The Experts below are selected from a list of 147 Experts worldwide ranked by ideXlab platform
Yi Pang - One of the best experts on this subject based on the ideXlab platform.
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efficient synthesis of nir emitting bis 2 2 hydroxylphenyl Benzoxazole Derivative and its potential for imaging applications
Bioorganic Chemistry, 2020Co-Authors: Junfeng Wang, Hannah J Baumann, Xiaoman Bi, Leah P Shriver, Zhaoda Zhang, Yi PangAbstract:Abstract Unassymetric bis[2-(2′-hydroxyphenylbenzoxole)] bis(HBO) Derivatives with a DPA functionality for zinc binding have been developed with an efficient synthetic route, using the retrosynthetic analysis. Comparison of bis(HBO) Derivatives with different substitution patterns allows us to verify and optimize their unique fluorescence properties. Upon binding zinc cation, bis(HBO) Derivatives give a large fluorescence turn-on in both visible (λem ≈ 536 nm) and near-infrared (NIR) window (λem ≈ 746 nm). The probes are readily excitable by a 488 nm laser, making this series of compounds a suitable imaging tool for in vitro and in vivo study on a confocal microscope. The application of zinc binding-induced fluorescence turn-on is successfully demonstrated in cellular environments and thrombus imaging.
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zn2 triggered excited state intramolecular proton transfer a sensitive probe with near infrared emission from bis Benzoxazole Derivative
Dalton Transactions, 2011Co-Authors: Yongqian Xu, Yi PangAbstract:Near-infrared (NIR) emission can offer distinct advantages for biological applications. A fluorescent sensor, Zinhbo-1, based on bis(Benzoxazole) ligand with 2,2′-dipicolylamine (DPA) as receptor, was synthesized. In aqueous solution, Zinhbo-1 demonstrates high sensitivity and selectivity for sensing Zn2+ with about 10-fold enhancement and nanomolar sensitivity (Kd = 0.29 nM). Moreover, sensor Zinhbo-1 can detect Zn2+ in near-infrared region (over 700 nm) with large Stokes shift (ca. 230 nm) attributing to the Zn2+-induced excited state intramolecular proton transfer (ESIPT).
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zinc binding induced near ir emission from excited state intramolecular proton transfer of a bis Benzoxazole Derivative
Chemical Communications, 2010Co-Authors: Yongqian Xu, Yi PangAbstract:A bis(Benzoxazole) Derivative with metal-chelating ligand (DPA), Zinhbo-1, exhibits a large fluorescence turn-on effect (up to 10-fold) upon zinc-binding. The metal chelation enables excited state intramolecular proton transfer (ESIPT), giving an additional emission band in the near-IR region (∼710 nm) with a large Stokes shift (ca. 230 nm).
Soo Young Park - One of the best experts on this subject based on the ideXlab platform.
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excited state intramolecular proton transfer and charge transfer dynamics of a 2 2 hydroxyphenyl Benzoxazole Derivative in solution
Journal of Physical Chemistry A, 2010Co-Authors: Chul Kim, Jaehun Park, Jangwon Seo, Soo Young Park, Taiha JooAbstract:Excited state intramolecular proton transfer (ESIPT) and subsequent intramolecular charge transfer (ICT) dynamics of a 2-(2′-hydroxyphenyl)Benzoxazole Derivative conjugated with an electron withdrawing group (HBOCE) in solutions and a polymer film has been investigated by femtosecond time-resolved fluorescence (TRF) and TRF spectra measurements without the conventional spectral reconstruction method. TRF with high enough resolution (<100 fs) reveals that the ESIPT dynamics of HBOCE in liquids proceeds by at least two time constants of ∼250 fs and ∼1.2 ps. The relative amplitude of the slower picosecond component is smaller in the polymer film than that in solution. Conformational heterogeneity in the ground state originating from the dispersion of the dihedral angle between the phenolic and Benzoxazole groups is invoked to account for the dispersive ESIPT dynamics in liquids. From the TRF spectra of both the enol and keto isomers, we have identified the ICT reaction of the keto isomer occurring subsequent...
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excited state intramolecular proton transfer and charge transfer dynamics of a 2 2 hydroxyphenyl Benzoxazole Derivative in solution
Journal of Physical Chemistry A, 2010Co-Authors: Jaehun Park, Soo Young ParkAbstract:Excited state intramolecular proton transfer (ESIPT) and subsequent intramolecular charge transfer (ICT) dynamics of a 2-(2′-hydroxyphenyl)Benzoxazole Derivative conjugated with an electron withdrawing group (HBOCE) in solutions and a polymer film has been investigated by femtosecond time-resolved fluorescence (TRF) and TRF spectra measurements without the conventional spectral reconstruction method. TRF with high enough resolution (<100 fs) reveals that the ESIPT dynamics of HBOCE in liquids proceeds by at least two time constants of ∼250 fs and ∼1.2 ps. The relative amplitude of the slower picosecond component is smaller in the polymer film than that in solution. Conformational heterogeneity in the ground state originating from the dispersion of the dihedral angle between the phenolic and Benzoxazole groups is invoked to account for the dispersive ESIPT dynamics in liquids. From the TRF spectra of both the enol and keto isomers, we have identified the ICT reaction of the keto isomer occurring subsequent...
