The Experts below are selected from a list of 10062 Experts worldwide ranked by ideXlab platform
Claudia Schmidtdannert - One of the best experts on this subject based on the ideXlab platform.
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biocatalytic portfolio of Basidiomycota
Current Opinion in Chemical Biology, 2016Co-Authors: Claudia SchmidtdannertAbstract:Basidiomycota fungi have received little attention for applications in biocatalysis and biotechnology and remain greatly understudied despite their importance for carbon recycling, ecosystem functioning and medicinal properties. The steady influx of genome data has facilitated detailed studies aimed at understanding the evolution and function of fungal lignocellulose degradation. These studies and recent explorations into the secondary metabolomes have uncovered large portfolios of enzymes useful for biocatalysis and biosynthesis. This review will provide an overview of the biocatalytic repertoires of Basidiomycota characterized to date with the hope of motivation more research into the chemical toolkits of this diverse group of fungi.
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draft genome of omphalotus olearius provides a predictive framework for sesquiterpenoid natural product biosynthesis in Basidiomycota
Chemistry & Biology, 2012Co-Authors: Grayson Thomas Wawrzyn, Swati Choudhary, Maureen B. Quin, Fernando Lopezgallego, Claudia SchmidtdannertAbstract:Summary The secondary metabolome of Basidiomycota represents a largely uncharacterized source of pharmaceutically relevant natural products. Terpenoids are the primary class of bioactive compounds isolated from mushrooms. The Jack O'Lantern mushroom Omphalotus olearius was identified 50 years ago as a prolific producer of anticancer illudin sesquiterpenoids; however, to date there have been exceptionally few studies into the biosynthesis of these important compounds. Here, we report the draft genome sequence of O. olearius , which reveals a diverse network of sesquiterpene synthases and two metabolic gene clusters associated with illudin biosynthesis. Characterization of the sesquiterpene synthases enabled a comprehensive survey of all currently available Basidiomycota genomes, thereby creating a predictive resource for terpenoid natural product biosynthesis in these organisms. Our results will facilitate discovery and biosynthetic production of unique pharmaceutically relevant bioactive compounds from Basidiomycota.
Jaya Seelan Sathiya Seelan - One of the best experts on this subject based on the ideXlab platform.
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New Species of Termitomyces (Lyophyllaceae, Basidiomycota) from Sabah (Northern Borneo), Malaysia
Mycobiology, 2020Co-Authors: Jaya Seelan Sathiya Seelan, Mahadimenakbar Mohamed Dawood, Myung Soo ParkAbstract:AbstractThe genus Termitomyces (Lyophyllaceae, Basidiomycota) is often associated with fungus-feeding termites (Macrotermitinae) due to their strong symbiotic relationships. The genus is widely fou...
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new species of termitomyces lyophyllaceae Basidiomycota from sabah northern borneo malaysia
Mycobiology, 2020Co-Authors: Jaya Seelan Sathiya Seelan, Mahadimenakbar Mohamed Dawood, Myung Soo ParkAbstract:The genus Termitomyces (Lyophyllaceae, Basidiomycota) is often associated with fungus-feeding termites (Macrotermitinae) due to their strong symbiotic relationships. The genus is widely found exclu...
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Revision of Protohydnum (Auriculariales, Basidiomycota)
Mycological Progress, 2018Co-Authors: Vera Malysheva, Jaya Seelan Sathiya Seelan, Viacheslav Spirin, Otto Miettinen, Viviana Motato-vásquez, Karl-henrik LarssonAbstract:Three species currently addressed to Protohydnum ( Auriculariales ) are studied with morphological and DNA methods. The genus Protohydnum is retained for the type species only, P. cartilagineum , recently re-collected in Brazil. The European species, P. piceicola , is not congeneric with P. cartilagineum and, therefore, placed in its own genus, Hyalodon , gen. nov. Another Hyalodon species, H. antui , is described from East Asia. The third member of Protohydnum sensu lato, P. sclerodontium from South-East Asia, is transferred to Elmerina .
