The Experts below are selected from a list of 171 Experts worldwide ranked by ideXlab platform

Anastasia Chatzinikolaou - One of the best experts on this subject based on the ideXlab platform.

  • Red cell distribution width in iron deficiency anemia and beta-thalassemia minor.
    American journal of clinical pathology, 2008
    Co-Authors: George Ntaios, Anastasia Chatzinikolaou
    Abstract:

    . In this study, the authors investigated the discriminatory power of several peripheral blood morphologic findings such as prekeratocytes, pencil cells, RBCs with Basophilic Stippling, and target cells in the differential diagnosis between iron-deficiency anemia (IDA) and β-thalassemia minor. Moreover, they compared these morphologic features with RBC indices such as red cell distribution width (RDW) in the discrimination of these 2 conditions. They concluded that prekeratocytes and pencil cells may have a role in the differentiation of IDA from β-thalassemia minor, whereas target cells and RBCs with Basophilic Stippling were not found to be useful.In our opinion, another remarkable finding of this study was that RDW was found to be a reliable marker to distinguish IDA from β-thalassemia because it showed a sensitivity of 82% and a specificity of 89% at a cutoff value of 18%. These numbers are surprisingly high compared with the findings of several previous studies.

George Ntaios - One of the best experts on this subject based on the ideXlab platform.

  • Red cell distribution width in iron deficiency anemia and beta-thalassemia minor.
    American journal of clinical pathology, 2008
    Co-Authors: George Ntaios, Anastasia Chatzinikolaou
    Abstract:

    . In this study, the authors investigated the discriminatory power of several peripheral blood morphologic findings such as prekeratocytes, pencil cells, RBCs with Basophilic Stippling, and target cells in the differential diagnosis between iron-deficiency anemia (IDA) and β-thalassemia minor. Moreover, they compared these morphologic features with RBC indices such as red cell distribution width (RDW) in the discrimination of these 2 conditions. They concluded that prekeratocytes and pencil cells may have a role in the differentiation of IDA from β-thalassemia minor, whereas target cells and RBCs with Basophilic Stippling were not found to be useful.In our opinion, another remarkable finding of this study was that RDW was found to be a reliable marker to distinguish IDA from β-thalassemia because it showed a sensitivity of 82% and a specificity of 89% at a cutoff value of 18%. These numbers are surprisingly high compared with the findings of several previous studies.

Steven H. Kroft - One of the best experts on this subject based on the ideXlab platform.

  • Iron deficiency anemia, beta-thalassemia minor, and anemia of chronic disease: a morphologic reappraisal.
    American journal of clinical pathology, 2008
    Co-Authors: Alexandra M. Harrington, Patrick C. J. Ward, Steven H. Kroft
    Abstract:

    We observed increased numbers of an infrequently referenced poikilocyte, the prekeratocyte, in iron deficiency anemia (IDA) compared with beta-thalassemia minor and anemia of chronic disease (ACD) and, therefore, chose to quantify these cells and other morphologic features in these anemias. Prekeratocytes were observed in 31 (78%) of 40 IDAs vs 11 (37%) of 30 beta-thalassemias (P = .001) and 5 (13%) of 40 ACDs (P < .001) and averaged 0.78 per 1,000 RBCs in IDA vs 0.21 in beta-thalassemia (P < .001) and 0.075 in ACD (P < .001). Pencil cells also were more commonly seen and more numerous in IDAs than in beta-thalassemia or ACD. Target cells were present in most IDAs and thalassemia and in similar numbers. Basophilic Stippling was seen in only 5 (17%) of the beta-thalassemias. Our results lend quantitative support to prekeratocytes and pencil cells as morphologic features favoring the diagnosis of IDA but fail to support the diagnostic usefulness of target cells and Basophilic Stippling in discriminating IDA and beta-thalassemia minor.

Omar Kherad - One of the best experts on this subject based on the ideXlab platform.

  • Traditional medicine: a rare cause of lead poisoning in Western countries.
    F1000Research, 2013
    Co-Authors: Halima Muller, Simon Regard, Nicole Petriccioli, Omar Kherad
    Abstract:

    A 42-year-old man from Bhutan was admitted to the emergency department with a 5-day history of abdominal pain, nausea and vomiting. Enhanced abdominal CT scan was found negative, however laboratory tests showed hemolytic anemia and Basophilic Stippling which are often seen in lead and heavy metal poisoning. Additional tests revealed a high level of lead in blood and urine. The patient was administered a chelator treatment with rapid improvement of the symptoms. A detailed interview revealed that the patient had been taking daily Bhutanese traditional medicines to treat a Bell's palsy from which he had been suffering for a few months. The analysis of these medicines confirmed the presence of a high level of lead.