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gelation induced fluorescence enhancement of Benzoxazole based organogel and its naked eye fluoride detection
Chemical Communications, 2008Co-Authors: Moon Soo Choi, Soo Young Park, Byeonghyeok Sohn, Won Seok LyooAbstract:The Benzoxazole Derivative gelator 1 forms a stable DMF/toluene cosolvent gel with dramatically enhanced fluorescence emission compared to its mother solution. The translucent colorless gel was changed to a solution with strong greenish fluorescence in the presence of fluoride anion with disruption of the gel structure.
Jaehun Park - One of the best experts on this subject based on the ideXlab platform.
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excited state intramolecular proton transfer and charge transfer dynamics of a 2 2 hydroxyphenyl Benzoxazole Derivative in solution
Journal of Physical Chemistry A, 2010Co-Authors: Chul Kim, Jaehun Park, Jangwon Seo, Soo Young Park, Taiha JooAbstract:Excited state intramolecular proton transfer (ESIPT) and subsequent intramolecular charge transfer (ICT) dynamics of a 2-(2′-hydroxyphenyl)Benzoxazole Derivative conjugated with an electron withdrawing group (HBOCE) in solutions and a polymer film has been investigated by femtosecond time-resolved fluorescence (TRF) and TRF spectra measurements without the conventional spectral reconstruction method. TRF with high enough resolution (<100 fs) reveals that the ESIPT dynamics of HBOCE in liquids proceeds by at least two time constants of ∼250 fs and ∼1.2 ps. The relative amplitude of the slower picosecond component is smaller in the polymer film than that in solution. Conformational heterogeneity in the ground state originating from the dispersion of the dihedral angle between the phenolic and Benzoxazole groups is invoked to account for the dispersive ESIPT dynamics in liquids. From the TRF spectra of both the enol and keto isomers, we have identified the ICT reaction of the keto isomer occurring subsequent...
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excited state intramolecular proton transfer and charge transfer dynamics of a 2 2 hydroxyphenyl Benzoxazole Derivative in solution
Journal of Physical Chemistry A, 2010Co-Authors: Jaehun Park, Soo Young ParkAbstract:Excited state intramolecular proton transfer (ESIPT) and subsequent intramolecular charge transfer (ICT) dynamics of a 2-(2′-hydroxyphenyl)Benzoxazole Derivative conjugated with an electron withdrawing group (HBOCE) in solutions and a polymer film has been investigated by femtosecond time-resolved fluorescence (TRF) and TRF spectra measurements without the conventional spectral reconstruction method. TRF with high enough resolution (<100 fs) reveals that the ESIPT dynamics of HBOCE in liquids proceeds by at least two time constants of ∼250 fs and ∼1.2 ps. The relative amplitude of the slower picosecond component is smaller in the polymer film than that in solution. Conformational heterogeneity in the ground state originating from the dispersion of the dihedral angle between the phenolic and Benzoxazole groups is invoked to account for the dispersive ESIPT dynamics in liquids. From the TRF spectra of both the enol and keto isomers, we have identified the ICT reaction of the keto isomer occurring subsequent...
Yasuo Sato - One of the best experts on this subject based on the ideXlab platform.
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orally active Benzoxazole Derivative as 5 ht3 receptor partial agonist for treatment of diarrhea predominant irritable bowel syndrome
Journal of Medicinal Chemistry, 2005Co-Authors: Satoshi Yoshida, Sojiro Shiokawa, Kenichi Kawano, Hiroshi Murakami, Hisashi Suzuki, Yasuo SatoAbstract:During our search for therapeutic agents to treat diarrhea-predominant IBS, we found that 2-substituted Benzoxazole Derivatives have a characteristic 5-HT3 receptor partial agonist activity with high affinity. Some of these compounds showed high in vitro metabolical stability, and 6g showed marked antidiarrhetic activity with little side effect of constipation in in vivo tests. Our results indicate that 5-HT3 receptor partial agonists might be superior as therapeutic agents to the drugs currently used for IBS treatment.
Taiha Joo - One of the best experts on this subject based on the ideXlab platform.
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excited state intramolecular proton transfer and charge transfer dynamics of a 2 2 hydroxyphenyl Benzoxazole Derivative in solution
Journal of Physical Chemistry A, 2010Co-Authors: Chul Kim, Jaehun Park, Jangwon Seo, Soo Young Park, Taiha JooAbstract:Excited state intramolecular proton transfer (ESIPT) and subsequent intramolecular charge transfer (ICT) dynamics of a 2-(2′-hydroxyphenyl)Benzoxazole Derivative conjugated with an electron withdrawing group (HBOCE) in solutions and a polymer film has been investigated by femtosecond time-resolved fluorescence (TRF) and TRF spectra measurements without the conventional spectral reconstruction method. TRF with high enough resolution (<100 fs) reveals that the ESIPT dynamics of HBOCE in liquids proceeds by at least two time constants of ∼250 fs and ∼1.2 ps. The relative amplitude of the slower picosecond component is smaller in the polymer film than that in solution. Conformational heterogeneity in the ground state originating from the dispersion of the dihedral angle between the phenolic and Benzoxazole groups is invoked to account for the dispersive ESIPT dynamics in liquids. From the TRF spectra of both the enol and keto isomers, we have identified the ICT reaction of the keto isomer occurring subsequent...