Karl-henrik Larsson - One of the best experts on this subject based on the ideXlab platform.
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On Protomerulius and Heterochaetella (Auriculariales, Basidiomycota)
Mycological Progress, 2019Co-Authors: Viacheslav Spirin, Renato Lúcio Mendes Alvarenga, Vera Malysheva, Tatiana Baptista Gibertoni, Leif Ryvarden, Josef Vlasák, Otto Miettinen, Karl-henrik LarssonAbstract:The taxonomy of Protomerulius and Heterochaetella is revised based on DNA data and morphological evidence, and their type species, P. brasiliensis and H. dubia , are proved to be congeneric. As a consequence, H. dubia and related species, of which four are described as new, are placed in Protomerulius . Heterochaete microspora is also combined in Protomerulius , and the genus concept is redefined to encompass effused species with smooth or spiny hymenophore and monomitic hyphal structure. Psilochaete multifora , gen. and spec. nov. is a distant relative of Protomerulius spp. found in Norway. Heterochaetella cystidiophora is re-collected in Brazil and placed in the synonyms of Heterochaete sanctae-catharinae . This species does not belong to the Protomerulius–Heterochaetella lineage, and it is transferred to Metulochaete , gen. nov.
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Two new genera and six other novelties in Heterochaete sensu lato (Auriculariales, Basidiomycota)
Botany, 2019Co-Authors: Renato Lúcio Mendes Alvarenga, Viacheslav Spirin, Vera Malysheva, Tatiana Baptista Gibertoni, Karl-henrik LarssonAbstract:The genus Heterochaete (Auriculariales, Basidiomycota) is traditionally defined as comprising resupinate fungal species with sterile spines (hyphal pegs) that are distributed on hymenial surface. R...
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Revision of Protohydnum (Auriculariales, Basidiomycota)
Mycological Progress, 2018Co-Authors: Vera Malysheva, Jaya Seelan Sathiya Seelan, Viacheslav Spirin, Otto Miettinen, Viviana Motato-vásquez, Karl-henrik LarssonAbstract:Three species currently addressed to Protohydnum ( Auriculariales ) are studied with morphological and DNA methods. The genus Protohydnum is retained for the type species only, P. cartilagineum , recently re-collected in Brazil. The European species, P. piceicola , is not congeneric with P. cartilagineum and, therefore, placed in its own genus, Hyalodon , gen. nov. Another Hyalodon species, H. antui , is described from East Asia. The third member of Protohydnum sensu lato, P. sclerodontium from South-East Asia, is transferred to Elmerina .
Maureen B. Quin - One of the best experts on this subject based on the ideXlab platform.
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Mushroom hunting by using bioinformatics: Application of a predictive framework facilitates the selective identification of sesquiterpene synthases in Basidiomycota
ChemBioChem, 2013Co-Authors: Maureen B. Quin, Christopher M. Flynn, Swati Choudhary, Grayson Thomas Wawrzyn, C. Schmidt-dannertAbstract:The Basidiomycota fungi represent a diverse source of natural products, particularly the sesquiterpenoids. Recently, genome sequencing, genome mining, and the subsequent discovery of a suite of sesquiterpene synthases in Omphalotus olearius was described. A predictive framework was developed to facilitate the discovery of sesquiterpene synthases in Basidiomycota. Phylogenetic analyses indicated a conservation of both sequence and initial cyclization mechanisms used. Here, the first robust application of this predictive framework is reported. It was used to selectively identify sesquiterpene synthases that follow 1,6-, 1,10-, and 1,11-cyclization mechanisms in the crust fungus Stereum hirsutum. The successful identification and characterization of a 1,6- and a 1,10-cyclizing sesquiterpene synthase, as well as three 1,11-cyclizing Δ(6) -protoilludene synthases, is described. This study verifies the accuracy and utility of the predictive framework as a roadmap for the discovery of specific sesquiterpene synthases from Basidiomycota, and thus represents an important step forward in natural product discovery.
