The Experts below are selected from a list of 189 Experts worldwide ranked by ideXlab platform
Naglaa M Kamal - One of the best experts on this subject based on the ideXlab platform.
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gastrointestinal Basidiobolomycosis an emerging fungal infection causing bowel perforation in a child
Journal of Medical Microbiology, 2011Co-Authors: Mortada Elshabrawi, Naglaa M Kamal, Riyadh Jouini, Abdullah Alharbi, Kerstin Voigt, Talal AlmalkiAbstract:Basidiobolomycosis is an unusual fungal skin infection that rarely involves the gastrointestinal (GI) tract. We report a 10-year-old boy diagnosed as suffering GI Basidiobolomycosis after being misdiagnosed first as suffering intestinal malignancy then schistosomiasis. The patient presented with fever, abdominal pain, vomiting, abdominal tenderness and rigidity with marked blood eosinophilia. Abdominal ultrasonographic and computed tomographic scans revealed a large caecal mass. Biopsy of the mass showed transmural granulomatous inflammation interpreted as schistosomal granuloma, ruling out lymphoma. The patient’s condition deteriorated despite anti-schistosomal therapy. Emergency surgery was then performed, and caecal perforation was found. The mass was excised; cultures were negative and histopathological examination was suggestive of schistosomal granuloma. The mass recurred 3 weeks post-operatively. Second-opinion histopathological examination diagnosed Basidiobolus ranarum infection. Treatment with itraconazole produced marked improvement, with diminution of the mass. B. ranarum was unequivocally identified in the archival formalin-fixed and paraffin-embedded (FFPE) tissue by PCR. This case emphasizes the need to consider GI Basidiobolomycosis in children presenting with fever, abdominal mass and eosinophilia, especially those complicated by bowel perforation.
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gastrointestinal Basidiobolomycosis in children an overlooked emerging infection
Journal of Medical Microbiology, 2011Co-Authors: Mortada Elshabrawi, Naglaa M KamalAbstract:Basidiobolus ranarum is a known cause of chronic subcutaneous zygomycosis. During the past decade, many cases have been reported with extracutaneous Basidiobolomycosis. We aimed to review the medical literature on gastrointestinal Basidiobolomycosis (GIB) as an emerging fungal infection causing a serious, and occasionally fatal, paediatric disease. We reviewed all reported cases of visceral Basidiobolomycosis with special focus on the gastrointestinal involvement in children. Twenty-six cases of GIB have been reported worldwide, in 14 adults and 12 children. All cases presented with fever, abdominal pain with mass and high blood eosinophilia and were misdiagnosed as other chronic granulomatous diseases or malignancies. A few cases of retroperitoneal, pulmonary, nasal and disseminated Basidiobolomycosis have also been reported. Basidiobolomycosis mostly affects young males as a subcutaneous infection. The visceral form of infection is rare. GIB has been scarcely reported in the medical literature, but recently it has been increasingly recognized. GIB poses diagnostic difficulties. Abdominal pain with mass and eosinophilia were present in all cases, highlighting the necessity of considering GIB in the differential diagnosis of this presentation. B. ranarum has been reported to cause disseminated fatal disease in both immune-competent and -compromised individuals. Culture is the gold standard for diagnosis, but the characteristic histopathological picture of chronic granulomas rich in eosinophils and the Splendore-Hoeppli phenomenon are the usual diagnostic tools. Surgery plus long courses of itraconazole treatment, up to 1 year, appear to be the best management options. GIB is an emerging infection that might lead to diagnostic confusion, morbidity and mortality. Diagnosis requires a high index of suspicion in the differential diagnosis of patients with fever, abdominal pain with mass and eosinophilia.
Mortada Elshabrawi - One of the best experts on this subject based on the ideXlab platform.
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gastrointestinal Basidiobolomycosis an emerging fungal infection causing bowel perforation in a child
Journal of Medical Microbiology, 2011Co-Authors: Mortada Elshabrawi, Naglaa M Kamal, Riyadh Jouini, Abdullah Alharbi, Kerstin Voigt, Talal AlmalkiAbstract:Basidiobolomycosis is an unusual fungal skin infection that rarely involves the gastrointestinal (GI) tract. We report a 10-year-old boy diagnosed as suffering GI Basidiobolomycosis after being misdiagnosed first as suffering intestinal malignancy then schistosomiasis. The patient presented with fever, abdominal pain, vomiting, abdominal tenderness and rigidity with marked blood eosinophilia. Abdominal ultrasonographic and computed tomographic scans revealed a large caecal mass. Biopsy of the mass showed transmural granulomatous inflammation interpreted as schistosomal granuloma, ruling out lymphoma. The patient’s condition deteriorated despite anti-schistosomal therapy. Emergency surgery was then performed, and caecal perforation was found. The mass was excised; cultures were negative and histopathological examination was suggestive of schistosomal granuloma. The mass recurred 3 weeks post-operatively. Second-opinion histopathological examination diagnosed Basidiobolus ranarum infection. Treatment with itraconazole produced marked improvement, with diminution of the mass. B. ranarum was unequivocally identified in the archival formalin-fixed and paraffin-embedded (FFPE) tissue by PCR. This case emphasizes the need to consider GI Basidiobolomycosis in children presenting with fever, abdominal mass and eosinophilia, especially those complicated by bowel perforation.
