The Experts below are selected from a list of 142188957 Experts worldwide ranked by ideXlab platform

Charles B. Nemeroff - One of the best experts on this subject based on the ideXlab platform.

  • chromosome 22q and the mind brain interface bedside to bench to bedside
    Neurology, 2001
    Co-Authors: Alan K Percy, Charles B. Nemeroff
    Abstract:

    “All mental processes, even the most complex psychological processes, derive from operations of the brain.”—Eric Kandel, MD, 19981 An article in this issue of Neurology by Graf et al.2 explores the mind–brain interface through the implementation of pharmacologic intervention strategies based on the unique molecular genetics of the 22q11 deletion syndrome.3 This composite microdeletion syndrome, which encompasses DiGeorge syndrome, velocardiofacial syndrome, and conotruncal anomaly face syndrome (Takao syndrome), has an incidence of 1:4000 to 5000 per live births. In addition to numerous structural malformations associated with gene deletions at 22q11, developmental delay, learning disability, and neuropsychiatric disturbance are common. Cognitive function ranges from average intelligence to moderate mental retardation, the mean IQ being approximately 70. Psychiatric features are variable as well and may include attention deficit hyperactivity disorder and poor socialization in childhood, anxiety and depression during puberty, and …

  • chromosome 22q and the mind brain interface bedside to bench to bedside
    Neurology, 2001
    Co-Authors: Alan K Percy, Charles B. Nemeroff
    Abstract:

    “All mental processes, even the most complex psychological processes, derive from operations of the brain.”—Eric Kandel, MD, 19981 An article in this issue of Neurology by Graf et al.2 explores the mind–brain interface through the implementation of pharmacologic intervention strategies based on the unique molecular genetics of the 22q11 deletion syndrome.3 This composite microdeletion syndrome, which encompasses DiGeorge syndrome, velocardiofacial syndrome, and conotruncal anomaly face syndrome (Takao syndrome), has an incidence of 1:4000 to 5000 per live births. In addition to numerous structural malformations associated with gene deletions at 22q11, developmental delay, learning disability, and neuropsychiatric disturbance are common. Cognitive function ranges from average intelligence to moderate mental retardation, the mean IQ being approximately 70. Psychiatric features are variable as well and may include attention deficit hyperactivity disorder and poor socialization in childhood, anxiety and depression during puberty, and …

Paul E Marik - One of the best experts on this subject based on the ideXlab platform.

  • Bench-to-Bedside review: Rhabdomyolysis – an overview for clinicians
    Critical Care, 2004
    Co-Authors: Ana L Huerta-alardín, Joseph Varon, Paul E Marik
    Abstract:

    Rhabdomyolysis ranges from an asymptomatic illness with elevation in the creatine kinase level to a life-threatening condition associated with extreme elevations in creatine kinase, electrolyte imbalances, acute renal failure and disseminated intravascular coagulation. Muscular trauma is the most common cause of rhabdomyolysis. Less common causes include muscle enzyme deficiencies, electrolyte abnormalities, infectious causes, drugs, toxins and endocrinopathies. Weakness, myalgia and tea-colored urine are the main clinical manifestations. The most sensitive laboratory finding of muscle injury is an elevated plasma creatine kinase level. The management of patients with rhabdomyolysis includes early vigorous hydration.

  • bench to bedside review rhabdomyolysis an overview for clinicians
    Critical Care, 2004
    Co-Authors: Ana L Huertaalardin, Joseph Varon, Paul E Marik
    Abstract:

    Rhabdomyolysis ranges from an asymptomatic illness with elevation in the creatine kinase level to a life-threatening condition associated with extreme elevations in creatine kinase, electrolyte imbalances, acute renal failure and disseminated intravascular coagulation. Muscular trauma is the most common cause of rhabdomyolysis. Less common causes include muscle enzyme deficiencies, electrolyte abnormalities, infectious causes, drugs, toxins and endocrinopathies. Weakness, myalgia and tea-colored urine are the main clinical manifestations. The most sensitive laboratory finding of muscle injury is an elevated plasma creatine kinase level. The management of patients with rhabdomyolysis includes early vigorous hydration.

