5 years). Subjects were submitted to an intravenous TRH test at Baseline Condition and also to the oral administration of sequential and graded doses of L- T-3 ( 50, 100, and 200 mu g/day), each given over 3 days, at an outpatient clinic. Blood samples were obtained for thyrotropin (TSH) and prolactin (PRL) at basal and then 15, 30, and 60 minutes after the TRH injection. Effects of L- T3 administration on cholesterol, creatine kinase, retinol, ferritin, and sex hormone-binding globulin ( SHBG) were also measured at basal and after the oral administration of L- T-3. Main outcome: TRH administration resulted in an increase of 4-to 14-fold rise in serum TSH ( 8.3 +/- 2.5-fold), and in a slight rise in serum PRL concentrations ( 3.8 +/- 1.5-fold). Administration of graded doses of triiodothyronine ( T-3) resulted in a dose-dependent suppression of TSH and PRL. Basal thyroxine- binding globulin (TBG) and cholesterol levels decreased, and ferritin and SHBG increased after L- T-3 administration, while creatine kinase and retinol did not change throughout the study. There was a positive correlation between basal TSH and TSH peak response to TRH at basal Condition and after each sequential L- T-3 doses. On the other hand, TSH peak response to the TRH test did not predict cholesterol, TBG, ferritin, or SHBG values. Conclusion: Using the current methods on hormone and biochemical analysis, we standardized the response of many parameters to TRH stimulation test after sequential and graded T-3 suppression test in normal subjects. Our data suggest that the evaluation of the responses of the hypothalamus-pituitary axis to TRH test as well as the impact of L- T-3 on peripheral tissues were not modified by the current methods
