The Experts below are selected from a list of 608937 Experts worldwide ranked by ideXlab platform
Vincent Dorio - One of the best experts on this subject based on the ideXlab platform.
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computed tomographic pulmonary angiography and prognostic significance in patients with acute pulmonary embolism
Heart, 2006Co-Authors: Alexandre Ghuysen, Benoit Ghaye, Valerie Willems, Bernard Lambermont, Paul Gerard, Robert F Dondelinger, Vincent DorioAbstract:Background: Patients with acute pulmonary embolism (APE) present with a broad spectrum of prognoses. Computed tomographic pulmonary angiography (CTPA) has progressively been established as a first line test in the APE diagnostic algorithm, but estimation of short term Prognosis by this method remains to be explored. Methods: …
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computed tomographic pulmonary angiography and prognostic significance in patients with acute pulmonary embolism
Thorax, 2005Co-Authors: Alexandre Ghuysen, Benoit Ghaye, Valerie Willems, Bernard Lambermont, Paul Gerard, Robert F Dondelinger, Vincent DorioAbstract:Background: Patients with acute pulmonary embolism (APE) present with a broad spectrum of prognoses. Computed tomographic pulmonary angiography (CTPA) has progressively been established as a first line test in the APE diagnostic algorithm, but estimation of short term Prognosis by this method remains to be explored. Methods: Eighty two patients admitted with APE were divided into three groups according to their clinical presentation: pulmonary infarction (n = 21), prominent dyspnoea (n = 29), and circulatory failure (n = 32). CTPA studies included assessment of both pulmonary obstruction index and right heart overload. Haemodynamic evaluation was based on systolic aortic blood pressure, heart rate, and systolic pulmonary arterial pressure obtained non-invasively by echocardiography at the time of diagnosis of pulmonary embolism. Results: The mortality rate was 0%, 13.8% and 25% in the three groups, respectively. Neither the pulmonary obstruction index nor the pulmonary artery pressure could predict patient outcome. In contrast, a significant correlation with mortality was found using the systolic blood pressure (p Conclusion: These results suggest that CTPA quantification of right ventricular strain is an accurate predictor of in-hospital death related to pulmonary embolism.
Alexandre Ghuysen - One of the best experts on this subject based on the ideXlab platform.
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computed tomographic pulmonary angiography and prognostic significance in patients with acute pulmonary embolism
Heart, 2006Co-Authors: Alexandre Ghuysen, Benoit Ghaye, Valerie Willems, Bernard Lambermont, Paul Gerard, Robert F Dondelinger, Vincent DorioAbstract:Background: Patients with acute pulmonary embolism (APE) present with a broad spectrum of prognoses. Computed tomographic pulmonary angiography (CTPA) has progressively been established as a first line test in the APE diagnostic algorithm, but estimation of short term Prognosis by this method remains to be explored. Methods: …
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computed tomographic pulmonary angiography and prognostic significance in patients with acute pulmonary embolism
Thorax, 2005Co-Authors: Alexandre Ghuysen, Benoit Ghaye, Valerie Willems, Bernard Lambermont, Paul Gerard, Robert F Dondelinger, Vincent DorioAbstract:Background: Patients with acute pulmonary embolism (APE) present with a broad spectrum of prognoses. Computed tomographic pulmonary angiography (CTPA) has progressively been established as a first line test in the APE diagnostic algorithm, but estimation of short term Prognosis by this method remains to be explored. Methods: Eighty two patients admitted with APE were divided into three groups according to their clinical presentation: pulmonary infarction (n = 21), prominent dyspnoea (n = 29), and circulatory failure (n = 32). CTPA studies included assessment of both pulmonary obstruction index and right heart overload. Haemodynamic evaluation was based on systolic aortic blood pressure, heart rate, and systolic pulmonary arterial pressure obtained non-invasively by echocardiography at the time of diagnosis of pulmonary embolism. Results: The mortality rate was 0%, 13.8% and 25% in the three groups, respectively. Neither the pulmonary obstruction index nor the pulmonary artery pressure could predict patient outcome. In contrast, a significant correlation with mortality was found using the systolic blood pressure (p Conclusion: These results suggest that CTPA quantification of right ventricular strain is an accurate predictor of in-hospital death related to pulmonary embolism.
Francois Alhencgelas - One of the best experts on this subject based on the ideXlab platform.