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draft genome of omphalotus olearius provides a predictive framework for sesquiterpenoid natural product biosynthesis in Basidiomycota
Chemistry & Biology, 2012Co-Authors: Grayson Thomas Wawrzyn, Swati Choudhary, Maureen B. Quin, Fernando Lopezgallego, Claudia SchmidtdannertAbstract:Summary The secondary metabolome of Basidiomycota represents a largely uncharacterized source of pharmaceutically relevant natural products. Terpenoids are the primary class of bioactive compounds isolated from mushrooms. The Jack O'Lantern mushroom Omphalotus olearius was identified 50 years ago as a prolific producer of anticancer illudin sesquiterpenoids; however, to date there have been exceptionally few studies into the biosynthesis of these important compounds. Here, we report the draft genome sequence of O. olearius , which reveals a diverse network of sesquiterpene synthases and two metabolic gene clusters associated with illudin biosynthesis. Characterization of the sesquiterpene synthases enabled a comprehensive survey of all currently available Basidiomycota genomes, thereby creating a predictive resource for terpenoid natural product biosynthesis in these organisms. Our results will facilitate discovery and biosynthetic production of unique pharmaceutically relevant bioactive compounds from Basidiomycota.
Grayson Thomas Wawrzyn - One of the best experts on this subject based on the ideXlab platform.
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Mushroom hunting by using bioinformatics: Application of a predictive framework facilitates the selective identification of sesquiterpene synthases in Basidiomycota
ChemBioChem, 2013Co-Authors: Maureen B. Quin, Christopher M. Flynn, Swati Choudhary, Grayson Thomas Wawrzyn, C. Schmidt-dannertAbstract:The Basidiomycota fungi represent a diverse source of natural products, particularly the sesquiterpenoids. Recently, genome sequencing, genome mining, and the subsequent discovery of a suite of sesquiterpene synthases in Omphalotus olearius was described. A predictive framework was developed to facilitate the discovery of sesquiterpene synthases in Basidiomycota. Phylogenetic analyses indicated a conservation of both sequence and initial cyclization mechanisms used. Here, the first robust application of this predictive framework is reported. It was used to selectively identify sesquiterpene synthases that follow 1,6-, 1,10-, and 1,11-cyclization mechanisms in the crust fungus Stereum hirsutum. The successful identification and characterization of a 1,6- and a 1,10-cyclizing sesquiterpene synthase, as well as three 1,11-cyclizing Δ(6) -protoilludene synthases, is described. This study verifies the accuracy and utility of the predictive framework as a roadmap for the discovery of specific sesquiterpene synthases from Basidiomycota, and thus represents an important step forward in natural product discovery.
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draft genome of omphalotus olearius provides a predictive framework for sesquiterpenoid natural product biosynthesis in Basidiomycota
Chemistry & Biology, 2012Co-Authors: Grayson Thomas Wawrzyn, Swati Choudhary, Maureen B. Quin, Fernando Lopezgallego, Claudia SchmidtdannertAbstract:Summary The secondary metabolome of Basidiomycota represents a largely uncharacterized source of pharmaceutically relevant natural products. Terpenoids are the primary class of bioactive compounds isolated from mushrooms. The Jack O'Lantern mushroom Omphalotus olearius was identified 50 years ago as a prolific producer of anticancer illudin sesquiterpenoids; however, to date there have been exceptionally few studies into the biosynthesis of these important compounds. Here, we report the draft genome sequence of O. olearius , which reveals a diverse network of sesquiterpene synthases and two metabolic gene clusters associated with illudin biosynthesis. Characterization of the sesquiterpene synthases enabled a comprehensive survey of all currently available Basidiomycota genomes, thereby creating a predictive resource for terpenoid natural product biosynthesis in these organisms. Our results will facilitate discovery and biosynthetic production of unique pharmaceutically relevant bioactive compounds from Basidiomycota.
