The Experts below are selected from a list of 69 Experts worldwide ranked by ideXlab platform
Sugata Takahashi - One of the best experts on this subject based on the ideXlab platform.
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malignant lymphoma in the head and neck associated with Benign Lymphoepithelial Lesion of the parotid gland
Auris Nasus Larynx, 2002Co-Authors: Katsuro Sato, Masahiro Kawana, Yuichiro Sato, Sugata TakahashiAbstract:Lymphoepithelial Lesion is a Benign lymphoproliferative disease occasionally arises in the salivary glands, but association with malignant diseases or autoimmune diseases has also been discussed. We herein present three cases of malignant lymphoma arose in the parotid gland and the lacrimal gland, following parotid surgery for Benign Lymphoepithelial Lesion (BLEL) of the parotid gland. Two cases had mucosa associated lymphoid tissue (MALT) lymphoma in the parotid gland; one arose in the ipsilateral parotid gland as a recurrent swelling, and the other arose in the contralateral parotid gland of the previous BLEL surgery. The third case of malignant lymphoma arose in the lacrimal gland on the ipsilateral side, and the following contralateral parotid gland remained BLEL. All three patients were female, and one patient had a past history of Sjogren's syndrome and Hashimoto's disease. All three patients were treated by chemotherapy and one patient received additional radiotherapy. To follow-up lymphoproliferative diseases in the salivary glands such as BLEL, careful observation should be made on the same gland, other major salivary glands, and other organs in the head and neck, especially in females with autoimmune diseases.
Takashi Saku - One of the best experts on this subject based on the ideXlab platform.
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vascular endothelial cell participation in formation of Lymphoepithelial Lesions epi myoepithelial islands in Lymphoepithelial sialadenitis Benign Lymphoepithelial Lesion
Virchows Archiv, 2003Co-Authors: Hamdy Metwaly, Jun Cheng, Hiroko Idayonemochi, Kazufumi Ohshiro, Kai Yu Jen, Ai Ru Liu, Takashi SakuAbstract:Lymphoepithelial Lesions (LELs, or epi-myoepithelial islands) in Lymphoepithelial sialadenitis (LESA, or Benign Lymphoepithelial Lesion) of the salivary gland are known to be mainly composed of duct epithelial cells. However, other constituent cells are poorly characterized. Formalin-fixed paraffin sections obtained from six surgical specimens of LESA were examined using immunohistochemistry for cytoskeletal proteins, inflammatory cells, vascular endothelial cells, and extracellular matrix (ECM) molecules as well as by in situ hybridization for ECM molecules. In addition to keratin-immunopositive (+) duct-like epithelial cells, there were CD31/CD34+ vascular endothelial cells-which were either scattered in a singular fashion, in formed sheets, or in tubular structures-, CD20+ B lymphocytes, CD45RO+ T lymphocytes, and CD68 macrophages in the LELs. ECM molecules, such as heparan sulfate proteoglycan and tenascin, were immunolocalized in hyaline materials in the LELs. Their mRNAs were demonstrated mainly in endothelial cells and, to a lesser extent, in lympho-monocytic cells around hyaline materials, but were not as evident in epithelial constituent cells of LELs. The results indicate that endothelial cells as well as inflammatory cells are important constituents of the LELs, and the hyaline ECM cores mainly result from the intra-LEL angiogenesis by endothelial cells with the assistance of inflammatory cells. This intra-LEL vasculature seems to support regeneration and proliferation of salivary epithelial remnant cells.
St Yuen - One of the best experts on this subject based on the ideXlab platform.
