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So Hee Kim - One of the best experts on this subject based on the ideXlab platform.
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A Case of Huge Benign Tumor of the Ovary
Obstetrics & gynecology science, 2006Co-Authors: Yoon Sik Lee, Sung Il Cha, Chun June Lee, Sung-han Kim, Myeong Su Jeong, So Hee KimAbstract:Recently a huge Benign Tumor of the ovary (greater than 25 pounds) is rare because of early detection and operation. Although infrequently seen, many serious problems associated with the removal of such Tumors have been described, including cardiovascular and respiratory complications. For successful management and good prognosis, it certainly requires slow decompression. We have experienced one case of huge Benign Tumor of the ovary, and report this case with brief review of literatures.
K. P. Mankin - One of the best experts on this subject based on the ideXlab platform.
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Schwannoma: a rare Benign Tumor of soft tissues
MUSCULOSKELETAL SURGERY, 2014Co-Authors: H. J. Mankin, K. P. MankinAbstract:‘Schwannomas are unusual Benign Tumors which arise from the surface of neural elements of the body or within the brain. They do not as a rule metastasize but may cause sometimes severe local problems on the nerves, blood vessels and adjacent bone. The Tumors arise from the Sheath of Schwann, a structure on the surface of a nerve. The lesions may expand and cause considerable damage to adjacent tissues. They do not arise within bone since there are no Sheaths of Schwann within the osseous tissue but may cause local damage to the bony cortex and sometimes fractures. Rarely the lesions may metastasize and cause patients’ death. The treatment is usually local resection, and most often is successful although may cause damage to the adjacent nerve.
Elizabeth P Henske - One of the best experts on this subject based on the ideXlab platform.
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metastasis of Benign Tumor cells in tuberous sclerosis complex
Genes Chromosomes and Cancer, 2003Co-Authors: Elizabeth P HenskeAbstract:Lymphangiomyomatosis (LAM) is a life-threatening lung disease affecting almost exclusively young women. Histologically, LAM is characterized by the diffuse, bilateral proliferation of abnormal smooth muscle cells and cystic degeneration of the lung parenchyma. LAM can occur as an isolated disorder (sporadic LAM), or in women with tuberous sclerosis complex (TSC-LAM). Patients with both sporadic LAM and TSC-LAM often have Benign renal angiomyolipomas. The smooth muscle cells within the angiomyolipomas are very similar to the smooth muscle cells in pulmonary LAM. Genetic data suggest that pulmonary LAM is the result of a highly unusual disease mechanism: the metastasis of Benign cells. If LAM is the result of metastasis, it is remarkable that the metastasis occurs in women, but not in men. In this review, I discuss the genetic data supporting this metastatic model for LAM. The implications of the model for the functions of the TSC1 and TSC2 gene products, hamartin and tuberin, respectively, will also be considered. Hamartin and tuberin may play functional roles in the suppression of cell migration and/or metastasis, possibly through their regulation of the small GTPase Rho. © 2003 Wiley-Liss, Inc.
Christopher D M Fletcher - One of the best experts on this subject based on the ideXlab platform.
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Plexiform Myofibroblastoma: Clinicopathologic Analysis of 36 Cases of a Distinctive Benign Tumor of Soft Tissue Affecting Mainly Children and Young Adults.
The American journal of surgical pathology, 2020Co-Authors: David J. Papke, Alyaa Al-ibraheemi, Christopher D M FletcherAbstract:The spectrum of Benign superficial fibroblastic/myofibroblastic Tumors continues to expand and includes entities such as plexiform fibrohistiocytic Tumor, dermatomyofibroma and fibroblastic connective tissue nevus. Here, we describe a seemingly distinctive group of lesions which we have labeled "plexiform myofibroblastoma" (PM). PM is a rare superficial mesenchymal Tumor of fibroblastic/myofibroblastic lineage that predominantly occurs in children and young adults. Thirty-six cases from the consultation archives of one of the authors have been studied to characterize the clinicopathologic characteristics of PM. 19 patients (53%) were female and 17 were male, with age at presentation ranging from congenital (2 cases) to 50 years of age (median: 9.5 y). Three patients had multiple lesions. Males tended to develop Tumors during childhood (median: 2 y; range: congenital-37 y), while in females the age distribution was relatively uniform from childhood through adulthood (median age: 25 y; range: 4 mo to 50 y). Most Tumors occurred in truncal locations (25/40), including the back (11), anterolateral chest wall (4), axilla (4), abdominal wall (4), perineum (1) and suprapubic region (1). Other Tumor sites were the neck (10/40), occiput (2), lower extremity (2) and breast (1). The average greatest dimension was 2.7±1.7 cm (range: 0.6 to 8 cm). Three male patients, 2 of whom were brothers, presented between 6 months and 1 year of age with multiple lesions variably involving the back, occiput and axillae; these lesions spontaneously regressed after being present for about 2 years, with no evidence of recurrence at a mean follow-up of 11.4±3.2 years. Histologically, PM was composed of plexiform fascicles of fibroblastic/myofibroblastic spindle cells that ramify through the subcutis and reticular dermis. The bland neoplastic cells had indistinct cell borders, palely eosinophilic cytoplasm and ovoid or tapered nuclei. There was no histiocytoid component in any case, and no cases contained osteoclast-like giant cells. Twelve of thirty-four (35%) reviewed cases showed at least focal keloidal hyalinization, 6/34 (18%) contained somewhat fasciitis-like areas and 6/34 (18%) contained focal myxoid stroma. Immunohistochemical studies were positive for SMA (27/32 cases), desmin (9/21) and CD34 (13/24) and negative for β-catenin (0/14) and S-100 (0/22). EMA was weakly positive in 2/15 cases. An FGFR2 M535L tyrosine kinase domain variant of unknown significance was detected in 1/7 sequenced cases, and no somatic alterations, copy number alterations or gene fusions were detected in the other 6. Clinical follow-up data were available for 16/36 patients (44%; median duration: 5.5 y). Although most excisions had positive margins (11/16), only 1 patient developed a local recurrence 4 years after initial excision. No Tumors metastasized. PM is a Benign Tumor with characteristic histology, epidemiology and anatomic site distribution. Because PM rarely recurs, a watchful waiting approach would be reasonable for lesions excised with positive margins.
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angiomyofibroblastoma of the vulva a Benign neoplasm distinct from aggressive angiomyxoma
The American Journal of Surgical Pathology, 1992Co-Authors: Christopher D M Fletcher, Cyril Fisher, William Y W Tsang, John K C ChanAbstract:Aggressive angiomyxoma of pelvic soft parts is a rare lesion with a high risk of recurrence. We report 10 cases of angiomyofibroblastoma, a hitherto uncharacterized Benign Tumor of the vulva histologically mimicking aggressive angiomyxoma. All patients had a vulval mass, often clinically diagnosed a
Yoon Sik Lee - One of the best experts on this subject based on the ideXlab platform.
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A Case of Huge Benign Tumor of the Ovary
Obstetrics & gynecology science, 2006Co-Authors: Yoon Sik Lee, Sung Il Cha, Chun June Lee, Sung-han Kim, Myeong Su Jeong, So Hee KimAbstract:Recently a huge Benign Tumor of the ovary (greater than 25 pounds) is rare because of early detection and operation. Although infrequently seen, many serious problems associated with the removal of such Tumors have been described, including cardiovascular and respiratory complications. For successful management and good prognosis, it certainly requires slow decompression. We have experienced one case of huge Benign Tumor of the ovary, and report this case with brief review of literatures.