  • Review Bench-to-Bedside review: Rhabdomyolysis – an overview for clinicians
    2004
    Co-Authors: Ana L Huerta-alardín, Joseph Varon, Paul E Marik
    Abstract:

    Rhabdomyolysis ranges from an asymptomatic illness with elevation in the creatine kinase level to a life-threatening condition associated with extreme elevations in creatine kinase, electrolyte imbalances, acute renal failure and disseminated intravascular coagulation. Muscular trauma is the most common cause of rhabdomyolysis. Less common causes include muscle enzyme deficiencies, electrolyte abnormalities, infectious causes, drugs, toxins and endocrinopathies. Weakness, myalgia and tea-colored urine are the main clinical manifestations. The most sensitive laboratory finding of muscle injury is an elevated plasma creatine kinase level. The management of patients with rhabdomyolysis includes early vigorous hydration

Alan K Percy - One of the best experts on this subject based on the ideXlab platform.

  • chromosome 22q and the mind brain interface bedside to bench to bedside
    Neurology, 2001
    Co-Authors: Alan K Percy, Charles B. Nemeroff
    Abstract:

    “All mental processes, even the most complex psychological processes, derive from operations of the brain.”—Eric Kandel, MD, 19981 An article in this issue of Neurology by Graf et al.2 explores the mind–brain interface through the implementation of pharmacologic intervention strategies based on the unique molecular genetics of the 22q11 deletion syndrome.3 This composite microdeletion syndrome, which encompasses DiGeorge syndrome, velocardiofacial syndrome, and conotruncal anomaly face syndrome (Takao syndrome), has an incidence of 1:4000 to 5000 per live births. In addition to numerous structural malformations associated with gene deletions at 22q11, developmental delay, learning disability, and neuropsychiatric disturbance are common. Cognitive function ranges from average intelligence to moderate mental retardation, the mean IQ being approximately 70. Psychiatric features are variable as well and may include attention deficit hyperactivity disorder and poor socialization in childhood, anxiety and depression during puberty, and …

  • chromosome 22q and the mind brain interface bedside to bench to bedside
    Neurology, 2001
    Co-Authors: Alan K Percy, Charles B. Nemeroff
    Abstract:

    “All mental processes, even the most complex psychological processes, derive from operations of the brain.”—Eric Kandel, MD, 19981 An article in this issue of Neurology by Graf et al.2 explores the mind–brain interface through the implementation of pharmacologic intervention strategies based on the unique molecular genetics of the 22q11 deletion syndrome.3 This composite microdeletion syndrome, which encompasses DiGeorge syndrome, velocardiofacial syndrome, and conotruncal anomaly face syndrome (Takao syndrome), has an incidence of 1:4000 to 5000 per live births. In addition to numerous structural malformations associated with gene deletions at 22q11, developmental delay, learning disability, and neuropsychiatric disturbance are common. Cognitive function ranges from average intelligence to moderate mental retardation, the mean IQ being approximately 70. Psychiatric features are variable as well and may include attention deficit hyperactivity disorder and poor socialization in childhood, anxiety and depression during puberty, and …

Sangeeta Mehta - One of the best experts on this subject based on the ideXlab platform.

  • Bench-to-Bedside review: Recruitment and recruiting maneuvers
    Critical Care, 2004
    Co-Authors: Stephen E Lapinsky, Sangeeta Mehta
    Abstract:

    In patients with acute respiratory distress syndrome (ARDS), the lung comprises areas of aeration and areas of alveolar collapse, the latter producing intrapulmonary shunt and hypoxemia. The currently suggested strategy of ventilation with low lung volumes can aggravate lung collapse and potentially produce lung injury through shear stress at the interface between aerated and collapsed lung, and as a result of repetitive opening and closing of alveoli. An 'open lung strategy' focused on alveolar patency has therefore been recommended. While positive end-expiratory pressure prevents alveolar collapse, recruitment maneuvers can be used to achieve alveolar recruitment. Various recruitment maneuvers exist, including sustained inflation to high pressures, intermittent sighs, and stepwise increases in positive end-expiratory pressure or peak inspiratory pressure. In animal studies, recruitment maneuvers clearly reverse the derecruitment associated with low tidal volume ventilation, improve gas exchange, and reduce lung injury. Data regarding the use of recruitment maneuvers in patients with ARDS show mixed results, with increased efficacy in those with short duration of ARDS, good compliance of the chest wall, and in extrapulmonary ARDS. In this review we discuss the pathophysiologic basis for the use of recruitment maneuvers and recent evidence, as well as the practical application of the technique.

