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J Nazaruk - One of the best experts on this subject based on the ideXlab platform.
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Flavonol glycosides from the flowers of Bellis perennis
Fitoterapia, 2001Co-Authors: J Gudej, J NazarukAbstract:Three flavonol glycosides, isorhamnetin 3-O-beta-D-galactopyranoside, isorhamnetin 3-O-beta-D-(6"-acetyl)-galactopyranoside and kaempferol 3-O-beta-D-glucopyranoside were isolated from the flowers of Bellis perennis.
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Flavonol glycosides from the flowers of Bellis perennis
Fitoterapia, 2001Co-Authors: J Gudej, J NazarukAbstract:Abstract Three flavonol glycosides, isorhamnetin 3-O-β- d -galactopyranoside, isorhamnetin 3-O-β- d -(6″-acetyl)-galactopyranoside and kaempferol 3-O-β- d -glucopyranoside were isolated from the flowers of Bellis perennis.
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Apigenin glycosides from the flowers of Bellis perennis L.
Acta Poloniae Pharmaceutica, 2000Co-Authors: J Nazaruk, J GudejAbstract:: Two next apigenin glycosides, apigenin 7-O-beta-D-glucuronide [III], apigenin 7-O-beta-D-glucoside [IV] were isolated from the flowers of Bellis perennis L. Their structures were determined by means of chemical and spectroscopic methods.
Ethylin Wang Jabs - One of the best experts on this subject based on the ideXlab platform.
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autosomal dominant postaxial polydactyly nail dystrophy and dental abnormalities map to chromosome 4p16 in the region containing the ellis van creveld syndrome locus
American Journal of Human Genetics, 1997Co-Authors: Timothy D Howard, Alan E Guttmacher, Wendy Mckinnon, Mridula Sharma, Victor A Mckusick, Ethylin Wang JabsAbstract:Summary We have studied a four-generation family with features of Weyers acrofacial dysostosis, in which the proband has a more severe phenotype, resembling Ellis–van Creveld syndrome. Weyers acrofacial dysostosis is an autosomal dominant condition with dental anomalies, nail dystrophy, postaxial polydactyly, and mild short stature. Ellis–van Creveld syndrome is a similar condition, with autosomal recessive inheritance and the additional features of disproportionate dwarfism, thoracic dysplasia, and congenital heart disease. Linkage and haplotype analysis determined that the disease locus in this pedigree resides on chromosome 4p16, distal to the genetic marker D4S3007 and within a 17-cM region flanking the genetic locus D4S2366. This region includes the Ellis–van Creveld syndrome locus, which previously was reported to map within a 3-cM region between genetic markers D4S2957 and D4S827. Either the genes for the condition in our family and for Ellis–van Creveld syndrome are near one another or these two conditions are allelic with mutations in the same gene. These data also raise the possibility that Weyers acrofacial dysostosis is the heterozygous expression of a mutation that, in homozygous form, causes the autosomal recessive disorder Ellis–van Creveld syndrome.
Karl Hiller - One of the best experts on this subject based on the ideXlab platform.
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triterpenoid saponins from Bellis bernardii
Journal of Natural Products, 1996Co-Authors: Thomas Schöpke, Karl Hiller, Victor Wray, Horst Thiele, Manfred NimtzAbstract:Nine saponins were isolated from the deacylated saponin mixture obtained from the whole plants of Bellis bernardii. Their structures have been elucidated from NMR and MS data and by chemical derivatization. Three were glycosides of the recently reported Bellisonic acid (2β,3β,23-trihydroxy-16-oxoolean-12-en-28-oic acid), with the major compounds being related glycosides of polygalacic acid (2β,3β,16α,23-tetrahydroxyolean-12-en-28-oic acid). In addition, a saponin of bayogenin (2β,3β,23-trihydroxyolean-12-en-28-oic acid) was obtained and is the first acyl glycoside of this aglycon with a free hydroxyl group at C-3.
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Application of MS-MS for the rapid, comparative analysis of saponin mixtures as exemplified by the deacylated and partially deacylated triterpenoid saponins of Bellis annua.
Planta medica, 1996Co-Authors: Th. Schöpke, Karl Hiller, Victor Wray, Manfred NimtzAbstract:While most species of the Bellis genus are characterized by saponins in concentrations of ca.4% dry weight, Bellis annua only contains ca.0.3% saponins. Hence positive-ion electrospray ionization mass spectrometry, including MS-MS analysis, has been used extensively for the rapid identification of the saponins of B. annua obtained after mild alkaline hydrolysis. The saponin composition is similar to that of other Bellis species and, in addition, glycosides of the rare Bellisonic acid, which has recently been found in B. bernardii, have been identified.