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gastrointestinal Basidiobolomycosis in children an overlooked emerging infection
Journal of Medical Microbiology, 2011Co-Authors: Mortada Elshabrawi, Naglaa M KamalAbstract:Basidiobolus ranarum is a known cause of chronic subcutaneous zygomycosis. During the past decade, many cases have been reported with extracutaneous Basidiobolomycosis. We aimed to review the medical literature on gastrointestinal Basidiobolomycosis (GIB) as an emerging fungal infection causing a serious, and occasionally fatal, paediatric disease. We reviewed all reported cases of visceral Basidiobolomycosis with special focus on the gastrointestinal involvement in children. Twenty-six cases of GIB have been reported worldwide, in 14 adults and 12 children. All cases presented with fever, abdominal pain with mass and high blood eosinophilia and were misdiagnosed as other chronic granulomatous diseases or malignancies. A few cases of retroperitoneal, pulmonary, nasal and disseminated Basidiobolomycosis have also been reported. Basidiobolomycosis mostly affects young males as a subcutaneous infection. The visceral form of infection is rare. GIB has been scarcely reported in the medical literature, but recently it has been increasingly recognized. GIB poses diagnostic difficulties. Abdominal pain with mass and eosinophilia were present in all cases, highlighting the necessity of considering GIB in the differential diagnosis of this presentation. B. ranarum has been reported to cause disseminated fatal disease in both immune-competent and -compromised individuals. Culture is the gold standard for diagnosis, but the characteristic histopathological picture of chronic granulomas rich in eosinophils and the Splendore-Hoeppli phenomenon are the usual diagnostic tools. Surgery plus long courses of itraconazole treatment, up to 1 year, appear to be the best management options. GIB is an emerging infection that might lead to diagnostic confusion, morbidity and mortality. Diagnosis requires a high index of suspicion in the differential diagnosis of patients with fever, abdominal pain with mass and eosinophilia.
Carlos Ignacio Gomez - One of the best experts on this subject based on the ideXlab platform.
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infeccion orofacial por conidiobolus coronatus
Biomedica, 2016Co-Authors: Diana Carolina Moncada, Melisa Montes, Jorge Byron Velasquez, Veronica Molina, Carlos Ignacio GomezAbstract:La entomoftoromicosis es un tipo de micosis subcutanea en el cual se incluyen la basidiobolomicosis y la conidiobolomicosis; esta ultima es causada principalmente por Conidiobolus coronatus , un hongo saprobio que habita el suelo en paises tropicales y genera una afeccion rinofacial que compromete los tejidos blandos de la cara, los senos paranasales y la orofaringe, y tiene la capacidad de deformar el rostro en personas sin inmunodeficiencia aparente. La infeccion tiene un curso cronico con tendencia a la formacion de granulomas que se pueden observar en el estudio histopatologico. Se presenta el caso de un agricultor de 28 anos con un cuadro clinico de tumefaccion rinofacial, obstruccion nasal y escurrimiento posterior, de seis meses de evolucion, a quien se le diagnostico conidiobolomicosis a partir de un cultivo de tejido despues de multiples biopsias de tejidos del area facial. El paciente recibio tratamiento antifungico con anfotericina B y posteriomente con itraconazol, con lo cual su mejoria fue notable, por lo que no requirio tratamiento quirurgico. El tratamiento con itraconazol se extendio por un ano, al cabo del cual no habia evidencia de recaida. Dada la poca frecuencia de esta enfermedad, no hay una estrategia de tratamiento establecida; sin embargo, el uso de azoles, como el itraconazol, se senala cada vez mas en los diferentes reportes de caso, haya habido tratamiento quirurgico adyuvante o no. En este reporte de caso se describe, ademas, la respuesta clinica y terapeutica a largo plazo de esta micosis infrecuente en Colombia.
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Infección orofacial por Conidiobolus coronatus
Biomedica : revista del Instituto Nacional de Salud, 2016Co-Authors: Diana Carolina Moncada, Melisa Montes, Jorge Byron Velasquez, Veronica Molina, Carlos Ignacio GomezAbstract:Entomophtoramycosis is a type of subcutaneous mycosis which includes both Basidiobolomycosis and conidiobolomycosis; the latter is caused by Conidiobolus coronatus, a saprophytic fungus which lives in tropical soils. This mycosis characteristically affects the paranasal sinuses and oropharynx, with the potential to deform the face in patients without apparent immunodeficiency. It has a chronic course of infection with a tendency to form granulomas visible using histology. We present the case of a 28 year-old male agricultural worker, with a clinical profile of 6 months' evolution of rhinofacial tumefaction, nasal obstruction and post-nasal drip who was diagnosed with conidiobolomycosis by means of tissue culture after multiple biopsies of the facial area. The patient received antifungal treatment with amphotericin B and subsequently with itraconazol, resulting in a dramatic improvement without the need for surgical treatment; itraconazol was administered for one year and there was no evidence of relapse at the end of this period. Due to the low frequency of this disease there is no established treatment strategy; however, the use of azoles such as itraconazol with or without adjuvant surgical treatment is increasingly seen in case reports. The present report adds to the clinical experience in Colombia of this rare mycosis and also describes the long-term clinical and therapeutic response.