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Lymphoepithelial carcinoma of the salivary gland: In situ detection of Epstein-Barr virus
United Kingdom, 1995Co-Authors: Lp Chung, Mp Wong, Sy Leung, Sy Chan, St YuenAbstract:Aim - To examine the role of Epstein-Barr virus (EBV) in Lymphoepithelial carcinoma of the salivary gland in Hong Kong Chinese. Methods - Ten cases of Lymphoepithelial carcinoma of the salivary gland (eight parotid and two submandibular) were examined. In situ hybridisation was used to localise EBER RNA, immunohistochemical methods to detect expression of latent membrane protein 1 (LMP-1) in EBV positive tumours, and Southern blot analysis to examine the clonality of EBV in the two cases where frozen tissue was available. Results - None of the cases had a history of Sjogren's syndrome or histological evidence of a Benign Lymphoepithelial Lesion. The IgA antibody titre against EBV viral capsid antigen was elevated in four cases. All cases were EBV positive by in situ hybridisation, with a strong uniform positive signal in the epithelial cells, and all cases expressed LMP-1. Southern blot analysis revealed that the clonal episomal form of the virus was present. Two of the three female patients in this series also developed carcinoma of cervix. One of these carcinomas had histological features of a lymphoepithelioma-like carcinoma but was EBV negative. Conclusions - A consistent association between EBV and Lymphoepithelial carcinoma of the salivary gland was found. The presence of the virus in a clonal episomal form, and the expression of LMP-1 viral oncoprotein is further evidence of the role of EBV in the oncogenesis of this tumour.published_or_final_versio
Chan S Y - One of the best experts on this subject based on the ideXlab platform.
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Lymphoepithelial carcinoma of the salivary gland: in situ detection of Epstein-Barr virus.
1995Co-Authors: Leung S Y, Chung L P, Yuen S T, Ho C M, Wong M P, Chan S YAbstract:AIM--To examine the role of Epstein-Barr virus (EBV) in Lymphoepithelial carcinoma of the salivary gland in Hong Kong Chinese. METHODS--Ten cases of Lymphoepithelial carcinoma of the salivary gland (eight parotid and two submandibular) were examined. In situ hybridisation was used to localise EBER RNA, immunohistochemical methods to detect expression of latent membrane protein 1 (LMP-1) in EBV positive tumours, and Southern blot analysis to examine the clonality of EBV in the two cases where frozen tissue was available. RESULTS--None of the cases had a history of Sjögren's syndrome or histological evidence of a Benign Lymphoepithelial Lesion. The IgA antibody titre against EBV viral capsid antigen was elevated in four cases. All cases were EBV positive by in situ hybridisation, with a strong uniform positive signal in the epithelial cells, and all cases expressed LMP-1. Southern blot analysis revealed that the clonal episomal form of the virus was present. Two of the three female patients in this series also developed carcinoma of cervix. One of these carcinomas had histological features of a lymphoepithelioma-like carcinoma but was EBV negative. CONCLUSIONS--A consistent association between EBV and Lymphoepithelial carcinoma of the salivary gland was found. The presence of the virus in a clonal episomal form, and the expression of LMP-1 viral oncoprotein is further evidence of the role of EBV in the oncogenesis of this tumour
Katsuro Sato - One of the best experts on this subject based on the ideXlab platform.
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malignant lymphoma in the head and neck associated with Benign Lymphoepithelial Lesion of the parotid gland
Auris Nasus Larynx, 2002Co-Authors: Katsuro Sato, Masahiro Kawana, Yuichiro Sato, Sugata TakahashiAbstract:Lymphoepithelial Lesion is a Benign lymphoproliferative disease occasionally arises in the salivary glands, but association with malignant diseases or autoimmune diseases has also been discussed. We herein present three cases of malignant lymphoma arose in the parotid gland and the lacrimal gland, following parotid surgery for Benign Lymphoepithelial Lesion (BLEL) of the parotid gland. Two cases had mucosa associated lymphoid tissue (MALT) lymphoma in the parotid gland; one arose in the ipsilateral parotid gland as a recurrent swelling, and the other arose in the contralateral parotid gland of the previous BLEL surgery. The third case of malignant lymphoma arose in the lacrimal gland on the ipsilateral side, and the following contralateral parotid gland remained BLEL. All three patients were female, and one patient had a past history of Sjogren's syndrome and Hashimoto's disease. All three patients were treated by chemotherapy and one patient received additional radiotherapy. To follow-up lymphoproliferative diseases in the salivary glands such as BLEL, careful observation should be made on the same gland, other major salivary glands, and other organs in the head and neck, especially in females with autoimmune diseases.