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Triterpenoid Saponins from Bellis bernardii
Journal of natural products, 1996Co-Authors: Thomas Schöpke, Karl Hiller, Victor Wray, Horst Thiele, Manfred NimtzAbstract:Nine saponins were isolated from the deacylated saponin mixture obtained from the whole plants of Bellis bernardii. Their structures have been elucidated from NMR and MS data and by chemical derivatization. Three were glycosides of the recently reported Bellisonic acid (2 beta, 3 beta,-23-trihydroxy-16-oxoolean-12-en-28-oic acid), with the major compounds being related glycosides of polygalacic acid (2 beta, 3 beta, 16 alpha, 23-tetrahydroxyolean-12-en-28-oic acid). In addition, a saponin of bayogenin (2 beta, 3 beta, 23-trihydroxyolean-12-en-28-oic acid) was obtained and is the first acyl glycoside of this aglycon with a free hydroxyl group at C-3.
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Triterpenoid saponins from Bellis sylvestris. 2. Structures of partially deacylated saponins.
Journal of natural products, 1996Co-Authors: Thomas Schöpke, Karl Hiller, Victor Wray, Manfred Nimtz, Kazuo Yamasaki, Ryoji KasaiAbstract:Four saponins have been isolated from the herbal parts of Bellis sylvestris and the same, together with three further compounds, from the underground parts. The structures were elucidated by electrospray ionization mass spectrometry, including tandem mass spectrometry, and by 1D and 2D homonuclear and heteronuclear NMR spectroscopy. Two of the compounds are new saponins with the structures 3-O-beta-D-glucopyranosyl-2 beta, 3 beta, 23-trihydroxyolean-12-en-28-oic acid 28-O-beta-D-glucopyranosyl (1-->3)-[alpha-L-rhamnopyranosyl (1-->2)]-beta-D- glucopyranoside and 3-O-beta-D-glucopyranosyl-2 beta, 3 beta,16 alpha, 23-tetrahydroxyolean-12-en- 28-oic acid 28-O-alpha-L-rhamnopyranosyl (1-->3)-beta-D-xylopyranosyl(1-->4)-alpha-L- rhamnopyranosyl(1-->2)-[(E)-2-butenoic acid (1-->3)]-beta-D-fucopyranoside. Taxonomically these data provide significant evidence of a link between the Bellis genus and Bellium bellidioides.
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Triterpenoid saponins from Bellis sylvestris, I. Structures of the major deacylsaponins.
Journal of natural products, 1994Co-Authors: Thomas Schöpke, Karl Hiller, Victor Wray, K.-d. Köppel, Kazuo Yamasaki, Ryoji KasaiAbstract:Two major saponins from Bellis sylvestris have been isolated and their structures determined, mainly by high-field nmr spectroscopy. One of these [2] was identical with Bellissaponin BS1 from Bellis perennis, while the second is a new triterpenoid saponin [1], named besysaponin C12, and identified as 3-O-alpha-L-rhamnopyranosyl-2 beta,3 beta,16 alpha,23-tetrahydroxyolean-12-en-28-oic acid 28-O-beta-D-xylopyranosyl(1-->4)-alpha-L-rhamnopyranosyl(1-->2)-beta-D- fucopyranoside.
J Gudej - One of the best experts on this subject based on the ideXlab platform.
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Flavonol glycosides from the flowers of Bellis perennis
Fitoterapia, 2001Co-Authors: J Gudej, J NazarukAbstract:Three flavonol glycosides, isorhamnetin 3-O-beta-D-galactopyranoside, isorhamnetin 3-O-beta-D-(6"-acetyl)-galactopyranoside and kaempferol 3-O-beta-D-glucopyranoside were isolated from the flowers of Bellis perennis.
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Flavonol glycosides from the flowers of Bellis perennis
Fitoterapia, 2001Co-Authors: J Gudej, J NazarukAbstract:Abstract Three flavonol glycosides, isorhamnetin 3-O-β- d -galactopyranoside, isorhamnetin 3-O-β- d -(6″-acetyl)-galactopyranoside and kaempferol 3-O-β- d -glucopyranoside were isolated from the flowers of Bellis perennis.
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Apigenin glycosides from the flowers of Bellis perennis L.
Acta Poloniae Pharmaceutica, 2000Co-Authors: J Nazaruk, J GudejAbstract:: Two next apigenin glycosides, apigenin 7-O-beta-D-glucuronide [III], apigenin 7-O-beta-D-glucoside [IV] were isolated from the flowers of Bellis perennis L. Their structures were determined by means of chemical and spectroscopic methods.
Victor Wray - One of the best experts on this subject based on the ideXlab platform.