  • Review Bench-to-Bedside review: Recruitment and recruiting maneuvers
    2004
    Co-Authors: Stephen E Lapinsky, Sangeeta Mehta
    Abstract:

    In patients with acute respiratory distress syndrome (ARDS), the lung comprises areas of aeration and areas of alveolar collapse, the latter producing intrapulmonary shunt and hypoxemia. The currently suggested strategy of ventilation with low lung volumes can aggravate lung collapse and potentially produce lung injury through shear stress at the interface between aerated and collapsed lung, and as a result of repetitive opening and closing of alveoli. An ‘open lung strategy ’ focused on alveolar patency has therefore been recommended. While positive end-expiratory pressure prevents alveolar collapse, recruitment maneuvers can be used to achieve alveolar recruitment. Various recruitment maneuvers exist, including sustained inflation to high pressures, intermittent sighs, and stepwise increases in positive end-expiratory pressure or peak inspiratory pressure. In animal studies, recruitment maneuvers clearly reverse the derecruitment associated with low tidal volume ventilation, improve gas exchange, and reduce lung injury. Data regarding the use of recruitment maneuvers in patients with ARDS show mixed results, with increased efficacy in those with short duration of ARDS, good compliance of the chest wall, and in extrapulmonary ARDS. In this review we discuss the pathophysiologic basis for the use of recruitment maneuvers and recent evidence, as well as the practical application of the technique

Stephen E Lapinsky - One of the best experts on this subject based on the ideXlab platform.

  • Bench-to-Bedside review: Recruitment and recruiting maneuvers
    Critical Care, 2004
    Co-Authors: Stephen E Lapinsky, Sangeeta Mehta
    Abstract:

    In patients with acute respiratory distress syndrome (ARDS), the lung comprises areas of aeration and areas of alveolar collapse, the latter producing intrapulmonary shunt and hypoxemia. The currently suggested strategy of ventilation with low lung volumes can aggravate lung collapse and potentially produce lung injury through shear stress at the interface between aerated and collapsed lung, and as a result of repetitive opening and closing of alveoli. An 'open lung strategy' focused on alveolar patency has therefore been recommended. While positive end-expiratory pressure prevents alveolar collapse, recruitment maneuvers can be used to achieve alveolar recruitment. Various recruitment maneuvers exist, including sustained inflation to high pressures, intermittent sighs, and stepwise increases in positive end-expiratory pressure or peak inspiratory pressure. In animal studies, recruitment maneuvers clearly reverse the derecruitment associated with low tidal volume ventilation, improve gas exchange, and reduce lung injury. Data regarding the use of recruitment maneuvers in patients with ARDS show mixed results, with increased efficacy in those with short duration of ARDS, good compliance of the chest wall, and in extrapulmonary ARDS. In this review we discuss the pathophysiologic basis for the use of recruitment maneuvers and recent evidence, as well as the practical application of the technique.

  • Review Bench-to-Bedside review: Recruitment and recruiting maneuvers
    2004
    Co-Authors: Stephen E Lapinsky, Sangeeta Mehta
    Abstract:

    In patients with acute respiratory distress syndrome (ARDS), the lung comprises areas of aeration and areas of alveolar collapse, the latter producing intrapulmonary shunt and hypoxemia. The currently suggested strategy of ventilation with low lung volumes can aggravate lung collapse and potentially produce lung injury through shear stress at the interface between aerated and collapsed lung, and as a result of repetitive opening and closing of alveoli. An ‘open lung strategy ’ focused on alveolar patency has therefore been recommended. While positive end-expiratory pressure prevents alveolar collapse, recruitment maneuvers can be used to achieve alveolar recruitment. Various recruitment maneuvers exist, including sustained inflation to high pressures, intermittent sighs, and stepwise increases in positive end-expiratory pressure or peak inspiratory pressure. In animal studies, recruitment maneuvers clearly reverse the derecruitment associated with low tidal volume ventilation, improve gas exchange, and reduce lung injury. Data regarding the use of recruitment maneuvers in patients with ARDS show mixed results, with increased efficacy in those with short duration of ARDS, good compliance of the chest wall, and in extrapulmonary ARDS. In this review we discuss the pathophysiologic basis for the use of recruitment maneuvers and recent evidence, as well as the practical application of the technique