The Experts below are selected from a list of 13266 Experts worldwide ranked by ideXlab platform
Sandra J Bell - One of the best experts on this subject based on the ideXlab platform.
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determination of combined Benzidine in fd c yellow no 6 sunset yellow fcf
Food and Chemical Toxicology, 1995Co-Authors: Martha D. Peiperl, Michael J Prival, Sandra J BellAbstract:Samples from 67 manufactured lots of FDC Colour Index No. 15985) were analysed for combined Benzidine. These samples were selected from those submitted to the US Food and Drug Administration for certification between October 1991 and December 1992 by 13 dye distributors. Dithionite was used to reduce any combined Benzidine present in the form of azo or disazo dyes to free Benzidine. This reduction was followed by extraction, diazotization and coupling with 2-naphthol-3,6-disulfonic acid disodium salt (R salt). The total Benzidine was quantified as Benzidine-R salt disazo dye by HPLC with detection at 540 nm and a quantification limit of 10 ng Benzidine/g FD&C Yellow No. 6. Of the 67 samples analysed, 34 were found to contain more than 10 ng combined Benzidine/g. Of these, 30 samples were from one manufacturing company, including three of its subsidiaries. The level of combined Benzidine found ranged from 11 to 104 ng/g, except for one sample containing 941 ng/g.
Martha D. Peiperl - One of the best experts on this subject based on the ideXlab platform.
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determination of combined Benzidine in fd c yellow no 6 sunset yellow fcf
Food and Chemical Toxicology, 1995Co-Authors: Martha D. Peiperl, Michael J Prival, Sandra J BellAbstract:Samples from 67 manufactured lots of FDC Colour Index No. 15985) were analysed for combined Benzidine. These samples were selected from those submitted to the US Food and Drug Administration for certification between October 1991 and December 1992 by 13 dye distributors. Dithionite was used to reduce any combined Benzidine present in the form of azo or disazo dyes to free Benzidine. This reduction was followed by extraction, diazotization and coupling with 2-naphthol-3,6-disulfonic acid disodium salt (R salt). The total Benzidine was quantified as Benzidine-R salt disazo dye by HPLC with detection at 540 nm and a quantification limit of 10 ng Benzidine/g FD&C Yellow No. 6. Of the 67 samples analysed, 34 were found to contain more than 10 ng combined Benzidine/g. Of these, 30 samples were from one manufacturing company, including three of its subsidiaries. The level of combined Benzidine found ranged from 11 to 104 ng/g, except for one sample containing 941 ng/g.
Michael J Prival - One of the best experts on this subject based on the ideXlab platform.
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determination of combined Benzidine in fd c yellow no 6 sunset yellow fcf
Food and Chemical Toxicology, 1995Co-Authors: Martha D. Peiperl, Michael J Prival, Sandra J BellAbstract:Samples from 67 manufactured lots of FDC Colour Index No. 15985) were analysed for combined Benzidine. These samples were selected from those submitted to the US Food and Drug Administration for certification between October 1991 and December 1992 by 13 dye distributors. Dithionite was used to reduce any combined Benzidine present in the form of azo or disazo dyes to free Benzidine. This reduction was followed by extraction, diazotization and coupling with 2-naphthol-3,6-disulfonic acid disodium salt (R salt). The total Benzidine was quantified as Benzidine-R salt disazo dye by HPLC with detection at 540 nm and a quantification limit of 10 ng Benzidine/g FD&C Yellow No. 6. Of the 67 samples analysed, 34 were found to contain more than 10 ng combined Benzidine/g. Of these, 30 samples were from one manufacturing company, including three of its subsidiaries. The level of combined Benzidine found ranged from 11 to 104 ng/g, except for one sample containing 941 ng/g.
Marcia L A Temperini - One of the best experts on this subject based on the ideXlab platform.
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spectroscopic characterization of doped poly Benzidine and its nanocomposite with cationic clay
Journal of Physical Chemistry B, 2004Co-Authors: Gustavo Do M Nascimento, Vera R L Constantino, Marcia L A TemperiniAbstract:The resonance Raman spectroscopic characterization of doped poly(Benzidine) and poly(Benzidine)−clay nanocomposites is reported for the first time. The montmorillonite clay was used as a host struc...
H. -g. Neumann - One of the best experts on this subject based on the ideXlab platform.
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Biomonitoring of aromatic amines III: Hemoglobin binding of Benzidine and some Benzidine congeners
Archives of Toxicology, 1990Co-Authors: G. Birner, W. Albrecht, H. -g. NeumannAbstract:Covalent binding of Benzidine and some congeners to hemoglobin was studied in female Wistar rats after oral administration. Hemoglobin adducts were hydrolyzed under alkaline conditions, and the arylamines extracted and analysed by HPLC with electrochemical detector. With Benzidine, three cleavage products were observed, the major component being monoacetylBenzidine. This indicates that 4-nitroso-4′-N-acetylaminobiphenyl is the major reactive metabolite in erythrocytes. In addition Benzidine and 4-aminobiphenyl were identified. The latter indicates a hitherto unknown metabolic pathway of Benzidine. With 3,3′-dichloroBenzidine-dihydrochloride, 3,3′-dimethoxyBenzidine and 3,3′-dimethylBenzidine two cleavage products were observed, the parent diamines being present in excess to or in amounts comparable to the monoacetyl derivative. With 3,3′,5,5′-tetramethylBenzidine a hemoglobin adduct could not be found. When the azo dye direct red 28 was administered to the animals, the three cleavage products typical for Benzidine were found, indicating that Benzidine became bioavailable after reductive cleavage of the azo compound. In this case the fraction of 4-aminobiphenyl was greater than after Benzidine. It is proposed to use the analysis of hemoglobin adducts in human blood to control the exposure of individuals to these carcinogenic chemicals in the course of biochemical effect monitoring.