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Triterpenoid saponins of Bellis perennis
Scientia Pharmaceutica, 2001Co-Authors: Michał Gleńsk, Manfred Nimtz, Victor Wray, Th. SchöpkeAbstract:Ten saponins have been isolated from the deacylated saponin mixture of Bellis perennis L. The structures of these saponins can be divided into two groups that show differences both in the aglycone and the carbohydrate moieties bound at C-28. The first group consists of glycosides of polygalacic acid with tri- or tetrasaccharide moieties consisting mainly of deoxyhexoses and a second group of glycosides of bayogenin or asterogenic acid which possess glucose as major carbohydrate moiety and one xylose or rharnnose unit. From the most polar fraction of the alkaline hydrolysate obtained from the underground parts of Bellis perennis one saponin possessing only glucose residues has been obtained. On the basis of a sugar methylation analysis and NMR spectral data, the structure was established as 3-O-ß-D-glucopyranosyl-2ß,3ß,23-trihydroxyolean-12-en-28-oic acid 28-O-ß-D-glucoyranosyl-(1→2)-[ß-D-glucopyranosyl(1→6)]-ß-D-glucopyranoside.
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triterpenoid saponins from Bellis bernardii
Journal of Natural Products, 1996Co-Authors: Thomas Schöpke, Karl Hiller, Victor Wray, Horst Thiele, Manfred NimtzAbstract:Nine saponins were isolated from the deacylated saponin mixture obtained from the whole plants of Bellis bernardii. Their structures have been elucidated from NMR and MS data and by chemical derivatization. Three were glycosides of the recently reported Bellisonic acid (2β,3β,23-trihydroxy-16-oxoolean-12-en-28-oic acid), with the major compounds being related glycosides of polygalacic acid (2β,3β,16α,23-tetrahydroxyolean-12-en-28-oic acid). In addition, a saponin of bayogenin (2β,3β,23-trihydroxyolean-12-en-28-oic acid) was obtained and is the first acyl glycoside of this aglycon with a free hydroxyl group at C-3.
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Application of MS-MS for the rapid, comparative analysis of saponin mixtures as exemplified by the deacylated and partially deacylated triterpenoid saponins of Bellis annua.
Planta medica, 1996Co-Authors: Th. Schöpke, Karl Hiller, Victor Wray, Manfred NimtzAbstract:While most species of the Bellis genus are characterized by saponins in concentrations of ca.4% dry weight, Bellis annua only contains ca.0.3% saponins. Hence positive-ion electrospray ionization mass spectrometry, including MS-MS analysis, has been used extensively for the rapid identification of the saponins of B. annua obtained after mild alkaline hydrolysis. The saponin composition is similar to that of other Bellis species and, in addition, glycosides of the rare Bellisonic acid, which has recently been found in B. bernardii, have been identified.
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Triterpenoid Saponins from Bellis bernardii
Journal of natural products, 1996Co-Authors: Thomas Schöpke, Karl Hiller, Victor Wray, Horst Thiele, Manfred NimtzAbstract:Nine saponins were isolated from the deacylated saponin mixture obtained from the whole plants of Bellis bernardii. Their structures have been elucidated from NMR and MS data and by chemical derivatization. Three were glycosides of the recently reported Bellisonic acid (2 beta, 3 beta,-23-trihydroxy-16-oxoolean-12-en-28-oic acid), with the major compounds being related glycosides of polygalacic acid (2 beta, 3 beta, 16 alpha, 23-tetrahydroxyolean-12-en-28-oic acid). In addition, a saponin of bayogenin (2 beta, 3 beta, 23-trihydroxyolean-12-en-28-oic acid) was obtained and is the first acyl glycoside of this aglycon with a free hydroxyl group at C-3.
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Triterpenoid saponins from Bellis sylvestris. 2. Structures of partially deacylated saponins.
Journal of natural products, 1996Co-Authors: Thomas Schöpke, Karl Hiller, Victor Wray, Manfred Nimtz, Kazuo Yamasaki, Ryoji KasaiAbstract:Four saponins have been isolated from the herbal parts of Bellis sylvestris and the same, together with three further compounds, from the underground parts. The structures were elucidated by electrospray ionization mass spectrometry, including tandem mass spectrometry, and by 1D and 2D homonuclear and heteronuclear NMR spectroscopy. Two of the compounds are new saponins with the structures 3-O-beta-D-glucopyranosyl-2 beta, 3 beta, 23-trihydroxyolean-12-en-28-oic acid 28-O-beta-D-glucopyranosyl (1-->3)-[alpha-L-rhamnopyranosyl (1-->2)]-beta-D- glucopyranoside and 3-O-beta-D-glucopyranosyl-2 beta, 3 beta,16 alpha, 23-tetrahydroxyolean-12-en- 28-oic acid 28-O-alpha-L-rhamnopyranosyl (1-->3)-beta-D-xylopyranosyl(1-->4)-alpha-L- rhamnopyranosyl(1-->2)-[(E)-2-butenoic acid (1-->3)]-beta-D-fucopyranoside. Taxonomically these data provide significant evidence of a link between the Bellis genus and Bellium bellidioides.