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prognostic value of the insertion deletion polymorphism of angiotensin i converting enzyme gene in type 2 diabetic subjects results from the diabhycar diab2nephrogene surdiagene studies
Diabetes Care, 2008Co-Authors: Samy Hadjadj, Frederic Fumeron, Ronan Roussel, Pierrejean Saulnier, Y Gallois, Amos Ankotche, F Travert, Charbel Abi Khalil, Aurelie Miot, Francois AlhencgelasAbstract:Abstract Objective: We tested whether determining the Angiotensin I Converting Enzyme (ACE) Insertion/Deletion (I/D) polymorphism is useful for renal and cardiovascular prognoses of type 2 diabetic subjects. Design: the French participants (3126 of the 4912) in the DIABHYCAR trial were studied for their Prognosis over 4 years according to their ACE I/D polymorphism. We used 2 cohorts of French type 2 diabetic patients for replication: a 3-year follow-up study (n = 917, SURDIAGENE study) and a case-control study on diabetic nephropathy (n = 1277, DIAB2NEPHROGENE study). We investigated the effect of I/D polymorphism on primary outcome in the DIABHYCAR trial (first of the following events to occur: cardiovascular death, non-fatal myocardial infarction, stroke, heart failure leading to hospital admission, end-stage renal failure) and its components. Results: In DIABHYCAR, primary outcome and most of its components were not affected by the ACE I/D genotype. Only renal outcome was favored by the I allele (p = 0.03). The risk of myocardial infarction was not affected by ACE genotype, but the probability of fatal issue increased with the number of D alleles (p Conclusion: We were not able to demonstrate the manifest usefulness of ACE I/D polymorphism for the Prognosis of type 2 diabetic subjects.
Michael Snyde - One of the best experts on this subject based on the ideXlab platform.
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predicting non small cell lung cancer Prognosis by fully automated microscopic pathology image features
Nature Communications, 2016Co-Authors: Ce Zhang, Gerald J Erry, Russ Altma, Daniel L Rubi, Michael SnydeAbstract:Lung cancer is the most prevalent cancer worldwide, and histopathological assessment is indispensable for its diagnosis. However, human evaluation of pathology slides cannot accurately predict patients' prognoses. In this study, we obtain 2,186 haematoxylin and eosin stained histopathology whole-slide images of lung adenocarcinoma and squamous cell carcinoma patients from The Cancer Genome Atlas (TCGA), and 294 additional images from Stanford Tissue Microarray (TMA) Database. We extract 9,879 quantitative image features and use regularized machine-learning methods to select the top features and to distinguish shorter-term survivors from longer-term survivors with stage I adenocarcinoma (P<0.003) or squamous cell carcinoma (P=0.023) in the TCGA data set. We validate the survival prediction framework with the TMA cohort (P<0.036 for both tumour types). Our results suggest that automatically derived image features can predict the Prognosis of lung cancer patients and thereby contribute to precision oncology. Our methods are extensible to histopathology images of other organs.
Daniel P K Ng - One of the best experts on this subject based on the ideXlab platform.
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prognostic value of the insertion deletion polymorphism of the ace gene in type 2 diabetic subjects results from the non insulin dependent diabetes hypertension microalbuminuria or proteinuria cardiovascular events and ramipril diabhycar diabete de t
Diabetes Care, 2008Co-Authors: Daniel P K NgAbstract:OBJECTIVE—We tested whether determination of the ACE insertion/deletion polymorphism is useful for renal and cardiovascular prognoses of type 2 diabetic subjects. RESEARCH DESIGN AND METHODS—The French participants (3,126 of 4,912) in the Non-Insulin-Dependent Diabetes, Hypertension, Microalbuminuria or Proteinuria, Cardiovascular Events, and Ramipril (DIABHYCAR) trial were studied for their Prognosis over 4 years according to their ACE insertion/deletion polymorphism. We used two cohorts of French type 2 diabetic patients for replication: a 3-year follow-up study (n = 917; Survie, Diabete de type 2 et Genetique [SURDIAGENE] study) and a case-control study on diabetic nephropathy (n = 1,277; Diabete de type 2, Nephropathie et Genetique [DIAB2NEPHROGENE] study). We investigated the effect of the insertion/deletion polymorphism on the primary outcome in the DIABHYCAR trial (defined as the first of the following events to occur: cardiovascular death, nonfatal myocardial infarction, stroke, heart failure leading to hospital admission, or end-stage renal failure) and its components. RESULTS—In DIABHYCAR, the primary outcome and most of its components were not affected by the ACE insertion/deletion genotype. Only renal outcome was favored by the I allele (P = 0.03). The risk of myocardial infarction was not affected by ACE genotype, but the probability of fatal outcome increased with the number of D alleles (P < 0.03). In SURDIAGENE, the association between the ACE I allele and renal outcome was not replicated. In DIAB2NEPHROGENE, no association was found with nephropathy. CONCLUSIONS—We were not able to demonstrate the manifest usefulness of the ACE insertion/deletion polymorphism for the Prognosis of type 2 diabetic subjects.