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infeccion orofacial por conidiobolus coronatus reporte de caso
Biomedica, 2016Co-Authors: Diana Carolina Moncada, Melisa Montes, Jorge Byron Velasquez, Veronica Molina, Carlos Ignacio GomezAbstract:Entomophtoramycosis is a kind of subcutaneous mycosis, include both Basidiobolomycosis and conidiobolomycosis; last one is caused by Conidiobolus coronatus a saprophytic fungus that inhabits of the soil of the tropical countries. Typically this mycosis involves rhinofacial, soft tissues of the face, sinuses and oropharynx, with a potential capacity of deforming. Usually it’s happening in immunocompetent patients and it has a chronic course and in the histology granulomas are shaped. We report the case of a 28-year-old farmer with a clinical picture of 6 months of evolution of rhinofacial swelling, nasal obstruction and subsequent runoff; Diagnosis of conodiobolomycoses was made through tissue culture after multiple biopsies of the facial area. He received antifungal treatment with amphotericin B and after were changed by itraconazole with dramatic improvement without requiring surgery, treatment was extended for one year and at the end there was no evidence of relapse. There is no clear strategy of treatment because of the low frequency of this disease, however the use of azoles such as itraconazole is increasing with or without adjuvant surgical treatment. This case report is attached to the clinical experience in Colombia about this rare mycosis and describes the clinical and therapeutic response to long time.
Ahmad T Ghanem - One of the best experts on this subject based on the ideXlab platform.
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gastrointestinal Basidiobolomycosis in a child an unusual fungal infection mimicking fistulising crohn s disease
Journal of Crohn's and Colitis, 2012Co-Authors: Omar I Saadah, Mohammad F Farouq, Nawaf Al Daajani, Jamal S Kamal, Ahmad T GhanemAbstract:Background: Gastrointestinal Basidiobolomycosis is a rare disease caused by the fungus Basidiobolus ranarum. It has been reported in both children and adults. The disease mainly affects the colon and the small bowel; however, cases of the stomach, liver, pancreas, and renal system being affected have been reported. Case report: A 2 year old boy presented with the following symptoms; abdominal pain, vomiting, diarrhea, fever and palpable right iliac fossa mass. Laboratory investigations revealed elevated inflammatory markers and peripheraleosinophilia. Colonoscopy showedseverely inflamed mucosa of the terminal ileum, cecum and ascending colon. CT scan of the abdomen demonstrated an inflammatory mass with wall thickening of the terminal ileum and the colon. Surgical exploration demonstrated retroperitoneal mass and inflamed terminal ileum, cecum and ascending colon. Upon laparotomy, multiple internal fistulas involving the bowel loops, the urinary bladder, the right ureter and the gallbladder were observed. Further investigations using histopathology of the resected diseased bowel showed extensive necrosis, multinucleated giant cells and numerous eosinophils and large fungal hyphae surrounded by strongly eosinophilic material were seen in the tissue suggestive of B. ranarum infection. The patient responded well to treatment with voriconazole.
Talal Almalki - One of the best experts on this subject based on the ideXlab platform.
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gastrointestinal Basidiobolomycosis an emerging fungal infection causing bowel perforation in a child
Journal of Medical Microbiology, 2011Co-Authors: Mortada Elshabrawi, Naglaa M Kamal, Riyadh Jouini, Abdullah Alharbi, Kerstin Voigt, Talal AlmalkiAbstract:Basidiobolomycosis is an unusual fungal skin infection that rarely involves the gastrointestinal (GI) tract. We report a 10-year-old boy diagnosed as suffering GI Basidiobolomycosis after being misdiagnosed first as suffering intestinal malignancy then schistosomiasis. The patient presented with fever, abdominal pain, vomiting, abdominal tenderness and rigidity with marked blood eosinophilia. Abdominal ultrasonographic and computed tomographic scans revealed a large caecal mass. Biopsy of the mass showed transmural granulomatous inflammation interpreted as schistosomal granuloma, ruling out lymphoma. The patient’s condition deteriorated despite anti-schistosomal therapy. Emergency surgery was then performed, and caecal perforation was found. The mass was excised; cultures were negative and histopathological examination was suggestive of schistosomal granuloma. The mass recurred 3 weeks post-operatively. Second-opinion histopathological examination diagnosed Basidiobolus ranarum infection. Treatment with itraconazole produced marked improvement, with diminution of the mass. B. ranarum was unequivocally identified in the archival formalin-fixed and paraffin-embedded (FFPE) tissue by PCR. This case emphasizes the need to consider GI Basidiobolomycosis in children presenting with fever, abdominal mass and eosinophilia, especially those complicated by bowel perforation.