  • Traditional medicine: a rare cause of lead poisoning in Western countries [v1; ref status: indexed, http://f1000r.es/2c6]
    F1000 Research Ltd, 2013
    Co-Authors: Halima Muller, Simon Regard, Nicole Petriccioli, Omar Kherad
    Abstract:

    A 42-year-old man from Bhutan was admitted to the emergency department with a 5-day history of abdominal pain, nausea and vomiting. Enhanced abdominal CT scan was found negative, however laboratory tests showed hemolytic anemia and Basophilic Stippling which are often seen in lead and heavy metal poisoning. Additional tests revealed a high level of lead in blood and urine. The patient was administered a chelator treatment with rapid improvement of the symptoms. A detailed interview revealed that the patient had been taking daily Bhutanese traditional medicines to treat a Bell’s palsy from which he had been suffering for a few months. The analysis of these medicines confirmed the presence of a high level of lead

  • Traditional medicine: a rare cause of lead poisoning in Western
    2013
    Co-Authors: Widal Hospitalgarnier, Halima Muller, Simon Regard, Nicole Petriccioli, Omar Kherad
    Abstract:

    A 42-year-old man from Bhutan was admitted to the emergency department with a 5-day history of abdominal pain, nausea and vomiting. Enhanced abdominal CT scan was found negative, however laboratory tests showed hemolytic anemia and Basophilic Stippling which are often seen in lead and heavy metal poisoning. Additional tests revealed a high level of lead in blood and urine. The patient was administered a chelator treatment with rapid improvement of the symptoms. A detailed interview revealed that the patient had been taking daily Bhutanese traditional medicines to treat a Bell’s palsy from which he had been suffering for a few months. The analysis of these medicines confirmed the presence of a high level of lead

Hamed Shafaroodi - One of the best experts on this subject based on the ideXlab platform.

  • Lead Poisoning in Opium-Addicted Subjects, Its Correlation with Pyrimidine 5'-Nucleotidase Activity and Liver Function Tests.
    International journal of preventive medicine, 2019
    Co-Authors: Mandana Fakoor, Maryam Akhgari, Hamed Shafaroodi
    Abstract:

    Background : Lead may be added to the opium by drug smugglers. It can cause elevated blood lead level (BLL) in opium‑addicted patients. Erythrocyte pyrimidine 5′‑nucleotidase (P5N) activity is susceptible to high BLL. The aim of this study was to fnd out whether opium‑addicted patients show erythropathy and elevated liver enzymes explainable by high BLL and decreased P5N activity. Methods : Forty orally opium‑addicted subjects and 40 normal healthy volunteers were enrolled in this study. BLL was measured in whole blood specimens using atomic absorption spectrometry instrumentation. Enzymatic activity, protein amount of P5N, and erythrocyte purine/pyrimidine ratio were determined. Blood flms were analyzed for the presence of Basophilic Stippling of red cells and hemolytic anemia. The level of liver function enzymes was measured. Results : The mean BLL for opium‑addicted patients was signifcantly higher than control group ( P < 0.001). On the contrary, P5N activity showed a valid decrease in opium‑addicted patients when compared with control group ( P < 0.001). In line with repressed P5N activity, erythrocyte purine/pyrimidine ratio in patients was lower than control group ( P < 0.001). A statistically signifcant reverse correlation was found between BLL and P5N activity ( P < 0.05, r = -0.85). The prevalence of both Basophilic Stippling ( P < 0.001, z = 6.62) and hemolytic anemia ( P < 0.001, z = 6.52) in study population was signifcantly associated with elevated BLL. We could not fnd any signifcant correlation between serum level of liver enzymes and BLL. Conclusions : Opium‑addicted patients in Tehran, Iran, are at high risk of lead poisoning which may result in hematologic problems and possibly hepatic damage. Keywords : Anemia, lead poisoning, liver function tests, opium, pyrimidine 5′‑nucleotidase

  • Lead poisoning in opium-addicted subjects, its correlation with pyrimidine 5′-nucleotidase activity and liver function tests
    Wolters Kluwer Medknow Publications, 2019
    Co-Authors: Mandana Fakoor, Maryam Akhgari, Hamed Shafaroodi
    Abstract:

    Background: Lead may be added to the opium by drug smugglers. It can cause elevated blood lead level (BLL) in opium-addicted patients. Erythrocyte pyrimidine 5′-nucleotidase (P5N) activity is susceptible to high BLL. The aim of this study was to find out whether opium-addicted patients show erythropathy and elevated liver enzymes explainable by high BLL and decreased P5N activity. Methods: Forty orally opium-addicted subjects and 40 normal healthy volunteers were enrolled in this study. BLL was measured in whole blood specimens using atomic absorption spectrometry instrumentation. Enzymatic activity, protein amount of P5N, and erythrocyte purine/pyrimidine ratio were determined. Blood films were analyzed for the presence of Basophilic Stippling of red cells and hemolytic anemia. The level of liver function enzymes was measured. Results: The mean BLL for opium-addicted patients was significantly higher than control group (P < 0.001). On the contrary, P5N activity showed a valid decrease in opium-addicted patients when compared with control group (P < 0.001). In line with repressed P5N activity, erythrocyte purine/pyrimidine ratio in patients was lower than control group (P < 0.001). A statistically significant reverse correlation was found between BLL and P5N activity (P < 0.05, r = −0.85). The prevalence of both Basophilic Stippling (P < 0.001, z = 6.62) and hemolytic anemia (P < 0.001, z = 6.52) in study population was significantly associated with elevated BLL. We could not find any significant correlation between serum level of liver enzymes and BLL. Conclusions: Opium-addicted patients in Tehran, Iran, are at high risk of lead poisoning which may result in hematologic problems and possibly hepatic damage